GREMLIN Database
RS15 - 30S ribosomal protein S15
UniProt: P21473 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 89 (87)
Sequences: 2576 (1087)
Seq/√Len: 116.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_E84_K4.0661.00
35_S59_M3.3791.00
7_R10_Q2.7911.00
7_R34_D2.7311.00
75_V79_R2.6681.00
26_E77_R2.5761.00
80_E84_K2.2041.00
13_N16_K2.1111.00
10_Q14_E1.9881.00
17_T21_D1.9651.00
74_D77_R1.8981.00
34_D38_N1.8441.00
41_E44_R1.7651.00
50_H53_R1.7331.00
15_F84_K1.7301.00
33_T37_N1.6851.00
16_K20_S1.5841.00
76_T80_E1.5651.00
54_R58_K1.5111.00
29_I81_L1.4851.00
53_R57_L1.4391.00
78_Y82_I1.4071.00
4_T7_R1.3941.00
57_L60_V1.3681.00
64_R68_T1.3401.00
5_Q9_N1.3361.00
34_D37_N1.3341.00
7_R38_N1.2961.00
68_T71_R1.2710.99
12_I27_V1.2320.99
57_L61_G1.1880.99
80_E83_N1.1810.99
9_N13_N1.1670.99
68_T72_N1.1170.99
43_L61_G1.1140.99
3_I38_N1.0870.98
51_H55_G1.0750.98
52_S55_G1.0740.98
58_K65_N1.0530.98
13_N19_E1.0500.98
61_G65_N1.0260.98
50_H61_G1.0160.97
43_L50_H1.0140.97
3_I31_I1.0080.97
25_P77_R0.9910.97
82_I87_L0.9890.97
77_R80_E0.9870.97
16_K19_E0.9830.97
21_D27_V0.9790.97
82_I86_G0.9680.96
17_T26_E0.9010.95
56_L60_V0.8830.94
40_N43_L0.8650.94
40_N44_R0.8590.93
77_R81_L0.8460.93
70_L77_R0.8440.93
16_K24_S0.8320.92
29_I67_L0.8300.92
43_L53_R0.8220.92
25_P70_L0.8150.91
43_L52_S0.8130.91
12_I31_I0.7980.90
76_T79_R0.7850.90
68_T89_R0.7760.89
44_R47_K0.7670.89
7_R14_E0.7540.88
11_L31_I0.7530.88
10_Q13_N0.7500.88
26_E70_L0.7350.86
21_D25_P0.7300.86
43_L71_R0.7300.86
35_S38_N0.7280.86
27_V32_L0.7260.86
32_L62_K0.7220.85
9_N12_I0.7220.85
79_R83_N0.7190.85
15_F30_A0.7170.85
58_K62_K0.7100.85
32_L59_M0.7000.84
46_H51_H0.6920.83
37_N40_N0.6900.83
21_D24_S0.6880.83
8_K12_I0.6870.83
41_E45_T0.6830.82
35_S40_N0.6750.81
65_N68_T0.6530.79
70_L73_K0.6440.78
58_K61_G0.6410.78
5_Q89_R0.6340.77
40_N64_R0.6340.77
45_T48_K0.6310.77
46_H54_R0.6230.76
21_D30_A0.6200.76
43_L54_R0.6130.75
17_T25_P0.6110.75
29_I70_L0.6070.74
32_L51_H0.6040.74
26_E81_L0.6000.73
85_L88_R0.5970.73
29_I66_L0.5940.73
43_L58_K0.5930.72
15_F81_L0.5900.72
29_I82_I0.5850.71
40_N56_L0.5740.70
25_P29_I0.5620.68
37_N56_L0.5600.68
6_E9_N0.5540.67
11_L34_D0.5530.67
31_I35_S0.5510.67
22_T27_V0.5500.67
71_R75_V0.5490.67
27_V31_I0.5480.66
79_R82_I0.5470.66
11_L15_F0.5460.66
53_R89_R0.5450.66
58_K89_R0.5370.65
35_S62_K0.5340.65
29_I77_R0.5300.64
37_N41_E0.5290.64
62_K65_N0.5280.64
27_V30_A0.5260.63
22_T30_A0.5220.63
55_G66_L0.5210.63
43_L65_N0.5170.62
3_I35_S0.5150.62
44_R87_L0.5090.61
51_H58_K0.5060.60
3_I11_L0.5020.60
48_K67_L0.5010.60
36_I60_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb5O 1 0.9888 100 0.066 Contact Map
4iylA 3 0.9551 100 0.072 Contact Map
1a32A 1 0.9551 100 0.086 Contact Map
4a5uB 1 0.8989 100 0.091 Contact Map
5aj3O 1 1 100 0.114 Contact Map
3bbnO 1 0.9326 100 0.194 Contact Map
3j20Q 1 0.9551 99.9 0.388 Contact Map
4ujpO 1 0.9888 99.4 0.6 Contact Map
3zeyG 1 0.8876 99.4 0.605 Contact Map
4bpeO 1 0.9888 99.4 0.605 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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