GREMLIN Database
RS12 - 30S ribosomal protein S12
UniProt: P21472 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (123)
Sequences: 1273 (360)
Seq/√Len: 32.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_R77_T6.0381.00
54_T62_L3.9121.00
51_G65_Y3.7751.00
42_Q111_V3.4481.00
52_T62_L3.1401.00
51_G77_T2.7921.00
100_V109_H2.6941.00
56_K99_R2.6631.00
79_Y109_H2.3970.99
110_I117_T2.3790.99
76_V95_I2.2710.99
40_S43_K2.0770.98
109_H129_K2.0720.98
56_K100_V1.8190.96
90_H120_V1.7870.95
43_K72_N1.6830.94
2_P7_L1.6490.93
10_K72_N1.6140.92
43_K71_T1.6090.92
12_R23_A1.6070.92
4_I7_L1.6020.92
45_G70_L1.5320.90
56_K104_P1.5010.89
44_R115_L1.4750.88
49_R74_I1.4690.88
124_A135_P1.4040.86
9_R114_A1.3900.85
10_K14_S1.3810.85
7_L10_K1.3670.84
21_S24_L1.3640.84
53_M77_T1.3410.83
78_A110_I1.2820.80
47_C136_K1.2730.79
96_R99_R1.2620.79
64_K79_Y1.2350.77
120_V123_R1.2260.77
96_R109_H1.2130.76
43_K95_I1.1840.74
49_R81_P1.1740.74
119_G134_K1.1670.73
46_V83_I1.1450.72
61_A103_L1.1440.72
125_Q129_K1.1380.71
40_S115_L1.1090.69
14_S124_A1.1060.69
85_H103_L1.1010.69
73_G135_P1.0790.67
17_E20_K1.0760.67
59_N102_D1.0510.65
15_K19_S1.0510.65
15_K18_N1.0440.65
86_N118_A1.0240.63
44_R75_E1.0050.62
67_R84_G1.0040.61
39_S44_R1.0030.61
78_A81_P0.9950.61
47_C51_G0.9790.59
73_G107_R0.9780.59
75_E90_H0.9700.59
54_T124_A0.9540.57
125_Q132_T0.9450.57
125_Q135_P0.9440.57
65_Y77_T0.9290.55
8_I11_G0.9270.55
95_I110_I0.9240.55
19_S22_P0.9220.55
2_P69_R0.9180.55
5_N8_I0.9120.54
117_T122_N0.9040.53
41_P98_G0.9030.53
55_P103_L0.8740.51
1_M7_L0.8740.51
12_R24_L0.8710.51
84_G112_R0.8480.49
61_A102_D0.8440.48
54_T101_K0.8400.48
63_R102_D0.8400.48
56_K59_N0.8340.48
96_R129_K0.8260.47
7_L11_G0.8260.47
84_G113_G0.8260.47
74_I118_A0.8220.47
82_G108_Y0.8160.46
82_G98_G0.8080.45
20_K103_L0.7920.44
82_G120_V0.7870.44
69_R75_E0.7840.44
7_L54_T0.7770.43
86_N91_S0.7760.43
53_M107_R0.7720.43
44_R118_A0.7700.42
50_V124_A0.7690.42
92_V101_K0.7630.42
61_A89_E0.7570.41
101_K107_R0.7530.41
3_T6_Q0.7490.41
41_P82_G0.7470.41
44_R117_T0.7460.40
66_A110_I0.7460.40
41_P44_R0.7460.40
9_R78_A0.7380.40
14_S49_R0.7370.40
49_R53_M0.7360.40
48_T132_T0.7360.40
95_I122_N0.7310.39
25_N74_I0.7300.39
22_P107_R0.7280.39
101_K126_G0.7240.39
76_V105_G0.7230.39
53_M76_V0.7210.38
90_H98_G0.7160.38
113_G120_V0.7160.38
4_I95_I0.7060.37
46_V118_A0.7050.37
62_L115_L0.6960.37
19_S25_N0.6950.36
20_K107_R0.6900.36
9_R17_E0.6900.36
64_K89_E0.6840.36
99_R112_R0.6800.35
126_G130_Y0.6770.35
62_L110_I0.6740.35
77_T117_T0.6730.35
75_E125_Q0.6590.34
82_G90_H0.6510.33
2_P11_G0.6500.33
18_N25_N0.6490.33
39_S93_V0.6410.32
74_I95_I0.6280.31
5_N17_E0.6280.31
68_V113_G0.6230.31
67_R134_K0.6230.31
64_K104_P0.6150.31
8_I40_S0.6130.30
73_G136_K0.6130.30
74_I129_K0.6120.30
65_Y72_N0.6110.30
55_P102_D0.6080.30
13_V122_N0.6080.30
64_K129_K0.6050.30
85_H91_S0.6040.30
122_N125_Q0.6020.30
89_E100_V0.6010.30
132_T135_P0.6000.30
53_M78_A0.5970.29
17_E21_S0.5970.29
25_N71_T0.5960.29
47_C91_S0.5950.29
91_S116_D0.5940.29
4_I22_P0.5880.29
1_M100_V0.5880.29
85_H90_H0.5870.29
113_G119_G0.5830.28
44_R74_I0.5790.28
64_K73_G0.5720.28
21_S40_S0.5710.28
50_V69_R0.5690.27
2_P25_N0.5680.27
11_G14_S0.5670.27
55_P80_I0.5650.27
66_A91_S0.5640.27
70_L105_G0.5620.27
80_I98_G0.5610.27
40_S129_K0.5600.27
10_K126_G0.5600.27
16_V20_K0.5550.27
47_C65_Y0.5540.26
12_R15_K0.5510.26
118_A132_T0.5500.26
53_M67_R0.5480.26
114_A134_K0.5460.26
74_I117_T0.5420.26
57_K91_S0.5390.26
2_P75_E0.5370.25
118_A122_N0.5340.25
5_N135_P0.5320.25
111_V127_R0.5280.25
85_H88_Q0.5180.24
25_N135_P0.5160.24
73_G89_E0.5150.24
81_P117_T0.5150.24
99_R109_H0.5050.23
25_N43_K0.5040.23
41_P45_G0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ji1L 1 0.8913 100 0.098 Contact Map
4rb5L 1 0.8841 100 0.098 Contact Map
5aj3L 1 0.7899 100 0.196 Contact Map
4bpeL 1 0.9058 100 0.253 Contact Map
3j20N 1 0.9203 100 0.255 Contact Map
4ujpY 1 0.9348 100 0.264 Contact Map
3zeyS 1 0.9348 100 0.264 Contact Map
3wbkC 1 0.0072 7.9 0.957 Contact Map
2jpjA 1 0.1159 7.3 0.958 Contact Map
4kzyn 1 0.5725 7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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