GREMLIN Database
RS6 - 30S ribosomal protein S6
UniProt: P21468 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 95 (94)
Sequences: 2193 (1230)
Seq/√Len: 126.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_L35_A3.8271.00
28_N32_S3.4011.00
9_I58_G3.3911.00
36_E66_Q3.3111.00
7_M62_I2.3371.00
38_T66_Q2.0811.00
51_E56_R2.0421.00
20_K42_D1.9911.00
27_N31_T1.9771.00
13_N55_F1.8961.00
24_E28_N1.8831.00
74_E77_R1.8341.00
12_P55_F1.7841.00
76_D88_H1.7791.00
3_K66_Q1.7731.00
11_R55_F1.7241.00
15_D18_S1.6741.00
6_V65_V1.6351.00
27_N40_T1.6151.00
45_K57_D1.6081.00
10_I22_V1.5781.00
6_V79_A1.5461.00
47_R57_D1.5171.00
28_N31_T1.5101.00
24_E27_N1.4991.00
52_I87_R1.4991.00
76_D90_V1.4851.00
10_I14_I1.4831.00
39_G64_N1.4381.00
2_R92_K1.4201.00
55_F86_I1.4091.00
75_F79_A1.3941.00
33_N71_A1.3441.00
6_V75_F1.3011.00
42_D59_F1.2711.00
68_D71_A1.2140.99
8_Y63_V1.2120.99
20_K24_E1.2040.99
67_S72_V1.1900.99
48_L86_I1.1230.99
69_A73_Q1.0950.99
22_V84_D1.0860.99
40_T63_V1.0620.99
31_T36_E1.0520.98
29_V33_N1.0310.98
30_L71_A1.0150.98
77_R81_I1.0070.98
8_Y61_Q0.9990.98
76_D80_K0.9880.98
72_V90_V0.9710.97
6_V90_V0.9220.96
70_A73_Q0.8900.96
16_E20_K0.8890.96
11_R84_D0.8860.95
64_N93_E0.8830.95
10_I85_I0.8690.95
19_K59_F0.8660.95
79_A85_I0.8590.95
21_A24_E0.8570.95
74_E78_L0.8520.94
46_R60_Y0.8350.94
42_D61_Q0.8250.93
25_R82_S0.8060.93
47_R59_F0.8020.92
7_M91_V0.7990.92
27_N63_V0.7980.92
26_F79_A0.7970.92
73_Q76_D0.7830.92
46_R87_R0.7780.91
43_W62_I0.7760.91
26_F75_F0.7710.91
29_V77_R0.7630.90
29_V78_L0.7600.90
26_F47_R0.7500.90
8_Y27_N0.7370.89
33_N68_D0.7370.89
31_T37_I0.7350.89
29_V71_A0.7300.88
26_F82_S0.7290.88
23_I61_Q0.7250.88
9_I86_I0.7220.88
10_I58_G0.7210.88
67_S71_A0.7100.87
65_V79_A0.6940.86
19_K42_D0.6820.85
78_L82_S0.6780.84
80_K88_H0.6700.84
25_R83_D0.6480.82
24_E40_T0.6470.82
35_A71_A0.6410.81
29_V74_E0.6370.81
18_S21_A0.6360.80
7_M89_I0.6350.80
78_L94_E0.6330.80
47_R56_R0.6310.80
71_A75_F0.6250.79
78_L81_I0.6110.78
19_K45_K0.6110.78
26_F78_L0.6100.78
13_N46_R0.6100.78
10_I23_I0.6060.77
38_T64_N0.6020.77
8_Y58_G0.6000.77
22_V26_F0.5990.76
27_N89_I0.5960.76
14_I22_V0.5900.75
16_E19_K0.5900.75
16_E59_F0.5860.75
53_N86_I0.5860.75
2_R69_A0.5850.75
69_A72_V0.5840.75
40_T61_Q0.5770.74
74_E91_V0.5710.73
8_Y23_I0.5600.72
17_E21_A0.5580.71
65_V90_V0.5480.70
7_M43_W0.5440.69
16_E45_K0.5390.69
11_R56_R0.5340.68
7_M93_E0.5330.68
30_L75_F0.5320.68
6_V63_V0.5270.67
45_K59_F0.5260.67
6_V81_I0.5250.67
25_R47_R0.5220.66
7_M44_G0.5210.66
64_N85_I0.5190.66
51_E54_D0.5150.65
43_W46_R0.5140.65
23_I27_N0.5130.65
18_S22_V0.5100.64
12_P16_E0.5060.64
27_N61_Q0.5040.64
22_V25_R0.5030.63
88_H91_V0.5030.63
37_I63_V0.5030.63
46_R79_A0.5020.63
69_A76_D0.5020.63
79_A88_H0.5020.63
34_G56_R0.5020.63
14_I19_K0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vmbA 1 1 100 0.1 Contact Map
1cqmA 1 1 100 0.104 Contact Map
3r3tA 3 0.9895 100 0.106 Contact Map
2j5aA 1 1 100 0.11 Contact Map
3bbnF 1 1 100 0.112 Contact Map
4kiyF 1 0.9895 100 0.116 Contact Map
4tp8F 1 0.9895 100 0.12 Contact Map
5aj3F 1 0.9789 100 0.167 Contact Map
2kjwA 1 0.5684 99.8 0.434 Contact Map
3zzpA 1 0.4105 99.1 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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