GREMLIN Database
RS3 - 30S ribosomal protein S3
UniProt: P21465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (208)
Sequences: 2445 (1148)
Seq/√Len: 79.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_S111_D5.5701.00
115_V201_I4.4761.00
189_D194_K4.1011.00
187_E194_K3.9621.00
45_R89_A3.4761.00
110_L145_A3.2641.00
82_E85_A2.9811.00
66_T101_N2.8921.00
43_S113_Q2.7151.00
140_T148_V2.6851.00
135_Q139_R2.6641.00
124_E188_A2.4901.00
202_Y205_E2.4171.00
127_V132_A2.2561.00
151_M164_S2.1931.00
113_Q117_D2.1211.00
112_A182_D2.0871.00
69_T75_V1.9731.00
16_R19_E1.9531.00
171_T202_Y1.9451.00
119_I150_T1.9061.00
117_D186_S1.8361.00
27_D30_D1.8171.00
46_L75_V1.7951.00
123_L129_F1.7431.00
8_V19_E1.7401.00
21_K55_E1.7291.00
19_E53_K1.7261.00
179_A202_Y1.7111.00
53_K68_H1.7041.00
119_I132_A1.6991.00
8_V16_R1.6721.00
28_Y32_L1.6641.00
68_H103_L1.6291.00
113_Q185_T1.6211.00
16_R180_D1.5791.00
43_S117_D1.5731.00
46_L86_L1.5711.00
113_Q186_S1.5510.99
151_M166_Y1.5510.99
146_Q171_T1.5420.99
113_Q184_A1.5370.99
10_L14_V1.5210.99
33_H37_K1.5150.99
180_D203_R1.5030.99
17_D21_K1.4870.99
153_S164_S1.4680.99
37_K93_L1.4550.99
133_Q167_Y1.4360.99
116_A186_S1.4330.99
119_I136_Q1.4320.99
15_I206_V1.4290.99
34_E96_K1.4140.99
41_Y89_A1.4010.99
21_K57_E1.3480.99
168_S171_T1.3280.98
110_L140_T1.3220.98
84_E88_K1.3220.98
10_L177_L1.3160.98
168_S172_V1.3110.98
33_H36_L1.3070.98
152_V195_L1.3040.98
85_A88_K1.2980.98
50_S69_T1.2950.98
18_W21_K1.2760.98
28_Y33_H1.2720.98
91_N97_R1.2630.98
166_Y171_T1.2610.98
129_F156_L1.2590.98
32_L36_L1.2580.98
63_V96_K1.2540.98
85_A89_A1.2260.97
137_I150_T1.2250.97
44_K47_S1.2100.97
134_K157_G1.2040.97
10_L15_I1.2030.97
42_I51_V1.1950.97
62_R97_R1.1940.97
118_N121_R1.1930.97
79_G135_Q1.1870.97
49_A69_T1.1750.96
137_I148_V1.1610.96
149_K174_L1.1450.96
42_I54_V1.1380.96
123_L195_L1.1330.96
73_G104_E1.1310.96
14_V177_L1.1170.95
57_E64_N1.1120.95
115_V136_Q1.1080.95
173_P179_A1.1020.95
88_K92_S1.1010.95
37_K40_E1.1000.95
121_R125_N1.0960.95
6_N10_L1.0940.95
88_K91_N1.0920.95
66_T103_L1.0830.94
116_A199_V1.0770.94
8_V12_I1.0740.94
116_A197_V1.0670.94
45_R85_A1.0640.94
133_Q152_V1.0580.94
43_S47_S1.0240.93
49_A74_M1.0220.92
29_A33_H1.0110.92
53_K111_D1.0060.92
117_D121_R0.9900.91
128_S157_G0.9760.91
36_L40_E0.9710.90
65_I100_I0.9710.90
77_G80_G0.9700.90
115_V140_T0.9630.90
120_A186_S0.9570.90
138_Q169_E0.9480.89
9_G13_G0.9430.89
120_A197_V0.9420.89
72_P76_I0.9370.89
42_I46_L0.9290.88
41_Y90_L0.9130.88
15_I19_E0.9070.87
7_P11_R0.9000.87
73_G77_G0.8990.87
123_L165_E0.8980.87
62_R99_H0.8980.87
90_L98_V0.8970.87
5_V10_L0.8930.86
81_S85_A0.8910.86
5_V101_N0.8840.86
153_S161_I0.8830.86
129_F165_E0.8680.85
180_D206_V0.8630.84
94_T98_V0.8490.83
182_D203_R0.8470.83
72_P77_G0.8420.83
173_P202_Y0.8420.83
83_V94_T0.8410.83
73_G80_G0.8370.83
16_R203_R0.8360.82
73_G76_I0.8320.82
150_T167_Y0.8300.82
46_L51_V0.8240.82
44_K93_L0.8210.81
140_T201_I0.8160.81
27_D31_F0.8060.80
139_R142_R0.7950.79
118_N122_Q0.7920.79
110_L201_I0.7910.79
183_Y200_W0.7890.79
127_V131_R0.7890.79
73_G78_K0.7860.78
51_V67_I0.7860.78
172_V202_Y0.7840.78
80_G104_E0.7830.78
156_L192_Y0.7820.78
137_I167_Y0.7810.78
30_D33_H0.7770.78
156_L195_L0.7750.77
12_I17_D0.7740.77
133_Q184_A0.7700.77
179_A204_G0.7680.77
35_D39_R0.7650.77
138_Q142_R0.7510.75
34_E37_K0.7480.75
35_D56_I0.7470.75
193_G196_G0.7460.75
75_V102_I0.7400.74
24_A31_F0.7390.74
109_D139_R0.7360.74
118_N172_V0.7320.73
91_N99_H0.7280.73
76_I80_G0.7270.73
35_D126_R0.7230.72
155_R192_Y0.7230.72
55_E68_H0.7190.72
110_L203_R0.7170.72
79_G139_R0.7140.71
130_R165_E0.7090.71
146_Q202_Y0.7020.70
27_D79_G0.7010.70
19_E55_E0.6990.70
146_Q204_G0.6920.69
107_R143_A0.6910.69
150_T166_Y0.6900.69
71_K90_L0.6850.68
42_I65_I0.6840.68
6_N171_T0.6810.68
4_K190_T0.6810.68
1_M11_R0.6780.67
39_R56_I0.6760.67
135_Q138_Q0.6740.67
129_F191_T0.6660.66
44_K92_S0.6640.66
25_G100_I0.6620.66
129_F157_G0.6610.66
175_H202_Y0.6610.66
55_E66_T0.6610.66
123_L130_R0.6600.65
58_R112_A0.6590.65
25_G172_V0.6580.65
175_H179_A0.6580.65
109_D143_A0.6550.65
3_Q142_R0.6540.65
123_L136_Q0.6530.65
93_L98_V0.6530.65
166_Y172_V0.6530.65
105_I114_L0.6510.64
150_T197_V0.6500.64
110_L143_A0.6460.64
161_I165_E0.6430.63
141_M145_A0.6410.63
71_K208_P0.6410.63
39_R54_V0.6370.63
174_L200_W0.6360.63
41_Y45_R0.6300.62
151_M168_S0.6300.62
174_L190_T0.6260.61
173_P198_K0.6250.61
49_A72_P0.6250.61
183_Y198_K0.6240.61
149_K155_R0.6240.61
12_I168_S0.6200.61
120_A124_E0.6180.60
30_D96_K0.6170.60
1_M7_P0.6140.60
47_S54_V0.6140.60
83_V102_I0.6120.60
55_E82_E0.6070.59
44_K67_I0.6050.59
89_A197_V0.6050.59
140_T145_A0.6050.59
152_V157_G0.6050.59
125_N161_I0.6050.59
163_R178_R0.6020.58
140_T203_R0.6010.58
65_I95_G0.6000.58
40_E43_S0.5980.58
138_Q208_P0.5980.58
145_A156_L0.5960.58
192_Y195_L0.5950.57
1_M4_K0.5940.57
116_A184_A0.5900.57
22_W35_D0.5880.57
137_I202_Y0.5880.57
161_I164_S0.5870.56
155_R160_D0.5870.56
29_A36_L0.5870.56
12_I15_I0.5860.56
57_E66_T0.5860.56
50_S70_A0.5850.56
42_I67_I0.5830.56
134_K162_A0.5800.56
134_K174_L0.5770.55
69_T156_L0.5770.55
109_D115_V0.5770.55
4_K11_R0.5760.55
137_I169_E0.5740.55
133_Q150_T0.5720.55
23_Y36_L0.5710.54
109_D118_N0.5690.54
17_D201_I0.5690.54
71_K77_G0.5680.54
132_A152_V0.5680.54
48_D107_R0.5670.54
15_I208_P0.5670.54
31_F65_I0.5660.54
47_S124_E0.5650.54
40_E44_K0.5630.53
64_N125_N0.5630.53
15_I18_W0.5630.53
151_M200_W0.5610.53
176_T179_A0.5600.53
119_I199_V0.5570.53
126_R188_A0.5540.52
140_T143_A0.5520.52
126_R163_R0.5510.52
51_V69_T0.5490.52
64_N101_N0.5480.51
28_Y168_S0.5460.51
32_L39_R0.5430.51
90_L93_L0.5430.51
129_F161_I0.5430.51
63_V94_T0.5420.51
161_I166_Y0.5360.50
39_R159_A0.5340.50
147_G154_G0.5340.50
107_R110_L0.5330.50
64_N85_A0.5320.49
83_V101_N0.5300.49
4_K7_P0.5300.49
131_R135_Q0.5280.49
12_I171_T0.5270.49
65_I99_H0.5260.49
35_D58_R0.5260.49
84_E87_R0.5240.48
133_Q181_I0.5220.48
110_L115_V0.5210.48
108_A144_G0.5200.48
128_S161_I0.5190.48
59_A87_R0.5170.47
188_A195_L0.5160.47
31_F96_K0.5160.47
38_I99_H0.5140.47
39_R179_A0.5130.47
38_I41_Y0.5110.47
111_D182_D0.5080.46
174_L181_I0.5080.46
134_K141_M0.5070.46
36_L46_L0.5030.46
45_R60_A0.5030.46
111_D203_R0.5030.46
178_R204_G0.5010.45
59_A62_R0.5000.45
90_L94_T0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb5C 1 0.9404 100 0.025 Contact Map
4kiyC 1 0.9404 100 0.032 Contact Map
3bbnC 1 0.9404 100 0.052 Contact Map
4tp8C 1 0.9404 100 0.057 Contact Map
3j20C 1 0.8394 100 0.269 Contact Map
4ujpE 1 0.9083 100 0.289 Contact Map
4w23D 1 0.8991 100 0.293 Contact Map
3j7aD 1 0.6651 100 0.297 Contact Map
3zeyX 1 0.8761 100 0.306 Contact Map
4bpeC 1 0.9128 100 0.307 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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