GREMLIN Database
RS2 - 30S ribosomal protein S2
UniProt: P21464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (229)
Sequences: 2233 (909)
Seq/√Len: 60.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_K85_Q4.4331.00
65_G159_D4.0501.00
92_V100_T3.2471.00
83_E86_R3.1921.00
186_I202_A3.1071.00
162_F217_M3.0591.00
57_T217_M3.0151.00
49_K52_E2.9851.00
56_F184_I2.8671.00
118_E152_K2.7701.00
113_R140_E2.7541.00
31_I189_T2.6381.00
83_E215_S2.5941.00
121_Q138_K2.5671.00
220_A224_A2.4961.00
60_L160_A2.4881.00
119_K123_N2.4621.00
145_E149_G2.3291.00
177_R195_E2.3281.00
61_A67_I2.3221.00
163_I183_I2.3191.00
57_T184_I2.3021.00
161_L176_A2.2981.00
86_R219_D2.2041.00
87_S221_I2.1451.00
124_G127_D2.1241.00
60_L65_G2.0721.00
118_E141_L2.0201.00
26_K194_D1.9731.00
160_A184_I1.9541.00
186_I213_L1.8921.00
50_V216_K1.8341.00
121_Q126_F1.8201.00
76_A210_V1.8021.00
14_V202_A1.7720.99
56_F160_A1.7590.99
41_I189_T1.7530.99
60_L184_I1.7460.99
141_L145_E1.7130.99
58_K223_E1.6900.99
121_Q141_L1.6890.99
54_Y220_A1.6790.99
42_D45_K1.6730.99
174_A178_K1.6720.99
187_V199_V1.6660.99
9_L14_V1.6410.99
177_R197_D1.6210.99
79_S83_E1.5880.99
126_F129_L1.5460.98
162_F214_T1.4920.98
126_F134_V1.4860.98
117_I137_L1.4640.98
121_Q124_G1.4470.98
115_K153_D1.4470.98
94_Q147_F1.4400.98
14_V209_A1.4240.97
86_R222_L1.3940.97
164_I186_I1.3760.97
24_N192_D1.3610.96
170_R174_A1.3590.96
10_L14_V1.3540.96
13_G16_F1.3510.96
4_I50_V1.3420.96
215_S219_D1.3400.96
18_H205_D1.3190.96
138_K142_E1.3190.96
177_R183_I1.3170.96
185_G196_I1.3110.96
115_K152_K1.3000.95
118_E145_E1.2740.95
3_V54_Y1.2590.95
94_Q146_K1.2470.94
135_V139_K1.2380.94
56_F60_L1.2360.94
173_V196_I1.2360.94
188_D205_D1.2340.94
23_W39_Y1.2250.94
30_Y49_K1.2200.94
49_K201_P1.1950.93
52_E55_N1.1830.93
105_E109_K1.1820.92
61_A221_I1.1720.92
66_K159_D1.1710.92
157_L181_I1.1600.92
166_P196_I1.1490.91
167_R191_C1.1450.91
59_N63_E1.1410.91
129_L137_L1.1390.91
56_F198_V1.1300.91
145_E152_K1.1230.90
83_E218_A1.1140.90
112_K116_D1.1100.90
54_Y217_M1.1060.90
66_K90_Y1.0820.89
138_K141_L1.0810.89
159_D182_P1.0800.89
26_K192_D1.0770.88
104_F156_D1.0740.88
136_Q139_K1.0730.88
176_A183_I1.0720.88
20_T34_E1.0710.88
73_K76_A1.0680.88
8_Q216_K1.0510.87
61_A225_K1.0460.87
82_E211_K1.0460.87
117_I141_L1.0360.86
45_K49_K1.0260.86
221_I225_K1.0250.86
77_Q104_F1.0180.85
97_L100_T1.0170.85
95_R98_G1.0150.85
81_K93_N1.0150.85
58_K227_G1.0090.85
54_Y216_K1.0060.85
55_N58_K0.9990.84
70_V161_L0.9970.84
170_R195_E0.9940.84
26_K150_G0.9930.84
154_M157_L0.9830.83
187_V196_I0.9780.83
129_L134_V0.9780.83
110_R113_R0.9650.82
130_P135_V0.9650.82
107_I151_I0.9630.82
128_V134_V0.9610.82
9_L50_V0.9580.82
86_R218_A0.9380.80
57_T221_I0.9240.79
77_Q94_Q0.9220.79
30_Y199_V0.9170.79
68_L161_L0.9100.78
125_T129_L0.9050.78
120_M124_G0.9010.78
132_K136_Q0.8930.77
127_D134_V0.8820.76
228_E231_A0.8750.76
83_E211_K0.8710.75
71_G76_A0.8690.75
115_K155_K0.8680.75
163_I173_V0.8640.75
6_M14_V0.8610.74
202_A209_A0.8560.74
18_H204_D0.8550.74
188_D204_D0.8540.74
120_M129_L0.8510.74
211_K215_S0.8450.73
5_S8_Q0.8450.73
101_L179_L0.8430.73
90_Y166_P0.8420.73
134_V138_K0.8380.72
18_H188_D0.8380.72
124_G134_V0.8360.72
87_S218_A0.8300.72
173_V183_I0.8290.72
53_A199_V0.8230.71
73_K169_E0.8230.71
113_R117_I0.8220.71
216_K219_D0.8160.70
60_L159_D0.8110.70
67_I160_A0.8020.69
120_M125_T0.8020.69
126_F137_L0.8010.69
87_S222_L0.8000.69
97_L148_L0.7940.68
66_K89_M0.7940.68
78_D117_I0.7920.68
57_T67_I0.7910.68
50_V213_L0.7900.68
79_S210_V0.7870.68
119_K122_E0.7830.67
5_S178_K0.7830.67
200_I213_L0.7740.66
85_Q91_Y0.7730.66
116_D120_M0.7670.66
58_K224_A0.7630.65
22_R75_Q0.7620.65
67_I221_I0.7540.64
28_K39_Y0.7540.64
222_L226_Q0.7510.64
202_A213_L0.7440.63
57_T160_A0.7400.63
60_L67_I0.7380.63
213_L217_M0.7320.62
62_A227_G0.7320.62
3_V50_V0.7300.62
214_T217_M0.7260.61
125_T128_V0.7240.61
166_P185_G0.7240.61
97_L106_T0.7220.61
226_Q229_E0.7220.61
56_F59_N0.7210.61
61_A89_M0.7210.61
166_P195_E0.7170.60
4_I216_K0.7160.60
83_E219_D0.7140.60
8_Q11_E0.7000.59
183_I195_E0.6990.58
126_F152_K0.6990.58
47_V186_I0.6980.58
187_V191_C0.6970.58
196_I199_V0.6950.58
89_M225_K0.6930.58
184_I198_V0.6910.58
58_K62_A0.6910.58
140_E167_R0.6850.57
24_N194_D0.6830.57
92_V151_I0.6830.57
121_Q127_D0.6820.57
219_D222_L0.6790.56
33_T50_V0.6780.56
80_V164_I0.6780.56
185_G199_V0.6760.56
143_R147_F0.6700.55
79_S208_R0.6690.55
10_L35_R0.6680.55
66_K225_K0.6670.55
7_K162_F0.6600.54
106_T179_L0.6590.54
61_A159_D0.6590.54
22_R167_R0.6580.54
16_F205_D0.6580.54
59_N62_A0.6460.53
120_M126_F0.6460.53
67_I162_F0.6460.53
193_P205_D0.6450.52
38_I206_A0.6450.52
16_F75_Q0.6440.52
85_Q136_Q0.6420.52
200_I217_M0.6410.52
120_M137_L0.6410.52
58_K226_Q0.6390.52
192_D195_E0.6370.52
165_D168_K0.6360.51
81_K118_E0.6340.51
79_S209_A0.6330.51
85_Q153_D0.6280.51
161_L172_A0.6260.50
109_K148_L0.6240.50
51_E110_R0.6210.50
135_V138_K0.6190.50
164_I169_E0.6160.49
114_L141_L0.6140.49
76_A169_E0.6130.49
114_L152_K0.6110.49
113_R208_R0.6090.48
78_D126_F0.6000.47
73_K165_D0.6000.47
108_Q112_K0.5940.47
89_M104_F0.5920.46
130_P134_V0.5920.46
224_A228_E0.5920.46
80_V226_Q0.5890.46
169_E191_C0.5880.46
9_L212_L0.5860.46
97_L189_T0.5850.46
148_L179_L0.5830.45
3_V51_E0.5830.45
195_E199_V0.5830.45
126_F141_L0.5820.45
162_F213_L0.5820.45
90_Y211_K0.5810.45
42_D75_Q0.5810.45
99_G175_E0.5780.45
66_K156_D0.5760.45
155_K186_I0.5740.44
222_L225_K0.5730.44
185_G210_V0.5720.44
104_F174_A0.5720.44
137_L141_L0.5720.44
57_T162_F0.5710.44
107_I110_R0.5700.44
35_R212_L0.5690.44
120_M134_V0.5680.44
19_Q22_R0.5680.44
66_K155_K0.5660.44
90_Y154_M0.5660.44
66_K88_G0.5650.43
43_L206_A0.5630.43
69_F218_A0.5630.43
104_F160_A0.5630.43
110_R117_I0.5630.43
45_K104_F0.5620.43
161_L177_R0.5610.43
113_R194_D0.5570.43
50_V217_M0.5560.43
67_I89_M0.5530.42
127_D138_K0.5520.42
108_Q111_I0.5520.42
130_P133_E0.5500.42
121_Q128_V0.5500.42
168_K185_G0.5500.42
111_I144_L0.5470.42
123_N126_F0.5460.41
108_Q143_R0.5460.41
165_D185_G0.5440.41
130_P136_Q0.5440.41
135_V167_R0.5440.41
139_K213_L0.5420.41
117_I120_M0.5400.41
45_K77_Q0.5390.41
173_V177_R0.5380.41
106_T118_E0.5380.41
69_F84_A0.5370.40
142_E146_K0.5360.40
90_Y160_A0.5350.40
116_D141_L0.5350.40
27_M39_Y0.5340.40
74_K138_K0.5330.40
77_Q93_N0.5300.40
99_G103_N0.5290.40
225_K228_E0.5290.40
54_Y110_R0.5270.39
69_F89_M0.5270.39
122_E129_L0.5260.39
87_S90_Y0.5250.39
7_K44_Q0.5250.39
59_N185_G0.5230.39
61_A224_A0.5220.39
50_V185_G0.5210.39
52_E59_N0.5200.39
130_P171_I0.5190.39
122_E126_F0.5160.38
226_Q230_E0.5150.38
104_F155_K0.5150.38
37_G75_Q0.5140.38
100_T147_F0.5140.38
120_M123_N0.5130.38
135_V211_K0.5120.38
129_L228_E0.5120.38
24_N106_T0.5120.38
35_R129_L0.5110.38
174_A177_R0.5110.38
3_V12_A0.5100.38
177_R196_I0.5090.37
108_Q168_K0.5070.37
9_L42_D0.5060.37
9_L216_K0.5050.37
151_I154_M0.5040.37
128_V152_K0.5020.37
20_T23_W0.5020.37
143_R173_V0.5010.37
97_L110_R0.5010.37
80_V109_K0.5010.37
130_P138_K0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb5B 1 0.939 100 0.099 Contact Map
3bbnB 1 0.939 100 0.114 Contact Map
5aj3B 1 0.7967 100 0.274 Contact Map
4toiA 2 0.9837 100 0.292 Contact Map
4ujpB 1 0.7602 100 0.301 Contact Map
3j7aC 1 0.748 100 0.302 Contact Map
3zeyC 1 0.7439 100 0.303 Contact Map
4bpeB 1 0.7561 100 0.307 Contact Map
3j38A 1 0.8008 100 0.31 Contact Map
3j60A 1 0.7439 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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