GREMLIN Database
PAIB - Protease synthase and sporulation protein PAI 2
UniProt: P21341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (200)
Sequences: 1684 (1282)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_M162_I3.6161.00
185_Q200_E3.3741.00
105_Y161_D3.3571.00
109_S156_K3.2641.00
172_R176_D3.1031.00
25_G42_L2.9891.00
37_A74_L2.9501.00
42_L55_G2.9421.00
15_I164_A2.8401.00
73_V157_I2.7001.00
39_H103_H2.5141.00
38_T63_Q2.4111.00
17_N21_E2.3601.00
20_Q46_K2.2131.00
116_L154_G2.2051.00
29_T63_Q2.1371.00
26_T76_M2.1141.00
7_F171_N2.0671.00
28_V76_M1.9991.00
109_S158_K1.9551.00
84_I184_L1.9391.00
19_V104_M1.9371.00
179_N183_Q1.9141.00
98_N199_M1.8681.00
120_L152_I1.8441.00
26_T78_Q1.8351.00
67_F108_A1.8071.00
178_M182_E1.7871.00
72_D160_E1.7581.00
100_Q166_Y1.7441.00
9_V14_E1.7171.00
18_F102_V1.6871.00
18_F100_Q1.6291.00
31_E34_K1.6051.00
53_I75_V1.6001.00
82_A195_M1.5561.00
75_V157_I1.5521.00
9_V166_Y1.5271.00
76_M103_H1.5231.00
19_V44_F1.5201.00
42_L75_V1.5121.00
131_R187_E1.5101.00
60_G151_G1.4981.00
39_H101_A1.4911.00
118_E122_I1.4901.00
195_M199_M1.4801.00
16_W44_F1.4671.00
187_E192_A1.4550.99
121_T138_D1.4480.99
107_K158_K1.4370.99
192_A195_M1.4350.99
173_N176_D1.4340.99
52_Y156_K1.4150.99
149_L152_I1.4090.99
86_S95_P1.3830.99
54_T156_K1.3740.99
125_E136_L1.3700.99
182_E186_N1.3500.99
11_N14_E1.3500.99
168_L195_M1.3400.99
106_G157_I1.3210.99
100_Q198_L1.3030.99
98_N169_S1.2980.99
77_F104_M1.2770.99
145_L148_E1.2760.99
54_T122_I1.2710.99
174_E178_M1.2690.99
46_K51_Y1.2600.99
87_S131_R1.2420.98
50_H158_K1.2280.98
14_E17_N1.2250.98
55_G155_F1.2080.98
176_D179_N1.2000.98
51_Y159_V1.1950.98
72_D105_Y1.1940.98
188_E193_K1.1900.98
117_A121_T1.1750.98
111_L115_E1.1690.98
196_A199_M1.1630.97
20_Q126_K1.1620.97
185_Q196_A1.1580.97
45_N122_I1.1530.97
19_V162_I1.1490.97
147_S150_K1.1390.97
24_F81_H1.1390.97
40_L57_F1.1160.97
142_P146_E1.1040.97
39_H76_M1.1020.97
53_I77_F1.0990.96
54_T119_E1.0830.96
19_V25_G1.0740.96
12_A16_W1.0650.96
33_G66_T1.0640.96
148_E151_G1.0630.96
46_K49_D1.0540.95
181_I185_Q1.0530.95
74_L105_Y1.0480.95
183_Q186_N1.0420.95
195_M198_L1.0170.95
30_T35_P1.0010.94
16_W51_Y0.9990.94
16_W46_K0.9940.94
23_S127_Y0.9940.94
185_Q197_E0.9930.94
53_I104_M0.9890.94
59_Y112_E0.9890.94
72_D161_D0.9870.94
64_W153_V0.9810.93
83_Y128_E0.9790.93
168_L199_M0.9750.93
107_K160_E0.9670.93
119_E123_M0.9650.93
189_N192_A0.9600.93
169_S172_R0.9560.92
43_G119_E0.9500.92
57_F63_Q0.9470.92
29_T38_T0.9380.92
119_E122_I0.9380.92
141_S144_L0.9370.92
121_T137_W0.9370.92
44_F51_Y0.9350.92
88_W184_L0.9340.92
3_I165_A0.9300.91
92_E139_K0.9290.91
89_Y180_V0.9070.90
79_G100_Q0.8940.90
92_E141_S0.8930.90
19_V77_F0.8900.90
52_Y158_K0.8820.89
121_T125_E0.8800.89
35_P72_D0.8720.89
43_G126_K0.8630.88
22_N81_H0.8560.88
125_E137_W0.8540.88
45_N54_T0.8500.87
49_D52_Y0.8500.87
29_T66_T0.8490.87
58_A61_N0.8370.86
120_L149_L0.8320.86
144_L148_E0.8260.86
100_Q168_L0.8230.86
59_Y153_V0.8230.86
90_S179_N0.8220.85
115_E156_K0.8180.85
104_M164_A0.8100.85
19_V186_N0.8080.84
193_K196_A0.8080.84
25_G55_G0.8070.84
90_S176_D0.8060.84
5_K8_K0.7960.84
73_V108_A0.7820.83
131_R134_P0.7810.82
45_N48_D0.7780.82
3_I163_Q0.7730.82
61_N99_Y0.7720.82
9_V15_I0.7720.82
24_F77_F0.7720.82
36_I66_T0.7710.82
29_T73_V0.7660.81
115_E119_E0.7660.81
118_E121_T0.7650.81
82_A192_A0.7640.81
189_N193_K0.7620.81
25_G75_V0.7590.81
85_S183_Q0.7580.81
104_M159_V0.7510.80
7_F170_Q0.7490.80
25_G77_F0.7340.78
84_I180_V0.7330.78
94_V148_E0.7320.78
116_L120_L0.7320.78
187_E193_K0.7290.78
80_P100_Q0.7280.78
190_P193_K0.7270.78
15_I102_V0.7250.77
2_Y165_A0.7230.77
23_S77_F0.7230.77
38_T101_A0.7210.77
137_W140_L0.7200.77
85_S128_E0.7180.77
83_Y86_S0.7170.77
108_A158_K0.7110.76
147_S151_G0.7110.76
39_H147_S0.7100.76
28_V37_A0.7090.76
37_A76_M0.7050.76
82_A187_E0.6990.75
116_L119_E0.6970.75
26_T39_H0.6970.75
28_V74_L0.6860.74
18_F24_F0.6850.73
92_E124_L0.6750.72
4_P61_N0.6720.72
123_M127_Y0.6660.71
63_Q66_T0.6620.71
182_E185_Q0.6620.71
116_L152_I0.6600.71
72_D107_K0.6590.71
148_E171_N0.6540.70
188_E200_E0.6510.70
112_E116_L0.6490.69
105_Y163_Q0.6470.69
181_I200_E0.6460.69
102_V164_A0.6450.69
112_E115_E0.6440.69
89_Y96_T0.6420.69
37_A103_H0.6350.68
15_I166_Y0.6350.68
168_L198_L0.6300.67
31_E66_T0.6280.67
94_V151_G0.6280.67
3_I105_Y0.6260.67
68_E71_E0.6260.67
117_A149_L0.6250.66
9_V164_A0.6220.66
13_E16_W0.6160.65
26_T37_A0.6120.65
64_W110_M0.6120.65
140_L145_L0.6080.64
13_E17_N0.6080.64
91_R176_D0.6030.64
177_Y199_M0.6010.63
45_N49_D0.5970.63
90_S180_V0.5940.63
60_G81_H0.5940.63
116_L149_L0.5930.62
174_E177_Y0.5920.62
27_V40_L0.5910.62
89_Y170_Q0.5910.62
16_W50_H0.5880.62
124_L139_K0.5850.61
59_Y150_K0.5840.61
110_M153_V0.5830.61
63_Q172_R0.5830.61
106_G160_E0.5800.61
110_M155_F0.5790.61
44_F159_V0.5760.60
5_K151_G0.5750.60
55_G77_F0.5740.60
103_H163_Q0.5730.60
18_F22_N0.5720.60
28_V35_P0.5720.60
118_E197_E0.5710.60
8_K133_N0.5700.59
18_F25_G0.5690.59
77_F102_V0.5690.59
159_V162_I0.5680.59
41_P152_I0.5670.59
85_S89_Y0.5630.58
180_V184_L0.5600.58
5_K13_E0.5580.58
37_A78_Q0.5570.58
2_Y6_Y0.5540.57
60_G166_Y0.5540.57
30_T76_M0.5530.57
24_F39_H0.5520.57
15_I162_I0.5500.57
148_E172_R0.5500.57
99_Y165_A0.5460.56
16_W104_M0.5460.56
10_T112_E0.5450.56
24_F99_Y0.5410.55
38_T115_E0.5380.55
22_N77_F0.5380.55
181_I196_A0.5350.55
85_S199_M0.5350.55
115_E154_G0.5340.55
86_S135_V0.5340.55
9_V18_F0.5330.54
30_T33_G0.5320.54
3_I38_T0.5290.54
84_I181_I0.5290.54
48_D54_T0.5270.54
43_G122_I0.5240.53
2_Y152_I0.5240.53
114_D117_A0.5200.53
10_T160_E0.5200.53
118_E125_E0.5190.52
150_K153_V0.5180.52
117_A145_L0.5170.52
124_L148_E0.5170.52
86_S124_L0.5150.52
117_A137_W0.5150.52
78_Q85_S0.5140.52
85_S168_L0.5130.52
13_E70_C0.5130.52
191_N195_M0.5130.52
117_A124_L0.5120.52
72_D108_A0.5110.51
51_Y54_T0.5100.51
30_T85_S0.5090.51
47_K160_E0.5090.51
89_Y179_N0.5090.51
35_P42_L0.5080.51
169_S180_V0.5070.51
25_G76_M0.5070.51
16_W164_A0.5070.51
91_R172_R0.5060.51
18_F155_F0.5040.50
26_T101_A0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ol5A 2 0.8937 100 0.346 Contact Map
2vpaA 2 0.8502 100 0.618 Contact Map
2furA 2 0.8937 99.9 0.629 Contact Map
2fg9A 4 0.744 99.9 0.638 Contact Map
2htiA 2 0.6039 99.9 0.66 Contact Map
3u5wA 2 0.5942 99.8 0.731 Contact Map
2hq9A 2 0.6377 99.7 0.737 Contact Map
3cp3A 2 0.6087 99.7 0.756 Contact Map
2aq6A 2 0.6618 99.5 0.777 Contact Map
2asfA 2 0.5942 99.5 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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