GREMLIN Database
PAIA - Protease synthase and sporulation negative regulatory protein PAI 1
UniProt: P21340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (145)
Sequences: 13114 (10517)
Seq/√Len: 873.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_K65_Y3.2801.00
116_I147_F2.9501.00
109_K145_M2.9071.00
74_V115_A2.8161.00
22_E99_K2.7671.00
62_F114_K2.3701.00
64_I107_L2.3161.00
109_K144_K2.2391.00
71_A102_F2.1901.00
139_I143_K2.1451.00
66_F102_F2.1241.00
6_K12_D2.0781.00
114_K117_E2.0271.00
118_I122_R1.9791.00
149_Q152_A1.9541.00
63_F70_I1.9461.00
113_N145_M1.9421.00
91_L119_A1.8831.00
143_K149_Q1.8691.00
8_C16_L1.8491.00
72_G98_I1.7831.00
112_L145_M1.7491.00
116_I127_I1.7161.00
76_V115_A1.7101.00
66_F105_H1.6961.00
66_F71_A1.6911.00
103_Q137_N1.6561.00
118_I121_E1.6261.00
102_F105_H1.6111.00
61_F75_K1.5861.00
140_A143_K1.5611.00
129_L142_Y1.5591.00
60_Q118_I1.5521.00
139_I149_Q1.5151.00
15_T18_Q1.5141.00
18_Q22_E1.3941.00
62_F118_I1.3661.00
78_I124_K1.3371.00
109_K113_N1.3361.00
69_E101_S1.3361.00
15_T70_I1.3341.00
65_Y70_I1.3311.00
47_T51_E1.2941.00
69_E99_K1.2901.00
17_Q21_I1.2871.00
77_N94_E1.2791.00
119_A127_I1.2661.00
114_K118_I1.2571.00
14_Q47_T1.2531.00
91_L124_K1.2521.00
19_L23_T1.2361.00
34_P38_K1.2101.00
8_C63_F1.2001.00
90_S128_W1.1941.00
76_V119_A1.1861.00
18_Q99_K1.1851.00
74_V111_L1.1741.00
74_V93_I1.1601.00
131_V135_N1.1491.00
65_Y68_H1.1361.00
90_S126_N1.1311.00
136_E140_A1.1241.00
60_Q122_R1.1231.00
5_M62_F1.1071.00
7_K118_I1.0911.00
133_E152_A1.0871.00
138_A142_Y1.0871.00
23_T97_Y1.0811.00
131_V139_I1.0781.00
19_L70_I1.0751.00
36_N39_A1.0721.00
10_R51_E1.0631.00
127_I147_F1.0581.00
117_E121_E1.0541.00
4_K65_Y1.0521.00
26_D100_N1.0481.00
22_E100_N1.0391.00
93_I112_L1.0331.00
46_N49_Q1.0281.00
136_E139_I1.0241.00
89_E125_K1.0131.00
66_F69_E0.9951.00
20_S73_Y0.9921.00
15_T69_E0.9811.00
51_E55_S0.9811.00
69_E102_F0.9531.00
104_K137_N0.9521.00
112_L147_F0.9501.00
33_S36_N0.9461.00
71_A107_L0.9411.00
19_L99_K0.9331.00
110_H113_N0.9311.00
22_E101_S0.9201.00
98_I107_L0.9061.00
92_E128_W0.8921.00
7_K62_F0.8711.00
141_F145_M0.8681.00
5_M114_K0.8671.00
5_M110_H0.8671.00
129_L138_A0.8581.00
9_S12_D0.8471.00
7_K60_Q0.8471.00
135_N138_A0.8341.00
17_Q47_T0.8331.00
76_V118_I0.8291.00
116_I120_L0.8271.00
13_L17_Q0.8141.00
113_N117_E0.8101.00
20_S50_L0.8101.00
119_A124_K0.8081.00
112_L142_Y0.8071.00
10_R55_S0.8031.00
108_G141_F0.8011.00
99_K102_F0.7981.00
153_H157_M0.7801.00
8_C13_L0.7751.00
154_S157_M0.7741.00
79_D128_W0.7731.00
113_N116_I0.7631.00
92_E130_G0.7551.00
106_G109_K0.7541.00
14_Q18_Q0.7491.00
79_D92_E0.7451.00
78_I91_L0.7451.00
107_L110_H0.7411.00
64_I71_A0.7401.00
8_C61_F0.7361.00
92_E95_R0.7361.00
75_K94_E0.7361.00
48_E52_K0.7361.00
6_K63_F0.7351.00
78_I122_R0.7301.00
153_H156_Y0.7291.00
64_I111_L0.7271.00
52_K56_N0.7261.00
20_S24_F0.7221.00
21_I25_N0.7201.00
64_I110_H0.7141.00
16_L73_Y0.7121.00
32_N37_M0.7061.00
112_L141_F0.7001.00
18_Q69_E0.6901.00
72_G111_L0.6881.00
35_E39_A0.6851.00
116_I145_M0.6841.00
64_I72_G0.6841.00
110_H114_K0.6841.00
33_S37_M0.6811.00
46_N54_L0.6811.00
93_I115_A0.6691.00
74_V96_I0.6621.00
48_E51_E0.6551.00
10_R13_L0.6551.00
79_D88_A0.6521.00
24_F97_Y0.6501.00
104_K140_A0.6461.00
93_I129_L0.6461.00
131_V138_A0.6451.00
53_E75_K0.6451.00
102_F107_L0.6421.00
12_D65_Y0.6421.00
15_T19_L0.6381.00
126_N150_T0.6301.00
96_I142_Y0.6221.00
60_Q76_V0.6191.00
109_K140_A0.6181.00
79_D90_S0.6121.00
34_P37_M0.6111.00
30_E33_S0.6061.00
140_A144_K0.5951.00
104_K144_K0.5941.00
24_F27_T0.5941.00
8_C12_D0.5931.00
96_I112_L0.5891.00
128_W150_T0.5871.00
50_L61_F0.5831.00
22_E26_D0.5811.00
49_Q53_E0.5791.00
89_E124_K0.5761.00
45_F49_Q0.5761.00
13_L51_E0.5751.00
112_L116_I0.5671.00
46_N50_L0.5671.00
14_Q17_Q0.5661.00
45_F50_L0.5631.00
72_G107_L0.5621.00
75_K95_R0.5601.00
59_S75_K0.5591.00
25_N29_K0.5561.00
117_E120_L0.5501.00
129_L147_F0.5491.00
35_E38_K0.5471.00
45_F53_E0.5471.00
49_Q52_K0.5441.00
98_I102_F0.5431.00
77_N92_E0.5421.00
134_K139_I0.5401.00
50_L53_E0.5281.00
32_N36_N0.5261.00
130_G157_M0.5241.00
50_L54_L0.5241.00
137_N140_A0.5211.00
5_M111_L0.5211.00
96_I129_L0.5191.00
62_F74_V0.5191.00
20_S97_Y0.5191.00
24_F28_F0.5121.00
22_E25_N0.5091.00
26_D103_Q0.5091.00
98_I111_L0.5081.00
18_Q21_I0.5071.00
73_Y97_Y0.5061.00
64_I98_I0.5051.00
20_S95_R0.5051.00
76_V91_L0.5041.00
60_Q78_I0.5021.00
143_K148_V0.5011.00
20_S45_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tiqA 1 0.9942 99.9 0.25 Contact Map
3fixA 2 0.9012 99.9 0.285 Contact Map
2j8mA 2 0.9419 99.9 0.287 Contact Map
4e2aA 2 0.9826 99.9 0.3 Contact Map
3dr6A 2 0.9419 99.9 0.305 Contact Map
2cy2A 1 0.9709 99.9 0.313 Contact Map
3fncA 2 0.9302 99.9 0.319 Contact Map
4h89A 2 0.936 99.9 0.324 Contact Map
4j3gA 2 0.936 99.9 0.332 Contact Map
3kkwA 1 0.9128 99.9 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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