GREMLIN Database
TADA - tRNA-specific adenosine deaminase
UniProt: P21335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (141)
Sequences: 8155 (5220)
Seq/√Len: 439.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E39_R3.3141.00
97_K127_E2.4431.00
9_K133_L2.3911.00
10_E13_K2.2881.00
76_L90_V2.2451.00
49_R60_D2.1951.00
101_G137_C2.1871.00
73_G96_E2.0821.00
75_T99_V2.0771.00
43_L57_L2.0091.00
88_G116_L1.9671.00
7_Y31_V1.9621.00
7_Y36_I1.9621.00
75_T97_K1.9421.00
102_A145_F1.9301.00
100_F103_F1.9231.00
134_E138_G1.9101.00
14_E39_R1.8941.00
97_K129_V1.8771.00
43_L47_E1.8751.00
103_F130_S1.8621.00
133_L136_E1.8201.00
14_E17_K1.7111.00
4_D97_K1.7111.00
30_L58_V1.6601.00
17_K41_H1.6391.00
28_A76_L1.6161.00
9_K136_E1.6021.00
115_N118_Q1.5701.00
138_G149_R1.5181.00
88_G92_L1.5181.00
115_N123_N1.5051.00
4_D129_V1.4741.00
100_F114_M1.4691.00
10_E36_I1.4611.00
90_V98_V1.4381.00
100_F130_S1.4321.00
139_G143_A1.4251.00
38_A61_E1.4121.00
14_E41_H1.3651.00
75_T96_E1.3481.00
16_K140_M1.3261.00
31_V77_Y1.3171.00
32_I73_G1.3131.00
44_R51_I1.2751.00
11_A79_T1.2711.00
32_I74_A1.2661.00
80_L141_L1.2651.00
4_D99_V1.2621.00
139_G142_S1.2621.00
143_A147_E1.2261.00
4_D77_Y1.2171.00
40_A57_L1.1981.00
138_G142_S1.1981.00
18_A41_H1.1951.00
131_G134_E1.1801.00
76_L95_V1.1731.00
52_A60_D1.1661.00
19_E147_E1.1571.00
56_M89_A1.1561.00
38_A58_V1.1481.00
45_E69_W1.1451.00
16_K136_E1.1251.00
10_E14_E1.1221.00
72_E94_R1.1101.00
21_K41_H1.1061.00
89_A93_S1.0921.00
5_E133_L1.0901.00
102_A138_G1.0891.00
143_A146_R1.0741.00
111_G115_N1.0731.00
26_I80_L1.0721.00
57_L61_E1.0551.00
19_E25_P1.0451.00
129_V132_V1.0421.00
30_L62_A1.0391.00
50_S63_C1.0341.00
16_K19_E1.0261.00
30_L76_L1.0161.00
52_A57_L1.0021.00
13_K16_K0.9881.00
32_I37_I0.9861.00
56_M60_D0.9681.00
44_R69_W0.9651.00
33_N73_G0.9511.00
87_A116_L0.9411.00
12_I137_C0.9401.00
15_A140_M0.9391.00
37_I74_A0.9361.00
12_I16_K0.9241.00
145_F149_R0.9191.00
11_A27_G0.9171.00
135_E139_G0.9171.00
9_K13_K0.9111.00
87_A91_V0.8981.00
91_V116_L0.8981.00
59_I93_S0.8961.00
22_G148_L0.8861.00
59_I71_L0.8761.00
6_L10_E0.8651.00
62_A71_L0.8651.00
16_K20_E0.8571.00
59_I89_A0.8531.00
91_V126_A0.8521.00
25_P141_L0.8511.00
30_L74_A0.8511.00
103_F134_E0.8491.00
4_D75_T0.8481.00
40_A58_V0.8471.00
59_I63_C0.8461.00
5_E9_K0.8241.00
8_M131_G0.7991.00
110_S117_L0.7991.00
61_E64_K0.7951.00
106_K148_L0.7921.00
98_V117_L0.7811.00
36_I39_R0.7801.00
99_V132_V0.7771.00
32_I35_E0.7731.00
19_E143_A0.7701.00
6_L9_K0.7661.00
12_I140_M0.7601.00
84_P116_L0.7551.00
109_C113_L0.7481.00
30_L38_A0.7461.00
51_I89_A0.7451.00
122_F126_A0.7401.00
90_V126_A0.7371.00
17_K21_K0.7341.00
43_L61_E0.7321.00
7_Y77_Y0.7281.00
98_V126_A0.7231.00
8_M11_A0.7201.00
16_K143_A0.7161.00
116_L124_H0.7151.00
108_G112_T0.7131.00
99_V129_V0.7121.00
47_E57_L0.7081.00
91_V123_N0.7021.00
117_L126_A0.7011.00
25_P42_N0.6921.00
114_M118_Q0.6911.00
47_E64_K0.6871.00
42_N51_I0.6821.00
100_F111_G0.6801.00
40_A61_E0.6781.00
35_E70_R0.6771.00
29_V36_I0.6751.00
103_F114_M0.6731.00
114_M117_L0.6721.00
39_R61_E0.6671.00
80_L102_A0.6671.00
141_L145_F0.6651.00
63_C71_L0.6601.00
52_A56_M0.6601.00
17_K20_E0.6591.00
7_Y10_E0.6551.00
47_E52_A0.6531.00
49_R52_A0.6480.99
109_C112_T0.6450.99
104_D107_G0.6390.99
59_I90_V0.6380.99
137_C140_M0.6360.99
48_Q67_G0.6320.99
12_I136_E0.6280.99
112_T116_L0.6250.99
32_I66_L0.6250.99
98_V110_S0.6210.99
31_V36_I0.6190.99
25_P143_A0.6110.99
91_V117_L0.6040.99
43_L52_A0.5950.99
44_R92_L0.5920.99
68_T72_E0.5910.99
45_E51_I0.5900.99
84_P104_D0.5860.99
19_E140_M0.5810.99
112_T115_N0.5780.99
72_E96_E0.5740.99
138_G145_F0.5740.99
51_I57_L0.5710.99
74_A95_V0.5700.99
48_Q68_T0.5650.99
56_M92_L0.5610.98
80_L104_D0.5600.98
130_S134_E0.5520.98
87_A117_L0.5520.98
114_M122_F0.5510.98
109_C114_M0.5470.98
91_V124_H0.5460.98
54_A78_V0.5450.98
59_I95_V0.5430.98
66_L74_A0.5410.98
11_A29_V0.5410.98
109_C116_L0.5380.98
30_L59_I0.5290.98
13_K17_K0.5270.98
12_I133_L0.5250.98
18_A45_E0.5240.98
142_S146_R0.5190.98
69_W94_R0.5180.97
57_L60_D0.5140.97
61_E71_L0.5120.97
31_V74_A0.5110.97
109_C122_F0.5090.97
33_N74_A0.5030.97
102_A137_C0.5030.97
110_S126_A0.5020.97
136_E139_G0.5020.97
103_F111_G0.5010.97
10_E29_V0.5010.97
32_I70_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nx8A 2 1 100 0.194 Contact Map
3dh1A 2 0.913 100 0.196 Contact Map
1z3aA 2 0.9503 100 0.198 Contact Map
2b3jA 2 0.9441 100 0.209 Contact Map
2a8nA 2 0.8696 100 0.245 Contact Map
1wwrA 3 0.9441 100 0.246 Contact Map
2g84A 2 0.9627 100 0.282 Contact Map
1wkqA 2 0.9441 100 0.295 Contact Map
2b3zA 3 0.9006 100 0.325 Contact Map
2hxvA 2 0.9317 100 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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