GREMLIN Database
YSZB - UPF0735 ACT domain-containing protein YszB
UniProt: P21204 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (141)
Sequences: 472 (329)
Seq/√Len: 27.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_K50_F3.7321.00
105_L144_G3.3281.00
17_A21_T3.3221.00
81_A136_F2.9431.00
16_D20_K2.9021.00
123_D126_T2.7651.00
23_E26_K2.7621.00
21_T45_L2.6350.99
78_R135_D2.3620.99
24_V33_A2.3000.98
13_V56_A2.2070.98
89_V113_L2.0690.97
49_A100_H1.9230.95
21_T106_Q1.8810.95
24_V50_F1.8740.95
25_K48_S1.8250.94
106_Q144_G1.8190.94
60_F107_G1.7910.93
18_M21_T1.7720.93
9_V14_L1.7510.92
71_L117_T1.7500.92
9_V57_V1.7030.91
88_A130_K1.6930.91
35_S144_G1.6770.90
25_K70_T1.6250.89
34_D118_S1.6120.89
13_V17_A1.5590.87
82_L101_Q1.5200.85
28_L36_V1.5100.85
72_F96_V1.4710.84
77_D107_G1.4440.82
30_R96_V1.3940.80
92_S130_K1.3710.79
27_L30_R1.3570.78
45_L49_A1.3550.78
24_V39_A1.3320.77
24_V27_L1.3250.76
13_V49_A1.3220.76
78_R133_K1.3180.76
122_E131_L1.2630.73
69_I143_L1.2190.70
50_F54_R1.2170.70
29_D95_N1.2070.69
102_T114_S1.2010.69
128_M133_K1.1950.69
10_R57_V1.1890.68
60_F112_T1.1880.68
84_Q135_D1.1740.67
50_F130_K1.1660.67
13_V54_R1.1550.66
82_L109_A1.1390.65
126_T129_N1.1370.65
74_H112_T1.1270.64
71_L133_K1.1140.63
35_S116_S1.0910.61
80_G101_Q1.0820.61
31_K34_D1.0670.60
21_T49_A1.0640.59
36_V79_S1.0420.58
49_A54_R1.0390.58
25_K49_A1.0310.57
5_T11_E1.0230.56
105_L110_N1.0160.56
17_A49_A1.0020.55
69_I100_H1.0010.55
36_V40_V0.9930.54
96_V111_V0.9920.54
83_S143_L0.9900.54
7_Y11_E0.9900.54
62_T85_L0.9870.54
98_S109_A0.9840.53
70_T103_I0.9820.53
7_Y57_V0.9800.53
38_D54_R0.9780.53
40_V71_L0.9670.52
93_G121_E0.9670.52
84_Q87_Q0.9560.51
42_K69_I0.9550.51
8_L41_Q0.9470.51
40_V57_V0.9340.50
7_Y22_L0.9320.49
59_P69_I0.9300.49
17_A45_L0.9280.49
35_S77_D0.9230.49
7_Y35_S0.9160.48
5_T113_L0.9160.48
129_N135_D0.9160.48
70_T94_S0.9100.48
37_A68_I0.9070.48
62_T96_V0.9070.48
129_N132_R0.8900.46
6_F74_H0.8890.46
48_S98_S0.8770.45
85_L107_G0.8760.45
21_T37_A0.8750.45
88_A142_I0.8750.45
57_V77_D0.8690.45
77_D116_S0.8670.45
74_H100_H0.8660.44
74_H102_T0.8640.44
112_T141_E0.8600.44
71_L140_V0.8530.43
48_S70_T0.8470.43
48_S52_K0.8400.42
37_A100_H0.8360.42
15_P85_L0.8350.42
79_S90_A0.8330.42
58_F131_L0.8320.42
60_F90_A0.8270.42
24_V43_V0.8270.42
61_Y144_G0.8220.41
49_A68_I0.8080.40
81_A131_L0.8070.40
71_L75_L0.8050.40
89_V94_S0.8030.40
54_R141_E0.8010.40
94_S136_F0.7960.39
55_D112_T0.7940.39
17_A144_G0.7810.38
10_R102_T0.7710.37
68_I105_L0.7690.37
26_K128_M0.7670.37
4_E129_N0.7580.37
96_V106_Q0.7540.36
106_Q116_S0.7510.36
92_S131_L0.7490.36
66_E83_S0.7450.36
19_R36_V0.7420.35
76_E138_E0.7410.35
24_V133_K0.7410.35
24_V31_K0.7400.35
17_A66_E0.7400.35
119_A134_F0.7370.35
107_G143_L0.7290.34
6_F50_F0.7280.34
69_I117_T0.7140.33
63_M102_T0.7090.33
117_T120_M0.7050.33
28_L70_T0.7040.33
120_M137_V0.6910.32
74_H139_K0.6890.32
12_D144_G0.6850.32
23_E129_N0.6840.31
68_I86_L0.6810.31
11_E49_A0.6810.31
28_L40_V0.6730.31
28_L31_K0.6730.31
27_L33_A0.6670.30
77_D94_S0.6670.30
119_A132_R0.6620.30
33_A43_V0.6590.30
125_H129_N0.6580.30
33_A124_I0.6520.29
12_D56_A0.6480.29
9_V117_T0.6470.29
9_V103_I0.6450.29
29_D56_A0.6440.29
27_L32_K0.6430.29
90_A97_L0.6410.29
24_V44_D0.6410.29
44_D103_I0.6380.29
40_V43_V0.6370.28
61_Y68_I0.6350.28
57_V102_T0.6320.28
33_A42_K0.6320.28
66_E116_S0.6300.28
78_R120_M0.6250.28
56_A100_H0.6250.28
88_A125_H0.6150.27
76_E114_S0.6150.27
130_K135_D0.6130.27
62_T108_R0.6130.27
89_V105_L0.6120.27
6_F26_K0.6060.27
19_R56_A0.5980.26
41_Q118_S0.5960.26
88_A133_K0.5960.26
75_L111_V0.5920.26
8_L29_D0.5880.26
37_A41_Q0.5850.25
19_R49_A0.5850.25
40_V90_A0.5850.25
119_A129_N0.5850.25
104_P109_A0.5840.25
68_I106_Q0.5680.24
122_E126_T0.5680.24
88_A91_D0.5660.24
91_D124_I0.5630.24
11_E144_G0.5630.24
27_L43_V0.5570.24
35_S41_Q0.5570.24
83_S109_A0.5570.24
8_L60_F0.5530.24
5_T93_G0.5520.23
38_D42_K0.5510.23
103_I123_D0.5450.23
73_F77_D0.5420.23
93_G131_L0.5380.23
19_R22_L0.5360.23
32_K83_S0.5340.23
36_V99_I0.5320.22
113_L135_D0.5290.22
85_L130_K0.5290.22
101_Q109_A0.5240.22
24_V138_E0.5230.22
59_P107_G0.5220.22
10_R28_L0.5130.21
14_L117_T0.5110.21
83_S94_S0.5100.21
95_N101_Q0.5090.21
44_D77_D0.5080.21
22_L136_F0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fgcA 2 0.5442 99.3 0.771 Contact Map
2pc6A 2 0.5442 98.7 0.819 Contact Map
2f1fA 4 0.5374 98.6 0.822 Contact Map
2ko1A 2 0.551 98.6 0.822 Contact Map
1y7pA 5 0.5374 98.6 0.824 Contact Map
1zpvA 3 0.551 98.4 0.836 Contact Map
2dtjA 4 0.6327 98.1 0.847 Contact Map
2lvwA 2 0.585 98 0.852 Contact Map
3s1tA 2 0.6259 97.9 0.853 Contact Map
2dt9A 2 0.619 97.9 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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