GREMLIN Database
PHEA - Prephenate dehydratase
UniProt: P21203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (264)
Sequences: 3626 (2443)
Seq/√Len: 150.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_D166_R3.4111.00
4_G45_V3.1341.00
105_S132_T2.8871.00
137_K141_D2.7781.00
36_C48_A2.7051.00
101_D146_N2.6261.00
88_L151_A2.5781.00
92_S162_K2.5561.00
100_L148_G2.5431.00
12_F85_Q2.5161.00
150_I168_I2.4991.00
102_K125_P2.4401.00
156_A163_I2.4381.00
205_V249_I2.4131.00
88_L136_A2.4041.00
136_A161_L2.1791.00
84_H167_D2.1241.00
251_I260_I2.1131.00
226_R262_G2.0901.00
65_D236_R2.0661.00
203_L251_I2.0461.00
134_A137_K2.0341.00
30_Y39_A2.0141.00
201_T279_A2.0061.00
217_H221_S2.0051.00
4_G30_Y1.9571.00
109_A132_T1.9411.00
102_K127_E1.9261.00
221_S225_W1.9111.00
265_Q268_E1.9041.00
116_F165_K1.8891.00
75_I179_V1.8761.00
116_F120_H1.8721.00
202_T250_D1.8611.00
17_V27_H1.8531.00
114_H170_D1.8521.00
219_V267_L1.8431.00
93_R99_E1.8181.00
5_Y29_A1.8071.00
225_W266_E1.7851.00
223_F230_L1.7611.00
76_V182_S1.7391.00
211_D229_N1.7391.00
84_H169_Q1.7181.00
212_Q218_R1.7051.00
90_H143_P1.6971.00
229_N252_E1.6941.00
2_K26_E1.6821.00
6_L131_S1.6691.00
202_T280_Y1.6641.00
14_H154_M1.6471.00
113_C150_I1.6461.00
85_Q108_H1.6351.00
103_I124_V1.6191.00
52_L179_V1.6181.00
105_S110_I1.5841.00
104_Y147_I1.5631.00
91_P162_K1.5611.00
5_Y9_A1.5471.00
89_V162_K1.5421.00
253_K260_I1.5281.00
250_D280_Y1.5261.00
40_A73_L1.5011.00
11_T133_G1.4871.00
43_G183_P1.4791.00
15_L154_M1.4751.00
89_V93_R1.4601.00
14_H18_S1.4561.00
89_V164_V1.4541.00
6_L13_T1.4421.00
226_R266_E1.4301.00
88_L156_A1.4211.00
110_I126_Y1.4201.00
50_V63_T1.3811.00
15_L19_S1.3791.00
153_D157_S1.3771.00
21_F180_I1.3651.00
82_P169_Q1.3631.00
104_Y127_E1.3501.00
40_A48_A1.3341.00
115_K170_D1.3171.00
37_I181_L1.2951.00
205_V219_V1.2941.00
37_I50_V1.2941.00
74_P185_E1.2901.00
9_A158_T1.2851.00
38_D42_A1.2841.00
218_R224_S1.2841.00
8_P131_S1.2721.00
110_I128_Y1.2691.00
57_E111_A1.2371.00
130_N134_A1.2371.00
237_P245_Y1.2351.00
41_V71_Q1.2271.00
9_A14_H1.2261.00
142_H146_N1.2051.00
33_I63_T1.1921.00
12_F152_N1.1841.00
238_T246_F1.1831.00
230_L251_I1.1781.00
86_H153_D1.1731.00
6_L11_T1.1641.00
253_K257_D1.1621.00
102_K147_I1.1601.00
206_M273_K1.1591.00
48_A181_L1.1581.00
78_E200_K1.1551.00
103_I117_L1.1551.00
100_L124_V1.1481.00
222_A266_E1.1411.00
241_G244_H1.1351.00
85_Q109_A1.1230.99
28_V45_V1.1170.99
116_F168_I1.1110.99
139_V142_H1.1110.99
19_S79_M1.1060.99
101_D125_P1.1060.99
18_S154_M1.1060.99
207_L215_A1.1000.99
199_P254_A1.1000.99
49_F180_I1.0960.99
39_A45_V1.0910.99
129_A135_A1.0830.99
258_V262_G1.0780.99
75_I280_Y1.0750.99
139_V149_V1.0660.99
86_H163_I1.0610.99
104_Y129_A1.0590.99
20_C180_I1.0570.99
39_A44_E1.0570.99
118_H126_Y1.0540.99
142_H147_I1.0490.99
196_S199_P1.0480.99
93_R162_K1.0440.99
87_L168_I1.0380.99
22_Q25_A1.0330.99
17_V49_F1.0290.99
88_L161_L1.0250.99
2_K28_V1.0210.99
80_T175_H1.0170.99
120_H124_V1.0160.99
93_R98_K1.0080.99
85_Q113_C1.0020.99
211_D244_H0.9920.99
138_F142_H0.9910.99
88_L163_I0.9900.99
208_P212_Q0.9850.99
40_A45_V0.9840.99
60_V108_H0.9830.99
86_H167_D0.9780.99
47_F76_V0.9670.98
41_V72_P0.9650.98
20_C77_G0.9630.98
214_G229_N0.9610.98
3_V21_F0.9580.98
223_F263_A0.9560.98
207_L219_V0.9520.98
131_S134_A0.9510.98
46_D183_P0.9500.98
87_L148_G0.9450.98
57_E60_V0.9440.98
117_L124_V0.9430.98
86_H166_R0.9380.98
28_V39_A0.9330.98
134_A138_F0.9280.98
8_P11_T0.9230.98
135_A149_V0.9230.98
252_E282_S0.9230.98
30_Y44_E0.9220.98
11_T131_S0.9200.98
271_G274_V0.9090.98
222_A226_R0.9070.98
59_S234_E0.9060.98
14_H27_H0.9010.98
223_F267_L0.8990.98
40_A181_L0.8900.97
64_I232_K0.8900.97
13_T51_P0.8870.97
199_P279_A0.8820.97
21_F47_F0.8800.97
205_V271_G0.8770.97
32_T35_E0.8660.97
4_G36_C0.8630.97
91_P160_E0.8570.97
59_S232_K0.8560.97
34_P118_H0.8550.97
5_Y27_H0.8520.97
37_I48_A0.8510.97
129_A138_F0.8480.96
37_I73_L0.8470.96
154_M157_S0.8440.96
2_K46_D0.8390.96
136_A151_A0.8350.96
151_A155_A0.8330.96
153_D163_I0.8290.96
218_R221_S0.8210.96
226_R263_A0.8210.96
77_G180_I0.8180.96
115_K119_R0.8130.96
34_P69_H0.8130.96
35_E118_H0.8120.95
99_E146_N0.8110.95
218_R270_L0.8090.95
234_E250_D0.8060.95
67_L179_V0.7960.95
214_G247_F0.7950.95
97_W165_K0.7880.95
34_P38_D0.7830.94
137_K159_Y0.7760.94
222_A270_L0.7720.94
73_L181_L0.7720.94
51_P132_T0.7710.94
197_S281_Q0.7670.94
214_G235_S0.7650.94
185_E255_F0.7630.94
201_T276_L0.7630.94
71_Q275_R0.7630.94
201_T253_K0.7600.94
85_Q152_N0.7460.93
89_V148_G0.7460.93
117_L126_Y0.7440.93
90_H142_H0.7430.93
202_T248_I0.7430.93
254_A279_A0.7410.93
232_K250_D0.7410.93
206_M246_F0.7390.93
199_P281_Q0.7350.92
253_K279_A0.7350.92
57_E108_H0.7330.92
12_F108_H0.7320.92
30_Y45_V0.7310.92
207_L233_I0.7280.92
85_Q174_N0.7280.92
85_Q150_I0.7270.92
228_L251_I0.7270.92
12_F86_H0.7260.92
97_W116_F0.7240.92
92_S99_E0.7210.92
196_S254_A0.7200.92
74_P184_D0.7150.91
240_T244_H0.7140.91
136_A140_S0.7100.91
72_P275_R0.7070.91
115_K118_H0.7060.91
69_H115_K0.6980.90
89_V146_N0.6970.90
4_G39_A0.6960.90
33_I66_Y0.6940.90
47_F180_I0.6920.90
197_S254_A0.6900.90
104_Y138_F0.6870.90
34_P62_L0.6820.89
59_S250_D0.6820.89
6_L133_G0.6780.89
260_I264_M0.6770.89
107_S128_Y0.6770.89
119_R165_K0.6760.89
35_E38_D0.6740.89
120_H123_S0.6730.89
237_P243_G0.6700.88
255_F264_M0.6690.88
60_V111_A0.6680.88
78_E177_R0.6660.88
261_P265_Q0.6630.88
75_I202_T0.6610.88
53_E245_Y0.6610.88
89_V92_S0.6590.88
203_L264_M0.6590.88
230_L249_I0.6590.88
103_I110_I0.6590.88
68_I246_F0.6570.88
13_T131_S0.6530.87
216_L229_N0.6530.87
204_M246_F0.6530.87
38_D41_V0.6500.87
93_R164_V0.6500.87
140_S160_E0.6420.86
2_K44_E0.6400.86
133_G136_A0.6400.86
83_I152_N0.6390.86
139_V143_P0.6370.86
21_F77_G0.6350.86
97_W164_V0.6320.85
75_I277_L0.6320.85
169_Q172_R0.6300.85
68_I204_M0.6250.85
257_D279_A0.6250.85
120_H165_K0.6230.85
90_H93_R0.6210.84
6_L33_I0.6200.84
10_A158_T0.6170.84
266_E270_L0.6140.84
33_I50_V0.6140.84
54_N112_Q0.6110.83
259_L262_G0.6100.83
93_R146_N0.6100.83
235_S245_Y0.6100.83
3_V25_A0.6090.83
65_D237_P0.6080.83
201_T254_A0.6070.83
117_L150_I0.6060.83
140_S143_P0.6050.83
102_K146_N0.6050.83
138_F141_D0.6030.83
201_T251_I0.6030.83
182_S185_E0.6020.83
130_N137_K0.6020.83
20_C79_M0.6010.82
51_P108_H0.5990.82
16_A79_M0.5930.82
97_W100_L0.5920.82
260_I279_A0.5920.82
254_A260_I0.5910.81
251_I263_A0.5900.81
256_D259_L0.5870.81
205_V274_V0.5860.81
6_L134_A0.5850.81
154_M158_T0.5840.81
256_D261_P0.5830.81
102_K142_H0.5800.80
8_P137_K0.5790.80
116_F124_V0.5790.80
255_F276_L0.5790.80
55_A108_H0.5780.80
230_L247_F0.5740.80
221_S224_S0.5740.80
132_T152_N0.5730.79
255_F279_A0.5730.79
80_T242_L0.5730.79
31_R35_E0.5710.79
82_P175_H0.5700.79
99_E102_K0.5700.79
204_M275_R0.5690.79
229_N247_F0.5670.79
230_L233_I0.5670.79
15_L18_S0.5670.79
33_I62_L0.5670.79
13_T62_L0.5630.78
67_L204_M0.5630.78
37_I248_I0.5630.78
129_A134_A0.5600.78
85_Q112_Q0.5590.78
56_L171_Y0.5560.77
84_H153_D0.5540.77
200_K250_D0.5530.77
155_A159_Y0.5520.77
19_S81_L0.5520.77
9_A29_A0.5510.77
219_V271_G0.5480.76
220_L230_L0.5480.76
79_M180_I0.5470.76
13_T63_T0.5460.76
62_L114_H0.5450.76
235_S247_F0.5450.76
106_H220_L0.5440.76
103_I126_Y0.5400.75
206_M238_T0.5390.75
15_L81_L0.5390.75
268_E274_V0.5390.75
30_Y35_E0.5380.75
216_L247_F0.5380.75
11_T33_I0.5370.75
8_P134_A0.5350.75
9_A137_K0.5340.75
119_R262_G0.5340.75
140_S161_L0.5330.74
29_A131_S0.5300.74
14_H62_L0.5280.74
214_G230_L0.5260.73
254_A281_Q0.5250.73
216_L233_I0.5220.73
215_A218_R0.5180.72
12_F83_I0.5170.72
78_E250_D0.5160.72
254_A261_P0.5160.72
90_H146_N0.5150.72
218_R269_A0.5150.72
198_R282_S0.5140.72
217_H224_S0.5130.72
229_N235_S0.5120.71
86_H108_H0.5120.71
254_A257_D0.5120.71
219_V222_A0.5110.71
182_S186_N0.5100.71
238_T244_H0.5090.71
51_P63_T0.5080.71
105_S109_A0.5070.71
56_L108_H0.5070.71
88_L159_Y0.5050.70
187_I256_D0.5040.70
21_F243_G0.5040.70
116_F122_P0.5030.70
230_L245_Y0.5020.70
37_I71_Q0.5020.70
156_A160_E0.5000.70
15_L85_Q0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qmxA 3 0.9649 100 0.039 Contact Map
3mwbA 3 0.9719 100 0.04 Contact Map
4lubA 2 0.6667 100 0.042 Contact Map
3luyA 2 0.9684 100 0.068 Contact Map
2qmwA 2 0.9228 100 0.082 Contact Map
1phzA 2 0.3439 99.9 0.729 Contact Map
2mdaA 2 0.3193 99.9 0.762 Contact Map
2ko1A 2 0.2912 97.4 0.914 Contact Map
2lvwA 2 0.3123 96.8 0.922 Contact Map
1zpvA 3 0.2877 96.4 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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