GREMLIN Database
OBG - GTPase ObgE
UniProt: P20964 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (337)
Sequences: 3447 (1764)
Seq/√Len: 96.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E113_R4.4811.00
45_V115_V4.2331.00
262_N277_Q3.6971.00
48_V107_L3.6021.00
178_V210_M3.5481.00
21_A34_A3.3881.00
105_A114_A3.2121.00
50_E110_H2.9691.00
48_V91_P2.8971.00
37_D128_R2.8761.00
176_S185_I2.8551.00
241_V324_V2.8401.00
58_F87_I2.8251.00
97_D149_R2.7881.00
124_R141_E2.7231.00
49_D88_K2.6411.00
14_D68_R2.6341.00
307_F323_E2.6051.00
47_E86_V2.5761.00
47_E88_K2.5601.00
96_T152_V2.5271.00
177_V314_R2.5061.00
282_N311_A2.4651.00
305_P323_E2.4281.00
73_M77_Q2.4111.00
46_F95_V2.3941.00
96_T103_V2.3391.00
11_K148_E2.3331.00
67_I83_D2.2881.00
121_R144_E2.2321.00
70_E73_M2.2281.00
108_T112_Q2.1911.00
40_K43_D2.1831.00
9_Y150_Y2.1721.00
76_N127_S2.1611.00
206_R329_E2.1391.00
68_R71_H2.1271.00
263_Q266_S2.1231.00
284_M308_P2.1141.00
174_L178_V2.0901.00
20_V140_S2.0751.00
86_V113_R2.0431.00
45_V113_R1.8541.00
174_L243_V1.8531.00
67_I82_A1.8431.00
99_D150_Y1.8431.00
10_V44_V1.8411.00
216_L228_H1.8391.00
14_D17_N1.8221.00
94_V103_V1.8121.00
11_K14_D1.8071.00
10_V151_I1.7951.00
242_H261_I1.7951.00
263_Q267_E1.7901.00
174_L320_L1.7841.00
244_I258_Y1.7781.00
40_K81_N1.7701.00
109_E112_Q1.7221.00
23_R28_V1.7091.00
156_K235_E1.7011.00
200_V208_F1.7001.00
134_N139_L1.6641.00
252_R257_D1.6461.00
221_H267_E1.6211.00
43_D84_D1.5751.00
238_R332_P1.5701.00
7_K150_Y1.5671.00
174_L210_M1.5661.00
243_V282_N1.5511.00
269_N273_T1.5471.00
295_A299_K1.5281.00
309_I320_L1.5271.00
256_D260_T1.4901.00
323_E326_N1.4841.00
19_M74_S1.4831.00
67_I80_R1.4801.00
58_F64_F1.4661.00
11_K65_K1.4661.00
9_Y148_E1.4471.00
258_Y304_Y1.4401.00
164_V240_I1.4371.00
178_V321_L1.4311.00
253_D256_D1.4140.99
280_V320_L1.4080.99
12_G117_A1.4020.99
239_V324_V1.3960.99
258_Y262_N1.3820.99
46_F116_I1.3810.99
9_Y63_H1.3770.99
297_K301_T1.3650.99
251_G257_D1.3630.99
161_V239_V1.3600.99
19_M73_M1.3590.99
45_V86_V1.3560.99
97_D100_T1.3550.99
168_S187_D1.3510.99
288_E291_E1.3450.99
255_Y259_L1.3400.99
17_N71_H1.3380.99
166_F260_T1.3350.99
270_L273_T1.3300.99
98_D152_V1.2970.99
5_Q152_V1.2920.99
239_V327_Q1.2910.99
318_R322_F1.2890.99
124_R128_R1.2860.99
12_G147_K1.2800.99
307_F316_G1.2760.99
78_H128_R1.2630.99
246_M281_A1.2590.99
325_A329_E1.2590.99
78_H81_N1.2540.99
278_I324_V1.2370.99
43_D115_V1.2360.99
46_F87_I1.2360.99
279_I306_V1.2310.99
127_S130_A1.2270.99
326_N330_N1.2180.98
286_M312_V1.2150.98
12_G44_V1.2140.98
14_D145_P1.2030.98
266_S273_T1.2030.98
96_T101_K1.1980.98
7_K98_D1.1910.98
5_Q229_Q1.1880.98
169_V189_H1.1850.98
294_E298_E1.1780.98
327_Q330_N1.1610.98
179_S210_M1.1580.98
97_D102_Q1.1390.98
255_Y299_K1.1350.98
161_V328_L1.1300.97
319_E323_E1.1230.97
245_D282_N1.1150.97
316_G319_E1.1150.97
43_D118_R1.1140.97
118_R147_K1.1110.97
246_M284_M1.1060.97
174_L317_L1.0920.97
163_L210_M1.0880.97
76_N128_R1.0830.97
141_E144_E1.0680.96
295_A298_E1.0590.96
203_D322_F1.0560.96
258_Y277_Q1.0520.96
218_E260_T1.0490.96
238_R328_L1.0470.96
201_E207_S1.0460.96
42_G66_A1.0450.96
280_V309_I1.0310.96
46_F114_A1.0220.95
173_T176_S1.0180.95
289_A292_N1.0170.95
121_R141_E1.0150.95
97_D104_I1.0090.95
58_F153_L1.0080.95
25_E28_V1.0070.95
259_L299_K1.0020.95
206_R325_A1.0000.95
241_V280_V0.9990.95
281_A293_L0.9980.95
281_A308_P0.9950.95
84_D113_R0.9950.95
166_F252_R0.9930.95
104_I151_I0.9810.94
326_N329_E0.9790.94
164_V234_I0.9780.94
260_T263_Q0.9740.94
22_F34_A0.9680.94
202_T322_F0.9660.94
8_V64_F0.9650.94
40_K122_G0.9650.94
321_L324_V0.9630.94
94_V156_K0.9610.94
239_V331_T0.9600.94
67_I70_E0.9560.94
235_E269_N0.9560.94
242_H277_Q0.9540.93
61_K64_F0.9510.93
247_S286_M0.9460.93
293_L297_K0.9450.93
105_A116_I0.9410.93
98_D150_Y0.9380.93
270_L274_E0.9370.93
199_M209_V0.9360.93
116_I151_I0.9320.93
57_D60_Y0.9240.92
287_P292_N0.9210.92
130_A135_P0.9210.92
10_V117_A0.9210.92
271_R274_E0.9190.92
297_K308_P0.9180.92
154_E232_R0.9110.92
324_V328_L0.9110.92
278_I323_E0.9070.92
5_Q232_R0.9050.92
173_T311_A0.9040.92
70_E77_Q0.9000.91
208_F328_L0.8960.91
17_N141_E0.8940.91
256_D259_L0.8870.91
296_F300_L0.8830.91
203_D206_R0.8820.90
162_G240_I0.8820.90
24_R29_P0.8770.90
176_S183_P0.8750.90
243_V309_I0.8750.90
115_V118_R0.8720.90
323_E327_Q0.8720.90
246_M296_F0.8700.90
258_Y279_I0.8640.90
250_E257_D0.8600.89
52_L57_D0.8560.89
290_A315_E0.8540.89
229_Q232_R0.8540.89
7_K152_V0.8540.89
284_M293_L0.8530.89
166_F257_D0.8500.89
244_I279_I0.8480.89
299_K302_D0.8430.88
40_K121_R0.8430.88
34_A76_N0.8420.88
46_F89_V0.8400.88
222_Q267_E0.8400.88
10_V149_R0.8390.88
239_V276_P0.8360.88
70_E80_R0.8350.88
210_M324_V0.8350.88
129_F141_E0.8340.88
11_K63_H0.8330.88
64_F87_I0.8300.88
266_S270_L0.8280.88
48_V111_G0.8270.87
202_T325_A0.8270.87
213_L240_I0.8240.87
294_E297_K0.8230.87
331_T334_F0.8230.87
322_F326_N0.8200.87
161_V324_V0.8190.87
64_F85_M0.8170.87
169_V257_D0.8130.87
284_M315_E0.8110.86
14_D146_G0.8110.86
228_H232_R0.8100.86
71_H74_S0.8070.86
297_K302_D0.8060.86
293_L296_F0.8030.86
282_N312_V0.8030.86
132_P135_P0.8000.86
293_L308_P0.7900.85
91_P107_L0.7890.85
203_D318_R0.7830.84
107_L114_A0.7780.84
310_S313_T0.7780.84
292_N315_E0.7770.84
175_L179_S0.7740.84
173_T286_M0.7680.83
17_N142_N0.7670.83
10_V116_I0.7630.83
298_E302_D0.7620.83
8_V153_L0.7610.83
296_F299_K0.7570.82
23_R29_P0.7570.82
255_Y295_A0.7560.82
49_D110_H0.7560.82
117_A147_K0.7550.82
173_T185_I0.7530.82
318_R321_L0.7510.82
278_I307_F0.7470.82
12_G146_G0.7470.82
279_I304_Y0.7460.81
29_P237_T0.7450.81
179_S200_V0.7400.81
239_V328_L0.7400.81
284_M292_N0.7400.81
217_I224_V0.7360.81
121_R124_R0.7360.81
164_V277_Q0.7340.80
189_H250_E0.7290.80
307_F319_E0.7270.80
53_R56_M0.7260.80
261_I277_Q0.7230.79
245_D283_K0.7190.79
287_P290_A0.7160.79
135_P175_L0.7150.79
25_E32_G0.7150.79
105_A112_Q0.7130.78
197_L223_G0.7110.78
91_P109_E0.7070.78
334_F338_D0.7040.78
293_L299_K0.7030.77
14_D71_H0.7020.77
284_M289_A0.7020.77
164_V210_M0.7010.77
21_A74_S0.6980.77
67_I85_M0.6970.77
6_V64_F0.6960.77
213_L234_I0.6950.77
74_S77_Q0.6930.76
117_A149_R0.6920.76
23_R76_N0.6850.76
162_G173_T0.6840.76
175_L196_N0.6820.75
179_S317_L0.6800.75
8_V87_I0.6770.75
303_D306_V0.6750.75
48_V110_H0.6750.75
26_K54_T0.6730.74
262_N279_I0.6730.74
17_N68_R0.6710.74
183_P196_N0.6690.74
243_V311_A0.6690.74
3_V56_M0.6680.74
169_V187_D0.6680.74
81_N84_D0.6660.74
168_S213_L0.6630.73
34_A74_S0.6620.73
22_F138_Q0.6620.73
97_D101_K0.6610.73
32_G137_P0.6610.73
40_K144_E0.6590.73
19_M34_A0.6590.73
46_F151_I0.6580.73
234_I261_I0.6580.73
22_F136_A0.6540.72
244_I282_N0.6520.72
281_A296_F0.6510.72
46_F153_L0.6510.72
276_P327_Q0.6490.72
242_H262_N0.6480.72
184_K196_N0.6460.71
56_M60_Y0.6450.71
288_E292_N0.6420.71
292_N295_A0.6370.70
12_G149_R0.6360.70
174_L321_L0.6350.70
202_T205_G0.6350.70
301_T304_Y0.6350.70
22_F74_S0.6310.70
281_A306_V0.6300.69
94_V154_E0.6290.69
6_V240_I0.6250.69
206_R326_N0.6240.69
193_L226_L0.6240.69
166_F261_I0.6210.68
44_V66_A0.6180.68
101_K152_V0.6180.68
91_P106_D0.6170.68
228_H243_V0.6170.68
294_E299_K0.6170.68
99_D102_Q0.6160.68
117_A151_I0.6160.68
129_F137_P0.6140.67
266_S274_E0.6140.67
6_V58_F0.6130.67
175_L194_V0.6110.67
177_V312_V0.6100.67
89_V116_I0.6090.67
177_V185_I0.6080.67
106_D156_K0.6070.67
63_H150_Y0.6060.66
228_H268_Y0.6050.66
232_R268_Y0.6050.66
139_L144_E0.6040.66
121_R128_R0.6030.66
178_V317_L0.6030.66
72_G125_G0.6030.66
301_T306_V0.6020.66
280_V308_P0.6020.66
53_R237_T0.6010.66
25_E31_G0.6000.66
23_R32_G0.6000.66
174_L309_I0.5970.65
24_R31_G0.5970.65
96_T154_E0.5970.65
32_G136_A0.5970.65
200_V210_M0.5950.65
251_G254_P0.5940.65
259_L263_Q0.5920.65
294_E302_D0.5890.64
184_K310_S0.5890.64
40_K128_R0.5880.64
121_R139_L0.5880.64
48_V108_T0.5880.64
9_Y14_D0.5870.64
255_Y296_F0.5870.64
328_L332_P0.5860.64
227_G264_E0.5830.63
48_V106_D0.5820.63
44_V117_A0.5820.63
298_E301_T0.5790.63
252_R256_D0.5780.63
130_A134_N0.5770.63
197_L209_V0.5760.63
164_V267_E0.5760.63
180_S201_E0.5750.62
17_N140_S0.5750.62
8_V151_I0.5740.62
176_S312_V0.5740.62
176_S186_A0.5740.62
34_A73_M0.5730.62
117_A146_G0.5720.62
83_D333_E0.5720.62
35_G125_G0.5700.62
319_E326_N0.5690.62
216_L234_I0.5690.62
6_V194_V0.5680.61
298_E303_D0.5650.61
219_G222_Q0.5650.61
91_P108_T0.5650.61
23_R27_Y0.5640.61
10_V46_F0.5640.61
279_I308_P0.5630.61
35_G126_N0.5630.61
34_A77_Q0.5620.61
324_V327_Q0.5600.60
221_H263_Q0.5590.60
333_E337_Y0.5580.60
34_A75_K0.5570.60
300_L304_Y0.5560.60
334_F337_Y0.5550.60
186_A193_L0.5540.60
42_G84_D0.5520.59
164_V242_H0.5510.59
78_H127_S0.5500.59
257_D261_I0.5500.59
279_I300_L0.5490.59
221_H228_H0.5440.58
162_G213_L0.5440.58
56_M158_L0.5440.58
12_G145_P0.5440.58
124_R129_F0.5410.58
44_V61_K0.5410.58
336_L339_E0.5400.58
30_K136_A0.5400.58
104_I116_I0.5360.57
179_S182_K0.5350.57
263_Q274_E0.5350.57
158_L286_M0.5340.57
166_F169_V0.5340.57
216_L242_H0.5340.57
328_L331_T0.5330.57
13_G16_G0.5330.57
158_L268_Y0.5330.57
52_L88_K0.5330.57
279_I320_L0.5320.57
3_V6_V0.5310.56
246_M299_K0.5310.56
190_F230_F0.5300.56
277_Q304_Y0.5300.56
257_D281_A0.5290.56
163_L208_F0.5270.56
228_H269_N0.5260.56
335_P339_E0.5260.56
86_V115_V0.5250.56
53_R59_R0.5240.55
122_G128_R0.5240.55
56_M180_S0.5240.55
244_I296_F0.5240.55
61_K87_I0.5230.55
331_T335_P0.5230.55
166_F218_E0.5230.55
294_E303_D0.5220.55
168_S173_T0.5210.55
213_L229_Q0.5210.55
82_A147_K0.5200.55
202_T208_F0.5200.55
246_M306_V0.5200.55
314_R317_L0.5170.54
6_V127_S0.5170.54
161_V210_M0.5160.54
135_P312_V0.5160.54
225_G230_F0.5150.54
246_M289_A0.5150.54
200_V328_L0.5140.54
164_V261_I0.5140.54
38_G41_G0.5140.54
177_V313_T0.5130.54
89_V93_T0.5130.54
20_V139_L0.5120.54
244_I320_L0.5120.54
210_M243_V0.5110.54
25_E137_P0.5110.54
184_K275_R0.5110.54
106_D236_R0.5080.53
107_L112_Q0.5080.53
166_F216_L0.5080.53
44_V87_I0.5080.53
130_A133_A0.5080.53
135_P168_S0.5070.53
51_G110_H0.5070.53
72_G126_N0.5070.53
47_E111_G0.5070.53
61_K85_M0.5060.53
114_A117_A0.5050.53
263_Q330_N0.5050.53
131_T137_P0.5050.53
327_Q331_T0.5050.53
179_S282_N0.5050.53
290_A308_P0.5040.53
244_I304_Y0.5030.52
158_L265_L0.5020.52
203_D325_A0.5020.52
162_G237_T0.5010.52
291_E295_A0.5000.52
238_R331_T0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1udxA 1 0.9556 100 0.294 Contact Map
1lnzA 1 0.7991 100 0.365 Contact Map
4csu9 1 0.771 100 0.394 Contact Map
1wxqA 1 0.4883 100 0.778 Contact Map
3gehA 2 0.778 100 0.785 Contact Map
3geeA 2 0.7547 100 0.79 Contact Map
2dbyA 1 0.5981 100 0.804 Contact Map
1ni3A 1 0.6238 100 0.811 Contact Map
4wnrA 1 0.5794 100 0.82 Contact Map
4a9aA 1 0.6776 100 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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