OBG - BACSU - GREMLIN Contacts

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OBG - GTPase ObgE

UniProt:	P20964	Sequences: MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDVVFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQVIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLADVGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIEGAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERPQIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEFPLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKRFARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	428 (337)
Sequences:	3447 (1764)
Seq/√Len:	96.1

ECOLI - OBG
BACSU - OBG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_E	113_R	4.481	1.00
45_V	115_V	4.233	1.00
262_N	277_Q	3.697	1.00
48_V	107_L	3.602	1.00
178_V	210_M	3.548	1.00
21_A	34_A	3.388	1.00
105_A	114_A	3.212	1.00
50_E	110_H	2.969	1.00
48_V	91_P	2.897	1.00
37_D	128_R	2.876	1.00
176_S	185_I	2.855	1.00
241_V	324_V	2.840	1.00
58_F	87_I	2.825	1.00
97_D	149_R	2.788	1.00
124_R	141_E	2.723	1.00
49_D	88_K	2.641	1.00
14_D	68_R	2.634	1.00
307_F	323_E	2.605	1.00
47_E	86_V	2.576	1.00
47_E	88_K	2.560	1.00
96_T	152_V	2.527	1.00
177_V	314_R	2.506	1.00
282_N	311_A	2.465	1.00
305_P	323_E	2.428	1.00
73_M	77_Q	2.411	1.00
46_F	95_V	2.394	1.00
96_T	103_V	2.339	1.00
11_K	148_E	2.333	1.00
67_I	83_D	2.288	1.00
121_R	144_E	2.232	1.00
70_E	73_M	2.228	1.00
108_T	112_Q	2.191	1.00
40_K	43_D	2.183	1.00
9_Y	150_Y	2.172	1.00
76_N	127_S	2.161	1.00
206_R	329_E	2.139	1.00
68_R	71_H	2.127	1.00
263_Q	266_S	2.123	1.00
284_M	308_P	2.114	1.00
174_L	178_V	2.090	1.00
20_V	140_S	2.075	1.00
86_V	113_R	2.043	1.00
45_V	113_R	1.854	1.00
174_L	243_V	1.853	1.00
67_I	82_A	1.843	1.00
99_D	150_Y	1.843	1.00
10_V	44_V	1.841	1.00
216_L	228_H	1.839	1.00
14_D	17_N	1.822	1.00
94_V	103_V	1.812	1.00
11_K	14_D	1.807	1.00
10_V	151_I	1.795	1.00
242_H	261_I	1.795	1.00
263_Q	267_E	1.790	1.00
174_L	320_L	1.784	1.00
244_I	258_Y	1.778	1.00
40_K	81_N	1.770	1.00
109_E	112_Q	1.722	1.00
23_R	28_V	1.709	1.00
156_K	235_E	1.701	1.00
200_V	208_F	1.700	1.00
134_N	139_L	1.664	1.00
252_R	257_D	1.646	1.00
221_H	267_E	1.621	1.00
43_D	84_D	1.575	1.00
238_R	332_P	1.570	1.00
7_K	150_Y	1.567	1.00
174_L	210_M	1.566	1.00
243_V	282_N	1.551	1.00
269_N	273_T	1.547	1.00
295_A	299_K	1.528	1.00
309_I	320_L	1.527	1.00
256_D	260_T	1.490	1.00
323_E	326_N	1.484	1.00
19_M	74_S	1.483	1.00
67_I	80_R	1.480	1.00
58_F	64_F	1.466	1.00
11_K	65_K	1.466	1.00
9_Y	148_E	1.447	1.00
258_Y	304_Y	1.440	1.00
164_V	240_I	1.437	1.00
178_V	321_L	1.431	1.00
253_D	256_D	1.414	0.99
280_V	320_L	1.408	0.99
12_G	117_A	1.402	0.99
239_V	324_V	1.396	0.99
258_Y	262_N	1.382	0.99
46_F	116_I	1.381	0.99
9_Y	63_H	1.377	0.99
297_K	301_T	1.365	0.99
251_G	257_D	1.363	0.99
161_V	239_V	1.360	0.99
19_M	73_M	1.359	0.99
45_V	86_V	1.356	0.99
97_D	100_T	1.355	0.99
168_S	187_D	1.351	0.99
288_E	291_E	1.345	0.99
255_Y	259_L	1.340	0.99
17_N	71_H	1.338	0.99
166_F	260_T	1.335	0.99
270_L	273_T	1.330	0.99
98_D	152_V	1.297	0.99
5_Q	152_V	1.292	0.99
239_V	327_Q	1.291	0.99
318_R	322_F	1.289	0.99
124_R	128_R	1.286	0.99
12_G	147_K	1.280	0.99
307_F	316_G	1.276	0.99
78_H	128_R	1.263	0.99
246_M	281_A	1.259	0.99
325_A	329_E	1.259	0.99
78_H	81_N	1.254	0.99
278_I	324_V	1.237	0.99
43_D	115_V	1.236	0.99
46_F	87_I	1.236	0.99
279_I	306_V	1.231	0.99
127_S	130_A	1.227	0.99
326_N	330_N	1.218	0.98
286_M	312_V	1.215	0.98
12_G	44_V	1.214	0.98
14_D	145_P	1.203	0.98
266_S	273_T	1.203	0.98
96_T	101_K	1.198	0.98
7_K	98_D	1.191	0.98
5_Q	229_Q	1.188	0.98
169_V	189_H	1.185	0.98
294_E	298_E	1.178	0.98
327_Q	330_N	1.161	0.98
179_S	210_M	1.158	0.98
97_D	102_Q	1.139	0.98
255_Y	299_K	1.135	0.98
161_V	328_L	1.130	0.97
319_E	323_E	1.123	0.97
245_D	282_N	1.115	0.97
316_G	319_E	1.115	0.97
43_D	118_R	1.114	0.97
118_R	147_K	1.111	0.97
246_M	284_M	1.106	0.97
174_L	317_L	1.092	0.97
163_L	210_M	1.088	0.97
76_N	128_R	1.083	0.97
141_E	144_E	1.068	0.96
295_A	298_E	1.059	0.96
203_D	322_F	1.056	0.96
258_Y	277_Q	1.052	0.96
218_E	260_T	1.049	0.96
238_R	328_L	1.047	0.96
201_E	207_S	1.046	0.96
42_G	66_A	1.045	0.96
280_V	309_I	1.031	0.96
46_F	114_A	1.022	0.95
173_T	176_S	1.018	0.95
289_A	292_N	1.017	0.95
121_R	141_E	1.015	0.95
97_D	104_I	1.009	0.95
58_F	153_L	1.008	0.95
25_E	28_V	1.007	0.95
259_L	299_K	1.002	0.95
206_R	325_A	1.000	0.95
241_V	280_V	0.999	0.95
281_A	293_L	0.998	0.95
281_A	308_P	0.995	0.95
84_D	113_R	0.995	0.95
166_F	252_R	0.993	0.95
104_I	151_I	0.981	0.94
326_N	329_E	0.979	0.94
164_V	234_I	0.978	0.94
260_T	263_Q	0.974	0.94
22_F	34_A	0.968	0.94
202_T	322_F	0.966	0.94
8_V	64_F	0.965	0.94
40_K	122_G	0.965	0.94
321_L	324_V	0.963	0.94
94_V	156_K	0.961	0.94
239_V	331_T	0.960	0.94
67_I	70_E	0.956	0.94
235_E	269_N	0.956	0.94
242_H	277_Q	0.954	0.93
61_K	64_F	0.951	0.93
247_S	286_M	0.946	0.93
293_L	297_K	0.945	0.93
105_A	116_I	0.941	0.93
98_D	150_Y	0.938	0.93
270_L	274_E	0.937	0.93
199_M	209_V	0.936	0.93
116_I	151_I	0.932	0.93
57_D	60_Y	0.924	0.92
287_P	292_N	0.921	0.92
130_A	135_P	0.921	0.92
10_V	117_A	0.921	0.92
271_R	274_E	0.919	0.92
297_K	308_P	0.918	0.92
154_E	232_R	0.911	0.92
324_V	328_L	0.911	0.92
278_I	323_E	0.907	0.92
5_Q	232_R	0.905	0.92
173_T	311_A	0.904	0.92
70_E	77_Q	0.900	0.91
208_F	328_L	0.896	0.91
17_N	141_E	0.894	0.91
256_D	259_L	0.887	0.91
296_F	300_L	0.883	0.91
203_D	206_R	0.882	0.90
162_G	240_I	0.882	0.90
24_R	29_P	0.877	0.90
176_S	183_P	0.875	0.90
243_V	309_I	0.875	0.90
115_V	118_R	0.872	0.90
323_E	327_Q	0.872	0.90
246_M	296_F	0.870	0.90
258_Y	279_I	0.864	0.90
250_E	257_D	0.860	0.89
52_L	57_D	0.856	0.89
290_A	315_E	0.854	0.89
229_Q	232_R	0.854	0.89
7_K	152_V	0.854	0.89
284_M	293_L	0.853	0.89
166_F	257_D	0.850	0.89
244_I	279_I	0.848	0.89
299_K	302_D	0.843	0.88
40_K	121_R	0.843	0.88
34_A	76_N	0.842	0.88
46_F	89_V	0.840	0.88
222_Q	267_E	0.840	0.88
10_V	149_R	0.839	0.88
239_V	276_P	0.836	0.88
70_E	80_R	0.835	0.88
210_M	324_V	0.835	0.88
129_F	141_E	0.834	0.88
11_K	63_H	0.833	0.88
64_F	87_I	0.830	0.88
266_S	270_L	0.828	0.88
48_V	111_G	0.827	0.87
202_T	325_A	0.827	0.87
213_L	240_I	0.824	0.87
294_E	297_K	0.823	0.87
331_T	334_F	0.823	0.87
322_F	326_N	0.820	0.87
161_V	324_V	0.819	0.87
64_F	85_M	0.817	0.87
169_V	257_D	0.813	0.87
284_M	315_E	0.811	0.86
14_D	146_G	0.811	0.86
228_H	232_R	0.810	0.86
71_H	74_S	0.807	0.86
297_K	302_D	0.806	0.86
293_L	296_F	0.803	0.86
282_N	312_V	0.803	0.86
132_P	135_P	0.800	0.86
293_L	308_P	0.790	0.85
91_P	107_L	0.789	0.85
203_D	318_R	0.783	0.84
107_L	114_A	0.778	0.84
310_S	313_T	0.778	0.84
292_N	315_E	0.777	0.84
175_L	179_S	0.774	0.84
173_T	286_M	0.768	0.83
17_N	142_N	0.767	0.83
10_V	116_I	0.763	0.83
298_E	302_D	0.762	0.83
8_V	153_L	0.761	0.83
296_F	299_K	0.757	0.82
23_R	29_P	0.757	0.82
255_Y	295_A	0.756	0.82
49_D	110_H	0.756	0.82
117_A	147_K	0.755	0.82
173_T	185_I	0.753	0.82
318_R	321_L	0.751	0.82
278_I	307_F	0.747	0.82
12_G	146_G	0.747	0.82
279_I	304_Y	0.746	0.81
29_P	237_T	0.745	0.81
179_S	200_V	0.740	0.81
239_V	328_L	0.740	0.81
284_M	292_N	0.740	0.81
217_I	224_V	0.736	0.81
121_R	124_R	0.736	0.81
164_V	277_Q	0.734	0.80
189_H	250_E	0.729	0.80
307_F	319_E	0.727	0.80
53_R	56_M	0.726	0.80
261_I	277_Q	0.723	0.79
245_D	283_K	0.719	0.79
287_P	290_A	0.716	0.79
135_P	175_L	0.715	0.79
25_E	32_G	0.715	0.79
105_A	112_Q	0.713	0.78
197_L	223_G	0.711	0.78
91_P	109_E	0.707	0.78
334_F	338_D	0.704	0.78
293_L	299_K	0.703	0.77
14_D	71_H	0.702	0.77
284_M	289_A	0.702	0.77
164_V	210_M	0.701	0.77
21_A	74_S	0.698	0.77
67_I	85_M	0.697	0.77
6_V	64_F	0.696	0.77
213_L	234_I	0.695	0.77
74_S	77_Q	0.693	0.76
117_A	149_R	0.692	0.76
23_R	76_N	0.685	0.76
162_G	173_T	0.684	0.76
175_L	196_N	0.682	0.75
179_S	317_L	0.680	0.75
8_V	87_I	0.677	0.75
303_D	306_V	0.675	0.75
48_V	110_H	0.675	0.75
26_K	54_T	0.673	0.74
262_N	279_I	0.673	0.74
17_N	68_R	0.671	0.74
183_P	196_N	0.669	0.74
243_V	311_A	0.669	0.74
3_V	56_M	0.668	0.74
169_V	187_D	0.668	0.74
81_N	84_D	0.666	0.74
168_S	213_L	0.663	0.73
34_A	74_S	0.662	0.73
22_F	138_Q	0.662	0.73
97_D	101_K	0.661	0.73
32_G	137_P	0.661	0.73
40_K	144_E	0.659	0.73
19_M	34_A	0.659	0.73
46_F	151_I	0.658	0.73
234_I	261_I	0.658	0.73
22_F	136_A	0.654	0.72
244_I	282_N	0.652	0.72
281_A	296_F	0.651	0.72
46_F	153_L	0.651	0.72
276_P	327_Q	0.649	0.72
242_H	262_N	0.648	0.72
184_K	196_N	0.646	0.71
56_M	60_Y	0.645	0.71
288_E	292_N	0.642	0.71
292_N	295_A	0.637	0.70
12_G	149_R	0.636	0.70
174_L	321_L	0.635	0.70
202_T	205_G	0.635	0.70
301_T	304_Y	0.635	0.70
22_F	74_S	0.631	0.70
281_A	306_V	0.630	0.69
94_V	154_E	0.629	0.69
6_V	240_I	0.625	0.69
206_R	326_N	0.624	0.69
193_L	226_L	0.624	0.69
166_F	261_I	0.621	0.68
44_V	66_A	0.618	0.68
101_K	152_V	0.618	0.68
91_P	106_D	0.617	0.68
228_H	243_V	0.617	0.68
294_E	299_K	0.617	0.68
99_D	102_Q	0.616	0.68
117_A	151_I	0.616	0.68
129_F	137_P	0.614	0.67
266_S	274_E	0.614	0.67
6_V	58_F	0.613	0.67
175_L	194_V	0.611	0.67
177_V	312_V	0.610	0.67
89_V	116_I	0.609	0.67
177_V	185_I	0.608	0.67
106_D	156_K	0.607	0.67
63_H	150_Y	0.606	0.66
228_H	268_Y	0.605	0.66
232_R	268_Y	0.605	0.66
139_L	144_E	0.604	0.66
121_R	128_R	0.603	0.66
178_V	317_L	0.603	0.66
72_G	125_G	0.603	0.66
301_T	306_V	0.602	0.66
280_V	308_P	0.602	0.66
53_R	237_T	0.601	0.66
25_E	31_G	0.600	0.66
23_R	32_G	0.600	0.66
174_L	309_I	0.597	0.65
24_R	31_G	0.597	0.65
96_T	154_E	0.597	0.65
32_G	136_A	0.597	0.65
200_V	210_M	0.595	0.65
251_G	254_P	0.594	0.65
259_L	263_Q	0.592	0.65
294_E	302_D	0.589	0.64
184_K	310_S	0.589	0.64
40_K	128_R	0.588	0.64
121_R	139_L	0.588	0.64
48_V	108_T	0.588	0.64
9_Y	14_D	0.587	0.64
255_Y	296_F	0.587	0.64
328_L	332_P	0.586	0.64
227_G	264_E	0.583	0.63
48_V	106_D	0.582	0.63
44_V	117_A	0.582	0.63
298_E	301_T	0.579	0.63
252_R	256_D	0.578	0.63
130_A	134_N	0.577	0.63
197_L	209_V	0.576	0.63
164_V	267_E	0.576	0.63
180_S	201_E	0.575	0.62
17_N	140_S	0.575	0.62
8_V	151_I	0.574	0.62
176_S	312_V	0.574	0.62
176_S	186_A	0.574	0.62
34_A	73_M	0.573	0.62
117_A	146_G	0.572	0.62
83_D	333_E	0.572	0.62
35_G	125_G	0.570	0.62
319_E	326_N	0.569	0.62
216_L	234_I	0.569	0.62
6_V	194_V	0.568	0.61
298_E	303_D	0.565	0.61
219_G	222_Q	0.565	0.61
91_P	108_T	0.565	0.61
23_R	27_Y	0.564	0.61
10_V	46_F	0.564	0.61
279_I	308_P	0.563	0.61
35_G	126_N	0.563	0.61
34_A	77_Q	0.562	0.61
324_V	327_Q	0.560	0.60
221_H	263_Q	0.559	0.60
333_E	337_Y	0.558	0.60
34_A	75_K	0.557	0.60
300_L	304_Y	0.556	0.60
334_F	337_Y	0.555	0.60
186_A	193_L	0.554	0.60
42_G	84_D	0.552	0.59
164_V	242_H	0.551	0.59
78_H	127_S	0.550	0.59
257_D	261_I	0.550	0.59
279_I	300_L	0.549	0.59
221_H	228_H	0.544	0.58
162_G	213_L	0.544	0.58
56_M	158_L	0.544	0.58
12_G	145_P	0.544	0.58
124_R	129_F	0.541	0.58
44_V	61_K	0.541	0.58
336_L	339_E	0.540	0.58
30_K	136_A	0.540	0.58
104_I	116_I	0.536	0.57
179_S	182_K	0.535	0.57
263_Q	274_E	0.535	0.57
158_L	286_M	0.534	0.57
166_F	169_V	0.534	0.57
216_L	242_H	0.534	0.57
328_L	331_T	0.533	0.57
13_G	16_G	0.533	0.57
158_L	268_Y	0.533	0.57
52_L	88_K	0.533	0.57
279_I	320_L	0.532	0.57
3_V	6_V	0.531	0.56
246_M	299_K	0.531	0.56
190_F	230_F	0.530	0.56
277_Q	304_Y	0.530	0.56
257_D	281_A	0.529	0.56
163_L	208_F	0.527	0.56
228_H	269_N	0.526	0.56
335_P	339_E	0.526	0.56
86_V	115_V	0.525	0.56
53_R	59_R	0.524	0.55
122_G	128_R	0.524	0.55
56_M	180_S	0.524	0.55
244_I	296_F	0.524	0.55
61_K	87_I	0.523	0.55
331_T	335_P	0.523	0.55
166_F	218_E	0.523	0.55
294_E	303_D	0.522	0.55
168_S	173_T	0.521	0.55
213_L	229_Q	0.521	0.55
82_A	147_K	0.520	0.55
202_T	208_F	0.520	0.55
246_M	306_V	0.520	0.55
314_R	317_L	0.517	0.54
6_V	127_S	0.517	0.54
161_V	210_M	0.516	0.54
135_P	312_V	0.516	0.54
225_G	230_F	0.515	0.54
246_M	289_A	0.515	0.54
200_V	328_L	0.514	0.54
164_V	261_I	0.514	0.54
38_G	41_G	0.514	0.54
177_V	313_T	0.513	0.54
89_V	93_T	0.513	0.54
20_V	139_L	0.512	0.54
244_I	320_L	0.512	0.54
210_M	243_V	0.511	0.54
25_E	137_P	0.511	0.54
184_K	275_R	0.511	0.54
106_D	236_R	0.508	0.53
107_L	112_Q	0.508	0.53
166_F	216_L	0.508	0.53
44_V	87_I	0.508	0.53
130_A	133_A	0.508	0.53
135_P	168_S	0.507	0.53
51_G	110_H	0.507	0.53
72_G	126_N	0.507	0.53
47_E	111_G	0.507	0.53
61_K	85_M	0.506	0.53
114_A	117_A	0.505	0.53
263_Q	330_N	0.505	0.53
131_T	137_P	0.505	0.53
327_Q	331_T	0.505	0.53
179_S	282_N	0.505	0.53
290_A	308_P	0.504	0.53
244_I	304_Y	0.503	0.52
158_L	265_L	0.502	0.52
203_D	325_A	0.502	0.52
162_G	237_T	0.501	0.52
291_E	295_A	0.500	0.52
238_R	331_T	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1udxA	1	0.9556	100	0.294	Contact Map
1lnzA	1	0.7991	100	0.365	Contact Map
4csu9	1	0.771	100	0.394	Contact Map
1wxqA	1	0.4883	100	0.778	Contact Map
3gehA	2	0.778	100	0.785	Contact Map
3geeA	2	0.7547	100	0.79	Contact Map
2dbyA	1	0.5981	100	0.804	Contact Map
1ni3A	1	0.6238	100	0.811	Contact Map
4wnrA	1	0.5794	100	0.82	Contact Map
4a9aA	1	0.6776	100	0.822	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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