GREMLIN Database
TYRA - Prephenate dehydrogenase
UniProt: P20692 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (287)
Sequences: 2112 (1487)
Seq/√Len: 87.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_D262_R4.3391.00
32_R54_D4.1121.00
45_A135_A3.7461.00
255_I259_D3.4451.00
281_K285_D3.3691.00
97_T123_G3.1671.00
22_L137_A2.9811.00
7_T32_R2.9671.00
255_I262_R2.8261.00
252_D266_E2.6271.00
164_K176_E2.6071.00
20_I170_T2.4901.00
23_A170_T2.3731.00
164_K168_K2.3501.00
244_K268_E2.3131.00
121_V163_L2.3081.00
264_Y272_N2.2751.00
269_D272_N2.2711.00
25_K53_D2.2621.00
230_S285_D2.2241.00
192_F247_I2.1991.00
155_T160_V2.1441.00
248_L266_E1.9601.00
7_T34_I1.9581.00
126_M186_T1.9541.00
40_D44_V1.9511.00
110_A120_F1.9361.00
129_S138_K1.9341.00
8_I24_I1.9231.00
51_V134_V1.9161.00
35_G52_I1.9101.00
148_I177_M1.8961.00
197_A229_A1.8851.00
52_I55_R1.8821.00
82_L110_A1.8551.00
240_L247_I1.8471.00
73_T81_M1.8331.00
75_V102_T1.8261.00
123_G149_L1.8161.00
37_D42_Q1.8021.00
178_S181_E1.7991.00
71_I82_L1.7821.00
9_L66_A1.7791.00
13_L35_G1.7631.00
58_S61_S1.7511.00
43_A55_R1.7491.00
7_T65_E1.7471.00
49_L134_V1.7331.00
26_K139_E1.7211.00
44_V48_K1.6991.00
71_I81_M1.6921.00
45_A48_K1.6861.00
91_E94_L1.6831.00
195_I261_I1.6581.00
21_A51_V1.6421.00
70_I97_T1.6271.00
104_Q108_D1.6231.00
251_F258_I1.6191.00
24_I166_L1.5491.00
184_G249_D1.5391.00
78_T100_G1.5371.00
275_R279_T1.5121.00
43_A52_I1.5091.00
104_Q180_E1.4961.00
80_V84_E1.4590.99
18_G137_A1.4480.99
200_L225_I1.4460.99
262_R266_E1.4410.99
107_V179_P1.4310.99
20_I70_I1.4210.99
79_L112_Q1.4200.99
240_L277_F1.4150.99
237_R270_A1.3980.99
165_N168_K1.3890.99
71_I78_T1.3800.99
230_S281_K1.3700.99
20_I166_L1.3500.99
195_I240_L1.3380.99
79_L109_Y1.3350.99
97_T163_L1.3160.99
196_V254_W1.2970.99
43_A57_D1.2810.99
234_A274_F1.2750.98
274_F278_K1.2750.98
189_I220_G1.2680.98
161_E164_K1.2650.98
248_L262_R1.2640.98
34_I65_E1.2570.98
181_E213_L1.2520.98
105_K242_H1.2360.98
63_V85_L1.2350.98
95_L159_A1.2310.98
252_D255_I1.2300.98
111_D154_K1.2270.98
67_A91_E1.2170.98
107_V122_G1.2160.98
203_Q257_E1.2150.98
237_R274_F1.2030.98
73_T77_Q1.2000.98
16_I99_V1.1870.98
123_G147_Y1.1850.98
132_S277_F1.1830.97
107_V152_G1.1820.97
79_L83_E1.1810.97
175_V217_F1.1780.97
70_I99_V1.1770.97
83_E109_Y1.1720.97
65_E91_E1.1700.97
26_K143_E1.1620.97
45_A49_L1.1370.97
186_T189_I1.1340.97
140_F143_E1.1330.97
109_Y112_Q1.1250.97
147_Y167_L1.1250.97
34_I54_D1.1140.96
68_T166_L1.1130.96
177_M213_L1.1120.96
231_S277_F1.1110.96
9_L36_I1.1090.96
101_S239_I1.1030.96
93_E118_Y1.1030.96
11_A85_L1.1030.96
8_I68_T1.1000.96
157_K161_E1.0990.96
221_G228_I1.0910.96
11_A81_M1.0870.96
95_L162_Q1.0860.96
16_I142_F1.0850.96
263_T267_Q1.0760.96
167_L174_F1.0700.95
63_V69_V1.0660.95
107_V120_F1.0650.95
42_Q134_V1.0650.95
39_S42_Q1.0640.95
63_V66_A1.0620.95
25_K33_I1.0580.95
6_D31_K1.0480.95
47_L55_R1.0440.95
77_Q80_V1.0440.95
11_A36_I1.0390.95
22_L49_L1.0390.95
126_M167_L1.0260.94
24_I29_P1.0250.94
147_Y172_A1.0230.94
221_G225_I1.0220.94
23_A139_E1.0210.94
241_L270_A1.0190.94
102_T105_K1.0150.94
18_G22_L1.0150.94
194_H228_I1.0120.94
231_S236_W1.0120.94
99_V142_F1.0110.94
93_E119_Q1.0060.94
44_V47_L1.0020.94
75_V100_G1.0000.93
38_I73_T0.9990.93
108_D112_Q0.9980.93
194_H236_W0.9970.93
121_V155_T0.9920.93
156_D159_A0.9900.93
87_H90_I0.9870.93
272_N275_R0.9850.93
152_G155_T0.9840.93
82_L86_A0.9840.93
236_W239_I0.9830.93
119_Q156_D0.9740.93
202_H279_T0.9710.92
278_K282_D0.9630.92
56_A62_G0.9620.92
13_L37_D0.9530.92
10_L21_A0.9530.92
52_I56_A0.9490.92
161_E168_K0.9450.91
13_L42_Q0.9450.91
90_I96_I0.9400.91
115_P118_Y0.9350.91
206_H257_E0.9140.90
126_M220_G0.9090.90
187_S246_K0.9070.90
59_F85_L0.9050.90
228_I236_W0.9050.90
10_L17_G0.9030.89
46_A52_I0.9030.89
198_A261_I0.8900.89
101_S191_H0.8880.89
195_I251_F0.8870.89
34_I56_A0.8810.88
275_R278_K0.8650.87
83_E87_H0.8610.87
47_L54_D0.8590.87
244_K248_L0.8580.87
106_V120_F0.8560.87
111_D117_R0.8550.87
261_I276_Y0.8540.87
221_G231_S0.8530.87
225_I230_S0.8510.86
76_E238_D0.8500.86
166_L170_T0.8500.86
263_T266_E0.8480.86
202_H276_Y0.8410.86
21_A35_G0.8390.86
157_K176_E0.8380.86
163_L167_L0.8380.86
11_A59_F0.8320.85
69_V94_L0.8290.85
96_I114_L0.8280.85
150_T179_P0.8270.85
41_E44_V0.8250.85
6_D162_Q0.8200.84
23_A140_F0.8180.84
60_I84_E0.8160.84
111_D152_G0.8140.84
202_H280_A0.8110.84
256_R263_T0.8100.84
10_L72_A0.8100.84
188_V250_R0.8090.84
9_L62_G0.8090.84
177_M185_V0.8070.83
95_L163_L0.8040.83
126_M147_Y0.7920.82
8_I30_G0.7900.82
248_L255_I0.7870.82
108_D111_D0.7830.82
21_A33_I0.7790.81
171_N187_S0.7760.81
188_V204_T0.7760.81
204_T232_S0.7730.81
145_A220_G0.7720.81
13_L134_V0.7720.81
114_L117_R0.7710.81
29_P166_L0.7690.80
188_V207_S0.7650.80
13_L46_A0.7640.80
185_V217_F0.7620.80
109_Y113_V0.7590.80
271_E275_R0.7580.79
28_H31_K0.7570.79
218_A287_L0.7570.79
192_F250_R0.7540.79
186_T217_F0.7500.79
196_V200_L0.7480.79
257_E260_K0.7470.78
122_G145_A0.7470.78
148_I217_F0.7440.78
220_G228_I0.7430.78
201_V219_A0.7360.77
153_Q178_S0.7330.77
111_D153_Q0.7330.77
126_M198_A0.7280.77
104_Q179_P0.7250.76
126_M189_I0.7220.76
22_L51_V0.7220.76
215_K283_Y0.7210.76
195_I247_I0.7200.76
132_S136_A0.7190.76
217_F288_P0.7190.76
259_D263_T0.7170.76
191_H239_I0.7170.76
223_R237_R0.7160.75
96_I110_A0.7070.75
161_E165_N0.7050.74
36_I56_A0.7040.74
73_T78_T0.7040.74
20_I24_I0.7010.74
9_L63_V0.7010.74
228_I239_I0.6940.73
126_M225_I0.6900.73
68_T163_L0.6880.73
75_V235_M0.6830.72
130_H171_N0.6830.72
102_T265_V0.6810.72
69_V92_H0.6800.72
60_I64_K0.6800.72
21_A194_H0.6800.72
146_F230_S0.6750.71
15_L191_H0.6740.71
249_D266_E0.6730.71
254_W258_I0.6720.71
264_Y269_D0.6710.71
68_T95_L0.6710.71
16_I123_G0.6710.71
156_D160_V0.6700.71
105_K108_D0.6680.70
188_V197_A0.6680.70
132_S232_S0.6660.70
165_N169_G0.6620.70
153_Q162_Q0.6600.69
26_K165_N0.6590.69
198_A217_F0.6570.69
151_P160_V0.6570.69
148_I174_F0.6560.69
12_G17_G0.6560.69
192_F200_L0.6560.69
207_S253_E0.6540.69
203_Q250_R0.6540.69
224_D229_A0.6510.68
100_G235_M0.6480.68
56_A61_S0.6480.68
121_V160_V0.6470.68
48_K135_A0.6460.68
97_T219_A0.6440.67
47_L52_I0.6430.67
203_Q254_W0.6420.67
149_L167_L0.6390.67
218_A280_A0.6390.67
197_A284_R0.6380.67
8_I31_K0.6340.66
131_K285_D0.6320.66
252_D259_D0.6310.66
230_S288_P0.6290.66
13_L52_I0.6280.66
160_V164_K0.6220.65
244_K266_E0.6220.65
251_F262_R0.6220.65
113_V117_R0.6190.64
81_M85_L0.6180.64
190_S224_D0.6180.64
162_Q165_N0.6160.64
75_V242_H0.6150.64
159_A166_L0.6150.64
122_G186_T0.6120.64
70_I166_L0.6100.63
206_H249_D0.6080.63
40_D57_D0.6070.63
110_A117_R0.6050.63
22_L35_G0.6040.63
175_V213_L0.6030.62
22_L134_V0.6000.62
130_H192_F0.5990.62
18_G21_A0.5990.62
148_I186_T0.5980.62
158_Q282_D0.5980.62
198_A231_S0.5970.62
87_H94_L0.5960.62
267_Q270_A0.5950.61
20_I68_T0.5940.61
76_E242_H0.5930.61
61_S64_K0.5920.61
84_E89_G0.5910.61
99_V234_A0.5870.60
159_A162_Q0.5860.60
18_G134_V0.5850.60
234_A237_R0.5850.60
97_T147_Y0.5840.60
234_A265_V0.5790.59
228_I231_S0.5780.59
22_L26_K0.5780.59
108_D180_E0.5780.59
121_V167_L0.5770.59
253_E260_K0.5760.59
196_V199_S0.5730.59
221_G229_A0.5730.59
222_F284_R0.5710.58
122_G147_Y0.5700.58
7_T67_A0.5670.58
154_K160_V0.5650.57
18_G35_G0.5640.57
37_D99_V0.5640.57
177_M197_A0.5640.57
57_D61_S0.5620.57
191_H231_S0.5610.57
8_I70_I0.5600.57
146_F173_H0.5590.57
64_K89_G0.5580.57
74_P191_H0.5580.57
265_V268_E0.5570.56
117_R154_K0.5570.56
105_K109_Y0.5570.56
134_V137_A0.5550.56
58_S84_E0.5550.56
231_S281_K0.5550.56
248_L252_D0.5550.56
21_A49_L0.5550.56
20_I99_V0.5540.56
219_A236_W0.5500.55
245_D266_E0.5470.55
231_S239_I0.5470.55
86_A115_P0.5450.55
15_L190_S0.5440.55
19_S141_L0.5440.55
78_T106_V0.5430.55
205_H279_T0.5430.55
82_L113_V0.5410.54
122_G152_G0.5410.54
30_G33_I0.5410.54
85_L90_I0.5400.54
192_F254_W0.5400.54
74_P239_I0.5390.54
167_L186_T0.5380.54
80_V83_E0.5380.54
132_S235_M0.5380.54
191_H224_D0.5370.54
194_H231_S0.5370.54
198_A276_Y0.5360.54
158_Q249_D0.5350.53
129_S137_A0.5320.53
187_S250_R0.5310.53
276_Y279_T0.5310.53
191_H221_G0.5310.53
79_L113_V0.5290.53
37_D288_P0.5280.53
18_G51_V0.5280.53
72_A242_H0.5270.52
194_H197_A0.5270.52
161_E271_E0.5270.52
74_P172_A0.5250.52
121_V159_A0.5240.52
34_I63_V0.5230.52
94_L149_L0.5210.52
9_L34_I0.5190.51
192_F276_Y0.5170.51
251_F265_V0.5160.51
74_P101_S0.5160.51
79_L105_K0.5140.51
37_D52_I0.5140.51
44_V55_R0.5130.50
230_S240_L0.5110.50
244_K265_V0.5110.50
127_A141_L0.5110.50
198_A265_V0.5110.50
146_F225_I0.5110.50
141_L193_P0.5090.50
10_L73_T0.5060.50
82_L123_G0.5040.49
22_L25_K0.5030.49
189_I204_T0.5020.49
189_I213_L0.5010.49
147_Y198_A0.5010.49
190_S227_R0.5000.49
190_S197_A0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ktdA 2 0.8383 100 0.487 Contact Map
3b1fA 2 0.7628 100 0.508 Contact Map
3ggoA 2 0.7601 100 0.539 Contact Map
4wjiA 2 0.7871 100 0.546 Contact Map
2g5cA 2 0.7493 100 0.548 Contact Map
2pv7A 2 0.7305 100 0.569 Contact Map
2f1kA 2 0.7466 100 0.574 Contact Map
1ygyA 4 0.9137 100 0.708 Contact Map
2izzA 5 0.7116 100 0.732 Contact Map
2b0jA 2 0.6846 100 0.737 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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