GREMLIN Database
AROA - 3-phosphoshikimate 1-carboxyvinyltransferase
UniProt: P20691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (394)
Sequences: 7856 (4858)
Seq/√Len: 244.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E252_K4.1391.00
357_E368_Y3.9021.00
39_K224_D3.5051.00
181_T215_A3.2181.00
416_T419_E3.1521.00
33_A219_K2.9111.00
204_K215_A2.8791.00
14_H252_K2.8041.00
39_K226_F2.7911.00
35_T71_H2.7811.00
152_S179_E2.7481.00
242_A272_A2.7071.00
198_L203_V2.6961.00
414_Y420_H2.6591.00
327_T368_Y2.6351.00
37_T224_D2.6021.00
111_A117_A2.5751.00
296_S325_E2.5101.00
378_A405_E2.4861.00
243_M393_I2.4791.00
134_K149_S2.4661.00
43_P48_L2.4461.00
39_K67_D2.3681.00
52_D55_R2.3631.00
350_E353_K2.3191.00
249_I424_L2.3141.00
239_A320_L2.2911.00
248_R290_L2.2901.00
378_A403_E2.2731.00
277_K280_A2.2711.00
35_T69_V2.1941.00
372_T399_E2.1891.00
37_T69_V2.1781.00
127_P171_V2.1491.00
37_T67_D2.1481.00
62_E69_V2.1331.00
164_S167_I2.1311.00
157_D185_T2.0911.00
181_T213_S2.0811.00
361_T364_G2.0791.00
395_S402_I2.0711.00
172_L195_E2.0391.00
323_Q397_I2.0301.00
301_E331_K1.9891.00
107_Y147_S1.9611.00
350_E391_L1.9551.00
43_P63_Q1.9551.00
248_R291_I1.9521.00
329_V366_K1.9491.00
10_H248_R1.9241.00
29_G36_T1.9131.00
122_K126_E1.8261.00
250_V277_K1.7891.00
351_L356_A1.7601.00
319_L390_M1.7371.00
27_M50_T1.7281.00
356_A373_L1.7081.00
22_S41_F1.7051.00
359_E366_K1.7021.00
99_G170_A1.6961.00
60_H71_H1.6881.00
298_K325_E1.6621.00
183_T213_S1.6551.00
51_I68_V1.6531.00
359_E368_Y1.6471.00
126_E130_K1.6311.00
327_T366_K1.6251.00
235_A313_E1.6141.00
354_L402_I1.6071.00
350_E382_H1.6011.00
158_Y185_T1.5951.00
25_S197_M1.5721.00
154_K179_E1.5691.00
185_T211_S1.5691.00
203_V220_L1.5631.00
183_T211_S1.5601.00
301_E329_V1.5561.00
136_D149_S1.5561.00
348_V358_I1.5521.00
250_V280_A1.5401.00
136_D147_S1.5181.00
34_G222_A1.5131.00
354_L377_A1.5071.00
63_Q68_V1.5011.00
199_S208_D1.5001.00
51_I61_I1.4991.00
155_G178_A1.4991.00
238_L264_I1.4901.00
206_S215_A1.4841.00
392_G417_F1.4811.00
345_D360_P1.4611.00
265_D268_Q1.4611.00
379_V391_L1.4531.00
26_V54_F1.4361.00
348_V360_P1.4301.00
322_T356_A1.4271.00
208_D212_V1.4241.00
12_E250_V1.4201.00
133_A153_L1.4031.00
117_A139_A1.3941.00
273_K293_E1.3891.00
299_A327_T1.3731.00
115_S118_K1.3691.00
228_P258_P1.3641.00
299_A328_T1.3531.00
55_R61_I1.3401.00
84_L109_A1.3271.00
125_T137_G1.3251.00
238_L251_L1.3181.00
201_F223_A1.3161.00
354_L394_A1.3151.00
26_V51_I1.3121.00
13_I424_L1.3091.00
342_N345_D1.3091.00
321_A328_T1.3091.00
348_V365_M1.3041.00
318_A330_I1.3031.00
240_A396_C1.2981.00
138_R147_S1.2981.00
15_I251_L1.2961.00
239_A263_I1.2961.00
420_H423_K1.2961.00
326_G369_G1.2941.00
95_R169_S1.2901.00
184_V187_P1.2881.00
156_I185_T1.2831.00
345_D349_S1.2821.00
48_L63_Q1.2801.00
248_R293_E1.2771.00
238_L267_L1.2691.00
234_A254_V1.2681.00
62_E71_H1.2621.00
59_V70_I1.2541.00
14_H253_N1.2471.00
41_F47_C1.2431.00
32_A36_T1.2401.00
267_L272_A1.2381.00
250_V290_L1.2371.00
248_R292_I1.2361.00
304_G332_D1.2331.00
199_S204_K1.2281.00
22_S47_C1.2181.00
52_D56_K1.2161.00
200_A223_A1.2151.00
179_E218_Q1.2111.00
270_M300_V1.2081.00
172_L214_I1.2081.00
195_E205_L1.1991.00
346_T382_H1.1961.00
38_V227_V1.1951.00
395_S404_I1.1921.00
90_S93_T1.1861.00
206_S213_S1.1801.00
25_S227_V1.1721.00
361_T366_K1.1681.00
134_K151_A1.1671.00
189_K210_T1.1671.00
237_F414_Y1.1641.00
388_G410_I1.1611.00
266_V302_I1.1611.00
146_L150_G1.1591.00
36_T197_M1.1531.00
107_Y149_S1.1461.00
243_M397_I1.1441.00
192_D196_R1.1401.00
129_K134_K1.1401.00
416_T420_H1.1231.00
23_H50_T1.1211.00
156_I183_T1.1211.00
38_V70_I1.1091.00
256_L276_I1.1021.00
323_Q370_K1.1011.00
175_G182_T1.0961.00
240_A393_I1.0891.00
34_G221_T1.0881.00
266_V317_I1.0851.00
356_A370_K1.0771.00
267_L320_L1.0751.00
157_D183_T1.0701.00
319_L394_A1.0701.00
125_T129_K1.0681.00
126_E129_K1.0681.00
358_I365_M1.0671.00
388_G409_A1.0631.00
55_R60_H1.0561.00
255_G258_P1.0551.00
303_G332_D1.0531.00
379_V402_I1.0461.00
244_V247_S1.0431.00
64_S67_D1.0421.00
236_F389_M1.0421.00
374_K399_E1.0411.00
270_M324_A1.0381.00
29_G70_I1.0231.00
49_S52_D1.0191.00
242_A295_S1.0181.00
169_S194_T1.0151.00
49_S88_G1.0121.00
79_K107_Y1.0081.00
268_Q276_I1.0041.00
153_L178_A1.0021.00
59_V72_G0.9991.00
419_E422_N0.9981.00
235_A316_I0.9971.00
36_T223_A0.9931.00
137_G142_E0.9891.00
398_T402_I0.9861.00
9_L240_A0.9831.00
53_C87_V0.9781.00
239_A267_L0.9761.00
195_E208_D0.9751.00
250_V291_I0.9751.00
180_G216_G0.9751.00
239_A313_E0.9731.00
25_S38_V0.9721.00
32_A222_A0.9711.00
321_A330_I0.9681.00
352_R357_E0.9641.00
158_Y161_P0.9611.00
266_V269_N0.9591.00
154_K180_G0.9581.00
299_A324_A0.9531.00
327_T369_G0.9511.00
233_S420_H0.9481.00
146_L149_S0.9481.00
299_A326_G0.9451.00
55_R63_Q0.9401.00
159_V185_T0.9351.00
334_A362_A0.9321.00
344_I365_M0.9311.00
377_A402_I0.9301.00
84_L111_A0.9301.00
383_G406_H0.9291.00
330_I365_M0.9261.00
268_Q273_K0.9231.00
241_G244_V0.9231.00
313_E316_I0.9201.00
231_I263_I0.9191.00
123_R162_V0.9181.00
131_M156_I0.9181.00
54_F59_V0.9171.00
353_K377_A0.9131.00
225_I228_P0.9121.00
45_A411_H0.9111.00
24_R27_M0.9061.00
198_L220_L0.9031.00
246_N294_T0.9001.00
406_H409_A0.8941.00
199_S207_E0.8901.00
318_A346_T0.8841.00
51_I63_Q0.8821.00
176_L203_V0.8821.00
124_V170_A0.8811.00
9_L247_S0.8811.00
51_I55_R0.8801.00
34_G72_G0.8770.99
41_F68_V0.8730.99
297_L324_A0.8730.99
109_A147_S0.8660.99
322_T370_K0.8650.99
330_I333_A0.8630.99
125_T135_I0.8590.99
208_D211_S0.8570.99
199_S205_L0.8560.99
196_R200_A0.8550.99
197_M201_F0.8540.99
40_N226_F0.8540.99
114_E385_H0.8530.99
381_S388_G0.8520.99
323_Q371_Q0.8510.99
238_L241_G0.8510.99
135_I148_V0.8460.99
322_T351_L0.8440.99
181_T216_G0.8410.99
344_I360_P0.8380.99
11_G424_L0.8380.99
270_M297_L0.8350.99
360_P364_G0.8340.99
333_A364_G0.8340.99
176_L220_L0.8320.99
264_I268_Q0.8310.99
324_A328_T0.8260.99
101_L133_A0.8250.99
99_G173_L0.8200.99
15_I234_A0.8200.99
192_D231_I0.8200.99
270_M321_A0.8190.99
87_V116_I0.8150.99
200_A225_I0.8130.99
161_P266_V0.8130.99
291_I294_T0.8120.99
31_L100_I0.8110.99
243_M323_Q0.8070.99
56_K81_P0.8070.99
226_F253_N0.8070.99
80_E138_R0.8050.99
63_Q66_S0.7960.99
318_A365_M0.7950.99
160_S163_A0.7940.99
197_M223_A0.7880.99
318_A367_V0.7880.99
160_S171_V0.7870.99
43_P66_S0.7860.99
273_K292_I0.7850.99
35_T72_G0.7840.99
30_A54_F0.7830.99
13_I251_L0.7820.99
16_P420_H0.7810.99
27_M100_I0.7800.99
196_R199_S0.7770.99
78_L104_R0.7760.99
94_I121_M0.7760.99
116_I341_T0.7750.99
135_I146_L0.7740.99
22_S227_V0.7720.99
407_T410_I0.7700.99
171_V184_V0.7670.99
66_S415_P0.7650.99
126_E161_P0.7630.99
178_A182_T0.7630.99
40_N253_N0.7620.99
172_L212_V0.7610.99
18_D22_S0.7590.99
277_K281_D0.7560.98
395_S421_L0.7550.98
316_I393_I0.7540.98
15_I237_F0.7540.98
408_D411_H0.7520.98
29_G72_G0.7510.98
21_I197_M0.7500.98
155_G179_E0.7490.98
98_L148_V0.7480.98
16_P233_S0.7470.98
300_V328_T0.7470.98
331_K361_T0.7440.98
272_A297_L0.7440.98
45_A49_S0.7430.98
270_M320_L0.7420.98
80_E83_S0.7410.98
411_H418_F0.7390.98
243_M319_L0.7380.98
331_K364_G0.7360.98
241_G249_I0.7320.98
263_I313_E0.7310.98
14_H40_N0.7310.98
83_S117_A0.7300.98
238_L242_A0.7280.98
354_L379_V0.7280.98
199_S206_S0.7260.98
276_I281_D0.7250.98
242_A267_L0.7250.98
26_V68_V0.7230.98
237_F420_H0.7220.98
375_G402_I0.7210.98
102_A133_A0.7200.98
55_R62_E0.7160.98
349_S382_H0.7150.98
392_G410_I0.7150.98
276_I280_A0.7100.98
122_K142_E0.7090.98
87_V110_V0.7090.98
240_A421_L0.7070.98
315_P387_I0.7060.98
28_F197_M0.7040.98
93_T412_V0.7030.98
175_G184_V0.7030.98
166_Q193_H0.7020.98
114_E118_K0.7020.98
147_S150_G0.7020.98
97_M128_L0.6990.97
35_T222_A0.6930.97
234_A251_L0.6930.97
160_S190_S0.6910.97
357_E370_K0.6910.97
266_V300_V0.6900.97
160_S184_V0.6890.97
131_M154_K0.6880.97
328_T367_V0.6860.97
123_R163_A0.6830.97
17_G227_V0.6810.97
94_I110_V0.6800.97
354_L398_T0.6770.97
174_A178_A0.6760.97
303_G331_K0.6750.97
21_I24_R0.6730.97
101_L108_S0.6720.97
59_V73_K0.6720.97
137_G146_L0.6720.97
8_T247_S0.6710.97
418_F422_N0.6710.97
293_E297_L0.6690.97
98_L110_V0.6690.97
264_I276_I0.6690.97
30_A59_V0.6680.97
319_L391_L0.6640.97
291_I295_S0.6630.97
26_V70_I0.6630.97
278_P281_D0.6610.96
98_L124_V0.6610.96
396_C421_L0.6600.96
84_L117_A0.6560.96
101_L110_V0.6550.96
196_R225_I0.6550.96
244_V396_C0.6550.96
290_L293_E0.6530.96
236_F316_I0.6530.96
182_T216_G0.6530.96
101_L128_L0.6520.96
81_P84_L0.6490.96
51_I70_I0.6490.96
352_R358_I0.6490.96
131_M182_T0.6470.96
95_R166_Q0.6460.96
204_K217_G0.6450.96
241_G251_L0.6430.96
87_V94_I0.6410.96
109_A138_R0.6410.96
13_I420_H0.6400.96
54_F97_M0.6380.96
25_S225_I0.6370.96
333_A344_I0.6350.96
235_A263_I0.6330.96
343_R384_D0.6330.96
238_L290_L0.6330.96
199_S203_V0.6320.95
119_R386_R0.6320.95
128_L133_A0.6300.95
304_G314_I0.6300.95
39_K66_S0.6300.95
315_P346_T0.6290.95
381_S404_I0.6270.95
22_S42_L0.6250.95
155_G182_T0.6250.95
322_T371_Q0.6240.95
207_E210_T0.6240.95
242_A297_L0.6230.95
246_N295_S0.6230.95
9_L249_I0.6230.95
87_V93_T0.6230.95
293_E296_S0.6220.95
95_R340_E0.6210.95
299_A325_E0.6200.95
241_G246_N0.6190.95
292_I295_S0.6180.95
123_R126_E0.6160.95
119_R343_R0.6140.95
121_M125_T0.6120.95
268_Q274_L0.6100.95
197_M225_I0.6100.95
275_E291_I0.6080.94
381_S406_H0.6080.94
269_N306_I0.6040.94
381_S409_A0.6030.94
410_I418_F0.6020.94
344_I348_V0.6010.94
375_G398_T0.6000.94
207_E212_V0.5990.94
264_I274_L0.5990.94
201_F220_L0.5960.94
238_L274_L0.5950.94
23_H27_M0.5950.94
239_A316_I0.5930.94
33_A72_G0.5920.94
32_A72_G0.5910.94
353_K391_L0.5900.94
42_L233_S0.5900.94
344_I364_G0.5880.93
392_G418_F0.5880.93
129_K135_I0.5860.93
304_G317_I0.5860.93
57_M101_L0.5850.93
24_R95_R0.5850.93
80_E84_L0.5850.93
237_F417_F0.5840.93
375_G395_S0.5830.93
318_A348_V0.5830.93
314_I344_I0.5830.93
319_L351_L0.5830.93
319_L322_T0.5820.93
172_L184_V0.5800.93
241_G247_S0.5790.93
373_L394_A0.5780.93
198_L201_F0.5780.93
341_T346_T0.5770.93
315_P341_T0.5760.93
32_A71_H0.5750.93
26_V50_T0.5750.93
374_K377_A0.5740.93
266_V307_I0.5730.93
43_P68_V0.5720.92
407_T418_F0.5720.92
302_I317_I0.5710.92
54_F61_I0.5690.92
48_L52_D0.5690.92
237_F421_L0.5680.92
322_T373_L0.5660.92
349_S352_R0.5650.92
383_G409_A0.5650.92
329_V364_G0.5630.92
64_S69_V0.5630.92
34_G223_A0.5620.92
229_G251_L0.5620.92
34_G71_H0.5620.92
145_P150_G0.5600.92
45_A48_L0.5600.92
243_M320_L0.5590.92
129_K137_G0.5580.92
356_A394_A0.5580.92
195_E212_V0.5550.91
215_A218_Q0.5550.91
162_V334_A0.5540.91
23_H93_T0.5540.91
322_T397_I0.5530.91
389_M417_F0.5530.91
346_T409_A0.5530.91
127_P131_M0.5520.91
13_I237_F0.5520.91
19_K119_R0.5490.91
330_I367_V0.5490.91
232_S385_H0.5470.91
196_R208_D0.5470.91
377_A400_E0.5460.91
75_I104_R0.5460.91
299_A369_G0.5450.91
419_E423_K0.5450.91
346_T387_I0.5430.90
53_C97_M0.5410.90
60_H63_Q0.5400.90
129_K136_D0.5400.90
99_G102_A0.5390.90
110_V146_L0.5380.90
72_G103_G0.5380.90
254_V258_P0.5380.90
36_T201_F0.5380.90
124_V127_P0.5370.90
275_E290_L0.5360.90
203_V217_G0.5360.90
203_V218_Q0.5360.90
248_R273_K0.5360.90
76_D104_R0.5340.90
300_V324_A0.5340.90
388_G418_F0.5340.90
107_Y145_P0.5340.90
273_K295_S0.5320.89
352_R356_A0.5320.89
83_S111_A0.5310.89
23_H413_S0.5290.89
329_V361_T0.5290.89
80_E107_Y0.5280.89
80_E87_V0.5280.89
145_P148_V0.5280.89
321_A367_V0.5280.89
89_N113_D0.5270.89
314_I330_I0.5270.89
241_G272_A0.5260.89
252_K280_A0.5260.89
318_A358_I0.5260.89
53_C96_L0.5260.89
275_E292_I0.5250.89
43_P65_S0.5230.89
138_R143_F0.5230.89
175_G198_L0.5230.89
125_T146_L0.5230.89
166_Q169_S0.5220.89
18_D228_P0.5190.88
153_L179_E0.5190.88
357_E371_Q0.5180.88
354_L373_L0.5180.88
103_G177_Q0.5160.88
277_K291_I0.5150.88
123_R160_S0.5150.88
123_R164_S0.5150.88
170_A174_A0.5130.88
231_I264_I0.5120.88
50_T95_R0.5110.88
203_V222_A0.5100.87
92_T96_L0.5080.87
128_L171_V0.5080.87
191_R207_E0.5080.87
325_E371_Q0.5080.87
195_E199_S0.5080.87
354_L400_E0.5070.87
60_H74_G0.5060.87
98_L170_A0.5050.87
15_I254_V0.5050.87
346_T412_V0.5040.87
270_M328_T0.5030.87
204_K218_Q0.5020.87
238_L291_I0.5020.87
290_L294_T0.5020.87
265_D269_N0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.9977 100 0.064 Contact Map
2pqcA 1 0.9953 100 0.078 Contact Map
3slhA 4 0.9907 100 0.115 Contact Map
1rf6A 1 0.9907 100 0.117 Contact Map
3nvsA 1 0.9579 100 0.186 Contact Map
2o0bA 1 0.9322 100 0.192 Contact Map
3zh4A 1 0.9299 100 0.249 Contact Map
3r38A 2 0.9393 100 0.256 Contact Map
4fqdA 2 0.9299 100 0.269 Contact Map
1ejdA 4 0.9439 100 0.272 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.