GREMLIN Database
GLTC - HTH-type transcriptional regulator GltC
UniProt: P20668 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (286)
Sequences: 79862 (58032)
Seq/√Len: 3431.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_T74_A3.6681.00
15_R24_H3.4461.00
159_K290_I2.7301.00
96_G141_I2.6171.00
67_H81_Q2.4931.00
11_E24_H2.3561.00
232_V239_T2.3131.00
174_H190_D2.2481.00
160_I163_T2.2431.00
92_T123_L2.2411.00
163_T267_T2.2351.00
160_I267_T2.1551.00
165_K243_E2.1431.00
92_T121_E2.1141.00
20_E23_D2.1131.00
45_V60_I2.1121.00
8_Y35_Q2.1101.00
163_T265_K2.0831.00
14_E69_K2.0451.00
67_H74_A2.0311.00
112_A288_F2.0211.00
10_M69_K2.0191.00
229_K249_T2.0181.00
183_H186_D2.0161.00
94_K123_L1.9941.00
10_M65_L1.9921.00
10_M14_E1.9761.00
167_Y243_E1.9521.00
11_E14_E1.9431.00
11_E15_R1.9411.00
193_V237_G1.9291.00
8_Y32_I1.9231.00
13_A57_L1.9121.00
71_A75_I1.8971.00
65_L69_K1.8521.00
18_V36_I1.7771.00
233_S249_T1.7541.00
64_F78_A1.7511.00
191_Q219_S1.7441.00
49_E56_K1.7391.00
179_Q186_D1.7101.00
63_E81_Q1.7071.00
158_G269_G1.6961.00
135_A140_D1.6711.00
13_A65_L1.6491.00
233_S254_T1.6411.00
170_V257_I1.6341.00
15_R20_E1.6171.00
113_F285_F1.6151.00
14_E24_H1.6031.00
10_M68_V1.5861.00
157_T274_K1.5711.00
9_F65_L1.5551.00
5_Q35_Q1.5471.00
8_Y27_V1.5351.00
134_E138_N1.5301.00
159_K272_K1.5121.00
67_H70_T1.5091.00
113_F120_V1.5081.00
17_H20_E1.5051.00
5_Q42_E1.4961.00
19_S29_Q1.4951.00
88_P119_H1.4911.00
28_A31_A1.4881.00
5_Q38_N1.4821.00
202_R206_I1.4691.00
59_P62_K1.4661.00
46_T49_E1.4601.00
11_E25_L1.4481.00
146_L271_I1.4461.00
286_Y290_I1.4341.00
278_L282_A1.4251.00
157_T272_K1.4221.00
103_S226_D1.4181.00
10_M72_M1.4111.00
67_H77_Y1.4091.00
71_A78_A1.3911.00
90_R119_H1.3651.00
136_V144_A1.3601.00
272_K286_Y1.3581.00
51_E56_K1.3541.00
94_K125_R1.3531.00
135_A141_I1.3451.00
164_E244_S1.3311.00
284_D287_E1.3291.00
64_F79_K1.3251.00
270_I286_Y1.3201.00
116_E288_F1.3201.00
74_A77_Y1.3161.00
137_R155_D1.3131.00
112_A116_E1.3071.00
143_L282_A1.3031.00
3_L75_I1.3011.00
143_L270_I1.2861.00
170_V238_V1.2851.00
228_I239_T1.2851.00
42_E79_K1.2771.00
114_K219_S1.2761.00
66_I70_T1.2741.00
190_D238_V1.2721.00
230_G233_S1.2561.00
67_H78_A1.2501.00
63_E66_I1.2291.00
160_I269_G1.2171.00
114_K191_Q1.2121.00
9_F48_F1.2101.00
111_S115_E1.2051.00
243_E247_A1.1941.00
62_K66_I1.1831.00
37_A41_E1.1831.00
27_V31_A1.1781.00
158_G271_I1.1761.00
34_R38_N1.1731.00
175_P190_D1.1711.00
9_F13_A1.1651.00
249_T254_T1.1651.00
111_S234_A1.1481.00
123_L221_E1.1401.00
127_G135_A1.1401.00
34_R37_A1.1341.00
209_C214_F1.1261.00
193_V228_I1.1181.00
9_F47_L1.1141.00
112_A115_E1.1131.00
191_Q217_L1.1121.00
181_T260_E1.1061.00
70_T77_Y1.1041.00
102_A126_Q1.1031.00
33_S37_A1.1021.00
287_E290_I1.1001.00
6_L68_V1.0991.00
117_Y284_D1.0981.00
18_V55_I1.0971.00
63_E67_H1.0931.00
113_F288_F1.0861.00
222_G228_I1.0841.00
93_V285_F1.0811.00
11_E21_A1.0791.00
108_T234_A1.0771.00
12_V21_A1.0761.00
159_K286_Y1.0691.00
71_A74_A1.0651.00
182_V186_D1.0601.00
283_N287_E1.0581.00
229_K233_S1.0541.00
137_R153_F1.0491.00
109_V289_V1.0431.00
35_Q38_N1.0421.00
171_P235_G1.0411.00
7_R76_D1.0401.00
230_G234_A1.0381.00
4_R7_R1.0361.00
203_E206_I1.0341.00
57_L61_G1.0331.00
79_K83_D1.0301.00
165_K265_K1.0201.00
247_A251_P1.0151.00
180_K256_K1.0091.00
248_E252_R1.0011.00
169_L246_F0.9981.00
64_F68_V0.9931.00
8_Y25_L0.9921.00
27_V32_I0.9861.00
12_V18_V0.9841.00
13_A48_F0.9831.00
73_K77_Y0.9811.00
76_D80_E0.9801.00
168_A238_V0.9801.00
194_L218_V0.9791.00
76_D79_K0.9671.00
288_F291_Q0.9651.00
113_F117_Y0.9641.00
9_F57_L0.9621.00
172_L253_F0.9551.00
125_R135_A0.9541.00
135_A138_N0.9461.00
38_N41_E0.9441.00
222_G231_L0.9411.00
170_V174_H0.9391.00
21_A32_I0.9381.00
116_E291_Q0.9381.00
174_H177_A0.9371.00
109_V288_F0.9301.00
279_A282_A0.9271.00
96_G144_A0.9261.00
9_F39_L0.9221.00
48_F55_I0.9151.00
20_E24_H0.9101.00
45_V82_I0.8961.00
203_E207_D0.8951.00
141_I144_A0.8941.00
13_A61_G0.8901.00
121_E217_L0.8871.00
70_T73_K0.8821.00
99_T224_D0.8811.00
66_I69_K0.8781.00
16_E56_K0.8771.00
174_H178_K0.8761.00
170_V175_P0.8651.00
191_Q218_V0.8651.00
273_P276_R0.8641.00
19_S23_D0.8641.00
178_K191_Q0.8621.00
25_L32_I0.8601.00
174_H191_Q0.8581.00
95_I143_L0.8551.00
120_V281_S0.8511.00
156_I271_I0.8511.00
175_P180_K0.8501.00
96_G146_L0.8491.00
186_D189_N0.8491.00
157_T160_I0.8481.00
155_D274_K0.8441.00
249_T252_R0.8361.00
51_E54_N0.8361.00
125_R141_I0.8271.00
60_I82_I0.8261.00
169_L239_T0.8261.00
176_L190_D0.8221.00
75_I79_K0.8211.00
278_L283_N0.8191.00
287_E291_Q0.8171.00
172_L255_V0.8151.00
246_F249_T0.8141.00
111_S236_M0.8131.00
16_E62_K0.8121.00
29_Q33_S0.8091.00
9_F64_F0.8071.00
91_G281_S0.8061.00
4_R35_Q0.8031.00
205_A209_C0.8021.00
165_K258_P0.8021.00
74_A78_A0.7991.00
63_E85_Y0.7991.00
12_V48_F0.7981.00
13_A16_E0.7981.00
114_K236_M0.7941.00
37_A46_T0.7941.00
75_I78_A0.7921.00
3_L72_M0.7921.00
185_I188_R0.7921.00
149_V269_G0.7911.00
12_V36_I0.7891.00
15_R21_A0.7871.00
14_E65_L0.7871.00
171_P236_M0.7871.00
60_I63_E0.7861.00
165_K263_Q0.7841.00
208_T212_A0.7831.00
77_Y81_Q0.7811.00
16_E54_N0.7801.00
91_G120_V0.7781.00
133_I137_R0.7771.00
280_P284_D0.7741.00
5_Q8_Y0.7671.00
192_F216_P0.7661.00
173_N177_A0.7631.00
7_R11_E0.7621.00
231_L236_M0.7601.00
143_L285_F0.7581.00
83_D86_L0.7531.00
183_H260_E0.7521.00
169_L241_L0.7491.00
89_H117_Y0.7471.00
184_L261_F0.7461.00
68_V71_A0.7461.00
97_F102_A0.7441.00
78_A82_I0.7421.00
60_I85_Y0.7391.00
257_I260_E0.7381.00
113_F284_D0.7381.00
137_R156_I0.7381.00
18_V32_I0.7381.00
49_E58_T0.7361.00
116_E284_D0.7351.00
233_S253_F0.7351.00
12_V32_I0.7301.00
69_K73_K0.7241.00
188_R214_F0.7211.00
56_K62_K0.7171.00
57_L62_K0.7141.00
60_I64_F0.7121.00
224_D227_A0.7121.00
208_T211_Q0.7101.00
31_A35_Q0.7101.00
242_P245_T0.7051.00
62_K65_L0.7021.00
171_P174_H0.7011.00
94_K141_I0.7011.00
185_I212_A0.6971.00
94_K142_D0.6951.00
204_M208_T0.6911.00
196_P221_E0.6891.00
169_L250_T0.6881.00
170_V176_L0.6871.00
142_D282_A0.6861.00
202_R221_E0.6851.00
59_P63_E0.6821.00
7_R10_M0.6811.00
139_R273_P0.6801.00
207_D211_Q0.6791.00
246_F250_T0.6781.00
40_E45_V0.6781.00
284_D288_F0.6761.00
64_F82_I0.6741.00
49_E54_N0.6731.00
103_S230_G0.6681.00
97_F106_L0.6661.00
195_F228_I0.6651.00
173_N235_G0.6631.00
176_L179_Q0.6611.00
189_N217_L0.6591.00
112_A291_Q0.6581.00
73_K76_D0.6561.00
220_T231_L0.6551.00
173_N176_L0.6551.00
192_F238_V0.6521.00
40_E50_R0.6511.00
205_A208_T0.6501.00
77_Y80_E0.6481.00
23_D26_H0.6461.00
67_H71_A0.6441.00
68_V72_M0.6391.00
206_I210_K0.6381.00
36_I40_E0.6371.00
248_E251_P0.6361.00
168_A187_L0.6321.00
93_V281_S0.6301.00
126_Q223_E0.6291.00
121_E221_E0.6281.00
12_V17_H0.6281.00
207_D210_K0.6261.00
276_R279_A0.6261.00
18_V54_N0.6251.00
172_L254_T0.6251.00
145_L289_V0.6241.00
280_P283_N0.6191.00
21_A25_L0.6181.00
99_T128_S0.6171.00
201_L205_A0.6161.00
168_A240_L0.6111.00
196_P223_E0.6101.00
108_T111_S0.6101.00
4_R38_N0.6091.00
106_L109_V0.6041.00
63_E82_I0.6031.00
136_V271_I0.6021.00
147_G266_R0.6021.00
203_E208_T0.5991.00
175_P179_Q0.5981.00
143_L286_Y0.5961.00
80_E84_E0.5951.00
93_V143_L0.5951.00
31_A34_R0.5951.00
7_R72_M0.5941.00
168_A192_F0.5931.00
90_R121_E0.5931.00
285_F289_V0.5921.00
162_F268_V0.5921.00
228_I232_V0.5911.00
209_C216_P0.5911.00
204_M207_D0.5901.00
4_R8_Y0.5871.00
136_V156_I0.5861.00
30_S34_R0.5831.00
43_L64_F0.5821.00
96_G127_G0.5811.00
206_I209_C0.5811.00
48_F57_L0.5781.00
164_E266_R0.5771.00
149_V267_T0.5761.00
43_L82_I0.5761.00
45_V49_E0.5751.00
126_Q224_D0.5741.00
108_T112_A0.5711.00
222_G227_A0.5711.00
28_A34_R0.5691.00
9_F61_G0.5671.00
166_I240_L0.5671.00
57_L65_L0.5641.00
72_M76_D0.5641.00
176_L182_V0.5621.00
231_L237_G0.5621.00
157_T275_N0.5611.00
172_L256_K0.5591.00
202_R205_A0.5581.00
272_K283_N0.5561.00
8_Y36_I0.5561.00
149_V153_F0.5551.00
96_G125_R0.5551.00
201_L204_M0.5541.00
117_Y120_V0.5511.00
241_L246_F0.5491.00
110_I122_F0.5471.00
91_G119_H0.5451.00
43_L46_T0.5451.00
197_E221_E0.5451.00
183_H261_F0.5441.00
101_L105_L0.5441.00
18_V29_Q0.5421.00
169_L256_K0.5421.00
174_H238_V0.5391.00
46_T60_I0.5351.00
66_I81_Q0.5351.00
225_L242_P0.5341.00
233_S251_P0.5331.00
170_V177_A0.5331.00
161_L270_I0.5301.00
115_E177_A0.5291.00
103_S224_D0.5281.00
105_L109_V0.5281.00
13_A62_K0.5281.00
72_M75_I0.5271.00
27_V35_Q0.5221.00
8_Y21_A0.5211.00
181_T258_P0.5201.00
175_P178_K0.5201.00
181_T186_D0.5191.00
80_E83_D0.5171.00
97_F124_L0.5161.00
108_T230_G0.5151.00
134_E140_D0.5121.00
16_E55_I0.5121.00
84_E89_H0.5091.00
36_I48_F0.5081.00
282_A286_Y0.5061.00
67_H82_I0.5061.00
18_V50_R0.5061.00
145_L270_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ixcA 4 0.9733 100 0.081 Contact Map
1al3A 1 0.7133 100 0.086 Contact Map
3fzvA 4 0.9533 100 0.087 Contact Map
2esnA 3 0.9733 100 0.09 Contact Map
4x6gA 4 0.9967 100 0.09 Contact Map
1uthA 2 0.7533 100 0.091 Contact Map
2h98A 2 0.69 100 0.095 Contact Map
3fxqA 3 0.97 100 0.098 Contact Map
2h9bA 2 0.6933 100 0.1 Contact Map
3szpA 3 0.9633 100 0.112 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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