GREMLIN Database
IF1 - Translation initiation factor IF-1
UniProt: P20458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 72 (71)
Sequences: 1009 (375)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_T71_Y3.2261.00
25_E29_G2.9361.00
12_T25_E2.8971.00
14_V25_E2.8511.00
16_T49_P2.6041.00
40_I69_Y2.5981.00
21_M33_L2.5261.00
27_E52_K2.5141.00
8_E54_T2.3861.00
25_E31_T2.1451.00
36_V47_I1.8710.99
10_E52_K1.8510.99
10_E71_Y1.8120.98
23_K31_T1.6030.97
36_V44_F1.5580.96
32_V55_V1.3450.92
12_T52_K1.3200.91
10_E27_E1.3130.90
9_V57_L1.3000.90
10_E54_T1.2920.90
13_I47_I1.2720.89
44_F47_I1.2500.88
17_L23_K1.2370.88
30_H62_L1.1840.85
32_V65_G1.1520.84
40_I43_H1.1100.81
42_M69_Y1.0950.80
18_P58_S1.0710.79
57_L62_L1.0690.79
8_E68_T1.0540.78
15_E23_K1.0370.77
18_P22_F1.0370.77
55_V65_G1.0030.74
2_A72_K0.9730.72
11_G24_V0.9680.71
59_P62_L0.9650.71
14_V31_T0.9240.68
20_A41_R0.9160.67
22_F66_R0.9060.66
26_L45_I0.8800.64
39_K58_S0.8800.64
22_F41_R0.8780.64
15_E18_P0.8780.64
21_M35_H0.8740.64
39_K42_M0.8670.63
57_L64_R0.8660.63
15_E46_R0.8420.61
19_N35_H0.8350.60
37_S40_I0.8230.59
24_V60_Y0.8040.57
18_P33_L0.7930.56
21_M36_V0.7870.55
68_T71_Y0.7860.55
33_L52_K0.7560.52
36_V40_I0.7390.51
32_V57_L0.7340.50
23_K33_L0.7270.50
19_N41_R0.7230.49
33_L64_R0.7150.49
36_V58_S0.7100.48
9_V55_V0.7070.48
16_T19_N0.7060.48
34_A55_V0.7060.48
36_V42_M0.7010.47
40_I71_Y0.6840.46
7_I62_L0.6800.45
28_N37_S0.6770.45
14_V63_T0.6370.41
37_S47_I0.6360.41
61_D64_R0.6300.40
8_E40_I0.6270.40
15_E48_L0.6240.40
35_H45_I0.6160.39
28_N63_T0.6140.39
19_N33_L0.6140.39
24_V34_A0.6120.39
16_T44_F0.6020.38
50_G54_T0.6010.38
50_G71_Y0.6000.38
41_R72_K0.5990.38
27_E67_I0.5980.37
22_F33_L0.5930.37
52_K71_Y0.5910.37
30_H63_T0.5880.37
8_E56_E0.5680.35
10_E14_V0.5660.35
12_T39_K0.5660.35
48_L68_T0.5640.34
4_D35_H0.5520.33
36_V41_R0.5460.33
2_A64_R0.5440.33
18_P46_R0.5430.33
33_L36_V0.5370.32
13_I24_V0.5360.32
23_K72_K0.5350.32
3_K48_L0.5300.32
42_M72_K0.5280.31
28_N58_S0.5180.31
28_N62_L0.5140.30
24_V66_R0.5100.30
56_E66_R0.5100.30
11_G61_D0.5090.30
47_I57_L0.5060.30
35_H64_R0.5050.29
57_L65_G0.5050.29
7_I59_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bpe0 1 0.9722 99.9 0.314 Contact Map
3wbkC 1 0 99.9 0.328 Contact Map
2oqkA 1 0.9722 99.9 0.331 Contact Map
3j80i 1 0.9861 99.9 0.334 Contact Map
4kzyn 1 0.9028 99.9 0.342 Contact Map
4mnoA 1 0.9583 99.9 0.345 Contact Map
1jt8A 1 0.9722 99.9 0.355 Contact Map
4ql5A 4 0.9444 99.9 0.372 Contact Map
1hr0W 1 0.9861 99.9 0.383 Contact Map
3i4oA 1 0.9306 99.9 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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