GREMLIN Database
TRPF - N-(5'-phosphoribosyl)anthranilate isomerase
UniProt: P20167 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (197)
Sequences: 3781 (3031)
Seq/√Len: 215.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_G78_L3.6491.00
64_E68_T2.9211.00
13_S16_D2.8871.00
8_Y189_I2.8581.00
17_L47_W2.8131.00
191_K196_D2.7241.00
33_A38_K2.6431.00
31_I186_A2.1761.00
63_N86_D2.1451.00
6_L204_E2.1021.00
162_F182_G2.0631.00
80_V104_W2.0081.00
23_S200_M1.9921.00
18_Q50_Q1.9771.00
33_A62_V1.9681.00
185_L203_L1.9281.00
11_I17_L1.8981.00
48_L57_V1.8761.00
65_S68_T1.8541.00
69_M91_D1.8481.00
40_S43_D1.8391.00
146_W175_L1.8071.00
58_A80_V1.7961.00
185_L189_I1.7301.00
31_I60_V1.7251.00
108_H132_S1.7131.00
168_N188_G1.6791.00
63_N87_E1.6121.00
87_E105_K1.5971.00
8_Y200_M1.5941.00
201_R205_E1.5791.00
104_W126_G1.5691.00
20_A200_M1.5631.00
30_F57_V1.5581.00
83_L95_L1.5551.00
32_F44_V1.5551.00
43_D46_K1.5521.00
109_H148_C1.5341.00
32_F59_G1.5091.00
56_Q79_D1.5041.00
173_T206_R1.4971.00
189_I200_M1.4471.00
19_L197_Q1.4361.00
73_A81_I1.4231.00
36_K192_N1.4161.00
61_F69_M1.4031.00
91_D95_L1.4001.00
61_F72_I1.3981.00
5_A27_Y1.3921.00
172_I183_I1.3841.00
163_I175_L1.3811.00
66_I91_D1.3621.00
73_A101_C1.3571.00
88_K91_D1.3351.00
45_K75_S1.3281.00
21_A55_K1.3091.00
173_T177_K1.2891.00
183_I203_L1.2851.00
104_W162_F1.2821.00
57_V79_D1.2811.00
62_V137_R1.2791.00
198_N202_L1.2741.00
198_N201_R1.2741.00
13_S194_Q1.2731.00
64_E69_M1.2691.00
129_I161_C1.2661.00
45_K49_N1.2411.00
126_G162_F1.2411.00
27_Y56_Q1.2391.00
25_A204_E1.2301.00
174_R177_K1.2211.00
134_K140_T1.2191.00
27_Y162_F1.2161.00
6_L208_N1.2101.00
107_L127_F1.2081.00
61_F78_L1.1911.00
14_L50_Q1.1881.00
202_L206_R1.1871.00
16_D197_Q1.1771.00
167_V183_I1.1761.00
34_E38_K1.1741.00
172_I203_L1.1641.00
93_A123_N1.1641.00
20_A25_A1.1631.00
163_I178_W1.1561.00
116_E119_R1.1441.00
32_F61_F1.1411.00
41_P72_I1.1371.00
80_V102_E1.1101.00
48_L76_L1.1081.00
19_L23_S1.1051.00
108_H137_R1.1001.00
71_R75_S1.0921.00
33_A36_K1.0901.00
167_V203_L1.0851.00
143_A171_S1.0761.00
110_Q132_S1.0721.00
109_H129_I1.0601.00
89_P120_F1.0451.00
83_L103_I1.0441.00
19_L200_M1.0431.00
23_S201_R1.0381.00
131_S140_T1.0351.00
204_E207_M1.0331.00
172_I176_L1.0271.00
83_L87_E1.0261.00
42_E75_S1.0191.00
205_E209_R1.0001.00
20_A28_L0.9901.00
14_L18_Q0.9771.00
86_D137_R0.9721.00
17_L28_L0.9721.00
63_N137_R0.9701.00
21_A52_R0.9681.00
176_L207_M0.9571.00
71_R74_K0.9521.00
61_F64_E0.9511.00
122_D159_K0.9501.00
68_T71_R0.9481.00
26_D208_N0.9481.00
91_D94_A0.9461.00
5_A181_E0.9451.00
8_Y204_E0.9391.00
191_K199_L0.9310.99
12_R194_Q0.9280.99
21_A51_V0.9270.99
23_S204_E0.9260.99
5_A182_G0.9250.99
64_E91_D0.9130.99
145_S148_C0.9060.99
22_E197_Q0.9000.99
12_R16_D0.8920.99
69_M81_I0.8850.99
135_G140_T0.8850.99
12_R43_D0.8780.99
19_L201_R0.8730.99
124_V127_F0.8720.99
66_I94_A0.8710.99
104_W128_V0.8630.99
129_I149_V0.8600.99
85_G105_K0.8590.99
176_L183_I0.8560.99
113_T116_E0.8550.99
169_P202_L0.8540.99
69_M95_L0.8530.99
39_V43_D0.8510.99
202_L205_E0.8450.99
117_I127_F0.8450.99
66_I70_S0.8450.99
206_R209_R0.8400.99
63_N105_K0.8380.99
86_D108_H0.8350.99
4_P207_M0.8310.99
51_V57_V0.8310.99
44_V76_L0.8290.99
19_L22_E0.8270.99
6_L207_M0.8240.99
14_L43_D0.8230.99
73_A77_K0.8160.99
175_L178_W0.8120.99
46_K49_N0.8080.99
51_V55_K0.8060.98
185_L207_M0.8060.98
110_Q113_T0.8050.98
22_E201_R0.8010.98
15_K18_Q0.7940.98
81_I95_L0.7850.98
189_I203_L0.7800.98
197_Q201_R0.7790.98
18_Q22_E0.7750.98
27_Y80_V0.7700.98
89_P93_A0.7680.98
161_C180_P0.7660.98
63_N85_G0.7640.98
196_D199_L0.7630.98
118_A121_K0.7620.98
41_P45_K0.7620.98
32_F78_L0.7590.98
48_L77_K0.7580.98
65_S91_D0.7570.98
172_I206_R0.7560.98
171_S175_L0.7510.98
136_S140_T0.7500.98
52_R55_K0.7490.98
7_K10_G0.7470.98
92_A103_I0.7460.97
5_A56_Q0.7450.97
26_D204_E0.7390.97
167_V185_L0.7370.97
200_M204_E0.7370.97
41_P71_R0.7360.97
12_R192_N0.7350.97
16_D194_Q0.7320.97
27_Y104_W0.7310.97
28_L55_K0.7290.97
143_A146_W0.7270.97
137_R140_T0.7270.97
14_L46_K0.7250.97
14_L47_W0.7250.97
66_I95_L0.7240.97
164_A187_S0.7130.97
185_L188_G0.7070.97
121_K158_G0.7050.96
114_T117_I0.7040.96
67_E70_S0.7020.96
92_A124_V0.7010.96
191_K194_Q0.7000.96
72_I76_L0.6980.96
11_I28_L0.6970.96
132_S140_T0.6960.96
167_V175_L0.6960.96
149_V161_C0.6830.96
131_S144_F0.6810.96
176_L180_P0.6760.96
17_L51_V0.6750.96
32_F38_K0.6700.95
170_D202_L0.6700.95
95_L103_I0.6700.95
70_S100_G0.6670.95
34_E68_T0.6670.95
80_V126_G0.6610.95
17_L30_F0.6600.95
38_K41_P0.6600.95
190_E195_K0.6580.95
41_P75_S0.6570.95
149_V153_Q0.6520.95
17_L21_A0.6520.95
16_D200_M0.6520.95
102_E125_D0.6510.95
61_F81_I0.6460.94
109_H144_F0.6430.94
161_C178_W0.6420.94
23_S197_Q0.6410.94
16_D20_A0.6370.94
199_L202_L0.6360.94
153_Q161_C0.6350.94
33_A137_R0.6320.94
89_P123_N0.6320.94
59_G72_I0.6320.94
67_E71_R0.6290.93
115_Q118_A0.6210.93
5_A26_D0.6210.93
20_A24_Q0.6170.93
30_F48_L0.6170.93
11_I20_A0.6160.93
117_I129_I0.6120.93
87_E91_D0.6110.92
30_F44_V0.6090.92
183_I204_E0.6080.92
27_Y58_A0.6020.92
70_S74_K0.5990.92
56_Q80_V0.5980.92
203_L207_M0.5970.92
81_I101_C0.5960.92
56_Q102_E0.5960.92
139_G187_S0.5910.91
144_F149_V0.5910.91
12_R193_G0.5900.91
70_S73_A0.5770.90
143_A174_R0.5760.90
63_N83_L0.5750.90
57_V78_L0.5700.90
70_S95_L0.5670.89
128_V162_F0.5670.89
147_E150_P0.5660.89
18_Q21_A0.5620.89
108_H138_G0.5620.89
24_Q52_R0.5610.89
37_R190_E0.5560.89
4_P182_G0.5520.88
32_F35_S0.5500.88
103_I124_V0.5480.88
186_A203_L0.5460.88
127_F159_K0.5440.87
170_D199_L0.5430.87
169_P206_R0.5420.87
106_A128_V0.5410.87
64_E72_I0.5400.87
167_V188_G0.5340.86
161_C181_E0.5250.86
13_S200_M0.5250.86
21_A25_A0.5220.85
186_A200_M0.5190.85
172_I185_L0.5180.85
139_G166_G0.5170.85
107_L129_I0.5160.85
32_F72_I0.5150.84
169_P188_G0.5120.84
149_V152_Y0.5110.84
30_F41_P0.5090.84
63_N91_D0.5060.83
47_W50_Q0.5050.83
117_I120_F0.5020.83
130_D141_G0.5020.83
17_L50_Q0.5000.83
27_Y55_K0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v5xA 2 0.9163 100 0.121 Contact Map
4aajA 1 0.8651 100 0.138 Contact Map
1nsjA 2 0.9302 100 0.226 Contact Map
1piiA 1 0.9163 100 0.248 Contact Map
4wuiA 1 0.9256 100 0.294 Contact Map
3ctlA 4 0.9302 99.9 0.662 Contact Map
3ovpA 2 0.9395 99.9 0.673 Contact Map
2tpsA 1 0.9442 99.9 0.68 Contact Map
2fliA 5 0.9209 99.8 0.698 Contact Map
1xi3A 2 0.8977 99.8 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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