MAP11 - BACSU - GREMLIN Contacts

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MAP11 - Methionine aminopeptidase 1

UniProt:	P19994	Sequences: MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIAERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGYHGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFSVVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNWTVVTVDGKKCAHFEHTIAITETGFDILTRV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	248 (220)
Sequences:	16082 (9840)
Seq/√Len:	663.4

ECOLI - MAP1 YPDF PEPQ AMPP
BACSU - MAP11 MAP12 YKVY YQHT
HALSA - Q9HRF6 Q9HQC0 Q9HMB3 Q9HP03
SULSO - Q981D7 Q980E9 MAP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_K	153_Y	2.849	1.00
46_R	50_K	2.763	1.00
30_H	43_I	2.639	1.00
22_L	51_Q	2.594	1.00
26_E	47_F	2.477	1.00
111_P	115_I	2.432	1.00
132_K	135_Q	2.335	1.00
119_D	227_K	2.203	1.00
120_K	124_E	2.198	1.00
36_S	84_V	2.168	1.00
45_E	49_K	2.152	1.00
124_E	128_E	2.129	1.00
47_F	51_Q	2.108	1.00
12_I	100_N	2.089	1.00
144_S	189_G	2.089	1.00
116_S	119_D	2.089	1.00
14_R	226_K	2.038	1.00
43_I	46_R	2.011	1.00
151_Q	155_E	2.008	1.00
13_M	197_V	1.983	1.00
15_E	18_R	1.950	1.00
127_E	131_Y	1.943	1.00
47_F	50_K	1.932	1.00
154_V	204_V	1.926	1.00
125_V	157_E	1.899	1.00
117_D	121_K	1.896	1.00
71_V	83_R	1.836	1.00
23_T	47_F	1.835	1.00
194_P	222_T	1.834	1.00
128_E	132_K	1.827	1.00
136_E	149_A	1.806	1.00
42_Q	46_R	1.782	1.00
26_E	29_K	1.775	1.00
147_S	151_Q	1.705	1.00
142_R	145_N	1.674	1.00
28_K	110_Y	1.659	1.00
118_D	209_R	1.655	1.00
20_V	106_S	1.651	1.00
148_H	152_T	1.650	1.00
138_K	141_E	1.642	1.00
152_T	156_N	1.623	1.00
153_Y	157_E	1.611	1.00
86_K	89_D	1.594	1.00
133_G	150_I	1.589	1.00
131_Y	135_Q	1.586	1.00
214_L	221_V	1.566	1.00
87_D	114_N	1.556	1.00
121_K	157_E	1.550	1.00
118_D	121_K	1.550	1.00
98_K	103_H	1.548	1.00
10_L	219_T	1.540	1.00
43_I	47_F	1.522	1.00
129_S	153_Y	1.520	1.00
15_E	99_L	1.510	1.00
14_R	18_R	1.500	1.00
4_C	193_K	1.490	1.00
117_D	120_K	1.479	1.00
111_P	123_L	1.461	1.00
33_P	87_D	1.455	1.00
139_P	194_P	1.454	1.00
128_E	153_Y	1.452	1.00
129_S	154_V	1.451	1.00
205_N	228_C	1.434	1.00
36_S	39_E	1.423	1.00
26_E	43_I	1.415	1.00
136_E	141_E	1.392	1.00
32_K	35_I	1.387	1.00
94_D	105_D	1.375	1.00
38_K	42_Q	1.358	1.00
83_R	89_D	1.345	1.00
20_V	104_G	1.337	1.00
38_K	82_S	1.335	1.00
85_L	112_V	1.334	1.00
130_L	134_L	1.322	1.00
165_Y	220_V	1.280	1.00
26_E	30_H	1.276	1.00
142_R	191_R	1.273	1.00
166_V	179_Q	1.269	1.00
18_R	22_L	1.269	1.00
41_D	45_E	1.241	1.00
19_I	53_A	1.236	1.00
102_Y	172_Q	1.226	1.00
122_L	210_Y	1.212	1.00
141_E	145_N	1.210	1.00
26_E	51_Q	1.208	1.00
7_P	11_G	1.200	1.00
121_K	125_V	1.198	1.00
27_L	44_A	1.196	1.00
15_E	100_N	1.191	1.00
6_T	9_E	1.185	1.00
62_G	103_H	1.183	1.00
90_I	119_D	1.182	1.00
8_R	11_G	1.152	1.00
11_G	15_E	1.139	1.00
193_K	196_M	1.132	1.00
133_G	149_A	1.125	1.00
12_I	15_E	1.125	1.00
170_V	217_N	1.120	1.00
22_L	47_F	1.116	1.00
192_L	198_L	1.114	1.00
145_N	148_H	1.113	1.00
8_R	12_I	1.109	1.00
133_G	146_I	1.102	1.00
24_H	110_Y	1.089	1.00
144_S	187_N	1.057	1.00
67_I	91_I	1.055	1.00
48_I	97_A	1.055	1.00
3_I	196_M	1.053	1.00
124_E	127_E	1.052	1.00
132_K	149_A	1.047	1.00
118_D	206_A	1.043	1.00
19_I	99_L	1.032	1.00
35_I	43_I	1.030	1.00
35_I	39_E	1.016	1.00
132_K	136_E	1.015	1.00
125_V	153_Y	1.010	1.00
200_I	218_W	1.010	1.00
24_H	106_S	1.008	1.00
144_S	148_H	0.996	1.00
4_C	196_M	0.994	1.00
121_K	124_E	0.983	1.00
54_I	98_K	0.982	1.00
122_L	206_A	0.982	1.00
69_V	91_I	0.980	1.00
75_L	211_V	0.977	1.00
11_G	14_R	0.973	1.00
115_I	120_K	0.969	1.00
44_A	48_I	0.965	1.00
17_G	21_A	0.965	1.00
5_K	176_E	0.963	1.00
137_A	200_I	0.958	1.00
20_V	97_A	0.948	1.00
165_Y	213_T	0.942	1.00
69_V	85_L	0.937	1.00
9_E	172_Q	0.926	1.00
39_E	42_Q	0.924	1.00
199_A	217_N	0.923	1.00
40_L	85_L	0.921	1.00
25_E	29_K	0.918	1.00
19_I	97_A	0.917	1.00
45_E	65_G	0.912	1.00
16_A	104_G	0.910	1.00
128_E	157_E	0.905	1.00
137_A	220_V	0.903	1.00
162_V	205_N	0.901	1.00
146_I	192_L	0.896	1.00
19_I	101_G	0.893	1.00
164_E	209_R	0.888	1.00
221_V	224_D	0.885	1.00
43_I	50_K	0.883	1.00
206_A	226_K	0.883	1.00
31_I	112_V	0.877	1.00
169_G	178_P	0.877	1.00
141_E	149_A	0.872	1.00
31_I	40_L	0.868	1.00
74_E	83_R	0.864	1.00
13_M	17_G	0.857	1.00
143_L	192_L	0.852	1.00
73_E	221_V	0.851	1.00
153_Y	156_N	0.851	1.00
87_D	113_G	0.840	1.00
92_S	107_A	0.833	1.00
48_I	53_A	0.829	1.00
53_A	97_A	0.827	1.00
147_S	166_V	0.826	1.00
90_I	111_P	0.826	1.00
83_R	86_K	0.825	1.00
126_T	229_A	0.825	1.00
150_I	166_V	0.823	1.00
137_A	192_L	0.822	1.00
44_A	67_I	0.821	1.00
68_C	78_G	0.819	1.00
28_K	108_W	0.819	1.00
64_R	79_I	0.817	1.00
77_H	175_H	0.811	1.00
134_L	200_I	0.809	1.00
134_L	218_W	0.806	1.00
103_H	174_L	0.805	1.00
9_E	102_Y	0.799	1.00
149_A	152_T	0.793	1.00
143_L	190_P	0.792	1.00
26_E	50_K	0.791	1.00
22_L	26_E	0.790	1.00
72_N	75_L	0.787	1.00
33_P	112_V	0.787	1.00
93_I	110_Y	0.786	1.00
128_E	156_N	0.782	1.00
115_I	119_D	0.782	1.00
114_N	120_K	0.782	1.00
148_H	186_P	0.781	1.00
137_A	146_I	0.779	1.00
149_A	153_Y	0.764	1.00
19_I	51_Q	0.759	1.00
155_E	160_S	0.754	1.00
30_H	35_I	0.750	1.00
94_D	168_H	0.746	1.00
136_E	139_P	0.746	1.00
18_R	21_A	0.745	1.00
69_V	83_R	0.742	1.00
21_A	25_E	0.741	1.00
23_T	44_A	0.734	1.00
122_L	159_F	0.730	1.00
133_G	136_E	0.730	1.00
65_G	79_I	0.730	1.00
125_V	154_V	0.727	1.00
39_E	50_K	0.724	1.00
38_K	65_G	0.722	1.00
23_T	97_A	0.721	1.00
141_E	146_I	0.721	1.00
142_R	189_G	0.719	1.00
70_S	89_D	0.718	1.00
31_I	110_Y	0.712	1.00
94_D	201_E	0.712	1.00
170_V	197_V	0.711	1.00
49_K	54_I	0.707	1.00
188_K	191_R	0.706	1.00
170_V	199_A	0.704	1.00
46_R	49_K	0.703	1.00
17_G	104_G	0.702	1.00
213_T	220_V	0.702	1.00
24_H	95_I	0.701	1.00
22_L	25_E	0.693	1.00
190_P	196_M	0.692	1.00
125_V	128_E	0.688	1.00
206_A	209_R	0.682	1.00
45_E	61_N	0.681	1.00
72_N	78_G	0.677	1.00
132_K	152_T	0.676	1.00
15_E	19_I	0.674	1.00
160_S	205_N	0.673	1.00
130_L	216_D	0.672	1.00
88_G	112_V	0.660	1.00
16_A	99_L	0.659	1.00
40_L	67_I	0.656	1.00
20_V	95_I	0.652	1.00
34_G	84_V	0.651	1.00
105_D	168_H	0.647	1.00
96_G	104_G	0.644	1.00
38_K	81_G	0.643	1.00
150_I	162_V	0.642	1.00
122_L	229_A	0.638	1.00
44_A	95_I	0.636	1.00
128_E	131_Y	0.634	1.00
111_P	119_D	0.634	1.00
75_L	78_G	0.633	1.00
105_D	201_E	0.633	1.00
25_E	108_W	0.627	1.00
74_E	216_D	0.625	1.00
30_H	47_F	0.623	1.00
20_V	23_T	0.621	1.00
123_L	127_E	0.621	1.00
129_S	133_G	0.616	1.00
126_T	212_K	0.615	1.00
24_H	28_K	0.615	1.00
154_V	159_F	0.615	1.00
139_P	193_K	0.612	1.00
27_L	30_H	0.609	1.00
13_M	172_Q	0.609	1.00
40_L	91_I	0.607	1.00
27_L	40_L	0.602	1.00
36_S	82_S	0.602	1.00
27_L	43_I	0.598	1.00
144_S	188_K	0.595	1.00
23_T	48_I	0.593	1.00
17_G	106_S	0.591	1.00
69_V	112_V	0.590	1.00
115_I	123_L	0.589	1.00
181_P	187_N	0.588	1.00
29_K	33_P	0.588	1.00
145_N	149_A	0.585	1.00
105_D	215_A	0.585	1.00
168_H	175_H	0.582	1.00
73_E	92_S	0.582	1.00
61_N	65_G	0.578	1.00
5_K	9_E	0.575	1.00
72_N	89_D	0.573	1.00
125_V	159_F	0.572	1.00
148_H	189_G	0.571	1.00
90_I	115_I	0.568	1.00
143_L	180_I	0.564	1.00
136_E	146_I	0.564	1.00
221_V	226_K	0.564	1.00
133_G	200_I	0.559	1.00
94_D	215_A	0.553	1.00
48_I	95_I	0.553	1.00
166_V	181_P	0.552	1.00
152_T	155_E	0.552	1.00
164_E	211_V	0.550	1.00
146_I	149_A	0.547	1.00
17_G	20_V	0.547	1.00
69_V	89_D	0.546	1.00
81_G	84_V	0.544	1.00
111_P	114_N	0.544	1.00
118_D	122_L	0.543	1.00
38_K	41_D	0.539	1.00
25_E	28_K	0.538	1.00
130_L	200_I	0.538	1.00
129_S	150_I	0.537	1.00
173_D	176_E	0.536	1.00
53_A	99_L	0.536	1.00
62_G	65_G	0.535	1.00
24_H	27_L	0.535	1.00
23_T	26_E	0.535	1.00
96_G	174_L	0.533	1.00
208_S	226_K	0.532	1.00
10_L	197_V	0.530	1.00
31_I	91_I	0.529	1.00
140_G	191_R	0.527	0.99
168_H	201_E	0.527	0.99
212_K	221_V	0.526	0.99
122_L	204_V	0.526	0.99
23_T	27_L	0.526	0.99
9_E	12_I	0.526	0.99
45_E	55_P	0.526	0.99
126_T	204_V	0.525	0.99
23_T	51_Q	0.518	0.99
45_E	66_S	0.518	0.99
212_K	215_A	0.516	0.99
157_E	160_S	0.516	0.99
73_E	90_I	0.514	0.99
7_P	194_P	0.512	0.99
136_E	145_N	0.511	0.99
37_T	81_G	0.511	0.99
129_S	149_A	0.510	0.99
119_D	206_A	0.509	0.99
17_G	217_N	0.505	0.99
41_D	66_S	0.504	0.99
159_F	206_A	0.503	0.99
68_C	73_E	0.501	0.99
72_N	83_R	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zsgA	2	0.9234	100	0.147	Contact Map
1o0xA	1	0.9919	100	0.15	Contact Map
4fukA	2	1	100	0.15	Contact Map
3q6dA	1	0.9234	100	0.15	Contact Map
3mx6A	1	0.996	100	0.151	Contact Map
1wy2A	2	0.9153	100	0.151	Contact Map
4fkcA	2	0.9234	100	0.152	Contact Map
3tb5A	1	0.996	100	0.152	Contact Map
3s6bA	1	1	100	0.152	Contact Map
1wn1A	2	0.9194	100	0.153	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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