GREMLIN Database
MAP11 - Methionine aminopeptidase 1
UniProt: P19994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (220)
Sequences: 16082 (9840)
Seq/√Len: 663.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_K153_Y2.8491.00
46_R50_K2.7631.00
30_H43_I2.6391.00
22_L51_Q2.5941.00
26_E47_F2.4771.00
111_P115_I2.4321.00
132_K135_Q2.3351.00
119_D227_K2.2031.00
120_K124_E2.1981.00
36_S84_V2.1681.00
45_E49_K2.1521.00
124_E128_E2.1291.00
47_F51_Q2.1081.00
12_I100_N2.0891.00
144_S189_G2.0891.00
116_S119_D2.0891.00
14_R226_K2.0381.00
43_I46_R2.0111.00
151_Q155_E2.0081.00
13_M197_V1.9831.00
15_E18_R1.9501.00
127_E131_Y1.9431.00
47_F50_K1.9321.00
154_V204_V1.9261.00
125_V157_E1.8991.00
117_D121_K1.8961.00
71_V83_R1.8361.00
23_T47_F1.8351.00
194_P222_T1.8341.00
128_E132_K1.8271.00
136_E149_A1.8061.00
42_Q46_R1.7821.00
26_E29_K1.7751.00
147_S151_Q1.7051.00
142_R145_N1.6741.00
28_K110_Y1.6591.00
118_D209_R1.6551.00
20_V106_S1.6511.00
148_H152_T1.6501.00
138_K141_E1.6421.00
152_T156_N1.6231.00
153_Y157_E1.6111.00
86_K89_D1.5941.00
133_G150_I1.5891.00
131_Y135_Q1.5861.00
214_L221_V1.5661.00
87_D114_N1.5561.00
121_K157_E1.5501.00
118_D121_K1.5501.00
98_K103_H1.5481.00
10_L219_T1.5401.00
43_I47_F1.5221.00
129_S153_Y1.5201.00
15_E99_L1.5101.00
14_R18_R1.5001.00
4_C193_K1.4901.00
117_D120_K1.4791.00
111_P123_L1.4611.00
33_P87_D1.4551.00
139_P194_P1.4541.00
128_E153_Y1.4521.00
129_S154_V1.4511.00
205_N228_C1.4341.00
36_S39_E1.4231.00
26_E43_I1.4151.00
136_E141_E1.3921.00
32_K35_I1.3871.00
94_D105_D1.3751.00
38_K42_Q1.3581.00
83_R89_D1.3451.00
20_V104_G1.3371.00
38_K82_S1.3351.00
85_L112_V1.3341.00
130_L134_L1.3221.00
165_Y220_V1.2801.00
26_E30_H1.2761.00
142_R191_R1.2731.00
166_V179_Q1.2691.00
18_R22_L1.2691.00
41_D45_E1.2411.00
19_I53_A1.2361.00
102_Y172_Q1.2261.00
122_L210_Y1.2121.00
141_E145_N1.2101.00
26_E51_Q1.2081.00
7_P11_G1.2001.00
121_K125_V1.1981.00
27_L44_A1.1961.00
15_E100_N1.1911.00
6_T9_E1.1851.00
62_G103_H1.1831.00
90_I119_D1.1821.00
8_R11_G1.1521.00
11_G15_E1.1391.00
193_K196_M1.1321.00
133_G149_A1.1251.00
12_I15_E1.1251.00
170_V217_N1.1201.00
22_L47_F1.1161.00
192_L198_L1.1141.00
145_N148_H1.1131.00
8_R12_I1.1091.00
133_G146_I1.1021.00
24_H110_Y1.0891.00
144_S187_N1.0571.00
67_I91_I1.0551.00
48_I97_A1.0551.00
3_I196_M1.0531.00
124_E127_E1.0521.00
132_K149_A1.0471.00
118_D206_A1.0431.00
19_I99_L1.0321.00
35_I43_I1.0301.00
35_I39_E1.0161.00
132_K136_E1.0151.00
125_V153_Y1.0101.00
200_I218_W1.0101.00
24_H106_S1.0081.00
144_S148_H0.9961.00
4_C196_M0.9941.00
121_K124_E0.9831.00
54_I98_K0.9821.00
122_L206_A0.9821.00
69_V91_I0.9801.00
75_L211_V0.9771.00
11_G14_R0.9731.00
115_I120_K0.9691.00
44_A48_I0.9651.00
17_G21_A0.9651.00
5_K176_E0.9631.00
137_A200_I0.9581.00
20_V97_A0.9481.00
165_Y213_T0.9421.00
69_V85_L0.9371.00
9_E172_Q0.9261.00
39_E42_Q0.9241.00
199_A217_N0.9231.00
40_L85_L0.9211.00
25_E29_K0.9181.00
19_I97_A0.9171.00
45_E65_G0.9121.00
16_A104_G0.9101.00
128_E157_E0.9051.00
137_A220_V0.9031.00
162_V205_N0.9011.00
146_I192_L0.8961.00
19_I101_G0.8931.00
164_E209_R0.8881.00
221_V224_D0.8851.00
43_I50_K0.8831.00
206_A226_K0.8831.00
31_I112_V0.8771.00
169_G178_P0.8771.00
141_E149_A0.8721.00
31_I40_L0.8681.00
74_E83_R0.8641.00
13_M17_G0.8571.00
143_L192_L0.8521.00
73_E221_V0.8511.00
153_Y156_N0.8511.00
87_D113_G0.8401.00
92_S107_A0.8331.00
48_I53_A0.8291.00
53_A97_A0.8271.00
147_S166_V0.8261.00
90_I111_P0.8261.00
83_R86_K0.8251.00
126_T229_A0.8251.00
150_I166_V0.8231.00
137_A192_L0.8221.00
44_A67_I0.8211.00
68_C78_G0.8191.00
28_K108_W0.8191.00
64_R79_I0.8171.00
77_H175_H0.8111.00
134_L200_I0.8091.00
134_L218_W0.8061.00
103_H174_L0.8051.00
9_E102_Y0.7991.00
149_A152_T0.7931.00
143_L190_P0.7921.00
26_E50_K0.7911.00
22_L26_E0.7901.00
72_N75_L0.7871.00
33_P112_V0.7871.00
93_I110_Y0.7861.00
128_E156_N0.7821.00
115_I119_D0.7821.00
114_N120_K0.7821.00
148_H186_P0.7811.00
137_A146_I0.7791.00
149_A153_Y0.7641.00
19_I51_Q0.7591.00
155_E160_S0.7541.00
30_H35_I0.7501.00
94_D168_H0.7461.00
136_E139_P0.7461.00
18_R21_A0.7451.00
69_V83_R0.7421.00
21_A25_E0.7411.00
23_T44_A0.7341.00
122_L159_F0.7301.00
133_G136_E0.7301.00
65_G79_I0.7301.00
125_V154_V0.7271.00
39_E50_K0.7241.00
38_K65_G0.7221.00
23_T97_A0.7211.00
141_E146_I0.7211.00
142_R189_G0.7191.00
70_S89_D0.7181.00
31_I110_Y0.7121.00
94_D201_E0.7121.00
170_V197_V0.7111.00
49_K54_I0.7071.00
188_K191_R0.7061.00
170_V199_A0.7041.00
46_R49_K0.7031.00
17_G104_G0.7021.00
213_T220_V0.7021.00
24_H95_I0.7011.00
22_L25_E0.6931.00
190_P196_M0.6921.00
125_V128_E0.6881.00
206_A209_R0.6821.00
45_E61_N0.6811.00
72_N78_G0.6771.00
132_K152_T0.6761.00
15_E19_I0.6741.00
160_S205_N0.6731.00
130_L216_D0.6721.00
88_G112_V0.6601.00
16_A99_L0.6591.00
40_L67_I0.6561.00
20_V95_I0.6521.00
34_G84_V0.6511.00
105_D168_H0.6471.00
96_G104_G0.6441.00
38_K81_G0.6431.00
150_I162_V0.6421.00
122_L229_A0.6381.00
44_A95_I0.6361.00
128_E131_Y0.6341.00
111_P119_D0.6341.00
75_L78_G0.6331.00
105_D201_E0.6331.00
25_E108_W0.6271.00
74_E216_D0.6251.00
30_H47_F0.6231.00
20_V23_T0.6211.00
123_L127_E0.6211.00
129_S133_G0.6161.00
126_T212_K0.6151.00
24_H28_K0.6151.00
154_V159_F0.6151.00
139_P193_K0.6121.00
27_L30_H0.6091.00
13_M172_Q0.6091.00
40_L91_I0.6071.00
27_L40_L0.6021.00
36_S82_S0.6021.00
27_L43_I0.5981.00
144_S188_K0.5951.00
23_T48_I0.5931.00
17_G106_S0.5911.00
69_V112_V0.5901.00
115_I123_L0.5891.00
181_P187_N0.5881.00
29_K33_P0.5881.00
145_N149_A0.5851.00
105_D215_A0.5851.00
168_H175_H0.5821.00
73_E92_S0.5821.00
61_N65_G0.5781.00
5_K9_E0.5751.00
72_N89_D0.5731.00
125_V159_F0.5721.00
148_H189_G0.5711.00
90_I115_I0.5681.00
143_L180_I0.5641.00
136_E146_I0.5641.00
221_V226_K0.5641.00
133_G200_I0.5591.00
94_D215_A0.5531.00
48_I95_I0.5531.00
166_V181_P0.5521.00
152_T155_E0.5521.00
164_E211_V0.5501.00
146_I149_A0.5471.00
17_G20_V0.5471.00
69_V89_D0.5461.00
81_G84_V0.5441.00
111_P114_N0.5441.00
118_D122_L0.5431.00
38_K41_D0.5391.00
25_E28_K0.5381.00
130_L200_I0.5381.00
129_S150_I0.5371.00
173_D176_E0.5361.00
53_A99_L0.5361.00
62_G65_G0.5351.00
24_H27_L0.5351.00
23_T26_E0.5351.00
96_G174_L0.5331.00
208_S226_K0.5321.00
10_L197_V0.5301.00
31_I91_I0.5291.00
140_G191_R0.5270.99
168_H201_E0.5270.99
212_K221_V0.5260.99
122_L204_V0.5260.99
23_T27_L0.5260.99
9_E12_I0.5260.99
45_E55_P0.5260.99
126_T204_V0.5250.99
23_T51_Q0.5180.99
45_E66_S0.5180.99
212_K215_A0.5160.99
157_E160_S0.5160.99
73_E90_I0.5140.99
7_P194_P0.5120.99
136_E145_N0.5110.99
37_T81_G0.5110.99
129_S149_A0.5100.99
119_D206_A0.5090.99
17_G217_N0.5050.99
41_D66_S0.5040.99
159_F206_A0.5030.99
68_C73_E0.5010.99
72_N83_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zsgA 2 0.9234 100 0.147 Contact Map
1o0xA 1 0.9919 100 0.15 Contact Map
4fukA 2 1 100 0.15 Contact Map
3q6dA 1 0.9234 100 0.15 Contact Map
3mx6A 1 0.996 100 0.151 Contact Map
1wy2A 2 0.9153 100 0.151 Contact Map
4fkcA 2 0.9234 100 0.152 Contact Map
3tb5A 1 0.996 100 0.152 Contact Map
3s6bA 1 1 100 0.152 Contact Map
1wn1A 2 0.9194 100 0.153 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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