GREMLIN Database
RL15 - 50S ribosomal protein L15
UniProt: P19946 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (144)
Sequences: 3029 (1532)
Seq/√Len: 127.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_K137_E3.7921.00
124_K144_E3.4261.00
17_N27_N3.0111.00
92_T95_L2.6771.00
125_A128_F2.6741.00
128_F143_A2.6731.00
27_N32_G2.6221.00
122_T142_T2.5831.00
113_G131_S2.4751.00
90_E124_K2.3461.00
83_N118_E2.2791.00
130_A133_K2.2311.00
94_E98_E2.2001.00
80_D114_N2.1011.00
134_E138_A2.0451.00
87_E120_K1.9521.00
90_E122_T1.9161.00
93_P126_N1.9001.00
111_I125_A1.7951.00
130_A134_E1.7851.00
19_V31_A1.7571.00
76_V129_S1.7171.00
92_T124_K1.6391.00
83_N119_K1.6351.00
23_I29_K1.6261.00
81_K84_G1.6131.00
36_K40_A1.6101.00
128_F133_K1.6081.00
89_T95_L1.6021.00
110_K127_K1.5991.00
117_L121_L1.5871.00
134_E137_E1.5481.00
39_N45_G1.5391.00
29_K35_H1.5341.00
137_E142_T1.4921.00
2_K5_E1.4921.00
83_N87_E1.4911.00
82_L123_V1.4651.00
78_N112_L1.3711.00
95_L99_T1.3691.00
39_N46_V1.3621.00
19_V33_K1.3571.00
9_S12_S1.3391.00
19_V27_N1.3351.00
38_Q44_G1.3291.00
35_H39_N1.3241.00
86_A89_T1.3211.00
116_K135_A1.2701.00
78_N113_G1.2591.00
30_T35_H1.2190.99
86_A119_K1.1970.99
85_F88_G1.1920.99
55_M58_F1.1610.99
93_P109_V1.1530.99
111_I136_V1.1400.99
86_A121_L1.1220.99
35_H40_A1.1200.99
91_V96_L1.1110.99
109_V125_A1.1030.99
51_E60_R1.0720.99
91_V121_L1.0700.99
8_P13_R1.0660.99
111_I123_V1.0570.99
39_N44_G1.0480.98
24_G27_N1.0270.98
87_E119_K1.0170.98
136_V141_G1.0150.98
68_N71_R1.0110.98
74_Y127_K1.0100.98
74_Y108_G1.0060.98
79_L135_A0.9970.98
97_L105_L0.9920.98
8_P12_S0.9790.98
75_A106_N0.9710.97
88_G91_V0.9700.97
45_G48_P0.9570.97
15_T27_N0.9550.97
81_K114_N0.9430.97
75_A108_G0.9400.97
55_M59_Q0.9340.97
47_R58_F0.9310.97
82_L121_L0.9300.97
123_V136_V0.9280.97
16_R19_V0.9270.97
95_L98_E0.9260.97
33_K40_A0.9170.96
112_L129_S0.9110.96
38_Q46_V0.9040.96
30_T36_K0.9010.96
78_N114_N0.8920.96
111_I128_F0.8910.96
128_F136_V0.8900.96
93_P102_I0.8890.96
81_K101_V0.8880.96
50_F54_Q0.8780.95
102_I109_V0.8760.95
89_T119_K0.8690.95
1_M5_E0.8650.95
78_N129_S0.8640.95
103_S106_N0.8610.95
72_K108_G0.8610.95
20_G31_A0.8490.94
19_V32_G0.8480.94
114_N135_A0.8390.94
51_E54_Q0.8270.94
57_L61_L0.8220.93
93_P97_L0.8190.93
120_K142_T0.8140.93
133_K143_A0.8110.93
120_K139_A0.8090.93
91_V95_L0.7990.92
117_L120_K0.7950.92
16_R27_N0.7870.92
27_N31_A0.7830.92
9_S13_R0.7820.92
75_A107_A0.7820.92
89_T99_T0.7800.91
29_K32_G0.7720.91
112_L115_G0.7680.91
85_F89_T0.7550.90
108_G127_K0.7540.90
14_K27_N0.7520.90
96_L102_I0.7520.90
79_L113_G0.7440.89
125_A136_V0.7430.89
80_D83_N0.7380.89
123_V128_F0.7270.88
72_K76_V0.7270.88
24_G64_R0.7210.88
122_T144_E0.7170.88
86_A91_V0.7040.87
112_L132_A0.7040.87
42_S45_G0.7010.86
23_I35_H0.6990.86
96_L101_V0.6960.86
93_P105_L0.6950.86
14_K17_N0.6870.85
23_I30_T0.6860.85
44_G47_R0.6820.85
15_T31_A0.6810.85
91_V99_T0.6740.84
40_A43_G0.6660.84
76_V127_K0.6630.83
133_K142_T0.6620.83
64_R70_N0.6530.82
76_V112_L0.6410.81
75_A103_S0.6390.81
96_L100_G0.6390.81
71_R74_Y0.6380.81
79_L117_L0.6380.81
51_E56_P0.6360.81
125_A143_A0.6350.81
79_L139_A0.6320.80
75_A102_I0.6230.79
102_I105_L0.6220.79
56_P59_Q0.6210.79
7_K12_S0.6200.79
43_G46_V0.6180.79
97_L102_I0.6180.79
131_S135_A0.6110.78
117_L136_V0.6100.78
40_A44_G0.6070.78
79_L83_N0.6030.77
31_A35_H0.6010.77
33_K39_N0.6000.77
113_G135_A0.5980.77
68_N74_Y0.5950.76
53_G56_P0.5940.76
108_G126_N0.5920.76
71_R76_V0.5850.75
12_S57_L0.5810.74
42_S46_V0.5810.74
117_L139_A0.5760.74
92_T98_E0.5760.74
7_K10_E0.5720.73
124_K142_T0.5720.73
79_L123_V0.5680.73
14_K31_A0.5590.72
77_V111_I0.5570.71
112_L135_A0.5560.71
67_T70_N0.5540.71
83_N88_G0.5530.71
78_N115_G0.5520.71
44_G55_M0.5500.70
85_F99_T0.5500.70
105_L108_G0.5480.70
88_G120_K0.5470.70
97_L106_N0.5460.70
82_L86_A0.5450.70
33_K59_Q0.5450.70
36_K103_S0.5430.69
122_T139_A0.5420.69
73_E105_L0.5380.69
88_G119_K0.5310.68
64_R112_L0.5310.68
1_M61_L0.5300.68
31_A40_A0.5280.67
44_G49_G0.5250.67
97_L104_K0.5250.67
7_K11_G0.5230.67
88_G121_L0.5210.66
27_N35_H0.5200.66
25_S36_K0.5180.66
56_P60_R0.5180.66
96_L125_A0.5140.65
135_A139_A0.5130.65
50_F53_G0.5120.65
76_V111_I0.5120.65
136_V143_A0.5110.65
77_V81_K0.5100.65
73_E110_K0.5100.65
94_E105_L0.5070.64
77_V101_V0.5070.64
135_A138_A0.5050.64
35_H43_G0.5010.63
79_L114_N0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3wL 1 1 100 0.039 Contact Map
1vw4J 1 0.9863 100 0.073 Contact Map
2zjrI 1 0.9589 100 0.074 Contact Map
4rb6P 1 0.9726 100 0.087 Contact Map
4tp9L 1 0.0137 100 0.091 Contact Map
3bboN 1 1 100 0.122 Contact Map
3j7yM 1 0.9726 100 0.138 Contact Map
1vq8L 1 0.863 100 0.33 Contact Map
4a17K 1 0.911 100 0.36 Contact Map
4ujrN 1 0.8699 100 0.381 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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