GREMLIN Database
YQXC - Putative rRNA methyltransferase YqxC
UniProt: P19672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (243)
Sequences: 2530 (1582)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_Q129_V3.6041.00
115_Y133_R3.5681.00
192_S207_D3.3811.00
18_A27_A3.2941.00
86_M100_A3.1861.00
188_A204_V2.8931.00
162_R211_R2.8311.00
75_K103_N2.7241.00
150_E173_V2.6111.00
198_I234_G2.4981.00
98_D102_Q2.3741.00
67_G71_E2.2951.00
177_D243_H2.2651.00
182_V242_L2.1721.00
81_V100_A2.1401.00
172_L176_S2.1311.00
62_Y71_E2.1221.00
36_N51_L2.1161.00
84_K177_D2.0341.00
34_Y39_R1.9671.00
123_R132_E1.9471.00
76_E227_S1.9081.00
6_E14_E1.8881.00
136_F164_I1.8731.00
161_L180_A1.8591.00
179_M241_L1.8421.00
8_L40_L1.8331.00
207_D211_R1.8321.00
86_M105_A1.8051.00
35_S53_L1.7851.00
136_F139_A1.7841.00
22_E25_K1.7611.00
228_F238_I1.7551.00
188_A208_V1.7421.00
83_D106_K1.7401.00
182_V209_L1.7091.00
156_V164_I1.6671.00
71_E75_K1.6601.00
140_T143_D1.6551.00
152_A172_L1.6131.00
34_Y56_K1.5841.00
169_R221_Y1.5711.00
8_L47_I1.5671.00
224_K245_H1.5661.00
62_Y102_Q1.5611.00
201_D204_V1.5581.00
216_S244_L1.5541.00
72_K241_L1.5491.00
89_I136_F1.5421.00
60_L68_L1.5181.00
177_D245_H1.5131.00
97_T128_V1.4991.00
34_Y54_T1.4931.00
154_I180_A1.4781.00
100_A153_T1.4741.00
11_L15_R1.4581.00
8_L35_S1.4551.00
67_G98_D1.4491.00
63_V119_A1.4481.00
131_M143_D1.4421.00
81_V151_F1.4381.00
204_V208_V1.4341.00
87_I111_V1.4301.00
61_R71_E1.4211.00
205_H240_F1.4171.00
89_I156_V1.4161.00
118_L130_V1.4141.00
213_I242_L1.4121.00
167_V170_T1.4081.00
85_I107_Q1.3941.00
74_L81_V1.3891.00
85_I109_Y1.3821.00
35_S40_L1.3610.99
86_M151_F1.3580.99
102_Q121_K1.3580.99
11_L53_L1.3230.99
169_R246_W1.3060.99
120_W124_Q1.3050.99
67_G99_C1.2960.99
212_M215_F1.2910.99
79_V179_M1.2910.99
21_R189_G1.2880.99
154_I178_C1.2830.99
91_S110_A1.2770.99
37_E54_T1.2620.99
91_S130_V1.2620.99
154_I161_L1.2600.99
61_R102_Q1.2480.99
162_R215_F1.2300.99
109_Y145_T1.2180.99
77_F225_G1.2160.99
223_C242_L1.2130.99
107_Q147_G1.2120.99
19_E23_K1.1920.99
48_D51_L1.1910.99
111_V139_A1.1860.98
222_I247_P1.1830.98
116_N133_R1.1810.98
72_K227_S1.1750.98
206_A210_K1.1750.98
198_I235_D1.1740.98
230_P241_L1.1650.98
71_E103_N1.1480.98
85_I147_G1.1420.98
8_L53_L1.1350.98
72_K230_P1.1300.98
62_Y99_C1.1290.98
6_E10_V1.1270.98
47_I51_L1.1240.98
27_A32_I1.1230.98
100_A151_F1.1110.98
99_C102_Q1.1110.98
224_K243_H1.1080.98
154_I168_L1.1020.98
63_V121_K1.0930.97
11_L47_I1.0810.97
84_K150_E1.0800.97
165_L216_S1.0760.97
32_I58_N1.0720.97
15_R53_L1.0690.97
225_G243_H1.0560.97
40_L45_E1.0560.97
71_E99_C1.0530.97
165_L219_E1.0480.97
6_E49_R1.0330.96
181_L241_L1.0320.96
151_F177_D1.0320.96
89_I168_L1.0310.96
26_R30_A1.0280.96
47_I53_L1.0260.96
109_Y129_V1.0250.96
144_F149_P1.0200.96
15_R52_P1.0080.96
116_N123_R0.9910.95
98_D121_K0.9890.95
8_L28_I0.9850.95
223_C244_L0.9750.95
162_R212_M0.9740.95
215_F219_E0.9620.95
79_V151_F0.9590.95
210_K214_S0.9480.94
205_H208_V0.9460.94
40_L51_L0.9450.94
74_L78_P0.9420.94
10_V14_E0.9400.94
135_N138_Y0.9390.94
72_K228_F0.9380.94
178_C221_Y0.9340.94
174_P246_W0.9340.94
97_T108_S0.9320.94
214_S218_A0.9290.94
68_L71_E0.9240.93
189_G192_S0.9060.93
35_S51_L0.8990.92
216_S242_L0.8980.92
29_M43_P0.8970.92
123_R130_V0.8960.92
188_A192_S0.8920.92
182_V226_L0.8900.92
232_T238_I0.8860.92
131_M144_F0.8810.92
34_Y55_V0.8790.92
11_L51_L0.8770.91
182_V212_M0.8750.91
25_K29_M0.8700.91
196_K235_D0.8690.91
29_M44_G0.8670.91
192_S204_V0.8630.91
77_F179_M0.8620.91
204_V207_D0.8590.91
209_L226_L0.8570.90
212_M242_L0.8480.90
137_R159_I0.8480.90
222_I245_H0.8440.90
72_K76_E0.8420.90
119_A124_Q0.8420.90
125_D128_V0.8360.89
152_A178_C0.8340.89
19_E119_A0.8330.89
136_F168_L0.8230.89
149_P171_L0.8190.88
231_I241_L0.8010.87
62_Y67_G0.8000.87
79_V243_H0.7950.87
149_P173_V0.7950.87
67_G102_Q0.7890.86
120_W123_R0.7750.85
101_L127_R0.7740.85
106_K147_G0.7670.85
63_V98_D0.7660.85
14_E49_R0.7630.85
91_S115_Y0.7600.84
152_A168_L0.7560.84
64_S234_G0.7550.84
81_V86_M0.7530.84
73_A77_F0.7510.84
109_Y149_P0.7500.84
203_K206_A0.7480.83
116_N120_W0.7470.83
209_L212_M0.7440.83
136_F156_V0.7400.83
86_M153_T0.7360.82
33_V55_V0.7340.82
202_P205_H0.7340.82
136_F154_I0.7310.82
148_M173_V0.7290.82
42_K189_G0.7280.82
20_T189_G0.7270.82
26_R60_L0.7230.81
17_L55_V0.7220.81
87_I136_F0.7210.81
134_T139_A0.7170.81
12_L27_A0.7140.80
17_L27_A0.7130.80
193_V199_V0.7120.80
164_I167_V0.7120.80
205_H238_I0.7100.80
23_K59_P0.7100.80
6_E46_K0.7070.80
89_I164_I0.7060.80
120_W133_R0.7050.80
161_L164_I0.7030.79
110_A118_L0.7000.79
68_L231_I0.6990.79
85_I129_V0.6990.79
15_R35_S0.6970.79
23_K26_R0.6950.79
208_V212_M0.6940.79
11_L17_L0.6930.78
131_M134_T0.6920.78
64_S135_N0.6900.78
36_N50_D0.6880.78
169_R219_E0.6860.78
87_I149_P0.6840.78
141_P148_M0.6810.77
8_L45_E0.6800.77
66_G98_D0.6790.77
36_N52_P0.6780.77
178_C244_L0.6770.77
192_S211_R0.6750.77
91_S118_L0.6750.77
27_A30_A0.6740.77
227_S241_L0.6730.76
109_Y147_G0.6700.76
212_M216_S0.6690.76
12_L18_A0.6690.76
41_D44_G0.6670.76
91_S116_N0.6620.75
65_R233_G0.6600.75
193_V198_I0.6550.74
139_A171_L0.6540.74
12_L55_V0.6540.74
11_L14_E0.6530.74
233_G236_G0.6520.74
32_I56_K0.6500.74
165_L215_F0.6460.73
182_V205_H0.6460.73
89_I111_V0.6360.72
141_P170_T0.6350.72
115_Y123_R0.6340.72
21_R195_K0.6340.72
39_R57_G0.6330.72
180_A242_L0.6310.72
131_M139_A0.6310.72
196_K199_V0.6310.72
87_I171_L0.6300.72
114_G117_Q0.6300.72
11_L50_D0.6270.71
142_A145_T0.6270.71
182_V213_I0.6270.71
166_P219_E0.6260.71
71_E98_D0.6250.71
208_V211_R0.6230.71
115_Y134_T0.6230.71
61_R68_L0.6220.71
221_Y246_W0.6200.70
172_L221_Y0.6190.70
211_R214_S0.6180.70
164_I168_L0.6180.70
85_I106_K0.6160.70
23_K119_A0.6140.70
74_L103_N0.6130.70
18_A30_A0.6120.69
141_P145_T0.6110.69
205_H209_L0.6070.69
115_Y120_W0.6040.68
81_V105_A0.6040.68
89_I154_I0.6030.68
214_S217_A0.6000.68
40_L47_I0.5970.68
77_F241_L0.5970.68
116_N130_V0.5940.67
136_F144_F0.5930.67
6_E11_L0.5930.67
99_C154_I0.5930.67
15_R50_D0.5920.67
35_S47_I0.5920.67
62_Y68_L0.5920.67
129_V147_G0.5890.66
18_A32_I0.5880.66
76_E225_G0.5870.66
111_V144_F0.5860.66
84_K243_H0.5850.66
55_V58_N0.5840.66
61_R75_K0.5830.66
32_I59_P0.5820.66
213_I226_L0.5810.65
202_P206_A0.5760.65
30_A61_R0.5740.64
137_R163_L0.5710.64
22_E26_R0.5710.64
16_G24_A0.5710.64
62_Y98_D0.5700.64
152_A171_L0.5690.64
109_Y131_M0.5680.64
175_G245_H0.5660.63
74_L79_V0.5660.63
145_T149_P0.5650.63
154_I164_I0.5620.63
40_L53_L0.5560.62
17_L53_L0.5510.61
31_G39_R0.5480.61
87_I157_S0.5470.61
211_R215_F0.5460.61
23_K68_L0.5450.61
193_V196_K0.5440.60
25_K178_C0.5430.60
35_S52_P0.5400.60
149_P152_A0.5390.60
199_V209_L0.5380.60
101_L128_V0.5380.60
215_F218_A0.5350.59
216_S221_Y0.5330.59
11_L44_G0.5310.59
145_T150_E0.5280.58
218_A247_P0.5230.57
37_E40_L0.5230.57
58_N61_R0.5220.57
111_V171_L0.5220.57
222_I248_G0.5220.57
66_G120_W0.5210.57
11_L48_D0.5210.57
175_G247_P0.5210.57
136_F167_V0.5200.57
209_L240_F0.5170.57
13_V43_P0.5130.56
122_L130_V0.5100.56
34_Y37_E0.5090.55
42_K137_R0.5090.55
113_V135_N0.5090.55
144_F171_L0.5070.55
81_V153_T0.5070.55
175_G222_I0.5070.55
18_A55_V0.5050.55
56_K60_L0.5050.55
209_L213_I0.5040.55
205_H226_L0.5040.55
175_G246_W0.5040.55
230_P238_I0.5030.55
16_G19_E0.5020.54
229_S238_I0.5020.54
138_Y167_V0.5000.54
39_R54_T0.5000.54
35_S45_E0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hp7A 1 0.968 100 0.51 Contact Map
1yb2A 2 0.7367 100 0.722 Contact Map
3opnA 1 0.7402 100 0.723 Contact Map
4r8rA 1 0.7402 100 0.726 Contact Map
3lkzA 1 0.7367 100 0.727 Contact Map
2wa2A 1 0.7794 100 0.747 Contact Map
4v0qA 2 0.8399 99.9 0.756 Contact Map
2px2A 1 0.7687 99.9 0.757 Contact Map
3eldA 1 0.7936 99.9 0.76 Contact Map
4k6mA 2 0.8434 99.9 0.767 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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