YQXC - BACSU - GREMLIN Contacts

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YQXC - Putative rRNA methyltransferase YqxC

UniProt:	P19672	Sequences: MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPGEKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQNGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFISLRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAAEGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKKADVPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	281 (243)
Sequences:	2530 (1582)
Seq/√Len:	101.5

BACSU - YQXC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_Q	129_V	3.604	1.00
115_Y	133_R	3.568	1.00
192_S	207_D	3.381	1.00
18_A	27_A	3.294	1.00
86_M	100_A	3.186	1.00
188_A	204_V	2.893	1.00
162_R	211_R	2.831	1.00
75_K	103_N	2.724	1.00
150_E	173_V	2.611	1.00
198_I	234_G	2.498	1.00
98_D	102_Q	2.374	1.00
67_G	71_E	2.295	1.00
177_D	243_H	2.265	1.00
182_V	242_L	2.172	1.00
81_V	100_A	2.140	1.00
172_L	176_S	2.131	1.00
62_Y	71_E	2.122	1.00
36_N	51_L	2.116	1.00
84_K	177_D	2.034	1.00
34_Y	39_R	1.967	1.00
123_R	132_E	1.947	1.00
76_E	227_S	1.908	1.00
6_E	14_E	1.888	1.00
136_F	164_I	1.873	1.00
161_L	180_A	1.859	1.00
179_M	241_L	1.842	1.00
8_L	40_L	1.833	1.00
207_D	211_R	1.832	1.00
86_M	105_A	1.805	1.00
35_S	53_L	1.785	1.00
136_F	139_A	1.784	1.00
22_E	25_K	1.761	1.00
228_F	238_I	1.755	1.00
188_A	208_V	1.742	1.00
83_D	106_K	1.740	1.00
182_V	209_L	1.709	1.00
156_V	164_I	1.667	1.00
71_E	75_K	1.660	1.00
140_T	143_D	1.655	1.00
152_A	172_L	1.613	1.00
34_Y	56_K	1.584	1.00
169_R	221_Y	1.571	1.00
8_L	47_I	1.567	1.00
224_K	245_H	1.566	1.00
62_Y	102_Q	1.561	1.00
201_D	204_V	1.558	1.00
216_S	244_L	1.554	1.00
72_K	241_L	1.549	1.00
89_I	136_F	1.542	1.00
60_L	68_L	1.518	1.00
177_D	245_H	1.513	1.00
97_T	128_V	1.499	1.00
34_Y	54_T	1.493	1.00
154_I	180_A	1.478	1.00
100_A	153_T	1.474	1.00
11_L	15_R	1.458	1.00
8_L	35_S	1.455	1.00
67_G	98_D	1.449	1.00
63_V	119_A	1.448	1.00
131_M	143_D	1.442	1.00
81_V	151_F	1.438	1.00
204_V	208_V	1.434	1.00
87_I	111_V	1.430	1.00
61_R	71_E	1.421	1.00
205_H	240_F	1.417	1.00
89_I	156_V	1.416	1.00
118_L	130_V	1.414	1.00
213_I	242_L	1.412	1.00
167_V	170_T	1.408	1.00
85_I	107_Q	1.394	1.00
74_L	81_V	1.389	1.00
85_I	109_Y	1.382	1.00
35_S	40_L	1.361	0.99
86_M	151_F	1.358	0.99
102_Q	121_K	1.358	0.99
11_L	53_L	1.323	0.99
169_R	246_W	1.306	0.99
120_W	124_Q	1.305	0.99
67_G	99_C	1.296	0.99
212_M	215_F	1.291	0.99
79_V	179_M	1.291	0.99
21_R	189_G	1.288	0.99
154_I	178_C	1.283	0.99
91_S	110_A	1.277	0.99
37_E	54_T	1.262	0.99
91_S	130_V	1.262	0.99
154_I	161_L	1.260	0.99
61_R	102_Q	1.248	0.99
162_R	215_F	1.230	0.99
109_Y	145_T	1.218	0.99
77_F	225_G	1.216	0.99
223_C	242_L	1.213	0.99
107_Q	147_G	1.212	0.99
19_E	23_K	1.192	0.99
48_D	51_L	1.191	0.99
111_V	139_A	1.186	0.98
222_I	247_P	1.183	0.98
116_N	133_R	1.181	0.98
72_K	227_S	1.175	0.98
206_A	210_K	1.175	0.98
198_I	235_D	1.174	0.98
230_P	241_L	1.165	0.98
71_E	103_N	1.148	0.98
85_I	147_G	1.142	0.98
8_L	53_L	1.135	0.98
72_K	230_P	1.130	0.98
62_Y	99_C	1.129	0.98
6_E	10_V	1.127	0.98
47_I	51_L	1.124	0.98
27_A	32_I	1.123	0.98
100_A	151_F	1.111	0.98
99_C	102_Q	1.111	0.98
224_K	243_H	1.108	0.98
154_I	168_L	1.102	0.98
63_V	121_K	1.093	0.97
11_L	47_I	1.081	0.97
84_K	150_E	1.080	0.97
165_L	216_S	1.076	0.97
32_I	58_N	1.072	0.97
15_R	53_L	1.069	0.97
225_G	243_H	1.056	0.97
40_L	45_E	1.056	0.97
71_E	99_C	1.053	0.97
165_L	219_E	1.048	0.97
6_E	49_R	1.033	0.96
181_L	241_L	1.032	0.96
151_F	177_D	1.032	0.96
89_I	168_L	1.031	0.96
26_R	30_A	1.028	0.96
47_I	53_L	1.026	0.96
109_Y	129_V	1.025	0.96
144_F	149_P	1.020	0.96
15_R	52_P	1.008	0.96
116_N	123_R	0.991	0.95
98_D	121_K	0.989	0.95
8_L	28_I	0.985	0.95
223_C	244_L	0.975	0.95
162_R	212_M	0.974	0.95
215_F	219_E	0.962	0.95
79_V	151_F	0.959	0.95
210_K	214_S	0.948	0.94
205_H	208_V	0.946	0.94
40_L	51_L	0.945	0.94
74_L	78_P	0.942	0.94
10_V	14_E	0.940	0.94
135_N	138_Y	0.939	0.94
72_K	228_F	0.938	0.94
178_C	221_Y	0.934	0.94
174_P	246_W	0.934	0.94
97_T	108_S	0.932	0.94
214_S	218_A	0.929	0.94
68_L	71_E	0.924	0.93
189_G	192_S	0.906	0.93
35_S	51_L	0.899	0.92
216_S	242_L	0.898	0.92
29_M	43_P	0.897	0.92
123_R	130_V	0.896	0.92
188_A	192_S	0.892	0.92
182_V	226_L	0.890	0.92
232_T	238_I	0.886	0.92
131_M	144_F	0.881	0.92
34_Y	55_V	0.879	0.92
11_L	51_L	0.877	0.91
182_V	212_M	0.875	0.91
25_K	29_M	0.870	0.91
196_K	235_D	0.869	0.91
29_M	44_G	0.867	0.91
192_S	204_V	0.863	0.91
77_F	179_M	0.862	0.91
204_V	207_D	0.859	0.91
209_L	226_L	0.857	0.90
212_M	242_L	0.848	0.90
137_R	159_I	0.848	0.90
222_I	245_H	0.844	0.90
72_K	76_E	0.842	0.90
119_A	124_Q	0.842	0.90
125_D	128_V	0.836	0.89
152_A	178_C	0.834	0.89
19_E	119_A	0.833	0.89
136_F	168_L	0.823	0.89
149_P	171_L	0.819	0.88
231_I	241_L	0.801	0.87
62_Y	67_G	0.800	0.87
79_V	243_H	0.795	0.87
149_P	173_V	0.795	0.87
67_G	102_Q	0.789	0.86
120_W	123_R	0.775	0.85
101_L	127_R	0.774	0.85
106_K	147_G	0.767	0.85
63_V	98_D	0.766	0.85
14_E	49_R	0.763	0.85
91_S	115_Y	0.760	0.84
152_A	168_L	0.756	0.84
64_S	234_G	0.755	0.84
81_V	86_M	0.753	0.84
73_A	77_F	0.751	0.84
109_Y	149_P	0.750	0.84
203_K	206_A	0.748	0.83
116_N	120_W	0.747	0.83
209_L	212_M	0.744	0.83
136_F	156_V	0.740	0.83
86_M	153_T	0.736	0.82
33_V	55_V	0.734	0.82
202_P	205_H	0.734	0.82
136_F	154_I	0.731	0.82
148_M	173_V	0.729	0.82
42_K	189_G	0.728	0.82
20_T	189_G	0.727	0.82
26_R	60_L	0.723	0.81
17_L	55_V	0.722	0.81
87_I	136_F	0.721	0.81
134_T	139_A	0.717	0.81
12_L	27_A	0.714	0.80
17_L	27_A	0.713	0.80
193_V	199_V	0.712	0.80
164_I	167_V	0.712	0.80
205_H	238_I	0.710	0.80
23_K	59_P	0.710	0.80
6_E	46_K	0.707	0.80
89_I	164_I	0.706	0.80
120_W	133_R	0.705	0.80
161_L	164_I	0.703	0.79
110_A	118_L	0.700	0.79
68_L	231_I	0.699	0.79
85_I	129_V	0.699	0.79
15_R	35_S	0.697	0.79
23_K	26_R	0.695	0.79
208_V	212_M	0.694	0.79
11_L	17_L	0.693	0.78
131_M	134_T	0.692	0.78
64_S	135_N	0.690	0.78
36_N	50_D	0.688	0.78
169_R	219_E	0.686	0.78
87_I	149_P	0.684	0.78
141_P	148_M	0.681	0.77
8_L	45_E	0.680	0.77
66_G	98_D	0.679	0.77
36_N	52_P	0.678	0.77
178_C	244_L	0.677	0.77
192_S	211_R	0.675	0.77
91_S	118_L	0.675	0.77
27_A	30_A	0.674	0.77
227_S	241_L	0.673	0.76
109_Y	147_G	0.670	0.76
212_M	216_S	0.669	0.76
12_L	18_A	0.669	0.76
41_D	44_G	0.667	0.76
91_S	116_N	0.662	0.75
65_R	233_G	0.660	0.75
193_V	198_I	0.655	0.74
139_A	171_L	0.654	0.74
12_L	55_V	0.654	0.74
11_L	14_E	0.653	0.74
233_G	236_G	0.652	0.74
32_I	56_K	0.650	0.74
165_L	215_F	0.646	0.73
182_V	205_H	0.646	0.73
89_I	111_V	0.636	0.72
141_P	170_T	0.635	0.72
115_Y	123_R	0.634	0.72
21_R	195_K	0.634	0.72
39_R	57_G	0.633	0.72
180_A	242_L	0.631	0.72
131_M	139_A	0.631	0.72
196_K	199_V	0.631	0.72
87_I	171_L	0.630	0.72
114_G	117_Q	0.630	0.72
11_L	50_D	0.627	0.71
142_A	145_T	0.627	0.71
182_V	213_I	0.627	0.71
166_P	219_E	0.626	0.71
71_E	98_D	0.625	0.71
208_V	211_R	0.623	0.71
115_Y	134_T	0.623	0.71
61_R	68_L	0.622	0.71
221_Y	246_W	0.620	0.70
172_L	221_Y	0.619	0.70
211_R	214_S	0.618	0.70
164_I	168_L	0.618	0.70
85_I	106_K	0.616	0.70
23_K	119_A	0.614	0.70
74_L	103_N	0.613	0.70
18_A	30_A	0.612	0.69
141_P	145_T	0.611	0.69
205_H	209_L	0.607	0.69
115_Y	120_W	0.604	0.68
81_V	105_A	0.604	0.68
89_I	154_I	0.603	0.68
214_S	217_A	0.600	0.68
40_L	47_I	0.597	0.68
77_F	241_L	0.597	0.68
116_N	130_V	0.594	0.67
136_F	144_F	0.593	0.67
6_E	11_L	0.593	0.67
99_C	154_I	0.593	0.67
15_R	50_D	0.592	0.67
35_S	47_I	0.592	0.67
62_Y	68_L	0.592	0.67
129_V	147_G	0.589	0.66
18_A	32_I	0.588	0.66
76_E	225_G	0.587	0.66
111_V	144_F	0.586	0.66
84_K	243_H	0.585	0.66
55_V	58_N	0.584	0.66
61_R	75_K	0.583	0.66
32_I	59_P	0.582	0.66
213_I	226_L	0.581	0.65
202_P	206_A	0.576	0.65
30_A	61_R	0.574	0.64
137_R	163_L	0.571	0.64
22_E	26_R	0.571	0.64
16_G	24_A	0.571	0.64
62_Y	98_D	0.570	0.64
152_A	171_L	0.569	0.64
109_Y	131_M	0.568	0.64
175_G	245_H	0.566	0.63
74_L	79_V	0.566	0.63
145_T	149_P	0.565	0.63
154_I	164_I	0.562	0.63
40_L	53_L	0.556	0.62
17_L	53_L	0.551	0.61
31_G	39_R	0.548	0.61
87_I	157_S	0.547	0.61
211_R	215_F	0.546	0.61
23_K	68_L	0.545	0.61
193_V	196_K	0.544	0.60
25_K	178_C	0.543	0.60
35_S	52_P	0.540	0.60
149_P	152_A	0.539	0.60
199_V	209_L	0.538	0.60
101_L	128_V	0.538	0.60
215_F	218_A	0.535	0.59
216_S	221_Y	0.533	0.59
11_L	44_G	0.531	0.59
145_T	150_E	0.528	0.58
218_A	247_P	0.523	0.57
37_E	40_L	0.523	0.57
58_N	61_R	0.522	0.57
111_V	171_L	0.522	0.57
222_I	248_G	0.522	0.57
66_G	120_W	0.521	0.57
11_L	48_D	0.521	0.57
175_G	247_P	0.521	0.57
136_F	167_V	0.520	0.57
209_L	240_F	0.517	0.57
13_V	43_P	0.513	0.56
122_L	130_V	0.510	0.56
34_Y	37_E	0.509	0.55
42_K	137_R	0.509	0.55
113_V	135_N	0.509	0.55
144_F	171_L	0.507	0.55
81_V	153_T	0.507	0.55
175_G	222_I	0.507	0.55
18_A	55_V	0.505	0.55
56_K	60_L	0.505	0.55
209_L	213_I	0.504	0.55
205_H	226_L	0.504	0.55
175_G	246_W	0.504	0.55
230_P	238_I	0.503	0.55
16_G	19_E	0.502	0.54
229_S	238_I	0.502	0.54
138_Y	167_V	0.500	0.54
39_R	54_T	0.500	0.54
35_S	45_E	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hp7A	1	0.968	100	0.51	Contact Map
1yb2A	2	0.7367	100	0.722	Contact Map
3opnA	1	0.7402	100	0.723	Contact Map
4r8rA	1	0.7402	100	0.726	Contact Map
3lkzA	1	0.7367	100	0.727	Contact Map
2wa2A	1	0.7794	100	0.747	Contact Map
4v0qA	2	0.8399	99.9	0.756	Contact Map
2px2A	1	0.7687	99.9	0.757	Contact Map
3eldA	1	0.7936	99.9	0.76	Contact Map
4k6mA	2	0.8434	99.9	0.767	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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