GREMLIN Database
MURA2 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2
UniProt: P19670 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (399)
Sequences: 7944 (4866)
Seq/√Len: 243.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_E281_L4.3581.00
15_T252_D4.0071.00
344_N355_T3.7331.00
42_E225_K3.3861.00
250_I281_L3.3631.00
248_E283_V3.2651.00
155_R183_E3.2341.00
179_K216_D3.1101.00
401_S404_K3.0231.00
42_E227_T2.8751.00
204_K216_D2.7931.00
150_R177_E2.7621.00
17_H252_D2.7451.00
36_N220_E2.7111.00
366_K390_T2.6961.00
399_Y405_K2.6281.00
38_E74_D2.6271.00
243_A271_Y2.6221.00
113_P119_G2.6131.00
40_T225_K2.5421.00
198_L203_A2.5381.00
320_T355_T2.5021.00
272_H283_V2.4181.00
157_Y183_E2.4161.00
288_N318_K2.4091.00
244_A378_V2.3751.00
46_E51_E2.3591.00
155_R181_I2.3471.00
364_K390_T2.3461.00
337_E340_R2.2861.00
55_D58_K2.2751.00
240_I313_L2.2481.00
249_V409_L2.2441.00
276_S279_Q2.2131.00
364_K388_E2.2111.00
65_H72_V2.1991.00
40_T72_V2.1701.00
38_E72_V2.1111.00
348_E351_S2.0951.00
162_S165_A2.0801.00
129_G169_I2.0641.00
42_E70_E2.0621.00
13_N248_E2.0101.00
46_E66_F2.0001.00
359_E384_D1.9961.00
316_R382_M1.9861.00
380_G387_T1.9701.00
179_K214_R1.9601.00
170_M195_A1.9431.00
40_T70_E1.9381.00
337_E376_L1.9291.00
293_D324_T1.9241.00
322_V353_I1.8701.00
25_A44_L1.8541.00
32_T39_V1.8281.00
63_N74_D1.7941.00
250_I279_Q1.7811.00
338_L343_A1.7791.00
124_D128_K1.7451.00
343_A360_L1.7101.00
30_P53_L1.7061.00
153_G176_A1.7021.00
250_I276_S1.6871.00
274_E281_L1.6871.00
100_A168_N1.6811.00
312_A375_C1.6641.00
346_K355_T1.6581.00
7_A386_V1.6451.00
290_K318_K1.6411.00
181_I214_R1.6091.00
128_K132_A1.6081.00
346_K353_I1.6071.00
183_E212_V1.5821.00
28_L197_L1.5801.00
337_E368_S1.5781.00
236_G306_L1.5771.00
341_M387_T1.5751.00
54_R71_M1.5711.00
203_A221_L1.5711.00
276_S281_L1.5551.00
181_I212_V1.5541.00
320_T353_I1.5471.00
107_Q147_R1.5441.00
293_D322_V1.5091.00
341_M363_A1.4971.00
152_R177_E1.4931.00
54_R64_V1.4831.00
335_I345_M1.4751.00
239_M263_T1.4671.00
377_V402_L1.4621.00
206_K216_D1.4581.00
199_T208_A1.4561.00
15_T250_I1.4531.00
109_V145_Y1.4431.00
365_V376_L1.4311.00
406_L411_A1.4301.00
29_I57_L1.4301.00
138_T147_R1.4281.00
264_A267_R1.4121.00
66_F71_M1.4081.00
335_I347_V1.3891.00
208_A213_I1.3811.00
315_T343_A1.3721.00
37_S223_G1.3631.00
117_H120_P1.3581.00
333_K347_V1.3581.00
229_I258_H1.3581.00
58_K64_V1.3521.00
405_K408_G1.3361.00
326_T330_A1.3221.00
319_G356_G1.3201.00
333_K336_D1.3131.00
311_T323_V1.3081.00
95_Y144_I1.3071.00
314_L321_S1.2951.00
28_L228_I1.2941.00
41_I228_I1.2911.00
56_L86_G1.2851.00
341_M379_A1.2851.00
119_G139_N1.2811.00
241_A381_L1.2651.00
29_I54_R1.2651.00
201_M224_C1.2611.00
96_Y167_I1.2571.00
109_V147_R1.2551.00
193_D226_H1.2541.00
239_M251_I1.2521.00
235_A254_V1.2511.00
51_E66_F1.2501.00
274_E283_V1.2491.00
291_P320_T1.2421.00
291_P321_S1.2421.00
62_G73_V1.2391.00
135_A151_L1.2321.00
65_H74_D1.2291.00
18_I251_I1.2291.00
266_L271_Y1.2291.00
269_M292_V1.2281.00
366_K391_G1.2281.00
91_L94_S1.2231.00
195_A205_I1.2221.00
55_D59_E1.2181.00
240_I262_L1.2101.00
200_S224_C1.2101.00
170_M215_I1.2081.00
330_A333_K1.2061.00
335_I352_A1.2041.00
137_V146_L1.2041.00
296_T325_D1.2031.00
199_T204_K1.2021.00
206_K214_R1.2011.00
182_I185_A1.1921.00
334_H368_S1.1901.00
239_M266_L1.1901.00
35_A39_V1.1891.00
16_V409_L1.1851.00
177_E219_K1.1791.00
82_P109_V1.1721.00
25_A50_I1.1711.00
44_L50_I1.1711.00
131_E136_E1.1661.00
348_E353_I1.1581.00
133_L154_A1.1531.00
41_I73_V1.1521.00
316_R357_P1.1461.00
373_G395_I1.1351.00
239_M282_I1.1271.00
380_G389_I1.1231.00
17_H253_N1.1191.00
238_F399_Y1.1161.00
252_D279_Q1.1121.00
56_L88_V1.1031.00
265_K294_V1.0991.00
207_G210_T1.0941.00
266_L313_L1.0931.00
187_K211_N1.0911.00
26_V53_L1.0871.00
401_S405_K1.0861.00
39_V197_L1.0841.00
241_A378_V1.0801.00
256_P275_T1.0671.00
295_K325_D1.0661.00
345_M352_A1.0651.00
312_A379_A1.0621.00
173_A180_T1.0601.00
244_A382_M1.0581.00
373_G394_H1.0571.00
237_T374_A1.0541.00
365_V387_T1.0531.00
7_A10_D1.0521.00
190_E196_T1.0481.00
243_A287_K1.0411.00
62_G75_P1.0391.00
39_V224_C1.0371.00
128_K131_E1.0351.00
48_S396_D1.0341.00
37_S222_H1.0321.00
136_E147_R1.0251.00
404_K407_E1.0251.00
58_K63_N1.0211.00
107_Q145_Y1.0161.00
52_T89_K1.0161.00
269_M317_A1.0131.00
267_R275_T1.0131.00
265_K310_M1.0081.00
67_E70_E1.0051.00
236_G309_P0.9991.00
52_T55_D0.9981.00
127_I131_E0.9921.00
32_T73_V0.9911.00
178_G217_G0.9871.00
284_G289_L0.9781.00
167_I194_V0.9741.00
361_Q384_D0.9721.00
195_A208_A0.9711.00
332_F352_A0.9661.00
265_K268_E0.9651.00
255_I258_H0.9641.00
240_I306_L0.9601.00
12_L241_A0.9561.00
35_A223_G0.9521.00
240_I266_L0.9491.00
151_L176_A0.9461.00
340_R363_A0.9441.00
383_A387_T0.9441.00
234_E405_K0.9421.00
314_L323_V0.9401.00
381_L411_A0.9281.00
158_L169_I0.9241.00
391_G394_H0.9221.00
306_L309_P0.9171.00
125_Q160_V0.9161.00
336_D368_S0.9161.00
58_K66_F0.9131.00
267_R272_H0.9101.00
28_L41_I0.9091.00
57_L62_G0.9061.00
339_R344_N0.9031.00
232_R262_L0.9021.00
226_H229_I0.9001.00
174_V221_L0.8971.00
363_A387_T0.8891.00
311_T334_H0.8881.00
291_P319_G0.8861.00
246_G286_Q0.8790.99
153_G180_T0.8770.99
320_T356_G0.8770.99
198_L221_L0.8760.99
44_L71_M0.8760.99
153_G177_E0.8750.99
136_E149_E0.8750.99
54_R58_K0.8740.99
27_A30_P0.8710.99
156_I159_D0.8710.99
323_V352_A0.8680.99
291_P317_A0.8670.99
111_G147_R0.8650.99
116_C370_L0.8600.99
126_H168_N0.8600.99
66_F69_G0.8590.99
43_G227_T0.8560.99
317_A321_S0.8480.99
367_A373_G0.8450.99
100_A171_L0.8420.99
227_T253_N0.8380.99
128_K159_D0.8380.99
190_E232_R0.8350.99
315_T338_L0.8330.99
102_L135_A0.8320.99
174_V203_A0.8320.99
241_A411_A0.8310.99
275_T280_L0.8270.99
269_M289_L0.8250.99
316_R358_V0.8240.99
199_T207_G0.8230.99
197_L201_M0.8230.99
127_I137_V0.8190.99
289_L317_A0.8160.99
199_T205_I0.8160.99
196_T200_S0.8150.99
30_P101_M0.8090.99
242_G245_M0.8080.99
284_G287_K0.8080.99
69_G400_S0.8060.99
244_A316_R0.8050.99
159_D265_K0.8050.99
18_I238_F0.8020.99
14_G409_L0.8010.99
332_F347_V0.8010.99
311_T352_A0.8000.99
343_A357_P0.7990.99
179_K217_G0.7970.99
263_T267_R0.7960.99
18_I235_A0.7890.99
309_P378_V0.7890.99
239_M242_G0.7870.99
118_L329_S0.7860.99
392_L395_I0.7840.99
200_S226_H0.7830.99
176_A180_T0.7820.99
37_S75_P0.7780.99
208_A212_V0.7780.99
197_L224_C0.7740.99
12_L247_K0.7730.99
393_E396_D0.7700.99
28_L226_H0.7680.99
315_T357_P0.7680.99
34_L101_M0.7640.99
243_A266_L0.7620.99
243_A282_I0.7600.99
95_Y123_I0.7590.99
88_V118_L0.7580.98
36_N222_H0.7560.98
367_A389_I0.7550.98
347_V351_S0.7530.98
24_S197_L0.7530.98
292_V321_S0.7500.98
196_T199_T0.7480.98
269_M314_L0.7480.98
246_G284_G0.7470.98
311_T354_I0.7410.98
54_R66_F0.7410.98
99_G148_A0.7380.98
380_G406_L0.7360.98
59_E84_P0.7360.98
125_Q159_D0.7340.98
103_G135_A0.7330.98
269_M313_L0.7320.98
244_A312_A0.7300.98
275_T279_Q0.7300.98
153_G178_G0.7280.98
24_S193_D0.7280.98
48_S52_T0.7280.98
43_G253_N0.7280.98
377_V395_I0.7270.98
133_L156_I0.7260.98
238_F405_K0.7260.98
38_E223_G0.7260.98
17_H43_G0.7260.98
362_G387_T0.7230.98
19_S234_E0.7230.98
38_E75_P0.7220.98
271_Y289_L0.7210.98
16_V251_I0.7200.98
262_L306_L0.7180.98
235_A251_I0.7180.98
116_C120_P0.7180.98
25_A228_I0.7180.98
324_T348_E0.7170.98
239_M243_A0.7160.98
31_A197_L0.7150.98
396_D403_E0.7130.98
88_V112_L0.7120.98
81_M107_Q0.7120.98
19_S405_K0.7110.98
33_I57_L0.7070.98
58_K65_H0.7070.98
315_T358_V0.7060.98
187_K190_E0.7060.98
57_L98_M0.6990.97
243_A289_L0.6980.97
170_M213_I0.6970.97
242_G249_V0.6960.97
308_Q372_A0.6950.97
125_Q161_V0.6950.97
172_A176_A0.6920.97
199_T206_K0.6910.97
324_T351_S0.6900.97
265_K292_V0.6900.97
263_T275_T0.6880.97
295_K324_T0.6880.97
29_I71_M0.6870.97
94_S397_R0.6850.97
169_I182_I0.6840.97
184_N189_P0.6840.97
21_A25_A0.6840.97
173_A182_I0.6810.97
158_L161_V0.6810.97
106_K150_R0.6800.97
273_I282_I0.6800.97
381_L406_L0.6740.97
190_E304_T0.6710.97
112_L144_I0.6710.97
237_T309_P0.6710.97
32_T75_P0.6700.97
296_T307_Q0.6700.97
57_L64_V0.6690.97
98_M130_F0.6690.97
241_A406_L0.6680.97
242_G284_G0.6680.97
204_K218_V0.6650.97
29_I73_V0.6650.97
158_L182_I0.6650.97
25_A45_P0.6640.97
164_G191_I0.6640.97
46_E69_G0.6630.96
193_D196_T0.6590.96
82_P85_N0.6590.96
118_L144_I0.6580.96
81_M84_P0.6580.96
321_S354_I0.6580.96
403_E407_E0.6570.96
99_G126_H0.6570.96
341_M365_V0.6560.96
256_P280_L0.6560.96
62_G76_T0.6550.96
42_E69_G0.6520.96
99_G112_L0.6510.96
312_A376_L0.6510.96
151_L178_G0.6470.96
158_L188_E0.6460.96
20_G228_I0.6460.96
131_E137_V0.6440.96
284_G288_N0.6440.96
236_G262_L0.6410.96
331_R369_D0.6400.96
102_L110_I0.6400.96
96_Y164_G0.6390.96
24_S27_A0.6380.96
123_I144_I0.6370.96
156_I182_I0.6360.96
188_E192_I0.6360.96
102_L130_F0.6360.96
67_E72_V0.6340.95
196_T226_H0.6320.95
308_Q334_H0.6310.95
246_G287_K0.6310.95
33_I62_G0.6270.95
185_A188_E0.6270.95
201_M221_L0.6270.95
121_R331_R0.6260.95
11_S247_K0.6250.95
48_S51_E0.6250.95
95_Y112_L0.6240.95
123_I127_I0.6240.95
242_G251_I0.6230.95
368_S372_A0.6230.95
75_P104_R0.6220.95
199_T203_A0.6210.95
341_M383_A0.6200.95
54_R73_V0.6200.95
271_Y282_I0.6200.95
362_G385_G0.6200.95
12_L411_A0.6180.95
180_T217_G0.6180.95
121_R371_R0.6170.95
267_R273_I0.6170.95
127_I146_L0.6150.95
332_F351_S0.6150.95
16_V405_K0.6150.95
152_R178_G0.6140.95
130_F135_A0.6140.95
88_V94_S0.6130.95
35_A75_P0.6120.95
344_N357_P0.6110.95
190_E193_D0.6100.94
197_L226_H0.6090.94
88_V95_Y0.6090.94
125_Q128_K0.6070.94
64_V71_M0.6060.94
311_T335_I0.6060.94
242_G247_K0.6040.94
341_M360_L0.6030.94
230_P251_I0.6020.94
357_P360_L0.6010.94
170_M182_I0.6010.94
395_I403_E0.6010.94
340_R366_K0.6000.94
312_A315_T0.6000.94
39_V223_G0.5970.94
60_I102_L0.5960.94
362_G383_A0.5920.94
238_F402_L0.5920.94
339_R345_M0.5900.93
133_L180_T0.5890.93
377_V403_E0.5890.93
27_A96_Y0.5880.93
367_A394_H0.5870.93
16_V238_F0.5870.93
240_I309_P0.5870.93
83_L88_V0.5870.93
373_G403_E0.5860.93
245_M284_G0.5840.93
160_V327_I0.5840.93
192_I195_A0.5840.93
334_H372_A0.5830.93
26_V30_P0.5830.93
315_T360_L0.5830.93
140_E145_Y0.5810.93
263_T273_I0.5800.93
323_V354_I0.5790.93
207_G211_N0.5730.92
265_K299_Y0.5730.92
184_N188_E0.5710.92
322_V348_E0.5700.92
325_D329_S0.5680.92
268_E298_V0.5670.92
238_F406_L0.5650.92
56_L98_M0.5650.92
22_K121_R0.5640.92
173_A198_L0.5610.92
254_V280_L0.5600.92
131_E138_T0.5600.92
102_L112_L0.5590.91
193_D229_I0.5570.91
37_S74_D0.5570.91
296_T310_M0.5560.91
256_P279_Q0.5560.91
239_M273_I0.5560.91
307_Q332_F0.5540.91
26_V94_S0.5530.91
35_A201_M0.5530.91
254_V258_H0.5490.91
46_E71_M0.5490.91
195_A213_I0.5490.91
374_A402_L0.5490.91
336_D339_R0.5480.91
336_D366_K0.5470.91
45_P234_E0.5470.91
315_T382_M0.5460.91
244_A313_L0.5460.91
51_E55_D0.5440.90
150_R176_A0.5440.90
192_I213_I0.5430.90
192_I210_T0.5430.90
39_V201_M0.5420.90
151_L172_A0.5410.90
340_R376_L0.5400.90
37_S224_C0.5400.90
145_Y148_A0.5390.90
233_I370_L0.5390.90
295_K326_T0.5390.90
392_L403_E0.5380.90
292_V317_A0.5380.90
245_M381_L0.5370.90
192_I207_G0.5360.90
90_K115_G0.5350.90
36_N75_P0.5350.90
131_E141_Q0.5330.89
362_G380_G0.5330.89
242_G246_G0.5330.89
216_D219_K0.5310.89
204_K219_K0.5310.89
129_G133_L0.5310.89
104_R175_L0.5290.89
18_I254_V0.5290.89
307_Q323_V0.5280.89
63_N66_F0.5280.89
334_H394_H0.5260.89
168_N172_A0.5240.89
164_G167_I0.5230.89
196_T208_A0.5210.88
149_E154_A0.5210.88
291_P318_K0.5200.88
203_A219_K0.5190.88
343_A379_A0.5190.88
124_D142_G0.5190.88
264_A268_E0.5190.88
203_A218_V0.5180.88
19_S400_S0.5180.88
261_S264_A0.5180.88
254_V279_Q0.5180.88
12_L249_V0.5170.88
8_G11_S0.5170.88
312_A316_R0.5170.88
339_R346_K0.5170.88
188_E207_G0.5170.88
322_V351_S0.5160.88
360_L379_A0.5150.88
273_I280_L0.5150.88
272_H275_T0.5150.88
21_A229_I0.5150.88
294_V310_M0.5140.88
363_A385_G0.5140.88
18_I230_P0.5130.88
120_P329_S0.5130.88
158_L213_I0.5130.88
141_Q361_Q0.5120.88
96_Y328_Y0.5110.87
332_F335_I0.5100.87
126_H129_G0.5100.87
99_G168_N0.5090.87
174_V218_V0.5080.87
26_V398_G0.5070.87
230_P253_N0.5070.87
93_A97_L0.5070.87
339_R343_A0.5060.87
56_L97_L0.5050.87
53_L96_Y0.5050.87
318_K357_P0.5050.87
242_G271_Y0.5040.87
344_N358_V0.5040.87
132_A157_Y0.5020.87
272_H287_K0.5010.86
314_L354_I0.5010.86
100_A103_G0.5010.86
312_A338_L0.5010.86
46_E68_N0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.9557 100 0.153 Contact Map
2pqcA 1 0.9557 100 0.187 Contact Map
3slhA 4 0.9627 100 0.201 Contact Map
3zh4A 1 0.9534 100 0.211 Contact Map
3r38A 2 0.993 100 0.213 Contact Map
1rf6A 1 0.9394 100 0.221 Contact Map
1ejdA 4 0.972 100 0.225 Contact Map
4fqdA 2 0.9557 100 0.228 Contact Map
2yvwA 1 0.9674 100 0.232 Contact Map
5bq2A 4 0.972 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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