GREMLIN Database
TAL - Transaldolase
UniProt: P19669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (204)
Sequences: 3741 (2000)
Seq/√Len: 140.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_K101_L6.2921.00
63_K66_E4.6511.00
68_I97_A3.0171.00
45_R49_D2.7801.00
67_M85_I2.5441.00
95_V107_V2.4571.00
9_N35_E2.4451.00
204_E208_A2.3851.00
149_K153_D2.3601.00
149_K161_I2.3231.00
15_E191_H2.2701.00
116_A148_V2.2051.00
23_A121_R2.1901.00
87_M110_I2.1701.00
96_R100_D2.1681.00
64_A93_K2.0581.00
65_E69_E2.0551.00
201_K205_Q2.0301.00
97_A101_L1.9981.00
135_D171_H1.9531.00
30_S209_D1.9331.00
188_K192_A1.8561.00
93_K96_R1.7801.00
64_A97_A1.7591.00
127_V152_F1.6811.00
85_I98_L1.6781.00
46_E49_D1.6281.00
61_S66_E1.6231.00
62_L90_D1.6201.00
14_R18_E1.5921.00
113_A151_I1.5901.00
99_T125_T1.5761.00
125_T160_Q1.5531.00
72_K97_A1.5391.00
11_D14_R1.5381.00
71_G98_L1.5341.00
85_I95_V1.5171.00
69_E73_E1.5171.00
198_L202_G1.5161.00
62_L203_I1.5141.00
57_A74_L1.4981.00
142_L175_A1.4921.00
68_I94_A1.4801.00
32_V40_F1.4491.00
41_H73_E1.4271.00
143_D147_E1.4201.00
202_G206_F1.3891.00
64_A90_D1.3881.00
62_L207_L1.3861.00
56_S106_N1.3571.00
120_A155_H1.3531.00
205_Q208_A1.3441.00
59_V67_M1.3391.00
72_K103_I1.3281.00
172_V189_V1.3241.00
15_E19_L1.3051.00
37_N43_R1.2951.00
200_D204_E1.2891.00
12_E187_L1.2871.00
9_N12_E1.2871.00
134_L139_H1.2671.00
113_A147_E1.2491.00
73_E76_K1.2481.00
58_E130_F1.2461.00
92_L118_L1.2421.00
163_A166_I1.2421.00
60_I207_L1.2401.00
146_S150_Q1.2401.00
201_K204_E1.2341.00
114_N173_T1.2261.00
64_A68_I1.2211.00
198_L206_F1.2181.00
140_N143_D1.1911.00
71_G83_V1.1831.00
16_A187_L1.1670.99
160_Q182_I1.1660.99
117_L151_I1.1610.99
71_G85_I1.1550.99
106_N128_S1.1460.99
47_I51_V1.1370.99
75_A103_I1.1370.99
170_Q174_E1.1350.99
14_R46_E1.1270.99
105_T125_T1.1270.99
185_M190_I1.1260.99
150_Q154_I1.1250.99
55_V78_A1.1140.99
87_M107_V1.1120.99
142_L174_E1.1070.99
199_T202_G1.0970.99
115_Q199_T1.0930.99
18_E93_K1.0870.99
120_A152_F1.0860.99
135_D141_G1.0800.99
162_I182_I1.0800.99
89_S194_T1.0750.99
104_K125_T1.0710.99
197_P206_F1.0510.99
5_V190_I1.0470.99
40_F210_W1.0430.99
44_L57_A1.0400.99
90_D93_K1.0390.99
68_I72_K1.0240.99
151_I155_H1.0230.99
39_S42_D1.0220.99
10_I43_R0.9960.98
65_E97_A0.9920.98
120_A151_I0.9880.98
132_G167_R0.9820.98
192_A195_K0.9810.98
43_R46_E0.9780.98
22_L190_I0.9700.98
82_T126_Y0.9670.98
75_A81_I0.9620.98
41_H45_R0.9600.98
121_R157_L0.9590.98
44_L81_I0.9550.98
143_D146_S0.9550.98
196_H200_D0.9500.98
95_V105_T0.9500.98
64_A94_A0.9430.98
32_V43_R0.9410.98
34_K188_K0.9390.98
75_A104_K0.9380.98
163_A175_A0.9310.97
136_D167_R0.9310.97
42_D78_A0.9290.97
175_A180_A0.9290.97
87_M95_V0.9270.97
204_E207_L0.9250.97
109_L130_F0.9230.97
69_E72_K0.9210.97
37_N46_E0.9180.97
57_A81_I0.9180.97
172_V185_M0.9070.97
139_H170_Q0.9060.97
36_A43_R0.9040.97
109_L202_G0.8800.96
131_L141_G0.8760.96
12_E191_H0.8750.96
48_T55_V0.8710.96
68_I98_L0.8700.96
187_L191_H0.8700.96
56_S128_S0.8660.96
163_A178_R0.8610.96
146_S178_R0.8610.96
107_V124_A0.8580.96
66_E69_E0.8560.96
132_G136_D0.8550.96
36_A39_S0.8540.96
133_R165_S0.8500.96
89_S191_H0.8490.96
5_V16_A0.8480.96
106_N130_F0.8480.96
97_A100_D0.8460.96
58_E128_S0.8440.96
71_G75_A0.8420.95
169_P192_A0.8370.95
110_I152_F0.8350.95
106_N109_L0.8330.95
129_P148_V0.8320.95
197_P201_K0.8220.95
67_M94_A0.8220.95
40_F44_L0.8220.95
16_A191_H0.8130.95
72_K76_K0.8060.94
165_S184_T0.8060.94
12_E15_E0.8000.94
84_K184_T0.7990.94
68_I71_G0.7880.94
191_H195_K0.7830.93
10_I46_E0.7730.93
17_N44_L0.7730.93
148_V152_F0.7720.93
134_L144_L0.7720.93
198_L201_K0.7710.93
30_S34_K0.7650.93
137_I197_P0.7620.92
74_L77_I0.7610.92
196_H206_F0.7590.92
197_P202_G0.7590.92
11_D15_E0.7560.92
113_A117_L0.7540.92
76_K101_L0.7540.92
13_I47_I0.7480.92
196_H199_T0.7470.92
87_M92_L0.7450.92
14_R50_V0.7360.91
58_E106_N0.7340.91
134_L137_I0.7330.91
110_I127_V0.7260.90
20_G194_T0.7230.90
20_G191_H0.7220.90
88_T203_I0.7150.90
32_V37_N0.7150.90
169_P173_T0.7120.90
169_P189_V0.7110.90
149_K181_H0.7100.90
28_N108_T0.7080.89
151_I154_I0.7030.89
149_K178_R0.6950.88
121_R155_H0.6930.88
48_T78_A0.6880.88
99_T104_K0.6860.88
56_S130_F0.6850.88
147_E150_Q0.6850.88
140_N174_E0.6830.88
10_I37_N0.6820.88
8_A27_T0.6790.87
146_S174_E0.6770.87
98_L101_L0.6760.87
111_F202_G0.6730.87
70_E73_E0.6630.86
75_A83_V0.6620.86
15_E18_E0.6590.86
19_L194_T0.6560.85
128_S202_G0.6550.85
19_L190_I0.6520.85
152_F159_T0.6480.85
75_A79_P0.6480.85
150_Q153_D0.6470.85
17_N50_V0.6430.84
89_S118_L0.6410.84
72_K98_L0.6410.84
163_A183_G0.6390.84
25_V47_I0.6380.84
32_V44_L0.6370.84
117_L155_H0.6350.84
104_K126_Y0.6340.83
63_K69_E0.6310.83
26_T184_T0.6280.83
137_I201_K0.6260.83
27_T31_L0.6220.82
37_N42_D0.6210.82
85_I94_A0.6170.82
47_I50_V0.6150.82
74_L81_I0.6110.81
24_G29_P0.6080.81
88_T91_G0.6060.81
153_D174_E0.6050.81
54_S82_T0.6040.80
32_V35_E0.5990.80
34_K205_Q0.5940.79
3_F193_L0.5930.79
196_H202_G0.5910.79
205_Q209_D0.5870.79
111_F130_F0.5840.78
19_L191_H0.5780.78
84_K108_T0.5750.77
82_T105_T0.5750.77
48_T80_N0.5730.77
6_D26_T0.5720.77
48_T81_I0.5710.77
12_E19_L0.5690.76
52_K78_A0.5690.76
58_E109_L0.5680.76
84_K165_S0.5680.76
30_S33_A0.5640.76
28_N164_A0.5610.75
106_N202_G0.5610.75
34_K209_D0.5600.75
130_F167_R0.5600.75
124_A157_L0.5580.75
145_I180_A0.5560.75
4_F106_N0.5540.75
17_N22_L0.5530.74
4_F82_T0.5500.74
88_T97_A0.5500.74
147_E173_T0.5490.74
120_A157_L0.5490.74
15_E194_T0.5490.74
109_L128_S0.5480.74
91_G94_A0.5450.73
15_E89_S0.5440.73
117_L154_I0.5420.73
202_G205_Q0.5420.73
201_K206_F0.5410.73
10_I55_V0.5390.72
130_F164_A0.5370.72
166_I171_H0.5360.72
168_H171_H0.5350.72
45_R48_T0.5340.72
191_H194_T0.5340.72
45_R77_I0.5340.72
144_L148_V0.5330.72
46_E50_V0.5290.71
172_V183_G0.5280.71
116_A152_F0.5270.71
33_A209_D0.5250.71
25_V44_L0.5240.70
54_S104_K0.5240.70
48_T79_P0.5230.70
16_A22_L0.5230.70
128_S184_T0.5220.70
110_I115_Q0.5200.70
69_E76_K0.5190.70
54_S126_Y0.5180.70
8_A43_R0.5180.70
61_S70_E0.5130.69
164_A184_T0.5130.69
56_S109_L0.5110.69
85_I91_G0.5100.68
131_L163_A0.5090.68
31_L132_G0.5080.68
115_Q129_P0.5020.67
10_I13_I0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r8rA 5 1 100 0.015 Contact Map
1wx0A 6 0.9575 100 0.019 Contact Map
1vpxA 6 0.9953 100 0.024 Contact Map
3s1xA 6 0.9953 100 0.028 Contact Map
1l6wA 6 0.9953 100 0.03 Contact Map
3cwnA 2 0.9717 100 0.164 Contact Map
3cq0A 2 0.9717 100 0.168 Contact Map
3m16A 2 0.9717 100 0.172 Contact Map
3tkfA 2 0.9717 100 0.173 Contact Map
3hjzA 1 0.9717 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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