GREMLIN Database
UDPK - Undecaprenol kinase
UniProt: P19638 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (111)
Sequences: 2393 (1738)
Seq/√Len: 165.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_V93_A3.3641.00
22_R94_K3.2701.00
27_T73_L2.8521.00
28_A38_A2.5881.00
71_L74_L2.5261.00
66_G110_I2.3241.00
25_W29_R2.0801.00
41_A65_I2.0501.00
71_L107_F1.9911.00
84_L93_A1.9011.00
48_G58_W1.8621.00
28_A39_A1.8341.00
53_L118_I1.7881.00
24_I102_G1.7351.00
80_H95_A1.7161.00
67_G107_F1.7131.00
70_S107_F1.7081.00
81_T96_A1.6741.00
52_E58_W1.6561.00
54_S57_E1.5161.00
27_T34_F1.4681.00
73_L99_A1.4631.00
56_I60_I1.4401.00
81_T85_I1.4031.00
92_L96_A1.4001.00
34_F37_H1.3791.00
57_E118_I1.3771.00
60_I64_L1.3771.00
68_M111_S1.3731.00
34_F69_F1.3511.00
76_T99_A1.3451.00
15_K18_V1.3441.00
69_F106_V1.2861.00
27_T99_A1.2791.00
13_F17_F1.2751.00
116_L120_L1.2691.00
30_T95_A1.2571.00
63_L110_I1.2561.00
20_A101_A1.2491.00
73_L102_G1.2431.00
45_L65_I1.2421.00
71_L103_A1.2301.00
68_M104_V1.2191.00
19_H22_R1.2131.00
46_I50_L1.2041.00
44_V65_I1.2011.00
62_F110_I1.1961.00
13_F32_R1.1811.00
13_F36_F1.1741.00
26_E95_A1.1541.00
16_S33_N1.1371.00
112_C116_L1.1011.00
55_I59_M1.0871.00
64_L114_I1.0821.00
37_H104_V1.0640.99
53_L61_I1.0630.99
17_F105_C1.0570.99
68_M107_F1.0420.99
59_M117_L1.0090.99
70_S74_L0.9940.99
86_T93_A0.9930.99
31_E80_H0.9860.99
73_L106_V0.9850.99
59_M114_I0.9740.99
55_I117_L0.9740.99
66_G106_V0.9720.99
33_N36_F0.9650.99
51_V119_F0.9580.99
76_T80_H0.9410.99
61_I64_L0.9270.99
77_A96_A0.9210.98
36_F40_A0.9130.98
76_T95_A0.9120.98
11_N15_K0.9080.98
15_K19_H0.9070.98
67_G70_S0.8940.98
85_I93_A0.8910.98
21_G25_W0.8820.98
33_N37_H0.8810.98
80_H83_D0.8700.98
12_R32_R0.8670.98
26_E31_E0.8640.98
64_L111_S0.8470.97
16_S20_A0.8360.97
100_A103_A0.8360.97
30_T76_T0.8350.97
86_T90_H0.8240.97
105_C109_V0.8220.97
48_G61_I0.8160.97
34_F73_L0.8130.97
26_E30_T0.7900.96
74_L103_A0.7890.96
14_F18_V0.7810.96
17_F36_F0.7800.96
82_V96_A0.7800.96
84_L90_H0.7770.96
38_A69_F0.7770.96
56_I59_M0.7740.95
113_I116_L0.7660.95
84_L96_A0.7630.95
17_F21_G0.7610.95
37_H68_M0.7470.95
108_A112_C0.7360.94
37_H108_A0.7340.94
55_I118_I0.7290.94
84_L92_L0.7090.93
59_M113_I0.7040.93
48_G62_F0.7030.93
41_A44_V0.6990.92
66_G113_I0.6910.92
96_A100_A0.6880.92
113_I117_L0.6860.92
83_D97_K0.6770.91
109_V113_I0.6730.91
37_H41_A0.6710.91
61_I119_F0.6640.90
104_V111_S0.6610.90
18_V22_R0.6560.90
22_R26_E0.6540.90
40_A108_A0.6470.89
95_A99_A0.6420.89
26_E94_K0.6400.89
91_P95_A0.6370.88
60_I110_I0.6360.88
68_M108_A0.6350.88
45_L49_F0.6300.88
30_T80_H0.6260.88
77_A103_A0.6240.87
86_T94_K0.6100.86
53_L58_W0.5960.85
64_L107_F0.5940.85
49_F58_W0.5920.84
77_A81_T0.5790.83
32_R35_Q0.5780.83
85_I89_H0.5770.83
28_A34_F0.5750.83
80_H96_A0.5700.82
19_H26_E0.5620.81
32_R36_F0.5600.81
44_V111_S0.5540.80
21_G105_C0.5520.80
18_V21_G0.5510.80
81_T93_A0.5500.80
80_H99_A0.5490.80
31_E98_D0.5480.80
46_I49_F0.5440.79
82_V86_T0.5430.79
62_F117_L0.5420.79
64_L68_M0.5410.79
43_A47_C0.5290.77
19_H33_N0.5280.77
63_L67_G0.5280.77
85_I96_A0.5240.77
65_I111_S0.5220.76
47_C51_V0.5210.76
26_E99_A0.5180.76
12_R36_F0.5170.76
43_A50_L0.5150.75
49_F117_L0.5120.75
85_I92_L0.5100.75
10_L13_F0.5100.75
115_G119_F0.5080.74
73_L103_A0.5040.74
36_F39_A0.5030.74
111_S114_I0.5010.73
16_S19_H0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ze3A 4 0.9268 100 0.104 Contact Map
4k1cA 4 0.8455 12.7 0.934 Contact Map
4w252 1 0.3821 12.5 0.934 Contact Map
4tq3A 1 0.7805 7.8 0.94 Contact Map
1rh5B 1 0.3252 6.5 0.942 Contact Map
4wrtC 1 0 5.1 0.945 Contact Map
1pi7A 1 0.1545 3.5 0.949 Contact Map
4rp9A 2 0.878 2.8 0.951 Contact Map
1m56D 1 0.2927 2.7 0.952 Contact Map
2lzrA 1 0.3171 2.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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