GREMLIN Database
DHOM - Homoserine dehydrogenase
UniProt: P19582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (422)
Sequences: 2384 (1522)
Seq/√Len: 74.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_E229_S6.6831.00
168_K172_E4.6521.00
84_E88_Q4.2881.00
91_V118_E3.8641.00
115_L126_I3.7521.00
5_R38_T3.6831.00
176_Y197_V3.5311.00
63_E66_D3.3201.00
194_T198_E3.2451.00
181_K185_D3.1371.00
77_I314_L3.1121.00
175_P178_E2.9231.00
65_Y92_D2.8171.00
19_V39_I2.7591.00
174_S179_V2.7251.00
87_K91_V2.5301.00
94_L124_C2.4891.00
69_D92_D2.4511.00
182_E185_D2.4381.00
241_R382_L2.4301.00
20_K303_S2.4161.00
164_F182_E2.3721.00
135_G291_V2.3561.00
117_A121_E2.2621.00
8_L19_V2.2601.00
371_E411_N2.2351.00
108_M208_I2.2261.00
5_R40_K2.2141.00
175_P179_V2.1561.00
281_F299_P2.1311.00
188_F280_E2.1061.00
17_G303_S2.1051.00
149_D289_E2.0891.00
288_G291_V2.0711.00
30_M36_P2.0521.00
91_V114_E2.0461.00
138_I286_V1.9911.00
153_K253_Q1.9721.00
141_T296_F1.9051.00
40_K70_D1.9021.00
372_R411_N1.9001.00
240_K270_D1.8831.00
46_D51_R1.8661.00
108_M126_I1.8641.00
224_K342_P1.8621.00
90_L107_L1.8431.00
95_R118_E1.8411.00
21_I307_A1.8381.00
245_T270_D1.8141.00
18_V311_V1.7991.00
90_L100_V1.7951.00
357_D398_H1.7901.00
94_L118_E1.7871.00
41_K70_D1.7861.00
401_S404_D1.7681.00
29_L315_V1.7661.00
214_F252_A1.7031.00
95_R121_E1.7021.00
91_V115_L1.6951.00
147_S315_V1.6921.00
346_Y399_H1.6911.00
206_M261_V1.6901.00
40_K72_D1.6681.00
95_R122_N1.6671.00
91_V95_R1.6551.00
174_S182_E1.6501.00
43_L64_V1.6491.00
90_L126_I1.6381.00
3_A38_T1.6321.00
3_A36_P1.6130.99
110_V221_E1.6130.99
47_L62_T1.6060.99
92_D96_S1.5910.99
154_M213_G1.5780.99
239_S267_L1.5780.99
272_H285_Y1.5760.99
253_Q260_E1.5760.99
20_K24_D1.5750.99
41_K66_D1.5750.99
99_H124_C1.5530.99
75_V314_L1.5380.99
3_A35_C1.5240.99
5_R72_D1.5230.99
19_V23_Q1.5180.99
367_S371_E1.5170.99
61_T66_D1.5130.99
280_E299_P1.5100.99
179_V182_E1.5060.99
372_R407_D1.5000.99
291_V294_T1.4810.99
255_D258_K1.4790.99
64_V93_A1.4670.99
206_M250_G1.4650.99
118_E122_N1.4600.99
277_V297_Y1.4600.99
16_S303_S1.4560.99
170_I236_I1.4540.99
153_K287_Y1.4540.99
210_A252_A1.4520.99
287_Y293_E1.4510.99
168_K179_V1.4410.99
200_L225_V1.4400.99
174_S178_E1.4380.99
41_K73_V1.4330.99
359_V370_S1.4310.99
79_V310_V1.4310.99
210_A261_V1.4300.99
111_Y114_E1.4280.99
99_H317_V1.4130.99
219_D222_D1.4110.99
195_S204_R1.3970.99
77_I101_V1.3940.98
239_S246_M1.3870.98
94_L126_I1.3860.98
149_D308_T1.3840.98
152_T287_Y1.3830.98
46_D49_K1.3820.98
164_F168_K1.3780.98
181_K184_Q1.3760.98
6_V314_L1.3740.98
171_K278_H1.3710.98
173_K233_D1.3620.98
355_V418_V1.3600.98
43_L89_Y1.3590.98
376_F379_I1.3490.98
267_L425_Y1.3480.98
133_A284_V1.3410.98
410_Q413_N1.3400.98
281_F297_Y1.3330.98
210_A223_V1.3310.98
47_L60_L1.3260.98
68_I89_Y1.3190.98
251_I264_Q1.3170.98
286_V296_F1.3170.98
140_R144_E1.3100.98
226_K264_Q1.3010.98
69_D96_S1.2990.98
87_K111_Y1.2940.98
33_V36_P1.2810.97
165_I180_L1.2780.97
9_L43_L1.2710.97
344_D401_S1.2710.97
97_K122_N1.2690.97
85_Q88_Q1.2640.97
65_Y68_I1.2630.97
390_L419_Q1.2610.97
9_L89_Y1.2570.97
17_G304_M1.2510.97
273_P295_M1.2370.97
180_L189_A1.2360.97
67_V70_D1.2340.97
26_Q36_P1.2340.97
170_I240_K1.2150.96
140_R316_A1.2080.96
41_K61_T1.2070.96
364_K417_V1.2070.96
375_S398_H1.2000.96
22_I39_I1.1940.96
5_R74_D1.1900.96
356_K419_Q1.1890.96
33_V37_V1.1790.96
264_Q426_R1.1780.96
9_L67_V1.1700.96
167_T171_K1.1700.96
25_H29_L1.1590.95
188_F279_N1.1570.95
4_I318_M1.1540.95
162_T202_A1.1420.95
410_Q414_D1.1400.95
170_I245_T1.1370.95
106_D204_R1.1330.95
125_D320_N1.1330.95
85_Q89_Y1.1290.95
94_L115_L1.1270.94
92_D95_R1.1270.94
292_G299_P1.1210.94
21_I290_A1.1200.94
94_L122_N1.1190.94
311_V314_L1.1160.94
344_D403_A1.1140.94
375_S381_Q1.1120.94
279_N299_P1.1040.94
6_V37_V1.1030.94
142_L151_I1.1000.94
88_Q92_D1.0990.94
65_Y69_D1.0860.93
11_L42_V1.0760.93
360_G381_Q1.0710.93
37_V318_M1.0710.93
44_V60_L1.0700.93
47_L61_T1.0680.93
40_K73_V1.0660.93
165_I176_Y1.0660.93
83_V111_Y1.0630.93
44_V49_K1.0610.93
18_V307_A1.0540.92
33_V315_V1.0540.92
148_S312_S1.0440.92
73_V98_K1.0440.92
168_K279_N1.0430.92
67_V76_V1.0410.92
362_F379_I1.0400.92
360_G375_S1.0390.92
251_I262_S1.0380.92
351_L405_F1.0360.92
203_A225_V1.0310.91
364_K367_S1.0230.91
357_D360_G1.0220.91
369_F408_I1.0160.91
226_K402_E1.0150.91
26_Q30_M1.0130.91
168_K174_S1.0110.91
118_E121_E1.0100.91
207_A223_V1.0020.90
11_L19_V1.0020.90
158_V206_M0.9950.90
415_L418_V0.9940.90
290_A304_M0.9940.90
194_T229_S0.9940.90
168_K182_E0.9880.90
44_V89_Y0.9860.89
402_E406_S0.9810.89
226_K230_Q0.9780.89
4_I75_V0.9770.89
355_V361_S0.9730.89
277_V283_A0.9720.89
226_K426_R0.9700.89
373_G404_D0.9630.88
363_S367_S0.9630.88
413_N421_V0.9630.88
150_R254_R0.9600.88
43_L61_T0.9590.88
19_V55_L0.9540.88
4_I321_M0.9500.88
5_R73_V0.9490.88
249_I266_T0.9490.88
161_T189_A0.9470.87
224_K264_Q0.9390.87
7_G73_V0.9340.87
113_S217_N0.9340.87
285_Y293_E0.9340.87
25_H289_E0.9330.87
353_I395_I0.9310.87
23_Q39_I0.9280.86
135_G292_G0.9250.86
70_D73_V0.9180.86
16_S53_V0.9170.86
288_G294_T0.9110.85
28_K32_Q0.9080.85
24_D289_E0.9060.85
162_T248_L0.9060.85
16_S52_E0.9050.85
141_T145_G0.9020.85
231_I425_Y0.9010.85
138_I141_T0.9010.85
369_F376_F0.9010.85
21_I304_M0.9000.85
348_Q377_E0.8930.84
176_Y180_L0.8930.84
73_V76_V0.8930.84
27_D30_M0.8920.84
84_E87_K0.8900.84
6_V311_V0.8860.84
408_I412_L0.8830.84
68_I92_D0.8820.83
258_K340_K0.8800.83
363_S370_S0.8790.83
42_V59_V0.8780.83
43_L67_V0.8760.83
175_P233_D0.8740.83
157_I277_V0.8700.83
47_L51_R0.8680.82
94_L100_V0.8680.82
86_T90_L0.8660.82
191_A194_T0.8660.82
277_V295_M0.8620.82
403_A407_D0.8620.82
83_V110_V0.8610.82
320_N326_T0.8600.82
87_K118_E0.8600.82
30_M33_V0.8580.82
352_R392_E0.8570.82
50_K53_V0.8550.82
360_G366_T0.8530.81
142_L213_G0.8520.81
50_K54_D0.8490.81
355_V393_I0.8480.81
195_S200_L0.8450.81
368_V411_N0.8440.81
396_V427_V0.8410.80
131_S208_I0.8340.80
138_I296_F0.8330.80
343_S406_S0.8320.80
106_D110_V0.8300.80
37_V75_V0.8300.80
368_V415_L0.8300.80
7_G41_K0.8300.80
343_S403_A0.8290.80
70_D98_K0.8280.79
99_H125_D0.8270.79
406_S410_Q0.8250.79
41_K67_V0.8240.79
127_Y317_V0.8230.79
102_T126_I0.8230.79
293_E299_P0.8230.79
7_G96_S0.8220.79
67_V73_V0.8190.79
362_F376_F0.8170.79
346_Y401_S0.8100.78
150_R289_E0.8070.78
264_Q402_E0.8070.78
46_D50_K0.8060.78
381_Q391_A0.8050.77
363_S366_T0.8040.77
358_E416_E0.8020.77
216_M259_I0.8020.77
184_Q189_A0.7990.77
244_Y267_L0.7960.77
200_L229_S0.7910.76
413_N422_K0.7910.76
93_A173_K0.7900.76
351_L369_F0.7890.76
7_G70_D0.7880.76
360_G398_H0.7870.76
262_S426_R0.7860.76
7_G67_V0.7790.75
106_D195_S0.7780.75
246_M267_L0.7750.75
258_K344_D0.7740.75
139_L212_L0.7740.75
236_I246_M0.7720.74
44_V51_R0.7720.74
6_V77_I0.7710.74
115_L118_E0.7700.74
402_E426_R0.7670.74
144_E316_A0.7670.74
400_T404_D0.7610.73
242_L380_L0.7570.73
357_D381_Q0.7560.73
11_L16_S0.7540.73
405_F424_T0.7510.72
110_V220_L0.7510.72
44_V47_L0.7510.72
375_S391_A0.7490.72
362_F375_S0.7470.72
149_D291_V0.7470.72
51_R62_T0.7450.72
184_Q193_P0.7450.72
409_L413_N0.7450.72
145_G294_T0.7440.72
312_S316_A0.7430.72
48_E62_T0.7410.71
233_D237_S0.7400.71
206_M252_A0.7390.71
164_F167_T0.7380.71
18_V314_L0.7380.71
140_R149_D0.7360.71
407_D411_N0.7340.71
381_Q398_H0.7330.71
372_R404_D0.7320.70
125_D317_V0.7300.70
27_D31_H0.7300.70
138_I294_T0.7270.70
7_G43_L0.7260.70
354_H392_E0.7250.70
7_G64_V0.7200.69
176_Y229_S0.7200.69
217_N331_V0.7180.69
90_L115_L0.7170.69
32_Q319_K0.7170.69
204_R220_L0.7140.69
286_V294_T0.7130.68
170_I270_D0.7130.68
19_V42_V0.7130.68
351_L424_T0.7090.68
178_E181_K0.7070.68
198_E230_Q0.7070.68
354_H390_L0.7030.67
48_E51_R0.7030.67
207_A220_L0.7020.67
391_A395_I0.7010.67
370_S379_I0.7000.67
22_I26_Q0.6970.67
177_E181_K0.6920.66
11_L44_V0.6910.66
125_D327_G0.6910.66
252_A261_V0.6910.66
44_V61_T0.6870.66
23_Q56_P0.6870.66
154_M209_L0.6840.65
55_L58_E0.6830.65
210_A218_V0.6820.65
378_K382_L0.6820.65
132_V139_L0.6810.65
171_K279_N0.6800.65
177_E221_E0.6780.65
170_I278_H0.6770.64
23_Q26_Q0.6760.64
245_T278_H0.6760.64
59_V70_D0.6760.64
70_D74_D0.6750.64
142_L209_L0.6750.64
108_M116_L0.6710.64
161_T180_L0.6710.64
197_V310_V0.6690.64
133_A136_I0.6650.63
45_K89_Y0.6650.63
262_S402_E0.6630.63
9_L93_A0.6630.63
140_R312_S0.6590.62
374_V383_P0.6590.62
29_L39_I0.6580.62
154_M206_M0.6580.62
186_L250_G0.6570.62
71_P98_K0.6570.62
251_I266_T0.6560.62
366_T381_Q0.6550.62
353_I365_I0.6540.62
97_K124_C0.6540.62
5_R70_D0.6540.62
56_P59_V0.6530.62
134_G305_P0.6510.61
42_V53_V0.6510.61
67_V71_P0.6500.61
155_M285_Y0.6480.61
362_F366_T0.6470.61
80_I89_Y0.6460.61
280_E305_P0.6460.61
87_K114_E0.6450.61
273_P285_Y0.6440.61
71_P96_S0.6440.61
218_V248_L0.6430.61
55_L60_L0.6430.61
51_R64_V0.6420.60
148_S308_T0.6390.60
384_I391_A0.6390.60
368_V372_R0.6370.60
6_V74_D0.6360.60
283_A295_M0.6360.60
165_I177_E0.6320.59
241_R380_L0.6300.59
145_G312_S0.6300.59
407_D410_Q0.6280.59
393_I398_H0.6260.58
359_V373_G0.6250.58
146_L308_T0.6250.58
251_I402_E0.6250.58
17_G305_P0.6250.58
362_F398_H0.6240.58
25_H32_Q0.6240.58
409_L424_T0.6210.58
83_V90_L0.6190.58
179_V184_Q0.6190.58
158_V250_G0.6180.57
371_E414_D0.6180.57
55_L59_V0.6180.57
80_I85_Q0.6180.57
235_D352_R0.6170.57
114_E118_E0.6170.57
141_T294_T0.6170.57
75_V317_V0.6150.57
374_V408_I0.6140.57
82_G191_A0.6140.57
162_T206_M0.6140.57
359_V381_Q0.6140.57
299_P305_P0.6130.57
44_V83_V0.6120.57
33_V318_M0.6110.57
43_L65_Y0.6110.57
172_E182_E0.6100.57
167_T278_H0.6090.56
289_E308_T0.6070.56
139_L213_G0.6070.56
406_S413_N0.6070.56
145_G148_S0.6060.56
13_T17_G0.6060.56
324_G327_G0.6040.56
365_I418_V0.6030.56
46_D62_T0.6030.56
15_G18_V0.6020.56
224_K402_E0.6020.56
28_K334_Q0.6020.56
21_I311_V0.6010.55
22_I37_V0.6010.55
400_T412_L0.6000.55
107_L112_G0.6000.55
228_I248_L0.6000.55
264_Q425_Y0.5990.55
20_K53_V0.5990.55
206_M223_V0.5980.55
110_V207_A0.5970.55
370_S400_T0.5970.55
285_Y295_M0.5960.55
70_D288_G0.5960.55
130_A307_A0.5960.55
149_D288_G0.5950.55
340_K344_D0.5940.55
281_F293_E0.5920.54
214_F223_V0.5920.54
13_T307_A0.5920.54
23_Q57_K0.5920.54
113_S117_A0.5920.54
25_H292_G0.5910.54
112_G116_L0.5910.54
41_K59_V0.5900.54
400_T405_F0.5900.54
200_L220_L0.5890.54
165_I186_L0.5880.54
363_S395_I0.5880.54
268_L272_H0.5860.54
281_F295_M0.5850.53
182_E186_L0.5850.53
11_L60_L0.5800.53
203_A220_L0.5800.53
226_K262_S0.5800.53
83_V107_L0.5780.53
357_D361_S0.5780.53
9_L68_I0.5770.52
364_K371_E0.5770.52
294_T297_Y0.5760.52
365_I376_F0.5750.52
402_E425_Y0.5750.52
128_F324_G0.5750.52
364_K415_L0.5740.52
90_L94_L0.5740.52
262_S425_Y0.5740.52
18_V303_S0.5730.52
101_V314_L0.5730.52
162_T204_R0.5730.52
227_G248_L0.5720.52
87_K107_L0.5720.52
181_K401_S0.5720.52
98_K235_D0.5700.52
370_S408_I0.5700.52
154_M283_A0.5680.51
13_T179_V0.5680.51
250_G266_T0.5680.51
44_V133_A0.5660.51
106_D191_A0.5660.51
258_K338_N0.5650.51
142_L212_L0.5640.51
238_F392_E0.5640.51
110_V200_L0.5610.50
288_G296_F0.5600.50
61_T70_D0.5590.50
416_E419_Q0.5580.50
152_T289_E0.5570.50
51_R56_P0.5560.50
379_I395_I0.5560.50
24_D290_A0.5540.50
128_F212_L0.5520.49
72_D98_K0.5520.49
65_Y84_E0.5510.49
117_A217_N0.5510.49
28_K31_H0.5510.49
238_F394_V0.5490.49
106_D203_A0.5490.49
11_L55_L0.5480.49
77_I310_V0.5440.48
272_H295_M0.5440.48
293_E311_V0.5430.48
24_D304_M0.5430.48
351_L395_I0.5430.48
249_I262_S0.5420.48
99_H122_N0.5420.48
244_Y269_P0.5410.48
119_A122_N0.5410.48
106_D280_E0.5410.48
172_E178_E0.5390.48
406_S424_T0.5390.48
200_L204_R0.5390.48
167_T299_P0.5390.48
76_V98_K0.5390.48
162_T195_S0.5380.48
76_V89_Y0.5380.48
322_R325_V0.5380.48
236_I245_T0.5370.47
224_K339_M0.5360.47
349_Q402_E0.5360.47
260_E340_K0.5360.47
146_L149_D0.5350.47
35_C322_R0.5350.47
421_V424_T0.5340.47
45_K191_A0.5340.47
389_E411_N0.5310.47
370_S376_F0.5310.47
358_E417_V0.5300.47
249_I264_Q0.5300.47
363_S400_T0.5290.46
131_S319_K0.5280.46
251_I426_R0.5270.46
411_N414_D0.5260.46
59_V66_D0.5260.46
21_I25_H0.5250.46
260_E426_R0.5250.46
152_T214_F0.5240.46
91_V126_I0.5230.46
174_S177_E0.5220.46
154_M284_V0.5210.45
349_Q403_A0.5210.45
267_L342_P0.5210.45
79_V103_A0.5210.45
46_D418_V0.5200.45
123_G271_H0.5190.45
27_D124_C0.5190.45
57_K414_D0.5180.45
355_V381_Q0.5180.45
341_S344_D0.5160.45
11_L53_V0.5150.45
360_G391_A0.5150.45
108_M127_Y0.5140.45
272_H275_S0.5140.45
127_Y316_A0.5140.45
42_V58_E0.5120.44
264_Q342_P0.5120.44
110_V204_R0.5120.44
385_K420_E0.5120.44
357_D375_S0.5100.44
124_C294_T0.5090.44
405_F420_E0.5090.44
277_V281_F0.5080.44
39_I58_E0.5080.44
41_K44_V0.5080.44
64_V80_I0.5060.44
226_K249_I0.5060.44
142_L351_L0.5050.43
135_G167_T0.5040.43
152_T365_I0.5040.43
310_V314_L0.5040.43
112_G119_A0.5030.43
8_L77_I0.5020.43
78_E86_T0.5010.43
43_L46_D0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mtjA 3 0.9769 100 0.331 Contact Map
4pg7A 2 0.9192 100 0.354 Contact Map
2ejwA 2 0.7644 100 0.473 Contact Map
3do5A 2 0.709 100 0.479 Contact Map
1ebfA 2 0.7136 100 0.479 Contact Map
3ingA 2 0.6905 100 0.496 Contact Map
3c8mA 2 0.709 100 0.536 Contact Map
4xb1A 2 0.6952 100 0.577 Contact Map
3wycA 2 0.6905 100 0.804 Contact Map
3bioA 4 0.5958 100 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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