GREMLIN Database
MTRB - Transcription attenuation protein MtrB
UniProt: P19466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 75 (69)
Sequences: 182 (74)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V63_I4.0430.98
10_V55_I2.5170.80
64_Q70_M2.4380.78
62_L69_E2.1350.68
21_V28_T2.1190.67
15_V72_S2.0120.63
21_V31_K1.8640.57
35_S66_A1.7360.51
11_V65_T1.7280.51
17_D50_E1.5790.44
12_I35_S1.5300.42
31_K35_S1.4990.41
15_V71_K1.4660.40
33_H52_T1.4560.39
13_K55_I1.4360.38
62_L71_K1.3980.37
9_F64_Q1.3810.36
43_V46_A1.3730.36
43_V72_S1.3360.34
45_I64_Q1.3170.34
28_T51_H1.2660.32
8_D17_D1.2510.31
16_E44_I1.2470.31
15_V62_L1.2400.31
28_T66_A1.2330.30
16_E37_K1.2240.30
7_S28_T1.2030.29
11_V67_Y1.1820.29
9_F62_L1.1440.27
6_S29_D1.1440.27
7_S66_A1.1360.27
25_T33_H1.1230.26
25_T32_F1.1130.26
63_I72_S1.1090.26
17_D72_S1.1050.26
20_N67_Y1.0970.26
20_N35_S1.0730.25
20_N66_A1.0650.25
10_V72_S1.0620.24
35_S44_I1.0590.24
33_H44_I1.0570.24
16_E28_T1.0520.24
5_H71_K1.0520.24
17_D69_E1.0470.24
13_K41_G1.0190.23
62_L72_S1.0060.23
9_F66_A0.9550.21
6_S62_L0.9360.21
41_G73_E0.9320.21
30_T39_D0.8760.19
7_S21_V0.8690.19
57_V63_I0.8540.18
64_Q69_E0.8420.18
25_T67_Y0.8370.18
11_V51_H0.8080.17
26_R53_S0.8040.17
6_S60_E0.7980.17
16_E57_V0.7960.17
6_S70_M0.7700.16
12_I69_E0.7650.16
46_A65_T0.7540.16
15_V45_I0.7460.16
43_V57_V0.7430.16
26_R58_R0.7300.15
5_H10_V0.7250.15
8_D62_L0.7240.15
40_K66_A0.7200.15
7_S10_V0.7130.15
7_S70_M0.7080.15
15_V21_V0.6960.15
18_G53_S0.6890.15
10_V57_V0.6690.14
44_I52_T0.6220.13
45_I57_V0.6190.13
17_D70_M0.6190.13
28_T63_I0.6180.13
16_E32_F0.6090.13
61_A72_S0.6030.13
5_H12_I0.6020.13
10_V44_I0.5990.13
37_K40_K0.5950.13
70_M73_E0.5800.12
17_D66_A0.5700.12
6_S66_A0.5690.12
6_S69_E0.5680.12
33_H67_Y0.5600.12
31_K46_A0.5590.12
44_I63_I0.5580.12
29_D33_H0.5550.12
24_L67_Y0.5470.12
7_S69_E0.5410.12
28_T55_I0.5400.12
44_I60_E0.5390.12
41_G61_A0.5390.12
20_N63_I0.5380.12
45_I71_K0.5310.11
15_V69_E0.5290.11
29_D63_I0.5240.11
8_D22_I0.5160.11
44_I50_E0.5080.11
25_T37_K0.5030.11
29_D44_I0.5030.11
32_F37_K0.5000.11
22_I35_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zteA 3 0.9067 100 0.075 Contact Map
1gtfA 3 0.92 100 0.076 Contact Map
3zzsA 3 0.8667 100 0.113 Contact Map
1xgsA 2 0.8133 11.3 0.933 Contact Map
4ft4B 1 1 9.9 0.935 Contact Map
4ipaA 1 0.8533 7.9 0.938 Contact Map
2e9xD 1 0.8267 7.9 0.938 Contact Map
1larA 1 0.4267 7.1 0.939 Contact Map
4dovA 1 1 6.5 0.94 Contact Map
4wxxA 1 0.9733 6.3 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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