GREMLIN Database
GCH1 - GTP cyclohydrolase 1
UniProt: P19465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (180)
Sequences: 2903 (1448)
Seq/√Len: 108.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E34_K3.2401.00
91_V106_L3.0981.00
34_K38_K3.0001.00
12_A15_Q2.5381.00
9_I16_I2.5181.00
6_K41_A2.4491.00
47_L117_P2.4291.00
92_A141_M2.2631.00
31_D34_K2.2211.00
14_R25_N2.1751.00
74_F146_A2.0901.00
96_R138_H2.0411.00
129_E169_R2.0381.00
8_Q15_Q2.0111.00
8_Q18_E1.9791.00
43_V83_V1.9681.00
50_D53_E1.9051.00
40_Y44_F1.9021.00
89_A144_V1.8731.00
52_K133_E1.8621.00
141_M168_V1.8311.00
66_L172_F1.8011.00
13_V36_V1.7881.00
92_A182_V1.7821.00
22_E26_R1.7611.00
12_A19_A1.7521.00
7_E10_E1.6861.00
113_V126_T1.6781.00
54_H112_A1.6621.00
64_E173_K1.6001.00
177_A180_A1.5951.00
15_Q18_E1.5871.00
128_A169_R1.5421.00
75_H149_M1.5171.00
66_L182_V1.5121.00
75_H153_M1.4951.00
11_Q15_Q1.4871.00
82_L117_P1.4741.00
88_K145_E1.4721.00
44_F117_P1.4551.00
116_R126_T1.4461.00
73_A160_G1.4441.00
90_H145_E1.4351.00
74_F110_V1.4341.00
147_E152_T1.4141.00
180_A184_E1.4131.00
138_H171_V1.4001.00
141_M182_V1.3831.00
171_V175_D1.3741.00
44_F77_M1.3711.00
132_V169_R1.3581.00
45_S49_E1.3461.00
145_E162_K1.3441.00
143_V186_I1.3441.00
111_E158_K1.3421.00
39_M43_V1.2930.99
94_I171_V1.2870.99
176_A180_A1.2790.99
49_E112_A1.2730.99
91_V110_V1.2640.99
9_I37_A1.2570.99
113_V130_S1.2470.99
143_V182_V1.2380.99
46_G116_R1.2360.99
42_E157_R1.2300.99
15_Q19_A1.2270.99
113_V123_I1.2200.99
143_V166_S1.2140.99
17_L82_L1.2100.99
149_M153_M1.1940.99
128_A167_A1.1910.99
96_R136_D1.1880.99
103_L163_T1.1590.99
131_I135_L1.1570.99
100_V119_L1.1540.99
17_L22_E1.1530.99
71_D88_K1.1360.98
31_D57_T1.1300.98
74_F144_V1.1140.98
55_F101_T1.1120.98
66_L92_A1.1060.98
7_E11_Q1.1040.98
27_E60_G1.0960.98
147_E160_G1.0940.98
110_V127_I1.0930.98
124_T165_T1.0720.98
69_V161_A1.0700.98
109_A131_I1.0680.98
166_S178_A1.0670.98
119_L122_R1.0500.97
101_T106_L1.0480.97
89_A127_I1.0470.97
168_V179_R1.0440.97
129_E133_E1.0330.97
105_K108_R1.0290.97
86_Y149_M1.0170.97
14_R24_P1.0140.97
58_I99_K0.9970.96
51_P112_A0.9940.96
22_E28_G0.9940.96
16_I40_Y0.9910.96
60_G99_K0.9880.96
77_M83_V0.9730.96
128_A142_V0.9590.95
75_H86_Y0.9520.95
123_I127_I0.9510.95
13_V16_I0.9450.95
45_S115_K0.9430.95
25_N30_L0.9410.95
66_L178_A0.9400.95
54_H109_A0.9340.95
26_R29_L0.9260.94
89_A110_V0.9240.94
49_E54_H0.9230.94
68_L92_A0.9220.94
13_V40_Y0.9180.94
128_A140_V0.9140.94
101_T141_M0.9080.94
20_I40_Y0.9040.94
147_E162_K0.9040.94
90_H143_V0.8850.93
61_E122_R0.8830.93
36_V40_Y0.8760.93
73_A88_K0.8750.93
69_V163_T0.8740.93
58_I61_E0.8720.92
132_V140_V0.8720.92
178_A181_E0.8630.92
74_F123_I0.8620.92
52_K134_T0.8620.92
83_V153_M0.8580.92
79_E122_R0.8460.91
6_K38_K0.8450.91
22_E29_L0.8430.91
6_K10_E0.8420.91
8_Q19_A0.8400.91
125_S129_E0.8360.91
172_F182_V0.8340.91
114_A123_I0.8330.91
14_R18_E0.8290.90
101_T109_A0.8270.90
124_T144_V0.8260.90
36_V82_L0.8250.90
12_A16_I0.8250.90
111_E115_K0.8220.90
182_V186_I0.8110.89
40_Y43_V0.8100.89
69_V106_L0.8100.89
24_P29_L0.7950.88
70_K164_V0.7910.88
85_F149_M0.7890.88
104_S108_R0.7880.88
104_S156_V0.7880.88
28_G79_E0.7790.87
9_I13_V0.7760.87
130_S133_E0.7750.87
43_V77_M0.7680.87
171_V174_D0.7630.86
69_V103_L0.7620.86
129_E167_A0.7530.86
101_T135_L0.7510.85
86_Y147_E0.7500.85
175_D178_A0.7450.85
47_L113_V0.7440.85
109_A130_S0.7410.85
99_K136_D0.7380.84
168_V178_A0.7370.84
65_E173_K0.7320.84
107_A151_M0.7300.84
123_I144_V0.7280.84
106_L131_I0.7280.84
152_T159_P0.7270.84
69_V95_P0.7260.84
65_E167_A0.7190.83
166_S181_E0.7190.83
168_V173_K0.7180.83
101_T107_A0.7080.82
168_V183_L0.7060.82
80_H121_E0.7060.82
63_H122_R0.7050.82
8_Q12_A0.7050.82
13_V82_L0.7050.82
78_C81_H0.7040.82
151_M163_T0.6950.81
81_H121_E0.6890.80
141_M166_S0.6890.80
149_M152_T0.6820.80
129_E132_V0.6810.79
168_V181_E0.6780.79
43_V153_M0.6770.79
87_G146_A0.6730.79
77_M153_M0.6720.79
132_V136_D0.6710.78
51_P55_F0.6710.78
105_K156_V0.6690.78
125_S167_A0.6680.78
86_Y152_T0.6660.78
94_I138_H0.6660.78
132_V137_P0.6650.78
68_L185_H0.6600.77
74_F86_Y0.6580.77
121_E150_C0.6560.77
107_A158_K0.6560.77
130_S134_T0.6540.77
168_V172_F0.6540.77
55_F109_A0.6530.77
73_A147_E0.6470.76
9_I19_A0.6460.76
75_H115_K0.6440.76
166_S173_K0.6420.75
6_K34_K0.6400.75
103_L108_R0.6390.75
133_E136_D0.6350.75
47_L82_L0.6340.74
13_V17_L0.6260.74
88_K162_K0.6250.73
120_Q150_C0.6230.73
90_H186_I0.6160.72
77_M85_F0.6150.72
154_R163_T0.6150.72
52_K56_Q0.6050.71
119_L163_T0.6030.71
73_A159_P0.6030.71
112_A130_S0.5990.70
115_K157_R0.5980.70
109_A113_V0.5970.70
10_E14_R0.5940.70
80_H150_C0.5890.69
81_H150_C0.5830.68
143_V185_H0.5820.68
67_V100_V0.5810.68
171_V178_A0.5730.67
139_G171_V0.5700.66
26_R79_E0.5670.66
32_T35_R0.5660.66
143_V178_A0.5570.65
173_K176_A0.5570.65
17_L36_V0.5550.64
89_A106_L0.5520.64
103_L119_L0.5520.64
74_F87_G0.5510.64
92_A143_V0.5430.63
64_E138_H0.5410.62
57_T61_E0.5400.62
56_Q112_A0.5370.62
69_V151_M0.5360.62
155_G163_T0.5360.62
65_E166_S0.5320.61
156_V163_T0.5290.61
103_L148_H0.5260.60
54_H57_T0.5250.60
71_D90_H0.5250.60
81_H120_Q0.5210.60
41_A48_N0.5200.59
100_V136_D0.5190.59
10_E41_A0.5180.59
166_S185_H0.5150.59
14_R68_L0.5150.59
80_H120_Q0.5120.58
48_N186_I0.5110.58
123_I126_T0.5100.58
35_R108_R0.5090.58
87_G110_V0.5070.58
180_A183_L0.5070.58
42_E155_G0.5070.58
71_D162_K0.5040.57
8_Q11_Q0.5020.57
19_A41_A0.5010.57
65_E178_A0.5010.57
37_A41_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uqfA 5 0.9789 100 0.002 Contact Map
1is8A 5 0.9737 100 0.012 Contact Map
1a8rA 7 0.9947 100 0.027 Contact Map
1wurA 6 0.9684 100 0.078 Contact Map
4f8bA 5 0.7158 95.7 0.913 Contact Map
3uxjA 2 0.8789 79.5 0.939 Contact Map
2nsaA 2 0.4211 35.5 0.954 Contact Map
2q2kA 3 0.1105 18 0.961 Contact Map
1w79A 1 0.6579 15.6 0.962 Contact Map
1w5dA 1 0.6263 15.2 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.