GREMLIN Database
ADAB - Methylated-DNA--protein-cysteine methyltransferase, inducible
UniProt: P19220 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (153)
Sequences: 5740 (4357)
Seq/√Len: 352.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_Q77_R3.6871.00
146_G152_T3.6121.00
163_L167_L3.2741.00
94_A119_K3.2491.00
98_A101_E2.9691.00
108_K116_D2.9131.00
111_S147_K2.7561.00
108_K112_D2.4131.00
162_T166_D2.4041.00
88_G96_W2.3741.00
86_Y139_V2.2841.00
111_S115_N2.2231.00
108_K113_I2.1721.00
98_A116_D2.0841.00
98_A113_I2.0801.00
71_Q76_K2.0591.00
25_T28_G1.8931.00
68_E80_F1.8821.00
112_D115_N1.8181.00
89_T92_Q1.7691.00
88_G92_Q1.7371.00
119_K122_A1.7341.00
97_N100_C1.6711.00
102_I144_V1.6451.00
68_E82_V1.6181.00
64_P68_E1.6081.00
136_L156_G1.5831.00
151_L158_F1.5741.00
123_V127_G1.5701.00
92_Q132_A1.5671.00
111_S123_V1.5501.00
95_V113_I1.5311.00
102_I108_K1.5291.00
101_E116_D1.5181.00
98_A117_I1.4981.00
108_K144_V1.4941.00
64_P67_V1.4701.00
65_Y138_T1.4651.00
99_L130_I1.4531.00
163_L166_D1.4521.00
153_G158_F1.4151.00
128_A131_G1.4101.00
166_D169_K1.4081.00
24_S62_L1.3961.00
131_G152_T1.3651.00
22_I29_L1.3401.00
25_T30_V1.3141.00
58_D63_E1.2841.00
93_L97_N1.2591.00
25_T85_E1.2501.00
66_A70_T1.2431.00
131_G157_G1.2351.00
82_V138_T1.2071.00
100_C139_V1.2001.00
86_Y93_L1.1901.00
128_A152_T1.1631.00
130_I145_I1.1571.00
107_T165_L1.1571.00
115_N120_P1.1521.00
67_V71_Q1.1501.00
159_E162_T1.1501.00
128_A132_A1.1501.00
61_K65_Y1.1411.00
97_N101_E1.1271.00
84_V135_V1.1071.00
68_E81_T1.0751.00
86_Y135_V1.0751.00
86_Y134_P1.0751.00
90_Q93_L1.0741.00
152_T158_F1.0651.00
117_I126_V1.0551.00
160_M163_L1.0531.00
69_I73_L1.0521.00
127_G131_G1.0351.00
78_K104_Y1.0211.00
62_L65_Y1.0011.00
72_Y167_L0.9991.00
68_E78_K0.9951.00
70_T74_E0.9931.00
68_E77_R0.9881.00
98_A108_K0.9761.00
130_I136_L0.9691.00
121_A124_R0.9671.00
103_P106_Q0.9621.00
59_D62_L0.9621.00
136_L160_M0.9541.00
24_S29_L0.9531.00
113_I130_I0.9461.00
131_G155_R0.9441.00
61_K83_P0.9381.00
35_Q38_P0.9361.00
33_G41_E0.9361.00
34_S59_D0.9131.00
117_I122_A0.9121.00
91_F129_A0.9081.00
92_Q96_W0.9081.00
23_A70_T0.8801.00
92_Q128_A0.8631.00
90_Q94_A0.8601.00
136_L155_R0.8581.00
91_F125_A0.8551.00
42_L138_T0.8511.00
137_I167_L0.8461.00
91_F95_V0.8421.00
61_K64_P0.8401.00
95_V117_I0.8331.00
166_D170_R0.8261.00
146_G150_S0.8231.00
35_Q85_E0.8231.00
133_N141_C0.8201.00
73_L167_L0.8191.00
18_W34_S0.8141.00
24_S65_Y0.8131.00
94_A117_I0.8121.00
32_V39_I0.8101.00
130_I154_Y0.8091.00
45_W49_R0.8001.00
146_G153_G0.7821.00
63_E67_V0.7681.00
137_I164_L0.7641.00
77_R80_F0.7621.00
122_A125_A0.7581.00
65_Y68_E0.7541.00
146_G151_L0.7531.00
151_L162_T0.7511.00
29_L34_S0.7481.00
99_L113_I0.7381.00
95_V126_V0.7341.00
94_A97_N0.7331.00
111_S127_G0.7321.00
70_T73_L0.7280.99
109_S147_K0.7240.99
108_K130_I0.7230.99
87_A93_L0.7230.99
69_I137_I0.7170.99
32_V65_Y0.7160.99
113_I127_G0.7080.99
96_W99_L0.7010.99
43_F47_R0.7000.99
112_D116_D0.6970.99
27_K30_V0.6930.99
34_S62_L0.6910.99
86_Y100_C0.6880.99
28_G85_E0.6860.99
72_Y104_Y0.6830.99
23_A30_V0.6830.99
135_V138_T0.6720.99
52_G55_L0.6710.99
20_F32_V0.6660.99
135_V139_V0.6630.99
77_R81_T0.6630.99
72_Y137_I0.6590.99
77_R104_Y0.6580.99
69_I138_T0.6580.99
107_T145_I0.6500.99
152_T155_R0.6490.99
32_V42_L0.6450.99
113_I144_V0.6440.99
72_Y77_R0.6430.99
65_Y82_V0.6420.99
107_T170_R0.6380.99
72_Y80_F0.6380.99
113_I117_I0.6360.99
31_F34_S0.6310.99
60_D63_E0.6250.98
33_G40_E0.6180.98
86_Y96_W0.6150.98
67_V70_T0.6150.98
113_I116_D0.6130.98
123_V128_A0.6070.98
133_N157_G0.6060.98
32_V138_T0.6050.98
88_G93_L0.6040.98
104_Y167_L0.6030.98
154_Y160_M0.6030.98
113_I126_V0.6010.98
29_L45_W0.6000.98
39_I42_L0.5980.98
35_Q40_E0.5970.98
21_Y34_S0.5960.98
99_L141_C0.5880.98
85_E93_L0.5870.98
146_G158_F0.5860.98
69_I72_Y0.5820.98
27_K85_E0.5810.98
102_I130_I0.5780.97
136_L139_V0.5720.97
44_E160_M0.5700.97
119_K123_V0.5690.97
64_P81_T0.5690.97
114_A120_P0.5680.97
80_F104_Y0.5660.97
30_V34_S0.5660.97
84_V100_C0.5650.97
71_Q80_F0.5630.97
109_S146_G0.5620.97
47_R50_F0.5610.97
68_E71_Q0.5600.97
49_R134_P0.5580.97
141_C157_G0.5580.97
158_F162_T0.5530.97
109_S112_D0.5510.97
64_P82_V0.5500.97
22_I31_F0.5450.96
40_E44_E0.5430.96
121_A127_G0.5420.96
118_N121_A0.5420.96
18_W29_L0.5390.96
114_A126_V0.5390.96
155_R160_M0.5380.96
145_I148_N0.5360.96
72_Y75_G0.5360.96
68_E72_Y0.5350.96
34_S38_P0.5320.96
152_T161_K0.5310.96
31_F45_W0.5300.96
156_G160_M0.5290.96
69_I164_L0.5250.96
130_I155_R0.5220.95
58_D61_K0.5190.95
38_P85_E0.5160.95
80_F138_T0.5130.95
18_W27_K0.5130.95
162_T169_K0.5120.95
128_A157_G0.5110.95
43_F136_L0.5100.95
39_I65_Y0.5090.95
161_K165_L0.5050.94
94_A120_P0.5040.94
34_S37_K0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sfeA 1 0.9218 100 0.169 Contact Map
1eh6A 1 0.8994 100 0.198 Contact Map
3l00A 1 0.838 100 0.2 Contact Map
4bhbA 1 0.9162 100 0.209 Contact Map
1wrjA 1 0.8324 100 0.227 Contact Map
2g7hA 1 0.8603 100 0.326 Contact Map
1mgtA 1 0.8659 100 0.343 Contact Map
3gvaA 1 0.5196 100 0.424 Contact Map
2kifA 1 0.514 100 0.426 Contact Map
3ugoA 1 0.4358 67.3 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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