GREMLIN Database
ADAA - Bifunctional transcriptional activator/DNA repair enzyme AdaA
UniProt: P19219 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (175)
Sequences: 6497 (5357)
Seq/√Len: 404.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V190_T3.2371.00
155_A158_K3.1811.00
165_K173_C3.1571.00
111_N114_E2.7741.00
157_K190_T2.6631.00
142_I150_Q2.6101.00
136_F147_Y2.6051.00
160_L167_I2.3001.00
119_E129_P2.2991.00
109_D151_V2.2821.00
156_A182_F2.2341.00
150_Q189_K2.2321.00
106_E110_K2.1401.00
57_S60_S2.1371.00
107_Y111_N2.1321.00
104_I125_C1.9861.00
117_T120_S1.9411.00
131_H134_R1.9251.00
179_A183_I1.8991.00
158_K162_Q1.8631.00
107_Y116_L1.8281.00
132_M144_L1.7691.00
144_L148_I1.7601.00
163_T198_R1.7371.00
121_L144_L1.7341.00
181_Y185_L1.6941.00
192_Q200_M1.6871.00
107_Y124_I1.6601.00
105_T147_Y1.6401.00
163_T170_I1.6161.00
153_V189_K1.6061.00
55_K58_C1.6021.00
166_A169_D1.5161.00
108_I148_I1.5011.00
127_G132_M1.4851.00
159_Y173_C1.4731.00
157_K161_I1.4661.00
160_L198_R1.4371.00
152_R174_V1.4261.00
64_K67_N1.4241.00
130_Y134_R1.4201.00
104_I132_M1.4141.00
104_I136_F1.3841.00
112_F151_V1.3691.00
133_H144_L1.3611.00
59_K78_L1.3561.00
127_G131_H1.3531.00
105_T109_D1.3511.00
98_S102_D1.3371.00
145_V149_Q1.3311.00
151_V155_A1.3271.00
80_A83_R1.3261.00
120_S124_I1.3041.00
118_L144_L1.2761.00
98_S139_I1.2711.00
145_V181_Y1.2691.00
180_P183_I1.2631.00
116_L121_L1.2371.00
105_T140_K1.2301.00
165_K169_D1.2251.00
176_I185_L1.2231.00
157_K197_F1.2201.00
165_K170_I1.2201.00
114_E120_S1.2151.00
107_Y125_C1.1971.00
104_I121_L1.1871.00
185_L188_K1.1751.00
195_A199_Q1.1741.00
196_R200_M1.1661.00
62_V67_N1.1591.00
159_Y165_K1.1461.00
101_V140_K1.1311.00
171_A179_A1.1241.00
155_A174_V1.1221.00
129_P133_H1.1211.00
149_Q188_K1.1031.00
183_I195_A1.0881.00
70_I88_C1.0871.00
170_I198_R1.0821.00
102_D106_E1.0791.00
186_F197_F1.0741.00
153_V176_I1.0741.00
168_G172_I1.0691.00
72_P84_P1.0671.00
183_I193_T1.0641.00
61_R65_K1.0601.00
136_F144_L1.0571.00
149_Q185_L1.0491.00
151_V154_H1.0421.00
41_N56_P1.0381.00
108_I151_V1.0381.00
159_Y174_V1.0331.00
142_I146_E1.0311.00
150_Q154_H1.0291.00
56_P60_S1.0261.00
55_K59_K0.9831.00
34_N84_P0.9811.00
168_G179_A0.9761.00
193_T196_R0.9731.00
57_S78_L0.9651.00
135_T139_I0.9631.00
161_I201_S0.9491.00
121_L125_C0.9441.00
31_A48_K0.9431.00
131_H135_T0.9241.00
52_I55_K0.9231.00
94_K97_D0.9211.00
112_F155_A0.9161.00
54_C57_S0.9111.00
100_W135_T0.9081.00
120_S123_D0.8841.00
100_W127_G0.8841.00
118_L130_Y0.8781.00
184_T188_K0.8761.00
159_Y170_I0.8711.00
153_V185_L0.8561.00
55_K60_S0.8561.00
143_T146_E0.8501.00
97_D139_I0.8501.00
172_I179_A0.8471.00
99_E103_L0.8461.00
112_F174_V0.8451.00
170_I174_V0.8421.00
148_I152_R0.8351.00
48_K69_C0.8301.00
169_D172_I0.8271.00
41_N54_C0.8201.00
111_N124_I0.8101.00
79_R87_R0.8051.00
178_N184_T0.8041.00
30_Q53_F0.8041.00
118_L133_H0.8041.00
128_S131_H0.8031.00
109_D155_A0.8001.00
93_E97_D0.7981.00
192_Q196_R0.7961.00
101_V139_I0.7951.00
137_K143_T0.7931.00
73_N76_Q0.7841.00
192_Q197_F0.7841.00
171_A174_V0.7821.00
164_N170_I0.7791.00
54_C60_S0.7781.00
107_Y120_S0.7771.00
61_R67_N0.7751.00
161_I197_F0.7731.00
103_L124_I0.7721.00
108_I121_L0.7701.00
113_T173_C0.7641.00
112_F148_I0.7611.00
136_F140_K0.7551.00
52_I58_C0.7541.00
100_W125_C0.7531.00
63_P67_N0.7501.00
40_N43_F0.7491.00
196_R199_Q0.7481.00
100_W104_I0.7431.00
79_R83_R0.7431.00
116_L120_S0.7411.00
52_I57_S0.7301.00
178_N188_K0.7291.00
52_I56_P0.7291.00
169_D173_C0.7261.00
118_L129_P0.7261.00
149_Q189_K0.7251.00
133_H143_T0.7221.00
108_I116_L0.7221.00
118_L148_I0.7211.00
101_V104_I0.7191.00
85_C88_C0.7181.00
121_L124_I0.7171.00
91_T97_D0.7141.00
154_H157_K0.7111.00
156_A159_Y0.7041.00
160_L197_F0.7031.00
35_N41_N0.7001.00
123_D126_H0.6981.00
156_A174_V0.6941.00
122_A129_P0.6881.00
131_H180_P0.6831.00
73_N77_A0.6821.00
180_P184_T0.6811.00
185_L189_K0.6800.99
155_A159_Y0.6800.99
149_Q176_I0.6770.99
61_R64_K0.6740.99
72_P76_Q0.6730.99
101_V135_T0.6710.99
101_V105_T0.6710.99
142_I147_Y0.6690.99
85_C89_K0.6690.99
69_C82_F0.6620.99
116_L124_I0.6610.99
104_I108_I0.6570.99
152_R175_G0.6550.99
119_E123_D0.6520.99
154_H189_K0.6500.99
99_E139_I0.6500.99
52_I59_K0.6450.99
103_L106_E0.6440.99
137_K146_E0.6420.99
160_L170_I0.6410.99
34_N37_A0.6390.99
83_R87_R0.6360.99
83_R86_K0.6320.99
107_Y121_L0.6290.99
101_V125_C0.6280.99
87_R90_P0.6270.99
35_N40_N0.6250.99
81_N84_P0.6250.99
135_T138_K0.6240.99
103_L125_C0.6210.99
178_N181_Y0.6140.99
181_Y184_T0.6140.99
84_P88_C0.6120.99
38_A42_Q0.6060.99
147_Y151_V0.6040.99
171_A183_I0.6020.99
104_I107_Y0.6010.99
54_C59_K0.5960.99
77_A81_N0.5950.99
106_E109_D0.5930.99
110_K124_I0.5890.99
95_M98_S0.5880.99
167_I195_A0.5880.99
109_D147_Y0.5860.99
195_A198_R0.5830.98
146_E188_K0.5830.98
167_I170_I0.5760.98
56_P59_K0.5760.98
31_A34_N0.5750.98
38_A41_N0.5720.98
45_Y54_C0.5680.98
86_K90_P0.5650.98
76_Q81_N0.5600.98
76_Q80_A0.5590.98
112_F116_L0.5590.98
164_N198_R0.5580.98
70_I77_A0.5570.98
115_K120_S0.5510.98
172_I177_A0.5510.98
109_D154_H0.5480.98
177_A181_Y0.5460.98
93_E96_P0.5430.98
58_C61_R0.5390.97
190_T197_F0.5360.97
157_K192_Q0.5330.97
97_D100_W0.5280.97
121_L152_R0.5240.97
121_L148_I0.5200.97
50_T55_K0.5180.97
45_Y49_S0.5170.97
187_K193_T0.5170.97
27_E30_Q0.5090.96
46_A49_S0.5080.96
67_N70_I0.5060.96
162_Q165_K0.5040.96
27_E65_K0.5040.96
149_Q153_V0.5030.96
168_G181_Y0.5020.96
30_Q34_N0.5010.96
105_T151_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8531 100 0.37 Contact Map
3oouA 1 0.4976 100 0.384 Contact Map
3oioA 1 0.5308 100 0.389 Contact Map
1bl0A 1 0.545 100 0.39 Contact Map
3mklA 1 0.5261 100 0.393 Contact Map
3mn2A 1 0.5024 100 0.393 Contact Map
2k9sA 1 0.5024 100 0.401 Contact Map
3w6vA 1 0.5261 100 0.406 Contact Map
3lsgA 2 0.4834 100 0.407 Contact Map
1d5yA 1 0.545 99.9 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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