GREMLIN Database
AROH - Chorismate mutase AroH
UniProt: P19080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (117)
Sequences: 660 (465)
Seq/√Len: 42.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D54_H4.4241.00
44_Q94_T3.9531.00
15_D55_A3.6431.00
111_K114_V3.4621.00
26_Q110_E2.6271.00
30_K34_E2.5971.00
28_L62_V2.2871.00
48_S76_M2.2121.00
23_K110_E2.1290.99
10_T110_E2.1000.99
75_C78_E2.0940.99
47_L62_V1.9280.99
11_T88_C1.9030.99
23_K26_Q1.8490.99
49_A79_M1.8310.98
12_V53_L1.8010.98
99_V103_Q1.7440.98
16_T19_E1.6980.97
51_P80_D1.6190.97
51_P77_Q1.5900.96
20_I55_A1.5900.96
54_H80_D1.5870.96
5_G43_V1.5730.96
14_R19_E1.5310.95
31_I93_M1.4830.94
100_P103_Q1.4590.94
15_D20_I1.4500.94
6_I95_V1.4370.93
13_E111_K1.4300.93
54_H82_T1.3800.92
25_K64_E1.3760.92
4_R97_T1.3700.92
32_I68_W1.3660.91
46_L76_M1.3650.91
31_I91_V1.3640.91
47_L91_V1.3480.91
17_E60_K1.3320.90
72_P119_L1.3310.90
3_I96_Q1.3230.90
74_T92_M1.2800.88
10_T26_Q1.2650.88
25_K29_E1.2610.88
62_V91_V1.2470.87
3_I73_V1.2370.87
20_I53_L1.1790.84
24_T61_A1.1580.83
28_L31_I1.1540.83
12_V20_I1.1470.82
59_A75_C1.1390.82
6_I104_I1.1260.81
5_G101_Q1.1230.81
6_I37_T1.1020.80
62_V73_V1.0800.78
49_A77_Q1.0790.78
74_T81_V1.0620.77
29_E65_L1.0430.76
71_V101_Q1.0180.74
48_S74_T0.9930.72
79_M82_T0.9830.71
13_E23_K0.9800.71
21_L61_A0.9670.70
32_I42_V0.9580.69
3_I43_V0.9400.68
59_A73_V0.9350.67
31_I107_V0.9210.66
21_L56_V0.9100.65
43_V94_T0.9070.65
76_M79_M0.8980.64
97_T104_I0.8910.64
28_L93_M0.8910.64
95_V104_I0.8860.63
34_E107_V0.8840.63
53_L87_K0.8810.63
17_E21_L0.8760.62
24_T60_K0.8750.62
93_M108_Y0.8710.62
39_P71_V0.8700.62
43_V96_Q0.8650.61
4_R104_I0.8630.61
10_T109_L0.8580.61
86_K111_K0.8500.60
38_K41_D0.8290.58
29_E33_E0.8270.58
17_E56_V0.8260.58
34_E105_R0.8220.57
33_E36_H0.8190.57
20_I54_H0.8150.57
21_L24_T0.8090.56
17_E55_A0.8030.56
85_L88_C0.7960.55
36_H48_S0.7920.55
28_L91_V0.7900.54
5_G92_M0.7860.54
36_H99_V0.7760.53
26_Q109_L0.7580.51
45_M93_M0.7480.50
74_T79_M0.7420.50
99_V104_I0.7100.47
30_K33_E0.6890.45
60_K69_Q0.6870.45
5_G68_W0.6860.44
14_R87_K0.6810.44
28_L110_E0.6740.43
12_V109_L0.6710.43
5_G37_T0.6690.43
51_P69_Q0.6660.43
56_V60_K0.6640.42
19_E23_K0.6600.42
37_T94_T0.6600.42
48_S75_C0.6550.42
75_C79_M0.6540.42
4_R57_F0.6530.41
45_M68_W0.6500.41
22_Q110_E0.6470.41
51_P84_G0.6460.41
57_F68_W0.6440.41
47_L92_M0.6400.40
32_I65_L0.6390.40
38_K105_R0.6380.40
40_E101_Q0.6370.40
57_F79_M0.6330.40
77_Q82_T0.6300.39
93_M96_Q0.6270.39
42_V97_T0.6260.39
46_L94_T0.6250.39
12_V107_V0.6180.38
63_R115_L0.6170.38
5_G72_P0.6130.38
49_A75_C0.6090.37
33_E86_K0.6070.37
28_L47_L0.6050.37
19_E22_Q0.6020.37
49_A57_F0.6000.37
30_K37_T0.5990.37
12_V38_K0.5970.36
22_Q33_E0.5960.36
39_P83_G0.5830.35
87_K110_E0.5770.35
68_W92_M0.5770.35
40_E69_Q0.5700.34
60_K74_T0.5660.34
15_D19_E0.5650.34
43_V101_Q0.5640.34
64_E87_K0.5620.33
53_L89_I0.5530.33
89_I117_P0.5530.33
38_K93_M0.5460.32
13_E29_E0.5420.32
13_E16_T0.5350.31
30_K40_E0.5330.31
61_A65_L0.5310.31
27_L102_D0.5300.31
55_A82_T0.5290.31
31_I71_V0.5280.31
19_E103_Q0.5270.30
16_T21_L0.5270.30
4_R71_V0.5220.30
54_H114_V0.5210.30
48_S88_C0.5200.30
22_Q41_D0.5190.30
70_Y101_Q0.5180.30
96_Q104_I0.5160.30
42_V73_V0.5160.30
49_A80_D0.5120.29
72_P76_M0.5110.29
30_K109_L0.5090.29
12_V119_L0.5080.29
46_L74_T0.5080.29
32_I60_K0.5060.29
5_G70_Y0.5050.29
71_V94_T0.5050.29
42_V68_W0.5040.29
49_A81_V0.5010.28
45_M62_V0.5010.28
57_F106_H0.5010.28
87_K111_K0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dbfA 3 1 100 0.028 Contact Map
1xhoA 3 0.8819 100 0.058 Contact Map
1ufyA 3 0.9449 100 0.07 Contact Map
2j6yA 2 0.4803 14.7 0.949 Contact Map
2e8vA 2 0.3937 9.5 0.953 Contact Map
4jgtA 1 0.685 9.5 0.953 Contact Map
1d6gA 1 0.3701 9 0.953 Contact Map
3d1pA 1 0.6929 7.8 0.955 Contact Map
1urhA 1 0.5984 7.6 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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