GREMLIN Database
MURB - UDP-N-acetylenolpyruvoylglucosamine reductase
UniProt: P18579 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (283)
Sequences: 4348 (3271)
Seq/√Len: 194.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_R291_D3.8901.00
35_D77_R3.7351.00
151_K190_V2.8761.00
153_H188_E2.6361.00
98_T190_V2.4711.00
252_A268_A2.4471.00
237_N241_K2.3791.00
244_L283_T2.3631.00
251_G267_G2.2861.00
165_T168_Q2.2741.00
151_K163_W2.2501.00
247_Y279_H2.2391.00
228_R293_H2.2131.00
43_V153_H2.2101.00
248_Q253_K2.2081.00
248_Q265_A2.2041.00
202_V206_Q2.1591.00
27_T67_S2.1521.00
145_M191_L2.1511.00
98_T188_E2.1291.00
156_F160_T2.1271.00
153_H163_W2.0781.00
175_T180_K2.0561.00
279_H283_T1.9941.00
271_K275_D1.9671.00
172_S175_T1.9581.00
130_V191_L1.9481.00
154_I164_L1.9451.00
29_K221_P1.9371.00
30_I273_V1.9331.00
149_L152_A1.9271.00
111_S115_K1.8941.00
249_I279_H1.8841.00
253_K265_A1.8771.00
253_K256_E1.8671.00
161_I187_L1.8661.00
154_I184_G1.8641.00
63_I69_L1.8431.00
20_E25_H1.8431.00
154_I162_E1.8371.00
278_D281_K1.8351.00
37_L82_K1.8131.00
233_N237_N1.7881.00
17_L20_E1.7461.00
104_S107_R1.7261.00
210_D214_N1.7131.00
197_D200_S1.7051.00
38_V49_I1.6951.00
281_K294_T1.6881.00
220_S263_V1.6751.00
245_K259_G1.6491.00
53_I79_V1.6461.00
283_T286_E1.6401.00
254_I280_V1.6361.00
20_E37_L1.6341.00
145_M149_L1.6201.00
120_L148_I1.6141.00
38_V79_V1.6101.00
240_E245_K1.5671.00
236_G259_G1.5641.00
156_F162_E1.5621.00
251_G272_D1.5581.00
169_M178_L1.5571.00
149_L189_A1.5411.00
108_L130_V1.5251.00
150_V192_Q1.5161.00
244_L247_Y1.5131.00
233_N290_I1.5121.00
178_L186_C1.4991.00
251_G265_A1.4991.00
61_T299_I1.4901.00
30_I270_A1.4871.00
130_V189_A1.4821.00
244_L279_H1.4671.00
242_A284_I1.4641.00
282_K286_E1.4641.00
96_Q150_V1.4601.00
274_L298_I1.4531.00
283_T287_K1.4441.00
149_L171_F1.4301.00
61_T76_I1.4111.00
39_I84_G1.3991.00
58_V79_V1.3801.00
281_K291_D1.3601.00
41_S45_A1.3591.00
25_H37_L1.3541.00
155_L159_G1.3521.00
118_S196_K1.3461.00
28_M223_A1.3371.00
204_Q207_S1.3321.00
18_A36_V1.3271.00
277_I294_T1.3261.00
26_T71_V1.3251.00
103_Y108_L1.3171.00
39_I82_K1.3161.00
164_L184_G1.3081.00
76_I80_V1.3031.00
108_L191_L1.3021.00
144_D147_E1.2961.00
36_V58_V1.2901.00
209_K213_K1.2861.00
60_W81_I1.2851.00
247_Y283_T1.2651.00
251_G266_G1.2601.00
99_V108_L1.2591.00
53_I60_W1.2501.00
42_S45_A1.2431.00
242_A287_K1.2411.00
242_A288_Y1.2341.00
226_I262_I1.2181.00
46_V185_V1.2141.00
36_V79_V1.2021.00
155_L187_L1.1941.00
248_Q251_G1.1861.00
100_G103_Y1.1831.00
170_D180_K1.1721.00
262_I273_V1.1641.00
207_S211_Y1.1461.00
92_L111_S1.1431.00
157_E183_P1.1371.00
162_E168_Q1.1361.00
97_V112_L1.1281.00
47_K51_D1.1201.00
205_M209_K1.1091.00
153_H161_I1.1091.00
100_G188_E1.1061.00
52_V56_Y1.1041.00
43_V161_I1.1031.00
239_V280_V1.1031.00
97_V108_L1.0911.00
133_A138_A1.0871.00
272_D275_D1.0841.00
275_D279_H1.0801.00
85_A100_G1.0721.00
212_R215_T1.0701.00
150_V190_V1.0521.00
284_I288_Y1.0501.00
229_N260_N1.0491.00
23_A31_G1.0491.00
200_S203_Q1.0311.00
92_L115_K1.0261.00
211_Y215_T1.0231.00
21_P31_G1.0201.00
28_M226_I1.0161.00
35_D76_I1.0001.00
20_E24_N0.9981.00
43_V47_K0.9981.00
22_L34_A0.9971.00
285_R289_E0.9891.00
252_A276_L0.9880.99
124_A205_M0.9850.99
226_I277_I0.9810.99
18_A35_D0.9790.99
72_L298_I0.9780.99
206_Q210_D0.9760.99
106_V124_A0.9740.99
199_E203_Q0.9690.99
153_H190_V0.9630.99
70_L296_V0.9570.99
255_S258_H0.9560.99
163_W190_V0.9540.99
203_Q207_S0.9500.99
134_V189_A0.9480.99
252_A273_V0.9440.99
241_K288_Y0.9410.99
83_L101_G0.9400.99
134_V149_L0.9320.99
72_L300_G0.9280.99
139_G174_R0.9240.99
170_D175_T0.9180.99
49_I53_I0.9170.99
59_K77_R0.9110.99
268_A273_V0.9080.99
113_S202_V0.9070.99
72_L270_A0.9030.99
30_I70_L0.9000.99
209_K215_T0.8990.99
134_V186_C0.8970.99
156_F183_P0.8970.99
44_D48_D0.8950.99
205_M215_T0.8930.99
196_K201_I0.8930.99
108_L120_L0.8900.99
154_I178_L0.8760.99
177_V182_R0.8760.99
112_L120_L0.8690.99
196_K200_S0.8630.99
116_G198_K0.8570.99
146_S166_N0.8550.99
91_E98_T0.8510.98
61_T80_V0.8500.98
85_A88_D0.8490.98
87_L103_Y0.8480.98
19_N33_P0.8440.98
193_L196_K0.8420.98
98_T153_H0.8390.98
96_Q190_V0.8360.98
170_D177_V0.8350.98
40_P81_I0.8310.98
62_V185_V0.8310.98
244_L280_V0.8230.98
90_L103_Y0.8230.98
47_K161_I0.8160.98
250_G272_D0.8150.98
110_T202_V0.8130.98
166_N171_F0.8130.98
96_Q192_Q0.8120.98
216_Q261_F0.8080.98
54_K157_E0.8080.98
71_V76_I0.8080.98
201_I205_M0.8080.98
99_V191_L0.8060.98
28_M273_V0.8060.98
235_A238_L0.8050.98
294_T298_I0.8040.98
26_T31_G0.7970.98
99_V130_V0.7920.98
129_S132_G0.7900.98
95_E192_Q0.7890.98
105_V133_A0.7890.98
236_G245_K0.7870.97
149_L166_N0.7810.97
219_S257_M0.7790.97
133_A191_L0.7780.97
40_P83_L0.7780.97
22_L25_H0.7780.97
249_I275_D0.7740.97
72_L274_L0.7740.97
35_D78_G0.7680.97
234_H237_N0.7680.97
65_R104_S0.7670.97
99_V103_Y0.7670.97
50_M155_L0.7670.97
25_H82_K0.7660.97
269_S272_D0.7650.97
21_P33_P0.7570.97
28_M70_L0.7560.97
156_F184_G0.7520.97
206_Q212_R0.7510.97
118_S201_I0.7480.97
52_V58_V0.7440.96
223_A226_I0.7400.96
43_V188_E0.7390.96
83_L87_L0.7370.96
253_K263_V0.7360.96
121_E204_Q0.7360.96
223_A296_V0.7340.96
254_I276_L0.7330.96
135_Y297_E0.7310.96
135_Y179_Q0.7290.96
209_K214_N0.7270.96
95_E195_Q0.7260.96
171_F176_S0.7260.96
169_M176_S0.7250.96
83_L185_V0.7230.96
46_V81_I0.7220.96
36_V52_V0.7190.96
17_L39_I0.7190.96
151_K165_T0.7160.96
51_D160_T0.7140.96
252_A262_I0.7130.96
113_S205_M0.7110.95
126_I140_A0.7110.95
16_V38_V0.7080.95
108_L112_L0.7060.95
208_N211_Y0.7060.95
124_A202_V0.7020.95
218_Y221_P0.7010.95
282_K285_R0.6980.95
123_A143_S0.6960.95
86_G103_Y0.6960.95
64_G129_S0.6960.95
164_L168_Q0.6960.95
134_V171_F0.6960.95
203_Q206_Q0.6960.95
133_A145_M0.6930.95
109_A124_A0.6930.95
49_I79_V0.6920.95
155_L161_I0.6910.95
113_S198_K0.6870.95
256_E265_A0.6860.95
32_G73_D0.6850.94
198_K201_I0.6850.94
105_V145_M0.6850.94
211_Y214_N0.6840.94
22_L71_V0.6840.94
264_N268_A0.6840.94
235_A284_I0.6820.94
143_S148_I0.6820.94
98_T151_K0.6820.94
31_G73_D0.6730.94
85_A89_H0.6720.94
235_A292_M0.6720.94
112_L117_L0.6710.94
46_V187_L0.6680.94
124_A209_K0.6670.94
153_H187_L0.6650.94
120_L191_L0.6640.94
234_H258_H0.6600.93
279_H282_K0.6580.93
22_L63_I0.6560.93
196_K204_Q0.6540.93
254_I262_I0.6530.93
48_D51_D0.6530.93
275_D278_D0.6520.93
23_A267_G0.6520.93
198_K202_V0.6510.93
117_L193_L0.6500.93
209_K212_R0.6500.93
85_A103_Y0.6480.93
43_V100_G0.6470.93
207_S210_D0.6450.93
111_S114_K0.6400.92
262_I276_L0.6400.92
278_D282_K0.6400.92
206_Q209_K0.6360.92
135_Y186_C0.6350.92
242_A283_T0.6320.92
59_K78_G0.6290.92
70_L252_A0.6280.91
48_D52_V0.6260.91
205_M212_R0.6250.91
233_N241_K0.6200.91
47_K155_L0.6190.91
152_A169_M0.6170.91
208_N212_R0.6170.91
54_K57_D0.6160.91
89_H100_G0.6160.91
140_A225_S0.6160.91
113_S206_Q0.6160.91
162_E184_G0.6130.90
233_N238_L0.6120.90
238_L242_A0.6100.90
43_V187_L0.6090.90
134_V152_A0.6070.90
93_E96_Q0.6050.90
113_S201_I0.6050.90
276_L280_V0.6040.90
71_V300_G0.6010.90
111_S117_L0.6000.90
50_M60_W0.5980.89
71_V299_I0.5980.89
143_S147_E0.5960.89
206_Q214_N0.5950.89
255_S261_F0.5950.89
90_L111_S0.5920.89
103_Y130_V0.5920.89
92_L97_V0.5910.89
277_I281_K0.5910.89
88_D98_T0.5860.88
51_D55_K0.5860.88
23_A26_T0.5840.88
202_V205_M0.5830.88
136_M179_Q0.5820.88
229_N234_H0.5810.88
21_P25_H0.5810.88
240_E259_G0.5780.88
26_T32_G0.5780.88
149_L191_L0.5780.88
248_Q266_G0.5770.88
106_V110_T0.5770.88
179_Q297_E0.5760.88
60_W76_I0.5760.88
28_M254_I0.5740.87
121_E201_I0.5680.87
278_D294_T0.5680.87
73_D270_A0.5680.87
28_M262_I0.5670.87
151_K188_E0.5660.87
87_L102_G0.5600.86
86_G89_H0.5570.86
204_Q215_T0.5570.86
61_T297_E0.5550.86
53_I58_V0.5550.86
76_I299_I0.5520.85
122_F143_S0.5510.85
107_R111_S0.5470.85
282_K291_D0.5460.85
61_T78_G0.5450.85
141_H225_S0.5430.84
30_I252_A0.5410.84
241_K287_K0.5400.84
74_E271_K0.5400.84
200_S204_Q0.5390.84
110_T113_S0.5380.84
105_V109_A0.5340.83
112_L115_K0.5330.83
118_S194_E0.5330.83
146_S171_F0.5330.83
177_V184_G0.5310.83
141_H211_Y0.5290.83
206_Q215_T0.5290.83
87_L100_G0.5280.83
154_I186_C0.5280.83
87_L90_L0.5270.83
223_A262_I0.5250.82
35_D61_T0.5240.82
89_H98_T0.5240.82
118_S121_E0.5240.82
146_S176_S0.5210.82
89_H92_L0.5210.82
176_S186_C0.5190.82
220_S265_A0.5190.82
27_T223_A0.5180.82
46_V83_L0.5160.81
247_Y276_L0.5160.81
202_V212_R0.5150.81
192_Q196_K0.5140.81
234_H240_E0.5130.81
215_T229_N0.5130.81
149_L169_M0.5120.81
52_V55_K0.5100.81
40_P185_V0.5100.81
204_Q211_Y0.5090.80
83_L103_Y0.5090.80
70_L294_T0.5070.80
251_G269_S0.5060.80
60_W157_E0.5040.80
97_V111_S0.5040.80
217_P261_F0.5030.80
139_G230_P0.5030.80
175_T179_Q0.5010.79
87_L91_E0.5000.79
19_N35_D0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pytA 1 0.9934 100 0.223 Contact Map
1hskA 1 0.9934 100 0.234 Contact Map
2gqtA 1 0.8812 100 0.241 Contact Map
3i99A 1 0.9538 100 0.247 Contact Map
4jb1A 1 0.934 100 0.273 Contact Map
3tx1A 1 0.967 100 0.299 Contact Map
1uxyA 1 0.9274 100 0.323 Contact Map
4mlaA 1 0.9241 100 0.734 Contact Map
1wvfA 2 0.9769 100 0.737 Contact Map
3pm9A 5 0.9373 99.9 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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