GREMLIN Database
XYNA - Endo-1,4-beta-xylanase A
UniProt: P18429 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (190)
Sequences: 671 (383)
Seq/√Len: 27.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_R147_D4.4141.00
128_S176_N4.3301.00
109_V174_F4.2451.00
137_T154_T3.9181.00
123_K186_M3.6971.00
173_T176_N3.6291.00
54_Y199_T3.3801.00
158_S177_H3.2481.00
96_L172_I3.1971.00
86_W92_G3.0411.00
175_S179_N2.9801.00
101_R193_A2.8581.00
134_D161_Q2.7081.00
139_T154_T2.6681.00
123_K137_T2.4930.99
53_N209_N2.4760.99
16_L19_I2.4620.99
174_F178_V2.4010.99
147_D151_T2.3780.99
84_G210_V2.3240.99
131_G162_S2.2930.98
199_T208_S2.1670.98
112_S165_P2.0050.96
74_S195_Q1.8520.94
132_T161_Q1.8180.94
137_T186_M1.7890.93
128_S173_T1.7710.93
79_I195_Q1.7710.93
113_W117_R1.6670.90
26_A33_Y1.6530.90
17_M20_S1.6430.90
24_A38_T1.6370.89
65_V198_A1.5800.88
111_D172_I1.5800.88
135_I180_A1.5730.87
105_I156_Y1.5730.87
79_I96_L1.5610.87
123_K154_T1.5580.87
172_I197_M1.5380.86
56_V64_F1.5270.86
54_Y208_S1.5240.86
135_I184_H1.5100.85
112_S163_K1.4430.82
166_T210_V1.4370.82
110_V159_V1.4280.82
49_G53_N1.3940.80
117_R134_D1.3910.80
116_Y119_T1.3870.80
49_G209_N1.3870.80
182_K187_N1.3740.79
109_V178_V1.3630.79
96_L197_M1.3590.78
56_V208_S1.3340.77
88_P115_T1.2970.75
42_G61_T1.2640.73
119_T136_Y1.2570.73
176_N179_N1.2470.72
17_M23_S1.2400.72
78_T171_T1.2280.71
131_G161_Q1.2030.69
16_L20_S1.1980.69
77_R195_Q1.1740.67
36_N66_V1.1690.67
21_L25_T1.1640.67
122_Y134_D1.1630.67
141_Y154_T1.1600.66
138_T143_A1.1480.66
145_S152_T1.1340.65
67_G70_W1.1330.65
179_N183_S1.1330.65
164_R167_G1.1300.64
42_G60_N1.1170.63
113_W119_T1.1040.63
19_I25_T1.0990.62
180_A184_H1.0980.62
122_Y136_Y1.0840.61
20_S23_S1.0800.61
74_S175_S1.0690.60
92_G208_S1.0640.60
29_A66_V1.0610.59
179_N182_K1.0530.59
21_L24_A1.0370.58
17_M21_L1.0200.56
175_S195_Q1.0120.56
126_V180_A0.9970.55
82_N211_T0.9960.55
35_Q196_V0.9940.54
61_T203_Q0.9940.54
98_G181_W0.9930.54
45_N89_N0.9880.54
58_W206_G0.9850.54
101_R151_T0.9670.52
31_T34_W0.9560.51
75_P175_S0.9560.51
67_G194_Y0.9550.51
82_N85_V0.9550.51
95_T197_M0.9370.50
143_A151_T0.9300.49
58_W114_G0.9000.47
38_T62_G0.8930.47
30_S49_G0.8900.46
132_T162_S0.8710.45
37_W63_N0.8690.45
135_I158_S0.8670.45
36_N64_F0.8620.44
56_V66_V0.8610.44
155_Q200_E0.8570.44
104_L146_I0.8560.44
78_T159_V0.8530.44
81_Y165_P0.8320.42
39_D63_N0.8300.42
73_G107_Y0.8300.42
79_I172_I0.8270.42
42_G45_N0.8230.41
95_T198_A0.8210.41
51_G211_T0.8190.41
87_A210_V0.8180.41
81_Y166_T0.8180.41
97_Y106_E0.8130.41
144_P152_T0.8080.40
114_G118_P0.8070.40
129_D173_T0.8040.40
16_L24_A0.8000.40
29_A68_K0.7980.40
138_T159_V0.7970.39
39_D62_G0.7890.39
44_V56_V0.7870.39
100_T191_N0.7850.39
84_G87_A0.7830.38
90_G115_T0.7810.38
157_W201_G0.7790.38
95_T138_T0.7770.38
156_Y182_K0.7760.38
65_V194_Y0.7750.38
44_V64_F0.7660.37
65_V153_F0.7650.37
95_T109_V0.7640.37
46_A172_I0.7560.37
59_S205_S0.7550.36
18_S21_L0.7480.36
128_S136_Y0.7470.36
108_Y200_E0.7390.35
35_Q194_Y0.7350.35
98_G107_Y0.7350.35
60_N203_Q0.7280.35
126_V134_D0.7160.34
20_S45_N0.7160.34
16_L21_L0.7060.33
70_W73_G0.7020.33
103_P189_G0.7010.33
125_T161_Q0.7000.33
149_D152_T0.6970.32
93_Y157_W0.6960.32
46_A56_V0.6920.32
157_W202_Y0.6900.32
92_G117_R0.6830.31
82_N210_V0.6820.31
138_T157_W0.6800.31
104_L189_G0.6790.31
75_P179_N0.6790.31
41_G61_T0.6710.31
22_F45_N0.6710.31
18_S43_I0.6700.31
26_A193_A0.6680.31
131_G160_R0.6680.31
91_N202_Y0.6670.30
97_Y155_Q0.6660.30
26_A30_S0.6640.30
48_N56_V0.6640.30
145_S149_D0.6640.30
77_R174_F0.6630.30
194_Y198_A0.6610.30
99_W153_F0.6610.30
52_G75_P0.6580.30
71_T193_A0.6550.30
43_I59_S0.6540.30
105_I186_M0.6510.29
107_Y181_W0.6460.29
103_P111_D0.6460.29
102_S147_D0.6440.29
99_W108_Y0.6430.29
148_G200_E0.6430.29
46_A66_V0.6410.29
50_S53_N0.6410.29
116_Y202_Y0.6380.29
197_M210_V0.6280.28
85_V90_G0.6260.28
57_N207_S0.6230.28
127_K132_T0.6230.28
108_Y148_G0.6230.28
23_S30_S0.6220.28
36_N42_G0.6160.27
118_P159_V0.6150.27
93_Y116_Y0.6150.27
81_Y131_G0.6130.27
38_T42_G0.6100.27
87_A207_S0.6060.27
144_P153_F0.6060.27
63_N203_Q0.6050.27
129_D176_N0.6040.27
67_G196_V0.6040.27
106_E177_H0.6020.26
84_G90_G0.6020.26
40_G43_I0.6020.26
18_S127_K0.6000.26
119_T122_Y0.5990.26
201_G204_S0.5960.26
156_Y187_N0.5950.26
21_L48_N0.5940.26
145_S153_F0.5910.26
60_N142_N0.5900.26
174_F191_N0.5900.26
98_G158_S0.5880.26
126_V176_N0.5850.25
27_S31_T0.5820.25
146_I153_F0.5810.25
69_G99_W0.5800.25
100_T188_L0.5770.25
139_T149_D0.5770.25
105_I188_L0.5720.25
32_D42_G0.5720.25
72_T193_A0.5710.25
82_N209_N0.5690.24
67_G73_G0.5670.24
32_D51_G0.5670.24
184_H187_N0.5650.24
37_W93_Y0.5650.24
123_K127_K0.5640.24
25_T28_A0.5610.24
119_T201_G0.5590.24
61_T109_V0.5570.24
112_S131_G0.5570.24
140_R143_A0.5560.24
177_H181_W0.5550.24
73_G181_W0.5550.24
63_N91_N0.5540.24
136_Y157_W0.5520.24
85_V166_T0.5510.23
70_W198_A0.5500.23
36_N61_T0.5480.23
91_N201_G0.5440.23
79_I197_M0.5420.23
26_A38_T0.5410.23
92_G203_Q0.5380.23
109_V131_G0.5380.23
185_G189_G0.5370.23
114_G117_R0.5370.23
63_N201_G0.5360.23
38_T41_G0.5360.23
30_S51_G0.5340.23
27_S204_S0.5320.22
39_D140_R0.5320.22
86_W203_Q0.5320.22
72_T101_R0.5300.22
203_Q209_N0.5280.22
120_G136_Y0.5260.22
75_P191_N0.5260.22
142_N145_S0.5250.22
152_T155_Q0.5210.22
111_D160_R0.5190.22
104_L145_S0.5170.22
44_V47_V0.5170.22
120_G143_A0.5160.22
34_W42_G0.5160.22
64_F89_N0.5150.22
86_W208_S0.5140.22
19_I56_V0.5140.22
41_G62_G0.5130.21
122_Y128_S0.5120.21
56_V68_K0.5110.21
84_G205_S0.5090.21
117_R120_G0.5090.21
66_V196_V0.5080.21
106_E155_Q0.5070.21
78_T174_F0.5060.21
127_K135_I0.5050.21
43_I61_T0.5050.21
82_N127_K0.5040.21
20_S46_A0.5020.21
19_I23_S0.5020.21
70_W77_R0.5010.21
122_Y125_T0.5010.21
66_V89_N0.5010.21
110_V157_W0.5010.21
108_Y153_F0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vgdA 1 0.892 100 -0.001 Contact Map
3wp3A 1 0.8779 100 0.034 Contact Map
3mf6A 1 0.8967 100 0.036 Contact Map
1ynaA 1 0.8826 100 0.036 Contact Map
3akqA 1 0.8826 100 0.038 Contact Map
1xnkA 3 0.8873 100 0.043 Contact Map
4ixlA 1 0.8873 100 0.044 Contact Map
3m4fA 1 0.8357 100 0.056 Contact Map
2dckA 1 0.8826 100 0.056 Contact Map
1h4gA 1 0.8873 100 0.073 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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