SYT1 - BACSU - GREMLIN Contacts

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SYT1 - Threonine--tRNA ligase 1

UniProt:	P18255	Sequences: MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLNGKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIENGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKLELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQRVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATIRRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLRPMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFVRPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLKEAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGEDGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKKVQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQNSETISLDEFVKKAVAEAKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	643 (623)
Sequences:	3568 (1624)
Seq/√Len:	65.1

ECOLI - SYT
BACSU - SYT1 SYT2
HALSA - SYT
SULSO - SYT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
507_G	513_H	5.989	1.00
560_H	607_D	4.112	1.00
566_K	613_G	3.827	1.00
398_K	451_E	3.817	1.00
126_E	129_K	3.460	1.00
88_R	126_E	3.418	1.00
450_K	454_D	3.341	1.00
134_N	191_S	3.284	1.00
398_K	455_E	3.195	1.00
44_N	56_E	3.180	1.00
78_A	224_A	3.081	1.00
42_K	61_E	3.005	1.00
254_K	348_D	2.961	1.00
140_K	176_E	2.920	1.00
304_K	308_E	2.907	1.00
296_V	344_I	2.879	1.00
23_T	41_G	2.875	1.00
502_D	514_R	2.851	1.00
141_E	171_T	2.828	1.00
499_E	514_R	2.812	1.00
38_S	62_I	2.760	1.00
148_K	164_D	2.759	1.00
110_E	215_Q	2.746	1.00
149_A	152_A	2.695	1.00
534_I	541_L	2.611	1.00
110_E	158_L	2.575	1.00
568_Q	578_V	2.572	1.00
509_D	513_H	2.556	1.00
86_I	109_V	2.525	1.00
257_A	270_L	2.487	1.00
228_K	232_E	2.472	1.00
88_R	133_A	2.453	1.00
507_G	511_K	2.439	1.00
81_L	131_V	2.429	1.00
81_L	195_I	2.335	1.00
43_L	58_G	2.304	1.00
570_R	631_D	2.300	1.00
138_V	176_E	2.273	1.00
148_K	160_L	2.246	1.00
42_K	69_E	2.242	1.00
427_R	435_Y	2.242	1.00
77_S	137_I	2.206	1.00
603_L	615_V	2.188	1.00
438_D	441_M	2.168	1.00
227_K	230_D	2.116	1.00
226_F	230_D	2.108	1.00
553_I	587_I	2.104	1.00
607_D	611_E	2.101	1.00
583_R	593_E	2.095	1.00
81_L	130_I	2.089	1.00
84_Q	177_Q	2.089	1.00
305_E	308_E	2.080	1.00
77_S	189_V	2.066	1.00
548_V	579_E	2.048	1.00
428_D	467_A	2.044	1.00
144_R	167_P	2.015	1.00
454_D	460_Y	2.013	1.00
567_V	630_L	1.998	1.00
176_E	181_F	1.980	1.00
287_K	410_D	1.977	1.00
152_A	164_D	1.971	1.00
287_K	291_L	1.961	1.00
447_S	451_E	1.953	1.00
568_Q	580_V	1.948	1.00
254_K	270_L	1.927	1.00
25_D	28_A	1.895	1.00
552_V	568_Q	1.894	1.00
287_K	290_S	1.878	1.00
402_I	455_E	1.871	1.00
556_S	560_H	1.861	1.00
632_E	635_K	1.856	1.00
435_Y	439_D	1.845	1.00
87_K	156_D	1.832	1.00
447_S	450_K	1.824	1.00
302_G	340_H	1.819	1.00
40_A	73_I	1.815	1.00
87_K	180_F	1.805	1.00
199_K	235_L	1.805	1.00
283_Y	414_D	1.804	1.00
61_E	67_S	1.798	1.00
134_N	193_G	1.788	1.00
272_K	597_Q	1.788	1.00
124_E	199_K	1.788	1.00
558_A	607_D	1.755	1.00
93_V	111_M	1.749	1.00
88_R	179_E	1.748	1.00
406_R	456_I	1.736	1.00
436_F	496_L	1.726	0.99
75_R	223_T	1.719	0.99
190_P	194_K	1.717	0.99
565_K	568_Q	1.714	0.99
234_H	238_L	1.712	0.99
149_A	153_E	1.710	0.99
342_M	517_V	1.710	0.99
279_V	282_R	1.703	0.99
450_K	462_E	1.700	0.99
568_Q	572_Q	1.698	0.99
17_F	21_T	1.695	0.99
111_M	115_I	1.692	0.99
82_L	123_I	1.664	0.99
48_I	52_T	1.664	0.99
33_G	37_K	1.642	0.99
17_F	29_S	1.627	0.99
158_L	215_Q	1.617	0.99
88_R	129_K	1.612	0.99
566_K	570_R	1.612	0.99
283_Y	410_D	1.611	0.99
562_D	565_K	1.609	0.99
555_V	587_I	1.605	0.99
144_R	168_E	1.594	0.99
71_L	75_R	1.585	0.99
394_P	444_K	1.582	0.99
276_I	530_V	1.581	0.99
463_A	466_E	1.569	0.99
272_K	579_E	1.557	0.99
543_T	637_A	1.557	0.99
38_S	50_L	1.556	0.99
576_L	637_A	1.552	0.99
84_Q	135_L	1.550	0.99
421_T	485_E	1.542	0.99
201_L	238_L	1.537	0.99
540_A	598_K	1.530	0.99
405_V	476_V	1.526	0.99
15_K	29_S	1.525	0.99
211_D	214_N	1.515	0.99
239_E	242_K	1.512	0.99
248_K	252_E	1.508	0.99
32_P	36_K	1.506	0.99
571_L	634_V	1.493	0.99
74_M	226_F	1.488	0.98
44_N	58_G	1.477	0.98
595_Q	598_K	1.477	0.98
87_K	92_D	1.466	0.98
26_I	60_V	1.454	0.98
125_K	128_K	1.449	0.98
565_K	582_S	1.447	0.98
151_F	174_I	1.443	0.98
608_Q	611_E	1.438	0.98
24_E	28_A	1.435	0.98
453_M	474_L	1.433	0.98
543_T	640_E	1.427	0.98
174_I	181_F	1.426	0.98
103_N	237_M	1.423	0.98
145_E	149_A	1.417	0.98
603_L	633_F	1.415	0.98
300_V	366_H	1.414	0.98
477_Q	485_E	1.406	0.98
31_S	37_K	1.405	0.98
347_Q	350_H	1.401	0.98
401_F	474_L	1.396	0.98
552_V	564_A	1.395	0.98
165_A	209_R	1.391	0.98
594_A	602_M	1.388	0.98
26_I	54_I	1.387	0.98
136_P	191_S	1.386	0.98
604_V	616_N	1.385	0.98
205_G	216_M	1.382	0.98
315_H	434_K	1.376	0.97
281_E	297_Y	1.375	0.97
635_K	639_A	1.374	0.97
140_K	146_E	1.373	0.97
553_I	602_M	1.367	0.97
263_G	266_L	1.366	0.97
23_T	48_I	1.363	0.97
137_I	177_Q	1.361	0.97
27_A	62_I	1.358	0.97
370_M	373_A	1.357	0.97
595_Q	602_M	1.356	0.97
563_Y	605_V	1.352	0.97
30_I	34_L	1.350	0.97
41_G	62_I	1.348	0.97
33_G	36_K	1.347	0.97
551_Q	594_A	1.335	0.97
8_T	59_T	1.331	0.97
95_F	156_D	1.321	0.97
570_R	613_G	1.314	0.97
161_E	209_R	1.312	0.97
54_I	58_G	1.311	0.97
504_T	512_Q	1.310	0.97
560_H	610_A	1.309	0.97
97_V	162_L	1.308	0.97
272_K	548_V	1.305	0.96
308_E	314_D	1.300	0.96
94_K	110_E	1.299	0.96
142_V	174_I	1.293	0.96
569_E	573_C	1.289	0.96
150_R	181_F	1.289	0.96
550_F	637_A	1.282	0.96
269_W	530_V	1.280	0.96
249_L	253_L	1.269	0.96
426_Y	450_K	1.264	0.96
129_K	133_A	1.261	0.96
143_S	146_E	1.260	0.96
506_I	512_Q	1.257	0.96
350_H	354_E	1.255	0.96
47_E	63_I	1.254	0.96
116_T	120_L	1.252	0.96
92_D	112_D	1.248	0.95
201_L	223_T	1.241	0.95
39_L	73_I	1.236	0.95
289_I	572_Q	1.235	0.95
22_T	25_D	1.234	0.95
65_E	71_L	1.233	0.95
426_Y	462_E	1.233	0.95
230_D	233_E	1.231	0.95
167_P	170_E	1.230	0.95
70_G	226_F	1.230	0.95
18_A	21_T	1.228	0.95
243_E	538_K	1.224	0.95
284_I	411_V	1.221	0.95
148_K	163_L	1.220	0.95
71_L	74_M	1.218	0.95
551_Q	597_Q	1.214	0.95
204_A	216_M	1.212	0.95
42_K	47_E	1.209	0.95
8_T	14_V	1.206	0.95
275_T	577_R	1.205	0.94
146_E	149_A	1.205	0.94
550_F	576_L	1.204	0.94
52_T	139_R	1.203	0.94
629_S	632_E	1.198	0.94
142_V	150_R	1.194	0.94
52_T	173_S	1.191	0.94
383_M	525_T	1.188	0.94
275_T	279_V	1.186	0.94
291_L	407_L	1.185	0.94
548_V	551_Q	1.185	0.94
574_E	638_V	1.181	0.94
358_R	400_E	1.177	0.94
291_L	410_D	1.172	0.94
397_I	493_L	1.171	0.94
304_K	330_T	1.168	0.94
76_H	99_P	1.156	0.93
350_H	357_I	1.153	0.93
566_K	569_E	1.151	0.93
565_K	580_V	1.150	0.93
570_R	634_V	1.149	0.93
364_T	382_G	1.147	0.93
636_K	640_E	1.147	0.93
28_A	32_P	1.146	0.93
37_K	66_G	1.146	0.93
290_S	573_C	1.145	0.93
589_Y	593_E	1.142	0.93
95_F	109_V	1.142	0.93
97_V	101_I	1.139	0.93
135_L	179_E	1.137	0.93
277_R	297_Y	1.136	0.93
133_A	179_E	1.135	0.93
555_V	588_G	1.133	0.92
284_I	288_E	1.132	0.92
27_A	30_I	1.132	0.92
342_M	503_L	1.130	0.92
619_K	622_E	1.129	0.92
562_D	566_K	1.125	0.92
135_L	192_T	1.125	0.92
254_K	257_A	1.125	0.92
41_G	48_I	1.123	0.92
617_V	633_F	1.122	0.92
628_I	633_F	1.115	0.92
570_R	574_E	1.113	0.92
43_L	60_V	1.112	0.92
72_Q	100_V	1.110	0.92
8_T	57_D	1.107	0.92
76_H	80_H	1.107	0.92
166_I	172_V	1.105	0.91
101_I	106_Y	1.102	0.91
111_M	218_Q	1.102	0.91
540_A	620_Y	1.100	0.91
435_Y	443_N	1.100	0.91
136_P	193_G	1.098	0.91
439_D	443_N	1.098	0.91
277_R	281_E	1.098	0.91
282_R	286_D	1.097	0.91
395_D	508_E	1.092	0.91
65_E	74_M	1.091	0.91
406_R	410_D	1.087	0.91
278_R	282_R	1.085	0.91
93_V	109_V	1.080	0.91
139_R	173_S	1.079	0.90
634_V	638_V	1.079	0.90
257_A	347_Q	1.079	0.90
402_I	456_I	1.078	0.90
422_F	458_H	1.077	0.90
137_I	189_V	1.076	0.90
570_R	630_L	1.074	0.90
61_E	69_E	1.073	0.90
441_M	496_L	1.072	0.90
233_E	236_R	1.072	0.90
229_A	232_E	1.072	0.90
409_Q	413_E	1.068	0.90
348_D	354_E	1.065	0.90
564_A	580_V	1.064	0.90
478_V	488_L	1.060	0.90
280_I	523_V	1.060	0.90
120_L	222_G	1.058	0.90
240_E	243_E	1.057	0.90
23_T	62_I	1.055	0.89
561_L	582_S	1.053	0.89
74_M	78_A	1.051	0.89
565_K	569_E	1.049	0.89
65_E	226_F	1.049	0.89
239_E	243_E	1.048	0.89
313_W	332_V	1.047	0.89
23_T	60_V	1.044	0.89
570_R	573_C	1.040	0.89
552_V	567_V	1.037	0.89
342_M	391_F	1.037	0.89
276_I	279_V	1.036	0.89
300_V	364_T	1.036	0.89
623_Q	626_E	1.034	0.89
44_N	59_T	1.030	0.88
263_G	302_G	1.030	0.88
135_L	177_Q	1.028	0.88
86_I	93_V	1.028	0.88
315_H	436_F	1.027	0.88
628_I	636_K	1.027	0.88
77_S	81_L	1.026	0.88
163_L	172_V	1.026	0.88
24_E	35_K	1.026	0.88
557_P	561_L	1.025	0.88
115_I	220_V	1.021	0.88
296_V	341_H	1.020	0.88
280_I	415_F	1.019	0.88
96_G	156_D	1.019	0.88
43_L	52_T	1.018	0.88
279_V	577_R	1.014	0.88
43_L	54_I	1.010	0.87
288_E	362_L	1.005	0.87
423_R	477_Q	1.004	0.87
63_I	73_I	1.002	0.87
7_I	26_I	1.001	0.87
43_L	48_I	1.000	0.87
390_I	404_T	1.000	0.87
304_K	313_W	0.991	0.86
601_Y	640_E	0.989	0.86
74_M	224_A	0.988	0.86
393_R	508_E	0.988	0.86
81_L	137_I	0.986	0.86
380_V	383_M	0.986	0.86
227_K	232_E	0.983	0.86
21_T	25_D	0.983	0.86
11_D	30_I	0.975	0.85
34_L	62_I	0.974	0.85
557_P	584_D	0.973	0.85
89_I	123_I	0.971	0.85
71_L	226_F	0.966	0.85
608_Q	612_N	0.965	0.85
296_V	359_I	0.963	0.85
236_R	239_E	0.963	0.85
603_L	617_V	0.962	0.85
554_P	564_A	0.955	0.84
451_E	455_E	0.955	0.84
140_K	174_I	0.952	0.84
229_A	233_E	0.952	0.84
124_E	128_K	0.952	0.84
94_K	157_D	0.952	0.84
7_I	60_V	0.951	0.84
134_N	192_T	0.951	0.84
117_P	121_P	0.943	0.83
586_K	589_Y	0.942	0.83
285_V	295_H	0.942	0.83
274_A	297_Y	0.942	0.83
631_D	635_K	0.940	0.83
303_S	329_E	0.940	0.83
159_K	182_D	0.938	0.83
90_Y	113_E	0.936	0.83
28_A	35_K	0.929	0.83
9_F	60_V	0.929	0.83
448_M	493_L	0.929	0.83
443_N	447_S	0.928	0.82
22_T	53_P	0.926	0.82
97_V	209_R	0.925	0.82
27_A	35_K	0.923	0.82
20_G	53_P	0.922	0.82
554_P	560_H	0.919	0.82
540_A	595_Q	0.918	0.82
307_Y	340_H	0.917	0.82
278_R	281_E	0.917	0.82
613_G	630_L	0.916	0.82
63_I	67_S	0.911	0.81
75_R	224_A	0.909	0.81
27_A	31_S	0.909	0.81
80_H	188_H	0.908	0.81
40_A	63_I	0.907	0.81
365_M	523_V	0.907	0.81
17_F	26_I	0.905	0.81
80_H	99_P	0.904	0.81
628_I	632_E	0.904	0.81
552_V	580_V	0.904	0.81
166_I	169_G	0.902	0.81
99_P	188_H	0.901	0.81
31_S	34_L	0.896	0.80
622_E	625_S	0.896	0.80
587_I	590_K	0.892	0.80
76_H	188_H	0.887	0.80
497_L	500_R	0.884	0.79
97_V	156_D	0.882	0.79
552_V	605_V	0.882	0.79
21_T	54_I	0.882	0.79
563_Y	567_V	0.881	0.79
324_M	328_N	0.881	0.79
191_S	194_K	0.880	0.79
163_L	166_I	0.879	0.79
423_R	463_A	0.878	0.79
135_L	178_G	0.877	0.79
109_V	115_I	0.877	0.79
111_M	114_A	0.876	0.79
550_F	603_L	0.875	0.79
184_C	188_H	0.875	0.79
9_F	31_S	0.874	0.78
607_D	610_A	0.873	0.78
23_T	26_I	0.871	0.78
87_K	93_V	0.869	0.78
112_D	215_Q	0.867	0.78
359_I	388_A	0.863	0.78
480_T	484_K	0.863	0.78
148_K	152_A	0.863	0.78
235_L	238_L	0.862	0.78
284_I	362_L	0.862	0.78
266_L	382_G	0.859	0.77
54_I	57_D	0.859	0.77
236_R	243_E	0.857	0.77
540_A	621_G	0.857	0.77
617_V	628_I	0.855	0.77
421_T	461_Y	0.855	0.77
166_I	170_E	0.854	0.77
120_L	200_L	0.854	0.77
11_D	34_L	0.853	0.77
21_T	26_I	0.852	0.77
378_Q	531_A	0.850	0.77
424_L	493_L	0.849	0.76
74_M	131_V	0.849	0.76
405_V	456_I	0.849	0.76
262_V	268_L	0.848	0.76
19_K	55_N	0.848	0.76
212_S	215_Q	0.846	0.76
613_G	631_D	0.844	0.76
42_K	63_I	0.843	0.76
161_E	214_N	0.842	0.76
361_E	384_T	0.841	0.76
551_Q	579_E	0.839	0.76
291_L	406_R	0.839	0.76
144_R	148_K	0.838	0.76
574_E	634_V	0.837	0.75
393_R	396_Q	0.837	0.75
249_L	252_E	0.837	0.75
115_I	121_P	0.836	0.75
426_Y	467_A	0.835	0.75
466_E	475_D	0.834	0.75
260_Q	343_M	0.833	0.75
288_E	360_A	0.832	0.75
405_V	474_L	0.830	0.75
212_S	370_M	0.830	0.75
158_L	214_N	0.829	0.75
413_E	418_S	0.825	0.74
76_H	184_C	0.825	0.74
561_L	565_K	0.824	0.74
288_E	404_T	0.824	0.74
79_A	185_R	0.824	0.74
294_E	359_I	0.823	0.74
9_F	13_A	0.823	0.74
258_N	267_P	0.823	0.74
554_P	580_V	0.822	0.74
401_F	491_V	0.820	0.74
74_M	189_V	0.819	0.74
446_Q	464_E	0.819	0.74
309_T	501_F	0.818	0.74
236_R	240_E	0.818	0.74
75_R	226_F	0.818	0.74
543_T	601_Y	0.818	0.74
581_D	590_K	0.817	0.74
107_Y	159_K	0.814	0.73
103_N	234_H	0.813	0.73
166_I	171_T	0.813	0.73
614_A	629_S	0.812	0.73
88_R	130_I	0.810	0.73
417_L	495_F	0.810	0.73
616_N	624_N	0.809	0.73
386_N	486_E	0.807	0.73
585_E	593_E	0.807	0.73
576_L	638_V	0.805	0.73
269_W	527_E	0.804	0.72
418_S	479_K	0.803	0.72
305_E	309_T	0.802	0.72
113_E	122_K	0.799	0.72
86_I	123_I	0.799	0.72
83_A	180_F	0.798	0.72
107_Y	182_D	0.797	0.72
624_N	627_T	0.797	0.72
386_N	480_T	0.793	0.71
201_L	235_L	0.790	0.71
7_I	58_G	0.789	0.71
99_P	184_C	0.789	0.71
541_L	546_A	0.788	0.71
23_T	50_L	0.786	0.71
361_E	365_M	0.785	0.71
255_L	541_L	0.785	0.71
480_T	487_T	0.784	0.71
46_K	52_T	0.783	0.70
253_L	540_A	0.782	0.70
151_F	163_L	0.781	0.70
427_R	439_D	0.781	0.70
552_V	630_L	0.779	0.70
321_F	327_D	0.779	0.70
79_A	100_V	0.779	0.70
399_D	403_R	0.777	0.70
424_L	450_K	0.777	0.70
596_M	620_Y	0.776	0.70
27_A	34_L	0.776	0.70
255_L	534_I	0.775	0.70
262_V	343_M	0.775	0.70
426_Y	463_A	0.775	0.70
80_H	98_G	0.775	0.70
80_H	184_C	0.775	0.70
404_T	518_I	0.774	0.70
422_F	476_V	0.774	0.70
385_L	521_G	0.771	0.69
563_Y	610_A	0.769	0.69
343_M	346_K	0.768	0.69
290_S	572_Q	0.768	0.69
307_Y	428_D	0.767	0.69
564_A	605_V	0.763	0.68
346_K	502_D	0.763	0.68
424_L	453_M	0.763	0.68
349_I	512_Q	0.762	0.68
291_L	403_R	0.762	0.68
52_T	55_N	0.761	0.68
283_Y	287_K	0.757	0.68
616_N	627_T	0.754	0.68
206_A	216_M	0.753	0.67
443_N	446_Q	0.752	0.67
78_A	198_F	0.751	0.67
411_V	521_G	0.749	0.67
17_F	20_G	0.748	0.67
161_E	165_A	0.746	0.67
160_L	164_D	0.745	0.67
9_F	34_L	0.745	0.67
30_I	33_G	0.745	0.67
150_R	176_E	0.744	0.67
40_A	47_E	0.743	0.66
76_H	98_G	0.742	0.66
633_F	637_A	0.740	0.66
92_D	111_M	0.740	0.66
17_F	54_I	0.740	0.66
84_Q	179_E	0.739	0.66
253_L	597_Q	0.738	0.66
550_F	578_V	0.738	0.66
130_I	133_A	0.736	0.66
294_E	357_I	0.736	0.66
302_G	332_V	0.735	0.66
98_G	186_G	0.733	0.65
601_Y	633_F	0.733	0.65
98_G	107_Y	0.732	0.65
113_E	119_D	0.731	0.65
96_G	217_L	0.730	0.65
267_P	382_G	0.724	0.64
249_L	598_K	0.724	0.64
237_M	482_I	0.724	0.64
119_D	122_K	0.724	0.64
71_L	223_T	0.721	0.64
386_N	487_T	0.720	0.64
67_S	70_G	0.720	0.64
145_E	168_E	0.719	0.64
521_G	525_T	0.718	0.64
147_A	172_V	0.718	0.64
567_V	571_L	0.717	0.64
82_L	86_I	0.715	0.63
34_L	64_T	0.713	0.63
290_S	410_D	0.713	0.63
277_R	384_T	0.712	0.63
349_I	506_I	0.711	0.63
346_K	503_L	0.710	0.63
543_T	633_F	0.709	0.63
159_K	188_H	0.709	0.63
408_I	417_L	0.708	0.63
78_A	81_L	0.707	0.63
321_F	368_Y	0.707	0.63
86_I	115_I	0.706	0.62
362_L	521_G	0.702	0.62
133_A	192_T	0.702	0.62
480_T	486_E	0.702	0.62
233_E	237_M	0.702	0.62
128_K	132_N	0.701	0.62
96_G	162_L	0.701	0.62
543_T	576_L	0.701	0.62
66_G	230_D	0.701	0.62
7_I	17_F	0.701	0.62
126_E	133_A	0.699	0.62
287_K	414_D	0.696	0.61
318_E	434_K	0.696	0.61
34_L	38_S	0.694	0.61
630_L	634_V	0.693	0.61
30_I	35_K	0.693	0.61
365_M	404_T	0.693	0.61
99_P	107_Y	0.691	0.61
266_L	302_G	0.690	0.61
576_L	634_V	0.689	0.61
144_R	172_V	0.689	0.61
180_F	183_L	0.688	0.60
32_P	35_K	0.687	0.60
175_Y	187_V	0.687	0.60
115_I	156_D	0.686	0.60
579_E	599_I	0.685	0.60
425_S	463_A	0.684	0.60
65_E	75_R	0.684	0.60
554_P	561_L	0.683	0.60
110_E	157_D	0.683	0.60
555_V	560_H	0.681	0.60
250_G	256_F	0.680	0.60
496_L	499_E	0.680	0.60
63_I	69_E	0.680	0.60
182_D	188_H	0.680	0.60
37_K	64_T	0.680	0.60
83_A	107_Y	0.679	0.59
554_P	587_I	0.678	0.59
471_G	495_F	0.678	0.59
625_S	628_I	0.677	0.59
571_L	630_L	0.676	0.59
41_G	60_V	0.676	0.59
144_R	170_E	0.675	0.59
423_R	485_E	0.675	0.59
404_T	491_V	0.674	0.59
427_R	446_Q	0.673	0.59
304_K	322_P	0.671	0.59
55_N	58_G	0.671	0.59
142_V	148_K	0.669	0.58
39_L	65_E	0.669	0.58
103_N	223_T	0.668	0.58
399_D	402_I	0.668	0.58
358_R	403_R	0.666	0.58
98_G	188_H	0.666	0.58
322_P	332_V	0.666	0.58
150_R	174_I	0.663	0.58
365_M	384_T	0.663	0.58
260_Q	270_L	0.661	0.57
98_G	182_D	0.660	0.57
307_Y	467_A	0.660	0.57
409_Q	420_Y	0.659	0.57
295_H	412_Y	0.659	0.57
441_M	499_E	0.658	0.57
271_P	359_I	0.658	0.57
400_E	403_R	0.658	0.57
288_E	523_V	0.658	0.57
101_I	221_Y	0.654	0.57
293_Y	404_T	0.654	0.57
313_W	412_Y	0.653	0.56
157_D	215_Q	0.652	0.56
140_K	181_F	0.652	0.56
408_I	476_V	0.652	0.56
161_E	208_W	0.651	0.56
571_L	576_L	0.650	0.56
554_P	605_V	0.650	0.56
139_R	175_Y	0.649	0.56
426_Y	466_E	0.648	0.56
316_Y	319_G	0.647	0.56
436_F	500_R	0.647	0.56
158_L	216_M	0.646	0.56
556_S	607_D	0.645	0.56
292_G	572_Q	0.643	0.55
445_A	495_F	0.643	0.55
257_A	260_Q	0.642	0.55
212_S	216_M	0.642	0.55
31_S	35_K	0.640	0.55
84_Q	137_I	0.639	0.55
463_A	477_Q	0.636	0.55
386_N	532_F	0.636	0.55
101_I	209_R	0.636	0.55
462_E	467_A	0.635	0.54
287_K	407_L	0.635	0.54
97_V	106_Y	0.635	0.54
144_R	169_G	0.635	0.54
162_L	165_A	0.634	0.54
200_L	222_G	0.634	0.54
47_E	73_I	0.633	0.54
614_A	627_T	0.631	0.54
65_E	70_G	0.631	0.54
300_V	382_G	0.631	0.54
232_E	236_R	0.631	0.54
491_V	518_I	0.631	0.54
76_H	107_Y	0.630	0.54
101_I	162_L	0.630	0.54
115_I	218_Q	0.629	0.54
84_Q	130_I	0.628	0.54
7_I	21_T	0.628	0.54
316_Y	475_D	0.628	0.54
200_L	220_V	0.627	0.53
24_E	50_L	0.627	0.53
107_Y	188_H	0.626	0.53
386_N	484_K	0.625	0.53
365_M	378_Q	0.625	0.53
78_A	195_I	0.625	0.53
9_F	35_K	0.624	0.53
54_I	60_V	0.624	0.53
74_M	223_T	0.624	0.53
345_Y	517_V	0.622	0.53
131_V	193_G	0.622	0.53
278_R	295_H	0.622	0.53
286_D	575_G	0.622	0.53
404_T	408_I	0.622	0.53
595_Q	621_G	0.621	0.53
81_L	197_E	0.621	0.53
532_F	536_E	0.621	0.53
341_H	495_F	0.619	0.53
102_E	479_K	0.619	0.53
9_F	12_G	0.618	0.52
385_L	525_T	0.618	0.52
38_S	64_T	0.618	0.52
284_I	523_V	0.618	0.52
425_S	497_L	0.617	0.52
281_E	341_H	0.616	0.52
366_H	412_Y	0.615	0.52
467_A	488_L	0.615	0.52
99_P	159_K	0.615	0.52
242_K	248_K	0.614	0.52
324_M	330_T	0.613	0.52
95_F	151_F	0.613	0.52
426_Y	453_M	0.613	0.52
530_V	534_I	0.612	0.52
121_P	125_K	0.612	0.52
498_P	517_V	0.612	0.52
49_D	187_V	0.611	0.52
462_E	466_E	0.610	0.51
73_I	77_S	0.610	0.51
333_L	481_A	0.609	0.51
364_T	384_T	0.608	0.51
142_V	146_E	0.608	0.51
567_V	570_R	0.607	0.51
122_K	125_K	0.607	0.51
531_A	534_I	0.606	0.51
125_K	229_A	0.604	0.51
556_S	584_D	0.604	0.51
425_S	477_Q	0.603	0.51
476_V	489_S	0.602	0.51
142_V	147_A	0.601	0.50
80_H	107_Y	0.600	0.50
253_L	541_L	0.598	0.50
131_V	198_F	0.598	0.50
254_K	272_K	0.598	0.50
323_P	368_Y	0.597	0.50
32_P	37_K	0.597	0.50
433_E	465_G	0.596	0.50
140_K	150_R	0.596	0.50
548_V	578_V	0.596	0.50
315_H	496_L	0.595	0.50
20_G	55_N	0.595	0.50
278_R	289_I	0.594	0.50
145_E	148_K	0.594	0.50
260_Q	303_S	0.594	0.50
165_A	169_G	0.594	0.50
601_Y	619_K	0.594	0.50
604_V	627_T	0.592	0.49
82_L	220_V	0.591	0.49
98_G	184_C	0.591	0.49
332_V	340_H	0.590	0.49
615_V	633_F	0.589	0.49
9_F	20_G	0.588	0.49
428_D	488_L	0.586	0.49
21_T	29_S	0.585	0.49
567_V	574_E	0.584	0.48
288_E	292_G	0.583	0.48
563_Y	614_A	0.582	0.48
345_Y	350_H	0.582	0.48
89_I	126_E	0.582	0.48
583_R	586_K	0.582	0.48
566_K	610_A	0.581	0.48
76_H	159_K	0.581	0.48
125_K	129_K	0.580	0.48
395_D	444_K	0.579	0.48
197_E	228_K	0.579	0.48
523_V	526_M	0.579	0.48
253_L	599_I	0.578	0.48
275_T	278_R	0.578	0.48
26_I	29_S	0.577	0.48
128_K	228_K	0.576	0.48
440_E	443_N	0.574	0.47
594_A	599_I	0.574	0.47
21_T	53_P	0.574	0.47
97_V	185_R	0.573	0.47
232_E	623_Q	0.573	0.47
80_H	186_G	0.572	0.47
620_Y	626_E	0.572	0.47
635_K	638_V	0.571	0.47
73_I	190_P	0.571	0.47
288_E	365_M	0.570	0.47
168_E	172_V	0.568	0.47
80_H	159_K	0.567	0.46
551_Q	605_V	0.567	0.46
53_P	56_E	0.567	0.46
159_K	184_C	0.566	0.46
75_R	198_F	0.564	0.46
295_H	362_L	0.564	0.46
309_T	497_L	0.563	0.46
48_I	58_G	0.562	0.46
161_E	166_I	0.561	0.46
625_S	636_K	0.561	0.46
278_R	285_V	0.561	0.46
551_Q	599_I	0.561	0.46
110_E	216_M	0.560	0.46
366_H	382_G	0.560	0.46
233_E	483_G	0.560	0.46
240_E	244_R	0.559	0.46
595_Q	618_R	0.559	0.46
98_G	159_K	0.559	0.46
117_P	218_Q	0.559	0.46
275_T	289_I	0.559	0.46
15_K	34_L	0.559	0.46
197_E	231_L	0.557	0.45
15_K	26_I	0.555	0.45
266_L	300_V	0.555	0.45
619_K	626_E	0.555	0.45
237_M	483_G	0.555	0.45
322_P	497_L	0.554	0.45
605_V	615_V	0.554	0.45
313_W	317_Q	0.553	0.45
385_L	487_T	0.552	0.45
240_E	538_K	0.552	0.45
78_A	223_T	0.552	0.45
90_Y	119_D	0.552	0.45
99_P	186_G	0.551	0.45
423_R	461_Y	0.551	0.45
95_F	180_F	0.551	0.45
619_K	640_E	0.551	0.45
24_E	51_R	0.550	0.44
375_S	378_Q	0.550	0.44
493_L	518_I	0.549	0.44
9_F	21_T	0.549	0.44
622_E	626_E	0.549	0.44
9_F	33_G	0.549	0.44
586_K	592_R	0.549	0.44
136_P	192_T	0.549	0.44
357_I	393_R	0.548	0.44
572_Q	578_V	0.548	0.44
145_E	169_G	0.547	0.44
448_M	452_A	0.547	0.44
176_E	180_F	0.546	0.44
140_K	143_S	0.546	0.44
45_G	61_E	0.546	0.44
263_G	300_V	0.545	0.44
96_G	161_E	0.545	0.44
388_A	497_L	0.545	0.44
13_A	30_I	0.544	0.44
93_V	115_I	0.544	0.44
616_N	625_S	0.543	0.44
304_K	332_V	0.543	0.44
397_I	401_F	0.543	0.44
487_T	525_T	0.543	0.44
344_I	495_F	0.542	0.44
295_H	489_S	0.541	0.43
288_E	386_N	0.541	0.43
308_E	330_T	0.540	0.43
284_I	365_M	0.539	0.43
365_M	526_M	0.539	0.43
393_R	505_Y	0.539	0.43
90_Y	122_K	0.537	0.43
211_D	215_Q	0.537	0.43
487_T	532_F	0.537	0.43
293_Y	520_R	0.537	0.43
23_T	53_P	0.537	0.43
301_L	323_P	0.537	0.43
13_A	29_S	0.536	0.43
46_K	149_A	0.536	0.43
148_K	166_I	0.536	0.43
13_A	34_L	0.536	0.43
332_V	412_Y	0.535	0.43
412_Y	478_V	0.535	0.43
27_A	41_G	0.534	0.43
277_R	365_M	0.534	0.43
397_I	448_M	0.533	0.43
212_S	373_A	0.533	0.43
12_G	34_L	0.533	0.43
297_Y	364_T	0.533	0.43
441_M	444_K	0.532	0.42
281_E	526_M	0.532	0.42
133_A	178_G	0.532	0.42
270_L	347_Q	0.532	0.42
484_K	487_T	0.531	0.42
29_S	32_P	0.531	0.42
84_Q	192_T	0.530	0.42
365_M	501_F	0.530	0.42
65_E	189_V	0.530	0.42
71_L	230_D	0.528	0.42
453_M	460_Y	0.528	0.42
480_T	532_F	0.528	0.42
394_P	513_H	0.528	0.42
550_F	605_V	0.527	0.42
68_E	72_Q	0.526	0.42
84_Q	88_R	0.525	0.42
188_H	221_Y	0.525	0.42
450_K	464_E	0.525	0.42
7_I	54_I	0.523	0.41
405_V	478_V	0.521	0.41
237_M	479_K	0.521	0.41
426_Y	446_Q	0.520	0.41
284_I	360_A	0.520	0.41
411_V	522_V	0.520	0.41
478_V	485_E	0.519	0.41
408_I	522_V	0.519	0.41
87_K	137_I	0.518	0.41
415_F	529_F	0.518	0.41
30_I	62_I	0.518	0.41
505_Y	513_H	0.516	0.41
417_L	437_D	0.516	0.41
289_I	295_H	0.515	0.40
257_A	268_L	0.515	0.40
148_K	165_A	0.515	0.40
244_R	538_K	0.515	0.40
49_D	52_T	0.514	0.40
543_T	603_L	0.514	0.40
410_D	414_D	0.512	0.40
574_E	635_K	0.511	0.40
107_Y	184_C	0.509	0.40
486_E	489_S	0.509	0.40
550_F	633_F	0.509	0.40
402_I	406_R	0.508	0.40
301_L	331_L	0.507	0.40
288_E	388_A	0.507	0.40
405_V	424_L	0.506	0.39
552_V	615_V	0.506	0.39
631_D	634_V	0.506	0.39
421_T	477_Q	0.506	0.39
101_I	185_R	0.506	0.39
174_I	180_F	0.505	0.39
288_E	521_G	0.505	0.39
189_V	197_E	0.505	0.39
546_A	599_I	0.505	0.39
254_K	350_H	0.504	0.39
71_L	224_A	0.504	0.39
437_D	480_T	0.504	0.39
285_V	362_L	0.503	0.39
302_G	478_V	0.503	0.39
319_G	370_M	0.503	0.39
319_G	323_P	0.502	0.39
281_E	362_L	0.500	0.39
298_T	359_I	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qf6A	1	0.9829	100	0.356	Contact Map
1nyrA	2	0.9953	100	0.37	Contact Map
3uh0A	2	0.6159	100	0.663	Contact Map
1evlA	2	0.6112	100	0.665	Contact Map
4hwtA	2	0.6096	100	0.666	Contact Map
3a32A	2	0.6174	100	0.674	Contact Map
3qneA	2	0.6656	100	0.722	Contact Map
1atiA	2	0.5661	100	0.726	Contact Map
2zt5A	2	0.5537	100	0.727	Contact Map
2j3lA	2	0.6252	100	0.727	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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