GREMLIN Database
OTC - Ornithine carbamoyltransferase
UniProt: P18186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (293)
Sequences: 7172 (3693)
Seq/√Len: 215.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_A282_E4.0871.00
157_K181_D3.9721.00
157_K183_S3.4131.00
42_P45_H3.3851.00
159_A224_A3.1911.00
267_F279_V3.1191.00
218_I260_H2.9981.00
36_K148_E2.8301.00
146_I226_V2.7831.00
31_E307_K2.7231.00
99_S123_D2.7131.00
225_D262_K2.6071.00
149_I290_A2.5791.00
100_G293_Q2.5771.00
266_T290_A2.5451.00
216_D219_E2.5231.00
33_G147_K2.5121.00
50_A102_V2.3131.00
16_T134_Y2.2931.00
30_A147_K2.2861.00
92_A117_E2.2591.00
68_M73_G2.2001.00
268_L290_A2.1731.00
26_N147_K2.1191.00
33_G144_L2.1141.00
49_L68_M2.0671.00
104_A306_L2.0431.00
139_A174_G2.0091.00
194_D198_E2.0011.00
188_K215_D1.9451.00
191_E215_D1.9391.00
185_A220_A1.9281.00
143_L174_G1.9241.00
150_K264_D1.9211.00
258_V265_Y1.8511.00
221_V227_I1.8431.00
70_Q303_K1.8391.00
69_A74_S1.8151.00
22_E26_N1.8011.00
175_C182_I1.7931.00
255_A259_S1.7921.00
100_G296_E1.7841.00
149_I293_Q1.7811.00
274_H277_E1.7781.00
181_D212_T1.7151.00
21_S24_D1.6871.00
27_A308_A1.6641.00
214_T219_E1.6621.00
183_S214_T1.6391.00
62_V98_L1.6301.00
111_E114_K1.6131.00
137_C305_L1.6031.00
35_L307_K1.5881.00
256_A259_S1.5701.00
150_K156_V1.5581.00
106_M129_G1.5581.00
261_A265_Y1.5391.00
49_L104_A1.5351.00
31_E308_A1.5071.00
188_K191_E1.5061.00
79_S82_D1.4991.00
265_Y288_N1.4901.00
28_L308_A1.4881.00
22_E177_K1.4851.00
190_Y247_V1.4841.00
134_Y173_I1.4731.00
12_K24_D1.4631.00
54_E114_K1.4591.00
22_E154_K1.4571.00
159_A185_A1.4501.00
171_L228_Y1.4461.00
43_I307_K1.4331.00
14_L140_L1.4301.00
181_D210_S1.4271.00
226_V266_T1.4181.00
104_A310_L1.4101.00
218_I257_L1.4051.00
159_A183_S1.3951.00
32_A144_L1.3911.00
243_E247_V1.3781.00
161_I221_V1.3611.00
137_C302_Q1.3461.00
228_Y294_Q1.3441.00
186_S191_E1.3381.00
217_P257_L1.3251.00
29_L144_L1.3171.00
96_K285_D1.3141.00
223_D262_K1.3121.00
276_E281_A1.3031.00
116_E120_K1.2881.00
222_K260_H1.2751.00
254_N280_T1.2741.00
252_Q280_T1.2701.00
31_E34_E1.2661.00
227_I253_V1.2641.00
95_A118_L1.2561.00
18_K173_I1.2531.00
17_L174_G1.2491.00
229_S253_V1.2401.00
29_L147_K1.2391.00
58_T94_T1.2261.00
96_K292_F1.2261.00
144_L301_V1.2211.00
214_T220_A1.2161.00
49_L106_M1.2151.00
61_R65_E1.2141.00
26_N178_M1.2111.00
14_L305_L1.2041.00
58_T88_G1.1971.00
183_S212_T1.1931.00
300_H303_K1.1811.00
258_V267_F1.1811.00
34_E38_N1.1791.00
58_T84_Q1.1631.00
175_C180_C1.1611.00
105_I124_I1.1541.00
13_D119_A1.1531.00
273_A284_I1.1421.00
221_V257_L1.1411.00
152_K156_V1.1371.00
92_A121_E1.1321.00
69_A75_A1.1221.00
258_V288_N1.1051.00
140_L305_L1.1011.00
197_A213_L1.0971.00
105_I118_L1.0921.00
16_T19_D1.0791.00
156_V226_V1.0761.00
67_G306_L1.0691.00
33_G148_E1.0671.00
68_M75_A1.0671.00
275_R285_D1.0661.00
296_E300_H1.0541.00
242_Q246_A1.0521.00
36_K297_N1.0521.00
97_V295_A1.0471.00
14_L20_L1.0471.00
253_V267_F1.0471.00
56_S86_G1.0451.00
113_E117_E1.0411.00
29_L33_G1.0401.00
150_K225_D1.0391.00
150_K266_T1.0371.00
26_N30_A1.0351.00
39_K70_Q1.0221.00
172_M184_I1.0221.00
286_G289_S1.0171.00
185_A214_T1.0131.00
158_V171_L0.9991.00
109_T131_T0.9981.00
139_A171_L0.9771.00
25_I178_M0.9721.00
127_I305_L0.9691.00
16_T173_I0.9691.00
70_Q299_L0.9681.00
158_V175_C0.9661.00
65_E77_F0.9631.00
99_S124_I0.9621.00
49_L73_G0.9611.00
139_A167_V0.9531.00
143_L178_M0.9531.00
29_L301_V0.9461.00
284_I291_V0.9451.00
36_K144_L0.9451.00
215_D251_Y0.9421.00
307_K311_Y0.9381.00
25_I177_K0.9370.99
148_E297_N0.9370.99
62_V78_L0.9360.99
96_K121_E0.9360.99
169_H196_A0.9320.99
146_I156_V0.9250.99
84_Q94_T0.9220.99
192_V213_L0.9190.99
104_A127_I0.9180.99
38_N41_Q0.9010.99
247_V250_P0.9000.99
152_K155_G0.8990.99
13_D99_S0.8990.99
92_A96_K0.8940.99
42_P72_G0.8940.99
243_E246_A0.8930.99
134_Y170_S0.8900.99
48_T74_S0.8900.99
92_A285_D0.8890.99
107_I118_L0.8870.99
185_A224_A0.8870.99
65_E69_A0.8850.99
150_K290_A0.8840.99
256_A260_H0.8790.99
112_H116_E0.8720.99
68_M306_L0.8710.99
17_L139_A0.8700.99
157_K223_D0.8670.99
48_T70_Q0.8660.99
255_A286_G0.8650.99
242_Q245_L0.8640.99
218_I222_K0.8610.99
219_E222_K0.8600.99
183_S224_A0.8540.99
84_Q87_R0.8530.99
144_L148_E0.8510.99
30_A34_E0.8490.99
293_Q296_E0.8470.99
65_E75_A0.8450.99
140_L301_V0.8420.99
133_K193_L0.8420.99
161_I227_I0.8370.99
115_V131_T0.8360.99
275_R284_I0.8350.99
13_D122_A0.8290.99
185_A217_P0.8240.99
84_Q88_G0.8180.99
281_A285_D0.8160.99
153_L178_M0.8150.99
64_F137_C0.8140.99
183_S223_D0.8110.99
258_V283_I0.8020.98
172_M182_I0.8010.98
146_I153_L0.7990.98
95_A122_A0.7980.98
27_A31_E0.7970.98
107_I114_K0.7960.98
11_G309_I0.7950.98
283_I286_G0.7940.98
117_E121_E0.7940.98
161_I257_L0.7910.98
116_E119_A0.7820.98
33_G37_Q0.7800.98
145_T290_A0.7800.98
212_T219_E0.7710.98
47_K103_D0.7680.98
245_L277_E0.7660.98
34_E37_Q0.7650.98
63_S101_Y0.7640.98
54_E85_L0.7620.98
157_K224_A0.7590.98
218_I256_A0.7550.98
220_A224_A0.7550.98
25_I174_G0.7550.98
96_K99_S0.7540.98
92_A281_A0.7530.98
168_A184_I0.7520.98
28_L301_V0.7510.98
48_T66_A0.7510.98
281_A284_I0.7470.98
32_A304_A0.7460.97
17_L25_I0.7440.97
15_L119_A0.7440.97
304_A308_A0.7440.97
254_N257_L0.7390.97
145_T297_N0.7360.97
20_L28_L0.7360.97
241_E245_L0.7320.97
151_G155_G0.7280.97
88_G94_T0.7230.97
233_T241_E0.7220.97
146_I150_K0.7210.97
171_L175_C0.7200.97
258_V261_A0.7190.97
109_T114_K0.7170.97
172_M192_V0.7140.97
290_A293_Q0.7140.97
150_K226_V0.7130.97
146_I175_C0.7120.97
102_V124_I0.7070.97
197_A211_V0.7050.96
253_V279_V0.7040.96
63_S302_Q0.7040.96
22_E207_S0.7030.96
67_G302_Q0.7010.96
14_L309_I0.7000.96
50_A105_I0.6990.96
249_A252_Q0.6980.96
23_E26_N0.6950.96
28_L304_A0.6940.96
240_E244_R0.6930.96
31_E35_L0.6930.96
44_F104_A0.6930.96
17_L20_L0.6900.96
255_A280_T0.6870.96
149_I266_T0.6840.96
12_K308_A0.6840.96
113_E130_L0.6830.96
113_E116_E0.6830.96
221_V260_H0.6830.96
191_E213_L0.6810.96
164_G186_S0.6800.96
227_I265_Y0.6800.96
146_I266_T0.6780.96
259_S288_N0.6780.96
91_V114_K0.6770.96
161_I217_P0.6750.96
257_L260_H0.6740.95
246_A249_A0.6730.95
191_E194_D0.6710.95
275_R281_A0.6690.95
117_E120_K0.6680.95
58_T87_R0.6670.95
42_P46_G0.6670.95
258_V279_V0.6650.95
35_L43_I0.6650.95
267_F283_I0.6650.95
99_S122_A0.6590.95
44_F73_G0.6590.95
104_A309_I0.6580.95
32_A301_V0.6580.95
49_L306_L0.6560.95
231_V235_M0.6520.95
273_A279_V0.6510.95
158_V228_Y0.6500.94
143_L147_K0.6500.94
217_P221_V0.6500.94
83_L88_G0.6490.94
111_E132_D0.6480.94
51_M68_M0.6450.94
51_M75_A0.6440.94
25_I140_L0.6440.94
112_H132_D0.6390.94
231_V274_H0.6310.94
51_M77_F0.6310.94
160_Y165_N0.6290.93
286_G291_V0.6290.93
11_G308_A0.6280.93
83_L87_R0.6270.93
56_S84_Q0.6180.93
161_I229_S0.6180.93
239_A243_E0.6160.93
48_T69_A0.6150.93
228_Y231_V0.6150.93
66_A76_L0.6140.93
146_I158_V0.6140.93
28_L305_L0.6130.93
261_A288_N0.6120.93
90_T285_D0.6120.93
127_I309_I0.6090.92
228_Y268_L0.6080.92
139_A294_Q0.6080.92
159_A220_A0.6070.92
17_L134_Y0.6060.92
248_F280_T0.6010.92
70_Q103_D0.6010.92
64_F302_Q0.5990.92
63_S137_C0.5980.92
105_I122_A0.5940.91
58_T83_L0.5920.91
255_A288_N0.5910.91
134_Y196_A0.5900.91
56_S88_G0.5880.91
127_I306_L0.5870.91
176_A182_I0.5870.91
192_V197_A0.5810.91
15_L116_E0.5800.90
159_A227_I0.5780.90
95_A105_I0.5770.90
147_K152_K0.5760.90
227_I258_V0.5750.90
66_A299_L0.5750.90
159_A214_T0.5750.90
64_F129_G0.5750.90
94_T98_L0.5740.90
139_A143_L0.5710.90
56_S82_D0.5700.90
143_L153_L0.5680.90
113_E133_K0.5650.89
181_D209_S0.5650.89
35_L38_N0.5650.89
156_V225_D0.5650.89
30_A33_G0.5640.89
186_S215_D0.5640.89
64_F106_M0.5630.89
173_I196_A0.5630.89
148_E293_Q0.5620.89
284_I289_S0.5610.89
186_S192_V0.5600.89
158_V180_C0.5600.89
189_G247_V0.5590.89
174_G178_M0.5590.89
66_A70_Q0.5590.89
226_V268_L0.5580.89
23_E27_A0.5580.89
54_E109_T0.5570.89
284_I292_F0.5550.88
19_D177_K0.5540.88
29_L32_A0.5530.88
41_Q45_H0.5520.88
63_S97_V0.5490.88
130_L133_K0.5490.88
57_S60_T0.5480.88
177_K207_S0.5470.88
53_F57_S0.5470.88
253_V258_V0.5450.88
176_A209_S0.5440.87
167_V228_Y0.5440.87
89_E93_D0.5440.87
36_K300_H0.5430.87
91_V107_I0.5420.87
167_V171_L0.5410.87
24_D27_A0.5410.87
55_K236_G0.5400.87
14_L25_I0.5370.87
266_T288_N0.5360.87
176_A207_S0.5360.87
280_T283_I0.5340.86
57_S61_R0.5310.86
267_F289_S0.5300.86
55_K235_M0.5290.86
13_D123_D0.5290.86
185_A221_V0.5270.86
153_L180_C0.5260.86
253_V257_L0.5260.86
27_A30_A0.5250.86
195_E198_E0.5250.86
97_V100_G0.5250.86
237_Q240_E0.5200.85
78_L83_L0.5180.85
215_D219_E0.5180.85
160_Y228_Y0.5170.85
107_I131_T0.5160.85
97_V101_Y0.5140.84
53_F60_T0.5140.84
130_L235_M0.5140.84
286_G290_A0.5130.84
260_H263_P0.5120.84
245_L249_A0.5120.84
189_G246_A0.5100.84
31_E304_A0.5100.84
271_L292_F0.5090.84
97_V292_F0.5090.84
24_D308_A0.5090.84
18_K134_Y0.5080.84
214_T217_P0.5080.84
16_T116_E0.5060.83
25_I29_L0.5060.83
87_R274_H0.5030.83
18_K177_K0.5030.83
130_L166_N0.5020.83
56_S77_F0.5020.83
190_Y248_F0.5010.83
234_S244_R0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nf2A 3 0.9624 100 0.039 Contact Map
3gd5A 4 0.8934 100 0.051 Contact Map
1pvvA 6 0.9687 100 0.053 Contact Map
4oh7A 3 0.9342 100 0.057 Contact Map
2i6uA 3 0.953 100 0.059 Contact Map
3tpfA 3 0.953 100 0.062 Contact Map
1vlvA 6 0.9436 100 0.064 Contact Map
4a8tA 3 0.9655 100 0.07 Contact Map
4amuA 6 0.9718 100 0.07 Contact Map
1duvG 3 0.9592 100 0.07 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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