GREMLIN Database
PGCA - Phosphoglucomutase
UniProt: P18159 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 581 (461)
Sequences: 8588 (5438)
Seq/√Len: 253.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
386_K389_E3.8091.00
290_L294_Q3.6191.00
241_A306_A3.4461.00
368_S450_E3.3791.00
233_V296_A3.3781.00
70_A112_Q3.2441.00
96_H269_N3.2031.00
438_M446_N3.1971.00
289_K293_E3.1691.00
316_D441_Y3.1411.00
247_R251_A2.8991.00
216_T251_A2.8151.00
87_G115_Q2.7981.00
134_Q210_V2.6621.00
74_A176_Q2.5801.00
209_K213_E2.5781.00
110_A200_I2.5221.00
62_I100_E2.4841.00
351_V372_D2.4631.00
78_K176_Q2.4271.00
231_K255_K2.3911.00
105_A141_I2.3511.00
115_Q201_K2.2961.00
88_V109_L2.2801.00
290_L293_E2.2791.00
69_S105_A2.2691.00
72_F139_G2.2481.00
288_I292_E2.2251.00
109_L141_I2.2171.00
89_V137_A2.2121.00
90_I106_A2.1971.00
317_Q321_T2.1501.00
285_E289_K2.1191.00
311_I426_A2.1081.00
73_A109_L2.1061.00
99_P103_M2.0861.00
258_T294_Q2.0711.00
334_H338_S2.0681.00
74_A112_Q2.0651.00
231_K258_T2.0361.00
363_R375_D2.0271.00
477_A481_Q2.0161.00
474_A478_S2.0051.00
331_L429_V1.9791.00
92_Y102_A1.9761.00
374_I386_K1.9651.00
321_T445_I1.9581.00
130_F134_Q1.9541.00
102_A118_V1.9431.00
438_M442_E1.9401.00
364_A367_S1.9401.00
52_E151_E1.9231.00
73_A112_Q1.9231.00
562_A566_E1.9121.00
175_E179_A1.9071.00
165_L173_V1.8921.00
247_R250_E1.8721.00
174_I178_N1.8591.00
176_Q179_A1.8591.00
209_K247_R1.8531.00
70_A74_A1.8321.00
477_A480_R1.8311.00
66_R104_E1.8261.00
92_Y98_S1.8251.00
172_I175_E1.8181.00
363_R367_S1.8151.00
302_T423_A1.7781.00
91_A128_L1.7731.00
472_I476_L1.7691.00
334_H369_F1.7671.00
473_E477_A1.7351.00
213_E251_A1.7331.00
337_L371_L1.7191.00
212_T248_G1.7101.00
52_E152_Y1.6691.00
491_Q527_E1.6691.00
268_S271_S1.6501.00
66_R107_K1.6331.00
566_E570_K1.6051.00
78_K172_I1.5941.00
439_S442_E1.5701.00
65_V155_Y1.5491.00
259_V264_E1.5431.00
66_R111_T1.5431.00
246_R250_E1.5351.00
258_T290_L1.5291.00
65_V101_F1.5271.00
53_I97_K1.5271.00
96_H268_S1.5261.00
69_S155_Y1.5211.00
472_I479_F1.5181.00
233_V290_L1.5101.00
478_S482_N1.5071.00
334_H443_A1.5061.00
490_K528_D1.4981.00
130_F214_K1.4921.00
486_K489_G1.4921.00
383_I401_G1.4881.00
300_I423_A1.4831.00
236_P264_E1.4731.00
361_I447_L1.4701.00
552_S558_E1.4651.00
291_G299_L1.4601.00
316_D439_S1.4521.00
554_L559_K1.4361.00
214_K217_S1.4351.00
476_L480_R1.4271.00
426_A440_L1.4241.00
473_E476_L1.4231.00
372_D396_Y1.4231.00
315_N321_T1.4201.00
94_S122_L1.4141.00
87_G138_Y1.3991.00
263_Q286_Y1.3951.00
385_E389_E1.3941.00
559_K563_V1.3931.00
89_V131_A1.3911.00
366_A371_L1.3831.00
334_H446_N1.3821.00
474_A477_A1.3821.00
130_F210_V1.3801.00
329_G402_Y1.3761.00
558_E562_A1.3731.00
86_R138_Y1.3711.00
109_L114_I1.3691.00
209_K251_A1.3691.00
87_G117_Y1.3681.00
561_L565_S1.3611.00
351_V374_I1.3541.00
255_K258_T1.3451.00
289_K292_E1.3401.00
252_L424_L1.3371.00
441_Y445_I1.3271.00
72_F157_V1.3121.00
330_A361_I1.3091.00
471_Q474_A1.3041.00
232_V298_I1.3031.00
79_Q172_I1.2991.00
73_A114_I1.2981.00
72_F141_I1.2971.00
106_A200_I1.2921.00
90_I105_A1.2901.00
69_S109_L1.2891.00
92_Y118_V1.2861.00
551_G554_L1.2841.00
175_E178_N1.2711.00
470_E473_E1.2701.00
208_D244_P1.2691.00
246_R264_E1.2601.00
141_I155_Y1.2301.00
231_K294_Q1.2231.00
286_Y289_K1.2211.00
230_V297_D1.2201.00
102_A106_A1.2171.00
317_Q441_Y1.2121.00
443_A446_N1.2111.00
91_A142_V1.2091.00
213_E217_S1.2091.00
77_S114_I1.2071.00
171_D174_I1.2051.00
210_V213_E1.2051.00
376_T386_K1.1931.00
354_K375_D1.1931.00
316_D442_E1.1911.00
169_E172_I1.1861.00
562_A565_S1.1851.00
249_L257_V1.1851.00
128_L140_G1.1841.00
208_D247_R1.1801.00
558_E561_L1.1771.00
174_I177_V1.1751.00
223_E226_E1.1641.00
120_D204_G1.1621.00
524_Y532_F1.1551.00
132_V140_G1.1531.00
242_N264_E1.1501.00
438_M443_A1.1491.00
172_I176_Q1.1491.00
62_I104_E1.1471.00
364_A550_K1.1421.00
52_E55_A1.1411.00
94_S266_P1.1411.00
565_S569_M1.1321.00
105_A143_V1.1311.00
171_D175_E1.1311.00
315_N441_Y1.1271.00
249_L423_A1.1261.00
165_L169_E1.1221.00
285_E288_I1.1191.00
106_A110_A1.1151.00
234_F241_A1.1141.00
109_L116_T1.1131.00
75_Y169_E1.1041.00
365_V369_F1.1021.00
330_A365_V1.1011.00
287_A312_A1.0981.00
138_Y160_D1.0961.00
242_N246_R1.0921.00
212_T244_P1.0911.00
97_K100_E1.0911.00
335_Y432_F1.0891.00
135_L207_I1.0891.00
71_G177_V1.0871.00
134_Q214_K1.0871.00
472_I475_I1.0851.00
287_A299_L1.0811.00
354_K373_T1.0791.00
339_E432_F1.0771.00
103_M107_K1.0731.00
180_I183_E1.0721.00
213_E216_T1.0721.00
442_E445_I1.0701.00
49_M157_V1.0701.00
230_V430_C1.0651.00
547_F561_L1.0631.00
86_R114_I1.0601.00
206_D209_K1.0541.00
106_A118_V1.0491.00
250_E259_V1.0441.00
119_F123_R1.0431.00
523_K531_W1.0431.00
234_F302_T1.0421.00
212_T251_A1.0381.00
486_K491_Q1.0381.00
123_R127_E1.0371.00
232_V427_V1.0311.00
364_A454_Y1.0291.00
476_L479_F1.0281.00
566_E569_M1.0271.00
400_F408_Y1.0231.00
338_S436_Q1.0231.00
124_P127_E1.0221.00
104_E108_T1.0221.00
366_A373_T1.0171.00
91_A123_R1.0161.00
333_L352_V1.0151.00
428_E432_F1.0111.00
475_I478_S1.0111.00
207_I210_V1.0101.00
75_Y172_I1.0051.00
298_I430_C1.0011.00
470_E474_A1.0011.00
70_A111_T0.9991.00
354_K358_T0.9961.00
215_L424_L0.9941.00
107_K111_T0.9911.00
92_Y99_P0.9891.00
336_L425_L0.9881.00
80_G86_R0.9811.00
134_Q207_I0.9811.00
351_V396_Y0.9811.00
386_K396_Y0.9801.00
234_F249_L0.9751.00
368_S451_Y0.9711.00
298_I427_V0.9661.00
567_D570_K0.9651.00
215_L421_Q0.9651.00
480_R518_K0.9651.00
81_E138_Y0.9651.00
85_K115_Q0.9641.00
75_Y176_Q0.9631.00
557_S561_L0.9621.00
473_E479_F0.9611.00
479_F482_N0.9611.00
353_L401_G0.9601.00
205_E209_K0.9581.00
122_L240_T0.9511.00
328_T426_A0.9511.00
263_Q272_T0.9451.00
334_H447_L0.9441.00
98_S153_N0.9441.00
233_V260_V0.9411.00
168_K172_I0.9371.00
258_T296_A0.9331.00
128_L142_V0.9331.00
254_Y257_V0.9331.00
64_T68_A0.9321.00
287_A301_A0.9311.00
287_A291_G0.9301.00
337_L369_F0.9291.00
456_E460_S0.9281.00
245_V420_I0.9271.00
102_A143_V0.9251.00
79_Q169_E0.9241.00
231_K297_D0.9231.00
131_A207_I0.9231.00
563_V566_E0.9221.00
350_G399_Q0.9191.00
105_A109_L0.9181.00
358_T362_G0.9171.00
235_T287_A0.9161.00
223_E227_E0.9161.00
212_T247_R0.9151.00
194_L198_G0.9141.00
267_D271_S0.9131.00
479_F534_L0.9091.00
350_G397_T0.8991.00
359_S402_Y0.8981.00
341_K350_G0.8951.00
233_V294_Q0.8951.00
300_I311_I0.8951.00
117_Y201_K0.8931.00
549_V557_S0.8921.00
69_S108_T0.8921.00
457_G565_S0.8891.00
71_G176_Q0.8861.00
475_I479_F0.8831.00
77_S86_R0.8821.00
77_S112_Q0.8811.00
200_I203_I0.8801.00
80_G138_Y0.8791.00
159_G169_E0.8781.00
330_A359_S0.8771.00
228_V255_K0.8761.00
69_S141_I0.8741.00
214_K218_I0.8731.00
216_T252_L0.8691.00
562_A569_M0.8671.00
127_E208_D0.8671.00
236_P259_V0.8600.99
517_P525_F0.8580.99
233_V258_T0.8570.99
382_F385_E0.8550.99
561_L568_V0.8540.99
563_V567_D0.8530.99
218_I425_L0.8530.99
367_S373_T0.8500.99
117_Y137_A0.8470.99
284_F312_A0.8460.99
354_K363_R0.8440.99
362_G402_Y0.8410.99
457_G558_E0.8400.99
458_L463_L0.8400.99
363_R373_T0.8380.99
89_V119_F0.8360.99
123_R142_V0.8360.99
331_L443_A0.8340.99
332_L429_V0.8330.99
104_E107_K0.8300.99
349_N371_L0.8290.99
196_E199_L0.8270.99
238_H272_T0.8270.99
389_E396_Y0.8260.99
74_A180_I0.8260.99
309_L423_A0.8240.99
230_V298_I0.8230.99
231_K295_N0.8200.99
98_S102_A0.8180.99
490_K527_E0.8170.99
458_L461_L0.8170.99
47_G355_T0.8170.99
353_L386_K0.8170.99
211_Y215_L0.8160.99
334_H450_E0.8150.99
123_R208_D0.8150.99
115_Q199_L0.8140.99
291_G312_A0.8110.99
282_A285_E0.8090.99
214_K413_F0.8070.99
173_V177_V0.8070.99
340_K350_G0.8050.99
523_K533_C0.8000.99
147_H156_K0.7980.99
300_I427_V0.7970.99
260_V263_Q0.7970.99
195_K202_I0.7930.99
286_Y290_L0.7930.99
350_G371_L0.7930.99
94_S240_T0.7920.99
166_P169_E0.7900.99
244_P420_I0.7890.99
333_L362_G0.7870.99
131_A135_L0.7870.99
479_F483_P0.7860.99
473_E480_R0.7860.99
132_V139_G0.7850.99
47_G458_L0.7830.99
340_K399_Q0.7830.99
478_S481_Q0.7820.99
150_P269_N0.7810.99
75_Y79_Q0.7780.99
338_S369_F0.7780.99
74_A77_S0.7770.99
281_H288_I0.7770.99
457_G561_L0.7760.99
91_A119_F0.7760.99
49_M68_A0.7750.99
560_R563_V0.7740.99
475_I480_R0.7740.99
88_V139_G0.7730.99
397_T411_G0.7730.99
87_G137_A0.7700.99
549_V554_L0.7690.99
117_Y205_E0.7660.99
407_G417_K0.7640.99
46_T538_G0.7630.99
457_G460_S0.7620.99
436_Q443_A0.7610.99
62_I66_R0.7570.99
335_Y339_E0.7560.99
483_P492_V0.7550.99
234_F245_V0.7530.99
89_V135_L0.7520.99
337_L352_V0.7520.99
92_Y122_L0.7520.99
332_L422_A0.7520.99
249_L254_Y0.7520.99
364_A368_S0.7500.99
55_A151_E0.7490.99
367_S372_D0.7470.99
165_L170_A0.7470.99
360_E525_F0.7450.99
212_T216_T0.7440.99
291_G296_A0.7420.98
331_L444_L0.7410.98
292_E295_N0.7400.98
119_F127_E0.7400.98
114_I138_Y0.7360.98
360_E548_A0.7360.98
173_V176_Q0.7330.98
329_G362_G0.7330.98
118_V202_I0.7330.98
456_E459_K0.7320.98
460_S463_L0.7280.98
232_V254_Y0.7260.98
488_A492_V0.7250.98
302_T419_A0.7250.98
194_L197_K0.7250.98
408_Y422_A0.7240.98
321_T327_Q0.7230.98
76_I139_G0.7220.98
490_K526_L0.7220.98
349_N372_D0.7220.98
206_D210_V0.7190.98
472_I483_P0.7180.98
410_I425_L0.7170.98
332_L410_I0.7170.98
487_M492_V0.7160.98
461_L569_M0.7160.98
246_R249_L0.7160.98
471_Q475_I0.7160.98
167_P170_A0.7150.98
196_E200_I0.7140.98
245_V302_T0.7140.98
352_V362_G0.7120.98
444_L448_F0.7090.98
197_K200_I0.7050.98
445_I449_N0.7050.98
54_G61_N0.7040.98
166_P170_A0.7020.98
72_F88_V0.7020.98
528_D550_K0.7010.98
299_L312_A0.6990.98
225_S228_V0.6990.98
461_L565_S0.6980.98
233_V299_L0.6980.98
328_T332_L0.6970.98
465_G470_E0.6960.98
107_K110_A0.6960.98
471_Q478_S0.6950.98
241_A302_T0.6950.98
107_K200_I0.6940.98
100_E104_E0.6910.98
317_Q445_I0.6900.98
377_L382_F0.6890.98
334_H365_V0.6870.97
183_E186_I0.6820.97
115_Q198_G0.6800.97
318_G321_T0.6800.97
529_G560_R0.6790.97
96_H150_P0.6790.97
148_N539_T0.6780.97
532_F560_R0.6760.97
365_V451_Y0.6750.97
74_A179_A0.6720.97
81_E85_K0.6710.97
352_V366_A0.6710.97
430_C443_A0.6700.97
427_V430_C0.6700.97
69_S73_A0.6660.97
288_I322_V0.6640.97
66_R108_T0.6600.97
387_I398_F0.6590.97
410_I421_Q0.6580.97
354_K360_E0.6570.97
45_G48_G0.6560.97
374_I396_Y0.6560.97
157_V173_V0.6530.97
553_S559_K0.6520.97
229_D431_A0.6510.97
248_G251_A0.6480.96
470_E475_I0.6450.96
89_V128_L0.6450.96
145_A148_N0.6450.96
357_V378_T0.6430.96
453_F456_E0.6410.96
45_G538_G0.6410.96
362_G373_T0.6370.96
311_I328_T0.6350.96
182_N185_T0.6340.96
228_V297_D0.6340.96
309_L426_A0.6340.96
459_K565_S0.6330.96
328_T408_Y0.6330.96
324_T327_Q0.6320.96
209_K212_T0.6320.96
290_L296_A0.6310.96
534_L545_F0.6310.96
75_Y173_V0.6290.96
224_L227_E0.6290.96
167_P382_F0.6280.96
199_L202_I0.6270.96
170_A173_V0.6270.96
47_G164_Q0.6270.96
532_F564_L0.6260.96
177_V180_I0.6260.96
235_T301_A0.6250.96
67_K177_V0.6240.96
272_T286_Y0.6240.96
337_L341_K0.6230.96
410_I422_A0.6220.96
245_V423_A0.6220.96
243_K247_R0.6210.95
312_A322_V0.6210.95
148_N152_Y0.6180.95
245_V249_L0.6140.95
353_L376_T0.6130.95
146_S156_K0.6120.95
234_F259_V0.6120.95
67_K181_E0.6110.95
81_E86_R0.6100.95
270_F278_P0.6090.95
351_V398_F0.6090.95
564_L568_V0.6080.95
230_V427_V0.6070.95
229_D255_K0.6070.95
167_P171_D0.6060.95
148_N156_K0.6050.95
194_L199_L0.6050.95
232_V257_V0.6040.95
66_R70_A0.6040.95
90_I109_L0.6020.95
328_T406_Y0.6020.95
254_Y431_A0.6010.95
146_S307_D0.6010.95
250_E255_K0.6000.95
309_L419_A0.5990.95
110_A199_L0.5980.94
68_A177_V0.5970.94
54_G100_E0.5960.94
194_L200_I0.5960.94
476_L483_P0.5960.94
288_I312_A0.5950.94
50_R147_H0.5940.94
211_Y419_A0.5920.94
284_F288_I0.5920.94
65_V69_S0.5880.94
323_L331_L0.5860.94
300_I309_L0.5850.94
231_K296_A0.5840.94
233_V287_A0.5830.94
161_D388_K0.5830.94
470_E476_L0.5830.94
529_G550_K0.5820.94
246_R259_V0.5810.94
117_Y203_I0.5810.94
429_V436_Q0.5790.93
238_H263_Q0.5790.93
353_L383_I0.5780.93
329_G400_F0.5760.93
472_I480_R0.5740.93
236_P260_V0.5730.93
335_Y429_V0.5730.93
60_M64_T0.5720.93
352_V371_L0.5700.93
351_V397_T0.5700.93
254_Y427_V0.5690.93
281_H322_V0.5680.93
448_F453_F0.5680.93
195_K200_I0.5670.93
364_A450_E0.5670.93
214_K414_A0.5670.93
105_A155_Y0.5660.93
389_E397_T0.5660.93
171_D177_V0.5660.93
257_V260_V0.5650.93
135_L210_V0.5650.93
76_I81_E0.5640.93
473_E478_S0.5630.93
74_A78_K0.5620.92
76_I138_Y0.5620.92
208_D212_T0.5610.92
365_V368_S0.5610.92
318_G441_Y0.5600.92
561_L564_L0.5600.92
369_F451_Y0.5600.92
208_D243_K0.5590.92
60_M68_A0.5580.92
444_L447_L0.5580.92
147_H307_D0.5580.92
280_E460_S0.5580.92
106_A116_T0.5580.92
158_Y164_Q0.5570.92
67_K178_N0.5560.92
291_G295_N0.5540.92
284_F299_L0.5530.92
474_A482_N0.5530.92
353_L374_I0.5510.92
310_G406_Y0.5510.92
380_F417_K0.5500.92
127_E244_P0.5500.92
65_V104_E0.5500.92
404_E546_Y0.5490.92
305_D403_E0.5490.92
301_A312_A0.5490.92
321_T441_Y0.5480.91
534_L568_V0.5480.91
218_I421_Q0.5480.91
354_K362_G0.5460.91
132_V137_A0.5450.91
227_E431_A0.5450.91
378_T544_K0.5450.91
309_L422_A0.5450.91
356_I519_S0.5430.91
250_E253_G0.5420.91
475_I482_N0.5410.91
559_K562_A0.5410.91
335_Y428_E0.5410.91
473_E536_P0.5400.91
43_E174_I0.5400.91
298_I311_I0.5390.91
249_L427_V0.5380.91
292_E317_Q0.5370.91
86_R115_Q0.5360.91
515_D525_F0.5360.91
146_S403_E0.5340.90
65_V105_A0.5330.90
463_L472_I0.5330.90
245_V253_G0.5310.90
383_I387_I0.5300.90
332_L425_L0.5300.90
168_K171_D0.5300.90
235_T299_L0.5300.90
185_T188_V0.5290.90
404_E544_K0.5290.90
323_L328_T0.5280.90
430_C436_Q0.5270.90
211_Y418_D0.5260.90
86_R160_D0.5260.90
337_L350_G0.5260.90
63_Y67_K0.5250.90
71_G75_Y0.5240.90
457_G461_L0.5230.90
528_D554_L0.5230.90
50_R307_D0.5220.89
111_T197_K0.5220.89
44_F68_A0.5220.89
249_L253_G0.5210.89
284_F322_V0.5210.89
62_I107_K0.5210.89
472_I482_N0.5210.89
168_K385_E0.5190.89
358_T402_Y0.5180.89
110_A116_T0.5180.89
540_E544_K0.5170.89
526_L532_F0.5170.89
63_Y66_R0.5150.89
446_N449_N0.5140.89
532_F568_V0.5130.89
333_L400_F0.5130.89
443_A447_L0.5130.89
404_E407_G0.5120.89
89_V140_G0.5120.89
547_F557_S0.5120.89
195_K199_L0.5110.88
455_R558_E0.5110.88
227_E254_Y0.5100.88
357_V544_K0.5100.88
240_T306_A0.5090.88
310_G328_T0.5090.88
436_Q439_S0.5080.88
171_D178_N0.5080.88
87_G135_L0.5070.88
337_L366_A0.5060.88
405_S417_K0.5050.88
357_V417_K0.5040.88
307_D403_E0.5030.88
357_V546_Y0.5020.88
236_P302_T0.5020.88
133_R162_G0.5020.88
456_E463_L0.5010.87
236_P419_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wqaA 3 0.7831 100 0.239 Contact Map
2f7lA 4 0.7797 100 0.243 Contact Map
1tuoA 1 0.7435 100 0.244 Contact Map
3na5A 2 0.8606 100 0.247 Contact Map
2z0fA 2 0.8176 100 0.255 Contact Map
3uw2A 1 0.7728 100 0.267 Contact Map
4qg5A 1 0.8503 100 0.269 Contact Map
3pdkA 2 0.7642 100 0.273 Contact Map
1p5dX 1 0.7814 100 0.275 Contact Map
3pmgA 1 0.8709 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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