GREMLIN Database
GLPK - Glycerol kinase
UniProt: P18157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 496 (472)
Sequences: 12528 (8563)
Seq/√Len: 394.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_D210_K4.1861.00
110_I145_D3.8231.00
21_N25_K3.5101.00
17_A58_V3.3411.00
113_E145_D3.3081.00
388_K482_Y2.9181.00
388_K392_D2.8681.00
192_N195_D2.8561.00
428_P470_E2.8541.00
395_E427_V2.8371.00
126_K199_D2.8001.00
32_K57_A2.7601.00
96_V150_A2.7471.00
419_Q423_D2.7251.00
37_Y98_N2.7011.00
363_V375_F2.6441.00
455_D458_E2.6211.00
454_K458_E2.6121.00
404_T430_E2.6021.00
30_A61_S2.5841.00
32_K61_S2.5611.00
191_F216_V2.5441.00
218_P221_H2.5391.00
415_N467_K2.5361.00
19_L62_V2.5051.00
97_Y147_V2.4911.00
49_N171_K2.4821.00
52_W171_K2.4421.00
90_K155_E2.4371.00
89_D153_K2.4341.00
388_K479_N2.3611.00
192_N199_D2.3391.00
56_L229_Y2.3371.00
197_K210_K2.3151.00
203_L210_K2.3081.00
8_L55_V2.1531.00
200_D204_D2.1521.00
242_A247_S2.1331.00
169_I241_A2.1311.00
175_G215_E2.1201.00
18_I439_A2.1131.00
339_D374_H2.1061.00
14_S31_Q2.0041.00
311_A379_T1.9991.00
472_E475_E1.9921.00
49_N94_S1.9761.00
122_K125_E1.9571.00
113_E117_K1.9451.00
371_T374_H1.9171.00
40_H43_W1.9131.00
35_T50_E1.9071.00
61_S65_E1.9041.00
268_C308_A1.9001.00
395_E401_S1.8771.00
5_I447_G1.8571.00
156_K178_H1.8551.00
173_S238_I1.8501.00
342_Y484_G1.8471.00
426_N476_E1.8461.00
6_L59_I1.8391.00
482_Y486_Q1.8371.00
407_V418_M1.8281.00
433_E464_N1.8201.00
4_Y27_V1.8161.00
126_K201_E1.8131.00
10_Q15_S1.8051.00
343_V363_V1.7991.00
6_L17_A1.7961.00
141_K145_D1.7891.00
315_L379_T1.7481.00
430_E468_R1.7391.00
122_K201_E1.7241.00
122_K126_K1.7191.00
239_A449_A1.7021.00
87_V143_I1.6761.00
112_E116_E1.6681.00
423_D475_E1.6641.00
179_V217_K1.6631.00
217_K221_H1.6531.00
93_G170_W1.6521.00
4_Y19_L1.6511.00
89_D94_S1.6491.00
329_E333_E1.6441.00
428_P468_R1.6281.00
259_M404_T1.6251.00
334_K374_H1.6091.00
423_D472_E1.6011.00
257_E275_G1.5991.00
222_V239_A1.5921.00
385_Y481_L1.5911.00
360_R367_T1.5811.00
476_E479_N1.5641.00
109_G113_E1.5491.00
86_V164_I1.5461.00
313_Q317_D1.5401.00
87_V212_M1.5391.00
115_R120_N1.5261.00
5_I452_F1.5201.00
149_G152_E1.5091.00
392_D486_Q1.5031.00
392_D395_E1.4711.00
121_D125_E1.4711.00
37_Y50_E1.4641.00
28_H62_V1.4611.00
47_N50_E1.4421.00
30_A62_V1.4421.00
474_E477_K1.4371.00
63_I70_A1.4291.00
30_A58_V1.4231.00
169_I223_Y1.4231.00
324_D327_L1.4161.00
52_W56_L1.4071.00
142_W146_N1.4051.00
233_G236_I1.4041.00
433_E466_D1.3971.00
415_N431_R1.3781.00
416_F420_F1.3781.00
28_H65_E1.3621.00
49_N53_G1.3621.00
8_L59_I1.3601.00
327_L331_Y1.3591.00
377_R381_E1.3591.00
415_N469_F1.3481.00
209_P212_M1.3341.00
194_Y278_A1.3301.00
167_W171_K1.3251.00
447_G453_W1.3221.00
108_S112_E1.3161.00
88_W162_G1.3151.00
260_G402_L1.3151.00
75_G446_A1.3131.00
475_E478_R1.3021.00
384_A420_F1.2971.00
404_T428_P1.2971.00
343_V347_F1.2961.00
91_D94_S1.2931.00
264_Y421_Q1.2921.00
426_N478_R1.2841.00
69_S72_Q1.2841.00
327_L330_S1.2801.00
182_Y196_L1.2771.00
323_Q326_S1.2721.00
217_K223_Y1.2621.00
169_I179_V1.2601.00
477_K480_E1.2601.00
384_A424_L1.2561.00
343_V379_T1.2521.00
334_K373_E1.2511.00
330_S333_E1.2501.00
82_R243_G1.2461.00
175_G179_V1.2391.00
431_R469_F1.2361.00
262_N421_Q1.2351.00
22_K452_F1.2341.00
122_K205_I1.2341.00
53_G57_A1.2331.00
323_Q327_L1.2311.00
15_S55_V1.2301.00
110_I141_K1.2271.00
203_L213_L1.2211.00
384_A421_Q1.2211.00
418_M469_F1.2191.00
305_I386_Q1.2161.00
144_L151_R1.2051.00
137_G206_L1.1981.00
420_F424_L1.1911.00
84_T99_A1.1891.00
173_S224_A1.1881.00
119_Y205_I1.1831.00
426_N479_N1.1811.00
242_A445_L1.1801.00
15_S54_S1.1791.00
222_V237_P1.1681.00
201_E204_D1.1681.00
329_E332_A1.1521.00
123_F131_I1.1511.00
8_L17_A1.1501.00
319_L375_F1.1501.00
57_A61_S1.1461.00
147_V150_A1.1431.00
117_K205_I1.1421.00
19_L68_I1.1401.00
258_G403_K1.1391.00
388_K425_L1.1391.00
47_N98_N1.1381.00
364_F488_A1.1371.00
307_V311_A1.1261.00
87_V154_A1.1211.00
256_E259_M1.1161.00
4_Y72_Q1.1131.00
392_D482_Y1.1131.00
389_D486_Q1.1091.00
182_Y191_F1.1081.00
45_E98_N1.1051.00
20_F26_I1.1051.00
366_L370_T1.1051.00
55_V168_L1.1031.00
256_E460_A1.1011.00
341_V370_T1.0981.00
259_M406_R1.0951.00
465_L468_R1.0951.00
109_G112_E1.0931.00
93_G178_H1.0881.00
87_V140_V1.0841.00
307_V310_S1.0831.00
48_A86_V1.0831.00
479_N483_K1.0821.00
68_I72_Q1.0801.00
111_C131_I1.0771.00
222_V449_A1.0771.00
361_G366_L1.0721.00
182_Y216_V1.0711.00
413_K435_N1.0701.00
20_F443_A1.0641.00
484_G487_K1.0621.00
330_S334_K1.0621.00
472_E476_E1.0571.00
5_I450_V1.0501.00
36_Q46_H1.0491.00
119_Y122_K1.0471.00
444_Y459_I1.0461.00
350_L353_P1.0451.00
149_G153_K1.0431.00
162_G178_H1.0411.00
110_I113_E1.0401.00
112_E115_R1.0381.00
60_A229_Y1.0361.00
61_S64_S1.0351.00
75_G450_V1.0301.00
391_L425_L1.0261.00
154_A212_M1.0251.00
331_Y416_F1.0231.00
78_I169_I1.0231.00
406_R430_E1.0201.00
179_V223_Y1.0191.00
311_A343_V1.0171.00
110_I146_N1.0101.00
151_R154_A1.0091.00
97_Y150_A1.0081.00
256_E457_S1.0081.00
51_I164_I1.0061.00
106_Q142_W1.0051.00
203_L208_V1.0031.00
76_I236_I1.0021.00
55_V59_I1.0001.00
50_E53_G0.9951.00
385_Y424_L0.9851.00
260_G272_M0.9851.00
60_A64_S0.9841.00
4_Y68_I0.9821.00
256_E461_N0.9801.00
370_T374_H0.9791.00
30_A65_E0.9751.00
191_F195_D0.9751.00
383_L411_A0.9741.00
125_E280_K0.9731.00
448_I459_I0.9721.00
113_E116_E0.9671.00
453_W459_I0.9661.00
458_E461_N0.9651.00
261_K408_D0.9651.00
343_V378_A0.9631.00
473_L478_R0.9631.00
180_T185_A0.9621.00
320_R372_K0.9611.00
75_G239_A0.9601.00
331_Y334_K0.9501.00
447_G452_F0.9481.00
377_R416_F0.9471.00
137_G189_L0.9471.00
56_L60_A0.9471.00
34_F54_S0.9461.00
444_Y463_W0.9451.00
320_R323_Q0.9451.00
388_K424_L0.9411.00
140_V161_F0.9411.00
239_A450_V0.9391.00
87_V161_F0.9391.00
17_A62_V0.9371.00
5_I75_G0.9371.00
322_F326_S0.9321.00
123_F189_L0.9321.00
256_E403_K0.9261.00
356_D359_V0.9251.00
331_Y376_I0.9251.00
182_Y292_G0.9241.00
6_L19_L0.9211.00
20_F440_L0.9211.00
44_V103_Q0.9211.00
225_E229_Y0.9171.00
74_A450_V0.9171.00
411_A417_L0.9171.00
473_L476_E0.9161.00
196_L218_P0.9161.00
270_M391_L0.9151.00
79_T438_T0.9141.00
404_T468_R0.9131.00
150_A153_K0.9131.00
21_N27_V0.9091.00
63_I73_I0.9081.00
328_S376_I0.9061.00
155_E211_S0.8971.00
148_E152_E0.8951.00
32_K58_V0.8941.00
94_S171_K0.8931.00
328_S414_N0.8921.00
125_E194_Y0.8901.00
19_L73_I0.8881.00
325_S328_S0.8831.00
226_T230_H0.8831.00
78_I168_L0.8811.00
330_S372_K0.8811.00
337_S340_G0.8781.00
182_Y218_P0.8771.00
405_L425_L0.8761.00
227_V230_H0.8751.00
71_S233_G0.8721.00
329_E415_N0.8701.00
143_I150_A0.8701.00
268_C387_T0.8691.00
366_L375_F0.8681.00
77_G239_A0.8671.00
97_Y143_I0.8641.00
170_W178_H0.8631.00
392_D396_A0.8611.00
141_K144_L0.8601.00
385_Y482_Y0.8601.00
425_L428_P0.8531.00
473_L477_K0.8501.00
96_V153_K0.8501.00
335_V338_T0.8491.00
154_A161_F0.8471.00
6_L73_I0.8451.00
85_T161_F0.8441.00
10_Q168_L0.8441.00
166_T180_T0.8421.00
226_T231_F0.8371.00
113_E141_K0.8371.00
289_I292_G0.8361.00
412_V435_N0.8321.00
248_A408_D0.8261.00
217_K240_G0.8251.00
204_D210_K0.8191.00
33_E313_Q0.8191.00
88_W93_G0.8171.00
448_I455_D0.8131.00
227_V234_K0.8121.00
191_F196_L0.8111.00
78_I172_M0.8101.00
331_Y373_E0.8091.00
199_D202_L0.8081.00
359_V362_S0.8071.00
228_D231_F0.8031.00
83_E187_R0.8001.00
197_K200_D0.8001.00
111_C133_P0.8001.00
197_K215_E0.7991.00
39_P43_W0.7991.00
105_R132_D0.7991.00
314_W317_D0.7981.00
90_K153_K0.7971.00
326_S330_S0.7961.00
201_E205_I0.7951.00
115_R131_I0.7951.00
163_T188_T0.7931.00
347_F350_L0.7931.00
430_E465_L0.7911.00
448_I456_R0.7911.00
332_A416_F0.7891.00
380_L420_F0.7861.00
330_S373_E0.7851.00
50_E54_S0.7851.00
340_G481_L0.7841.00
111_C138_T0.7841.00
342_Y364_F0.7831.00
74_A452_F0.7831.00
73_I236_I0.7821.00
88_W178_H0.7821.00
272_M394_M0.7801.00
477_K481_L0.7781.00
29_S436_E0.7781.00
363_V379_T0.7781.00
59_I63_I0.7741.00
278_A287_T0.7731.00
407_V431_R0.7731.00
391_L395_E0.7721.00
109_G146_N0.7701.00
458_E462_Q0.7681.00
419_Q472_E0.7631.00
20_F434_I0.7611.00
70_A73_I0.7591.00
480_E484_G0.7581.00
32_K54_S0.7551.00
262_N387_T0.7551.00
331_Y335_V0.7551.00
245_Q269_F0.7531.00
335_V339_D0.7531.00
333_E373_E0.7521.00
359_V363_V0.7501.00
328_S331_Y0.7481.00
252_Q408_D0.7471.00
34_F46_H0.7461.00
475_E479_N0.7451.00
179_V215_E0.7451.00
33_E316_R0.7441.00
380_L414_N0.7441.00
198_W213_L0.7421.00
48_A98_N0.7421.00
453_W462_Q0.7411.00
315_L375_F0.7401.00
165_D241_A0.7401.00
315_L376_I0.7381.00
26_I29_S0.7371.00
480_E483_K0.7371.00
260_G405_L0.7351.00
288_T292_G0.7351.00
87_V96_V0.7331.00
412_V418_M0.7311.00
481_L484_G0.7311.00
393_A396_A0.7311.00
63_I68_I0.7311.00
326_S329_E0.7311.00
226_T229_Y0.7311.00
275_G298_N0.7301.00
322_F328_S0.7291.00
269_F304_S0.7271.00
384_A417_L0.7271.00
424_L478_R0.7261.00
141_K207_G0.7261.00
53_G56_L0.7251.00
194_Y280_K0.7231.00
385_Y478_R0.7231.00
338_T342_Y0.7201.00
45_E106_Q0.7191.00
262_N268_C0.7191.00
89_D155_E0.7171.00
49_N167_W0.7161.00
192_N197_K0.7161.00
140_V190_M0.7141.00
12_T101_V0.7121.00
137_G190_M0.7121.00
82_R184_N0.7091.00
93_G155_E0.7091.00
407_V421_Q0.7091.00
126_K192_N0.7081.00
7_S77_G0.7071.00
82_R302_E0.7061.00
180_T216_V0.7051.00
388_K486_Q0.7051.00
254_C261_K0.7031.00
10_Q55_V0.7031.00
252_Q261_K0.7031.00
339_D370_T0.7001.00
354_Y359_V0.7001.00
320_R324_D0.6981.00
346_A350_L0.6971.00
56_L230_H0.6961.00
52_W226_T0.6951.00
56_L171_K0.6941.00
328_S416_F0.6941.00
109_G145_D0.6931.00
225_E235_N0.6931.00
169_I173_S0.6931.00
102_W267_G0.6931.00
180_T214_P0.6911.00
225_E228_D0.6890.99
457_S460_A0.6870.99
356_D363_V0.6870.99
123_F202_L0.6870.99
15_S34_F0.6860.99
112_E358_D0.6850.99
308_A383_L0.6830.99
389_D482_Y0.6830.99
75_G237_P0.6820.99
428_P471_P0.6820.99
59_I62_V0.6820.99
89_D96_V0.6820.99
336_D377_R0.6800.99
403_K427_V0.6790.99
334_K338_T0.6770.99
183_S291_W0.6760.99
254_C259_M0.6760.99
152_E156_K0.6760.99
248_A438_T0.6750.99
407_V429_V0.6750.99
356_D360_R0.6710.99
55_V58_V0.6710.99
49_N98_N0.6690.99
447_G451_G0.6680.99
465_L471_P0.6670.99
232_F235_N0.6670.99
5_I74_A0.6660.99
23_E462_Q0.6640.99
127_T202_L0.6630.99
57_A60_A0.6630.99
167_W170_W0.6620.99
188_T198_W0.6610.99
86_V99_A0.6610.99
141_K151_R0.6590.99
88_W156_K0.6580.99
219_S241_A0.6560.99
183_S186_S0.6550.99
459_I463_W0.6540.99
244_D266_T0.6530.99
166_T178_H0.6520.99
349_G353_P0.6510.99
340_G377_R0.6490.99
420_F478_R0.6490.99
455_D461_N0.6490.99
121_D124_R0.6470.99
10_Q54_S0.6470.99
56_L226_T0.6460.99
470_E473_L0.6440.99
88_W167_W0.6430.99
222_V450_V0.6420.99
53_G229_Y0.6410.99
335_V374_H0.6410.99
18_I26_I0.6410.99
479_N482_Y0.6380.99
262_N405_L0.6360.99
338_T374_H0.6350.99
22_K74_A0.6350.99
274_T279_I0.6350.99
405_L427_V0.6340.99
196_L292_G0.6340.99
234_K237_P0.6330.99
324_D331_Y0.6330.99
405_L429_V0.6310.99
183_S242_A0.6310.99
459_I462_Q0.6300.99
49_N95_P0.6290.99
344_V362_S0.6290.99
185_A188_T0.6270.99
88_W170_W0.6250.99
273_N298_N0.6250.99
340_G381_E0.6250.99
315_L319_L0.6210.99
49_N52_W0.6210.99
327_L376_I0.6190.99
227_V231_F0.6170.99
288_T291_W0.6170.99
215_E221_H0.6160.99
20_F439_A0.6160.99
444_Y462_Q0.6160.99
303_G390_V0.6140.99
334_K339_D0.6130.99
431_R466_D0.6120.99
85_T136_S0.6110.99
100_I106_Q0.6090.99
343_V382_S0.6080.99
108_S133_P0.6070.99
237_P450_V0.6060.99
402_L427_V0.6040.99
434_I440_L0.6040.99
232_F236_I0.6030.99
80_N184_N0.6030.99
291_W294_D0.6030.99
59_I230_H0.6020.99
444_Y448_I0.6020.99
404_T427_V0.6020.99
218_P292_G0.6010.99
460_A463_W0.6000.99
340_G374_H0.5990.99
48_A99_A0.5990.99
268_C421_Q0.5980.99
381_E420_F0.5970.99
202_L205_I0.5960.99
354_Y389_D0.5960.99
483_K486_Q0.5960.99
358_D361_G0.5940.99
56_L59_I0.5940.99
419_Q469_F0.5940.99
418_M431_R0.5930.98
140_V212_M0.5930.98
107_T138_T0.5930.98
190_M213_L0.5930.98
202_L206_L0.5920.98
457_S461_N0.5910.98
86_V95_P0.5910.98
456_R460_A0.5880.98
360_R363_V0.5870.98
415_N419_Q0.5870.98
185_A198_W0.5850.98
114_L206_L0.5850.98
84_T101_V0.5840.98
433_E465_L0.5830.98
271_L300_A0.5830.98
305_I390_V0.5820.98
227_V232_F0.5820.98
338_T381_E0.5800.98
181_D186_S0.5800.98
131_I189_L0.5790.98
204_D209_P0.5790.98
230_H235_N0.5770.98
227_V235_N0.5770.98
243_G246_Q0.5770.98
76_I238_I0.5760.98
253_A460_A0.5760.98
348_V368_R0.5750.98
223_Y240_G0.5750.98
414_N417_L0.5750.98
341_V378_A0.5740.98
396_A486_Q0.5740.98
26_I434_I0.5740.98
106_Q146_N0.5740.98
312_I328_S0.5740.98
81_Q102_W0.5740.98
347_F353_P0.5720.98
313_Q316_R0.5720.98
292_G295_G0.5720.98
80_N164_I0.5710.98
151_R207_G0.5690.98
245_Q263_T0.5690.98
478_R481_L0.5670.98
419_Q422_G0.5670.98
226_T235_N0.5650.98
337_S377_R0.5650.98
328_S334_K0.5650.98
337_S374_H0.5640.98
153_K156_K0.5630.98
38_F44_V0.5630.98
327_L335_V0.5600.98
100_I143_I0.5600.98
281_S284_G0.5600.98
129_L135_F0.5600.98
29_S65_E0.5590.98
5_I453_W0.5590.98
448_I453_W0.5590.98
219_S242_A0.5560.98
377_R420_F0.5560.98
175_G217_K0.5560.98
264_Y407_V0.5550.98
181_D184_N0.5550.98
259_M460_A0.5540.98
298_N456_R0.5540.98
331_Y336_D0.5540.98
338_T377_R0.5530.98
184_N187_R0.5530.98
204_D207_G0.5530.98
353_P356_D0.5530.98
114_L138_T0.5520.98
464_N471_P0.5510.98
47_N53_G0.5480.97
426_N473_L0.5480.97
208_V213_L0.5470.97
339_D369_G0.5470.97
45_E97_Y0.5460.97
344_V350_L0.5450.97
354_Y486_Q0.5450.97
95_P98_N0.5440.97
327_L334_K0.5440.97
251_G437_T0.5430.97
133_P357_S0.5410.97
141_K206_L0.5410.97
138_T189_L0.5410.97
93_G156_K0.5410.97
259_M403_K0.5400.97
186_S191_F0.5400.97
144_L207_G0.5400.97
183_S219_S0.5390.97
412_V431_R0.5390.97
220_S449_A0.5380.97
82_R187_R0.5380.97
25_K433_E0.5380.97
381_E385_Y0.5370.97
262_N270_M0.5370.97
135_F187_R0.5370.97
230_H236_I0.5360.97
4_Y71_S0.5350.97
162_G170_W0.5340.97
347_F363_V0.5320.97
342_Y385_Y0.5320.97
151_R155_E0.5320.97
249_L271_L0.5320.97
218_P295_G0.5310.97
39_P98_N0.5310.97
194_Y197_K0.5310.97
151_R209_P0.5310.97
327_L332_A0.5280.97
464_N469_F0.5280.97
421_Q425_L0.5280.97
73_I232_F0.5270.97
357_S361_G0.5260.97
270_M390_V0.5260.97
250_F444_Y0.5250.97
79_T442_A0.5240.97
274_T301_L0.5230.97
440_L444_Y0.5190.97
318_G371_T0.5190.97
59_I226_T0.5160.96
63_I69_S0.5140.96
220_S294_D0.5130.96
268_C305_I0.5130.96
43_W106_Q0.5120.96
422_G429_V0.5110.96
479_N486_Q0.5100.96
448_I451_G0.5100.96
383_L417_L0.5090.96
439_A442_A0.5070.96
181_D187_R0.5060.96
253_A463_W0.5050.96
249_L290_A0.5040.96
123_F206_L0.5030.96
328_S332_A0.5020.96
220_S448_I0.5020.96
13_T16_R0.5020.96
226_T232_F0.5000.96
426_N475_E0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ezwA 3 0.996 100 0.131 Contact Map
3g25A 3 0.998 100 0.132 Contact Map
3ll3A 2 0.9677 100 0.136 Contact Map
3h3nX 3 0.996 100 0.136 Contact Map
2d4wA 2 0.9899 100 0.141 Contact Map
2zf5O 3 0.9819 100 0.143 Contact Map
3wxlA 2 0.9879 100 0.144 Contact Map
2dpnA 2 0.9859 100 0.147 Contact Map
2itmA 2 0.9456 100 0.149 Contact Map
3hz6A 1 0.9617 100 0.152 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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