GLPF - BACSU - GREMLIN Contacts

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GLPF - Glycerol uptake facilitator protein

UniProt:	P18156	Sequences: MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGLNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVGPILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	274 (221)
Sequences:	5641 (3197)
Seq/√Len:	215.1

ECOLI - GLPF AQPZ
BACSU - GLPF
SULSO - Q97XW0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_V	95_I	4.146	1.00
72_A	79_W	3.577	1.00
138_V	221_L	3.355	1.00
138_V	225_F	3.291	1.00
68_T	82_V	3.057	1.00
12_M	99_I	2.999	1.00
134_V	218_G	2.974	1.00
72_A	82_V	2.875	1.00
4_F	84_V	2.850	1.00
8_V	91_I	2.813	1.00
147_G	168_L	2.659	1.00
73_F	224_S	2.640	1.00
4_F	88_A	2.640	1.00
140_G	176_L	2.606	1.00
45_G	170_V	2.586	1.00
3_A	81_E	2.394	1.00
12_M	96_G	2.274	1.00
134_V	138_V	2.234	1.00
86_I	220_I	2.219	1.00
18_G	44_W	2.170	1.00
69_I	220_I	1.963	1.00
183_A	189_D	1.951	1.00
55_V	63_L	1.951	1.00
142_F	226_G	1.940	1.00
128_P	208_N	1.884	1.00
190_L	216_V	1.856	1.00
173_G	182_Y	1.791	1.00
69_I	86_I	1.755	1.00
62_H	85_Y	1.745	1.00
51_A	55_V	1.711	1.00
136_S	179_T	1.692	1.00
140_G	184_I	1.672	1.00
16_I	99_I	1.666	1.00
190_L	194_I	1.647	1.00
49_A	166_G	1.642	1.00
105_L	109_K	1.581	1.00
42_F	170_V	1.554	1.00
98_V	195_A	1.554	1.00
172_I	184_I	1.527	1.00
133_N	180_T	1.516	1.00
108_W	120_V	1.512	1.00
212_A	216_V	1.503	1.00
88_A	92_G	1.497	1.00
142_F	229_F	1.495	1.00
220_I	224_S	1.478	1.00
10_G	63_L	1.473	1.00
90_M	216_V	1.457	1.00
79_W	82_V	1.453	1.00
196_H	207_S	1.442	1.00
41_V	174_I	1.423	1.00
75_G	231_N	1.406	1.00
70_A	145_V	1.402	1.00
48_V	169_I	1.400	1.00
222_G	226_G	1.385	1.00
67_L	148_I	1.381	1.00
145_V	223_G	1.372	1.00
19_A	100_I	1.359	1.00
190_L	212_A	1.347	1.00
83_P	87_A	1.329	1.00
173_G	177_G	1.325	1.00
82_V	86_I	1.314	1.00
52_A	162_P	1.303	1.00
94_I	195_A	1.302	1.00
94_I	191_G	1.299	1.00
20_G	100_I	1.291	1.00
22_C	26_N	1.288	1.00
90_M	190_L	1.287	1.00
12_M	95_I	1.279	1.00
11_T	93_A	1.264	1.00
28_K	33_F	1.243	1.00
169_I	184_I	1.240	1.00
71_L	77_F	1.225	1.00
70_A	74_V	1.220	1.00
213_W	217_V	1.218	1.00
46_L	167_F	1.210	1.00
77_F	82_V	1.202	1.00
65_P	187_A	1.202	1.00
46_L	171_A	1.199	1.00
95_I	98_V	1.192	1.00
134_V	214_V	1.189	1.00
68_T	89_Q	1.188	1.00
55_V	61_A	1.178	1.00
142_F	225_F	1.171	1.00
47_G	51_A	1.168	1.00
98_V	102_L	1.166	1.00
79_W	83_P	1.162	1.00
22_C	40_V	1.161	1.00
131_F	135_L	1.159	1.00
141_T	223_G	1.156	1.00
38_I	42_F	1.154	1.00
97_A	192_P	1.143	1.00
93_A	97_A	1.138	1.00
138_V	222_G	1.133	1.00
13_L	143_V	1.132	1.00
68_T	77_F	1.132	1.00
69_I	224_S	1.129	1.00
94_I	194_I	1.108	1.00
137_E	180_T	1.107	1.00
68_T	86_I	1.107	1.00
78_P	81_E	1.107	1.00
99_I	139_I	1.100	1.00
24_G	32_S	1.100	1.00
118_L	122_S	1.087	1.00
46_L	170_V	1.085	1.00
103_H	136_S	1.079	1.00
21_V	43_G	1.073	1.00
19_A	97_A	1.073	1.00
117_K	120_V	1.072	1.00
134_V	217_V	1.069	1.00
14_L	48_V	1.067	1.00
6_G	58_I	1.062	1.00
66_A	186_P	1.043	1.00
148_I	165_V	1.042	1.00
67_L	145_V	1.038	1.00
189_D	193_R	1.034	1.00
129_H	132_A	1.018	1.00
59_S	85_Y	1.014	1.00
209_W	212_A	1.010	1.00
51_A	61_A	1.006	1.00
118_L	121_F	0.995	1.00
17_F	47_G	0.988	1.00
188_R	192_P	0.986	1.00
62_H	68_T	0.982	1.00
103_H	179_T	0.980	1.00
6_G	59_S	0.978	1.00
136_S	140_G	0.974	1.00
136_S	180_T	0.964	1.00
138_V	218_G	0.963	1.00
11_T	187_A	0.962	1.00
72_A	77_F	0.960	1.00
113_D	116_A	0.957	1.00
13_L	51_A	0.955	1.00
124_G	127_I	0.951	1.00
35_S	39_V	0.951	1.00
142_F	146_L	0.947	1.00
73_F	227_G	0.941	1.00
70_A	227_G	0.937	0.99
15_I	100_I	0.934	0.99
93_A	191_G	0.930	0.99
163_L	167_F	0.928	0.99
146_L	229_F	0.917	0.99
39_V	174_I	0.914	0.99
49_A	53_Y	0.912	0.99
144_L	169_I	0.907	0.99
52_A	67_L	0.903	0.99
12_M	16_I	0.902	0.99
15_I	19_A	0.898	0.99
53_Y	162_P	0.883	0.99
123_T	207_S	0.882	0.99
51_A	63_L	0.878	0.99
4_F	8_V	0.873	0.99
125_P	128_P	0.869	0.99
38_I	174_I	0.867	0.99
153_A	230_Y	0.863	0.99
49_A	163_L	0.856	0.99
134_V	213_W	0.844	0.99
149_L	226_G	0.842	0.99
36_G	39_V	0.835	0.99
54_A	147_G	0.833	0.99
152_G	165_V	0.830	0.99
26_N	116_A	0.826	0.99
86_I	90_M	0.824	0.99
38_I	41_V	0.822	0.99
196_H	205_G	0.819	0.99
62_H	77_F	0.816	0.99
10_G	14_L	0.796	0.98
90_M	191_G	0.796	0.98
50_M	147_G	0.795	0.98
25_V	39_V	0.795	0.98
66_A	223_G	0.791	0.98
115_A	205_G	0.783	0.98
97_A	195_A	0.778	0.98
62_H	67_L	0.777	0.98
151_I	168_L	0.775	0.98
125_P	133_N	0.770	0.98
20_G	175_S	0.768	0.98
62_H	89_Q	0.763	0.98
74_V	227_G	0.763	0.98
92_G	96_G	0.763	0.98
223_G	227_G	0.756	0.98
77_F	81_E	0.749	0.98
73_F	228_V	0.747	0.97
130_T	214_V	0.743	0.97
6_G	60_G	0.739	0.97
24_G	179_T	0.738	0.97
136_S	176_L	0.736	0.97
33_F	37_W	0.734	0.97
161_N	165_V	0.732	0.97
71_L	148_I	0.731	0.97
94_I	190_L	0.728	0.97
182_Y	215_P	0.726	0.97
53_Y	164_I	0.722	0.97
8_V	88_A	0.718	0.97
43_G	174_I	0.712	0.97
151_I	164_I	0.706	0.96
150_A	230_Y	0.704	0.96
105_L	108_W	0.702	0.96
120_V	123_T	0.696	0.96
106_P	132_A	0.696	0.96
53_Y	159_G	0.696	0.96
118_L	124_G	0.694	0.96
19_A	96_G	0.692	0.96
101_Y	105_L	0.692	0.96
176_L	182_Y	0.692	0.96
71_L	76_D	0.690	0.96
37_W	177_G	0.688	0.96
16_I	143_V	0.685	0.96
132_A	135_L	0.685	0.96
172_I	182_Y	0.684	0.96
74_V	149_L	0.681	0.96
141_T	192_P	0.669	0.95
134_V	221_L	0.668	0.95
116_A	119_G	0.666	0.95
115_A	118_L	0.665	0.95
149_L	230_Y	0.658	0.95
8_V	12_M	0.658	0.95
187_A	191_G	0.657	0.95
42_F	167_F	0.655	0.95
13_L	50_M	0.645	0.94
56_G	59_S	0.644	0.94
78_P	83_P	0.642	0.94
121_F	125_P	0.640	0.94
45_G	166_G	0.635	0.94
19_A	120_V	0.633	0.94
11_T	15_I	0.633	0.94
220_I	223_G	0.632	0.94
170_V	174_I	0.632	0.94
16_I	103_H	0.631	0.94
17_F	143_V	0.630	0.93
78_P	82_V	0.628	0.93
101_Y	195_A	0.627	0.93
140_G	144_L	0.626	0.93
94_I	98_V	0.626	0.93
41_V	173_G	0.622	0.93
150_A	153_A	0.621	0.93
183_A	215_P	0.619	0.93
214_V	219_P	0.618	0.93
98_V	101_Y	0.615	0.93
17_F	171_A	0.614	0.93
217_V	220_I	0.613	0.93
228_V	232_A	0.613	0.93
133_N	214_V	0.608	0.92
186_P	216_V	0.608	0.92
37_W	126_S	0.607	0.92
106_P	129_H	0.604	0.92
114_P	117_K	0.604	0.92
229_F	233_A	0.602	0.92
22_C	44_W	0.599	0.92
97_A	191_G	0.599	0.92
120_V	124_G	0.599	0.92
49_A	164_I	0.597	0.92
24_G	178_G	0.597	0.92
130_T	210_K	0.596	0.91
22_C	169_I	0.591	0.91
196_H	206_S	0.589	0.91
69_I	82_V	0.588	0.91
147_G	151_I	0.587	0.91
84_V	87_A	0.586	0.91
177_G	182_Y	0.584	0.91
16_I	100_I	0.583	0.91
132_A	136_S	0.582	0.91
24_G	104_Y	0.582	0.91
211_Y	215_P	0.582	0.91
171_A	175_S	0.577	0.90
11_T	48_V	0.576	0.90
48_V	52_A	0.576	0.90
42_F	174_I	0.575	0.90
140_G	172_I	0.574	0.90
49_A	56_G	0.573	0.90
5_W	233_A	0.571	0.90
7_E	10_G	0.570	0.90
173_G	184_I	0.565	0.89
93_A	187_A	0.565	0.89
44_W	173_G	0.563	0.89
211_Y	214_V	0.563	0.89
122_S	125_P	0.560	0.89
37_W	173_G	0.559	0.89
168_L	172_I	0.558	0.89
77_F	84_V	0.558	0.89
66_A	70_A	0.555	0.88
20_G	104_Y	0.554	0.88
84_V	88_A	0.554	0.88
214_V	218_G	0.552	0.88
72_A	83_P	0.550	0.88
55_V	58_I	0.549	0.88
26_N	40_V	0.549	0.88
123_T	127_I	0.549	0.88
218_G	222_G	0.546	0.88
146_L	233_A	0.545	0.87
14_L	63_L	0.544	0.87
10_G	55_V	0.544	0.87
146_L	234_F	0.543	0.87
52_A	148_I	0.543	0.87
41_V	170_V	0.543	0.87
74_V	226_G	0.540	0.87
91_I	95_I	0.538	0.87
144_L	148_I	0.538	0.87
124_G	208_N	0.534	0.86
143_V	168_L	0.534	0.86
74_V	77_F	0.534	0.86
4_F	87_A	0.534	0.86
11_T	14_L	0.533	0.86
15_I	93_A	0.532	0.86
191_G	195_A	0.532	0.86
63_L	169_I	0.532	0.86
80_K	83_P	0.531	0.86
18_G	188_R	0.530	0.86
135_L	139_I	0.530	0.86
21_V	40_V	0.530	0.86
154_N	158_E	0.527	0.86
46_L	166_G	0.526	0.86
189_D	219_P	0.524	0.85
22_C	182_Y	0.521	0.85
14_L	169_I	0.520	0.85
55_V	234_F	0.520	0.85
123_T	215_P	0.518	0.85
41_V	182_Y	0.518	0.85
144_L	177_G	0.517	0.85
96_G	136_S	0.517	0.85
23_A	104_Y	0.513	0.84
74_V	231_N	0.512	0.84
77_F	89_Q	0.510	0.84
59_S	62_H	0.507	0.83
51_A	171_A	0.505	0.83
130_T	218_G	0.504	0.83
32_S	35_S	0.503	0.83
162_P	166_G	0.503	0.83
9_I	229_F	0.501	0.83
106_P	109_K	0.501	0.83
86_I	187_A	0.501	0.83
103_H	132_A	0.500	0.83
5_W	9_I	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ldfA	3	0.8577	100	0.185	Contact Map
1j4nA	4	0.8504	100	0.19	Contact Map
4oj2X	3	0.8942	100	0.197	Contact Map
2b6oA	6	0.8321	100	0.198	Contact Map
3d9sA	3	0.8431	100	0.203	Contact Map
3iyzA	3	0.7883	100	0.206	Contact Map
3c02A	3	0.854	100	0.209	Contact Map
2zz9A	3	0.7883	100	0.213	Contact Map
3cn5A	3	0.8212	100	0.227	Contact Map
2o9gA	3	0.8285	100	0.236	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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