GREMLIN Database
GLPF - Glycerol uptake facilitator protein
UniProt: P18156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (221)
Sequences: 5641 (3197)
Seq/√Len: 215.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_V95_I4.1461.00
72_A79_W3.5771.00
138_V221_L3.3551.00
138_V225_F3.2911.00
68_T82_V3.0571.00
12_M99_I2.9991.00
134_V218_G2.9741.00
72_A82_V2.8751.00
4_F84_V2.8501.00
8_V91_I2.8131.00
147_G168_L2.6591.00
73_F224_S2.6401.00
4_F88_A2.6401.00
140_G176_L2.6061.00
45_G170_V2.5861.00
3_A81_E2.3941.00
12_M96_G2.2741.00
134_V138_V2.2341.00
86_I220_I2.2191.00
18_G44_W2.1701.00
69_I220_I1.9631.00
183_A189_D1.9511.00
55_V63_L1.9511.00
142_F226_G1.9401.00
128_P208_N1.8841.00
190_L216_V1.8561.00
173_G182_Y1.7911.00
69_I86_I1.7551.00
62_H85_Y1.7451.00
51_A55_V1.7111.00
136_S179_T1.6921.00
140_G184_I1.6721.00
16_I99_I1.6661.00
190_L194_I1.6471.00
49_A166_G1.6421.00
105_L109_K1.5811.00
42_F170_V1.5541.00
98_V195_A1.5541.00
172_I184_I1.5271.00
133_N180_T1.5161.00
108_W120_V1.5121.00
212_A216_V1.5031.00
88_A92_G1.4971.00
142_F229_F1.4951.00
220_I224_S1.4781.00
10_G63_L1.4731.00
90_M216_V1.4571.00
79_W82_V1.4531.00
196_H207_S1.4421.00
41_V174_I1.4231.00
75_G231_N1.4061.00
70_A145_V1.4021.00
48_V169_I1.4001.00
222_G226_G1.3851.00
67_L148_I1.3811.00
145_V223_G1.3721.00
19_A100_I1.3591.00
190_L212_A1.3471.00
83_P87_A1.3291.00
173_G177_G1.3251.00
82_V86_I1.3141.00
52_A162_P1.3031.00
94_I195_A1.3021.00
94_I191_G1.2991.00
20_G100_I1.2911.00
22_C26_N1.2881.00
90_M190_L1.2871.00
12_M95_I1.2791.00
11_T93_A1.2641.00
28_K33_F1.2431.00
169_I184_I1.2401.00
71_L77_F1.2251.00
70_A74_V1.2201.00
213_W217_V1.2181.00
46_L167_F1.2101.00
77_F82_V1.2021.00
65_P187_A1.2021.00
46_L171_A1.1991.00
95_I98_V1.1921.00
134_V214_V1.1891.00
68_T89_Q1.1881.00
55_V61_A1.1781.00
142_F225_F1.1711.00
47_G51_A1.1681.00
98_V102_L1.1661.00
79_W83_P1.1621.00
22_C40_V1.1611.00
131_F135_L1.1591.00
141_T223_G1.1561.00
38_I42_F1.1541.00
97_A192_P1.1431.00
93_A97_A1.1381.00
138_V222_G1.1331.00
13_L143_V1.1321.00
68_T77_F1.1321.00
69_I224_S1.1291.00
94_I194_I1.1081.00
137_E180_T1.1071.00
68_T86_I1.1071.00
78_P81_E1.1071.00
99_I139_I1.1001.00
24_G32_S1.1001.00
118_L122_S1.0871.00
46_L170_V1.0851.00
103_H136_S1.0791.00
21_V43_G1.0731.00
19_A97_A1.0731.00
117_K120_V1.0721.00
134_V217_V1.0691.00
14_L48_V1.0671.00
6_G58_I1.0621.00
66_A186_P1.0431.00
148_I165_V1.0421.00
67_L145_V1.0381.00
189_D193_R1.0341.00
129_H132_A1.0181.00
59_S85_Y1.0141.00
209_W212_A1.0101.00
51_A61_A1.0061.00
118_L121_F0.9951.00
17_F47_G0.9881.00
188_R192_P0.9861.00
62_H68_T0.9821.00
103_H179_T0.9801.00
6_G59_S0.9781.00
136_S140_G0.9741.00
136_S180_T0.9641.00
138_V218_G0.9631.00
11_T187_A0.9621.00
72_A77_F0.9601.00
113_D116_A0.9571.00
13_L51_A0.9551.00
124_G127_I0.9511.00
35_S39_V0.9511.00
142_F146_L0.9471.00
73_F227_G0.9411.00
70_A227_G0.9370.99
15_I100_I0.9340.99
93_A191_G0.9300.99
163_L167_F0.9280.99
146_L229_F0.9170.99
39_V174_I0.9140.99
49_A53_Y0.9120.99
144_L169_I0.9070.99
52_A67_L0.9030.99
12_M16_I0.9020.99
15_I19_A0.8980.99
53_Y162_P0.8830.99
123_T207_S0.8820.99
51_A63_L0.8780.99
4_F8_V0.8730.99
125_P128_P0.8690.99
38_I174_I0.8670.99
153_A230_Y0.8630.99
49_A163_L0.8560.99
134_V213_W0.8440.99
149_L226_G0.8420.99
36_G39_V0.8350.99
54_A147_G0.8330.99
152_G165_V0.8300.99
26_N116_A0.8260.99
86_I90_M0.8240.99
38_I41_V0.8220.99
196_H205_G0.8190.99
62_H77_F0.8160.99
10_G14_L0.7960.98
90_M191_G0.7960.98
50_M147_G0.7950.98
25_V39_V0.7950.98
66_A223_G0.7910.98
115_A205_G0.7830.98
97_A195_A0.7780.98
62_H67_L0.7770.98
151_I168_L0.7750.98
125_P133_N0.7700.98
20_G175_S0.7680.98
62_H89_Q0.7630.98
74_V227_G0.7630.98
92_G96_G0.7630.98
223_G227_G0.7560.98
77_F81_E0.7490.98
73_F228_V0.7470.97
130_T214_V0.7430.97
6_G60_G0.7390.97
24_G179_T0.7380.97
136_S176_L0.7360.97
33_F37_W0.7340.97
161_N165_V0.7320.97
71_L148_I0.7310.97
94_I190_L0.7280.97
182_Y215_P0.7260.97
53_Y164_I0.7220.97
8_V88_A0.7180.97
43_G174_I0.7120.97
151_I164_I0.7060.96
150_A230_Y0.7040.96
105_L108_W0.7020.96
120_V123_T0.6960.96
106_P132_A0.6960.96
53_Y159_G0.6960.96
118_L124_G0.6940.96
19_A96_G0.6920.96
101_Y105_L0.6920.96
176_L182_Y0.6920.96
71_L76_D0.6900.96
37_W177_G0.6880.96
16_I143_V0.6850.96
132_A135_L0.6850.96
172_I182_Y0.6840.96
74_V149_L0.6810.96
141_T192_P0.6690.95
134_V221_L0.6680.95
116_A119_G0.6660.95
115_A118_L0.6650.95
149_L230_Y0.6580.95
8_V12_M0.6580.95
187_A191_G0.6570.95
42_F167_F0.6550.95
13_L50_M0.6450.94
56_G59_S0.6440.94
78_P83_P0.6420.94
121_F125_P0.6400.94
45_G166_G0.6350.94
19_A120_V0.6330.94
11_T15_I0.6330.94
220_I223_G0.6320.94
170_V174_I0.6320.94
16_I103_H0.6310.94
17_F143_V0.6300.93
78_P82_V0.6280.93
101_Y195_A0.6270.93
140_G144_L0.6260.93
94_I98_V0.6260.93
41_V173_G0.6220.93
150_A153_A0.6210.93
183_A215_P0.6190.93
214_V219_P0.6180.93
98_V101_Y0.6150.93
17_F171_A0.6140.93
217_V220_I0.6130.93
228_V232_A0.6130.93
133_N214_V0.6080.92
186_P216_V0.6080.92
37_W126_S0.6070.92
106_P129_H0.6040.92
114_P117_K0.6040.92
229_F233_A0.6020.92
22_C44_W0.5990.92
97_A191_G0.5990.92
120_V124_G0.5990.92
49_A164_I0.5970.92
24_G178_G0.5970.92
130_T210_K0.5960.91
22_C169_I0.5910.91
196_H206_S0.5890.91
69_I82_V0.5880.91
147_G151_I0.5870.91
84_V87_A0.5860.91
177_G182_Y0.5840.91
16_I100_I0.5830.91
132_A136_S0.5820.91
24_G104_Y0.5820.91
211_Y215_P0.5820.91
171_A175_S0.5770.90
11_T48_V0.5760.90
48_V52_A0.5760.90
42_F174_I0.5750.90
140_G172_I0.5740.90
49_A56_G0.5730.90
5_W233_A0.5710.90
7_E10_G0.5700.90
173_G184_I0.5650.89
93_A187_A0.5650.89
44_W173_G0.5630.89
211_Y214_V0.5630.89
122_S125_P0.5600.89
37_W173_G0.5590.89
168_L172_I0.5580.89
77_F84_V0.5580.89
66_A70_A0.5550.88
20_G104_Y0.5540.88
84_V88_A0.5540.88
214_V218_G0.5520.88
72_A83_P0.5500.88
55_V58_I0.5490.88
26_N40_V0.5490.88
123_T127_I0.5490.88
218_G222_G0.5460.88
146_L233_A0.5450.87
14_L63_L0.5440.87
10_G55_V0.5440.87
146_L234_F0.5430.87
52_A148_I0.5430.87
41_V170_V0.5430.87
74_V226_G0.5400.87
91_I95_I0.5380.87
144_L148_I0.5380.87
124_G208_N0.5340.86
143_V168_L0.5340.86
74_V77_F0.5340.86
4_F87_A0.5340.86
11_T14_L0.5330.86
15_I93_A0.5320.86
191_G195_A0.5320.86
63_L169_I0.5320.86
80_K83_P0.5310.86
18_G188_R0.5300.86
135_L139_I0.5300.86
21_V40_V0.5300.86
154_N158_E0.5270.86
46_L166_G0.5260.86
189_D219_P0.5240.85
22_C182_Y0.5210.85
14_L169_I0.5200.85
55_V234_F0.5200.85
123_T215_P0.5180.85
41_V182_Y0.5180.85
144_L177_G0.5170.85
96_G136_S0.5170.85
23_A104_Y0.5130.84
74_V231_N0.5120.84
77_F89_Q0.5100.84
59_S62_H0.5070.83
51_A171_A0.5050.83
130_T218_G0.5040.83
32_S35_S0.5030.83
162_P166_G0.5030.83
9_I229_F0.5010.83
106_P109_K0.5010.83
86_I187_A0.5010.83
103_H132_A0.5000.83
5_W9_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ldfA 3 0.8577 100 0.185 Contact Map
1j4nA 4 0.8504 100 0.19 Contact Map
4oj2X 3 0.8942 100 0.197 Contact Map
2b6oA 6 0.8321 100 0.198 Contact Map
3d9sA 3 0.8431 100 0.203 Contact Map
3iyzA 3 0.7883 100 0.206 Contact Map
3c02A 3 0.854 100 0.209 Contact Map
2zz9A 3 0.7883 100 0.213 Contact Map
3cn5A 3 0.8212 100 0.227 Contact Map
2o9gA 3 0.8285 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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