GREMLIN Database
SYFB - Phenylalanine--tRNA ligase beta subunit
UniProt: P17922 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 804 (785)
Sequences: 3833 (2688)
Seq/√Len: 95.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_D339_T6.1311.00
602_G689_F4.5921.00
724_D762_K4.4941.00
295_M303_E4.2471.00
725_K754_E4.2061.00
53_E67_L4.1671.00
295_M305_K3.8191.00
50_H90_K3.6591.00
565_V603_A3.5591.00
275_F321_A3.4641.00
227_A341_L3.4281.00
49_G93_V3.3531.00
267_E384_R3.1711.00
52_L75_P3.0941.00
443_F463_I3.0611.00
50_H69_D3.0551.00
89_Q143_V3.0071.00
229_I277_Y2.9791.00
301_D329_A2.8741.00
225_Y275_F2.8721.00
230_I342_L2.8331.00
59_N114_E2.7631.00
51_V85_V2.6501.00
56_Q64_N2.6471.00
292_E308_A2.6331.00
232_N396_E2.5971.00
656_R672_Q2.5861.00
18_D21_V2.5791.00
78_I93_V2.5691.00
52_L69_D2.5511.00
279_R334_Q2.5351.00
735_V798_Y2.5281.00
86_D89_Q2.5161.00
230_I395_G2.5121.00
417_S466_E2.4941.00
310_H358_D2.4891.00
86_D143_V2.4701.00
224_L403_E2.4321.00
520_T564_S2.4291.00
725_K761_G2.4261.00
745_K772_V2.4231.00
645_V659_N2.4101.00
261_T274_A2.4051.00
526_E551_S2.3851.00
281_G317_T2.3781.00
320_Q331_S2.3631.00
744_L769_L2.3581.00
215_K284_E2.3551.00
238_S242_M2.3531.00
728_T731_Q2.3161.00
437_I476_L2.3121.00
420_K466_E2.3091.00
148_A157_A2.2921.00
225_Y321_A2.2831.00
720_A766_A2.2821.00
421_V434_L2.2791.00
749_V765_V2.2661.00
13_D195_K2.2451.00
298_T304_R2.2351.00
730_G734_S2.2241.00
290_A306_L2.1921.00
661_L666_L2.1901.00
10_D245_K2.1821.00
156_A161_D2.1821.00
659_N666_L2.1511.00
422_S428_T2.1441.00
771_Y787_H2.1281.00
672_Q685_E2.1051.00
773_N776_Q2.0971.00
645_V661_L2.0931.00
776_Q782_E2.0661.00
70_I76_V2.0621.00
288_R294_E2.0571.00
53_E87_K2.0231.00
280_F320_Q2.0161.00
129_E138_A2.0161.00
226_T382_A1.9651.00
282_S316_G1.9571.00
518_A578_L1.9511.00
376_A458_S1.9511.00
90_K148_A1.9501.00
45_G95_T1.9491.00
231_K396_E1.9491.00
231_K339_T1.9441.00
515_L628_I1.9411.00
237_P243_Q1.9411.00
34_E168_G1.9371.00
454_V469_L1.9251.00
307_S358_D1.9051.00
418_A434_L1.9051.00
416_V469_L1.8901.00
296_I322_V1.8901.00
20_A24_E1.8591.00
597_T692_D1.8581.00
733_E737_K1.8421.00
558_V688_V1.8401.00
297_V303_E1.8361.00
54_R64_N1.8351.00
436_S440_R1.8321.00
518_A564_S1.8281.00
221_A289_K1.8131.00
213_S284_E1.8111.00
750_F766_A1.8111.00
430_S433_E1.8101.00
228_K383_E1.8081.00
90_K150_T1.8051.00
387_Q391_L1.7771.00
608_W618_K1.7771.00
240_L244_T1.7591.00
70_I95_T1.7571.00
415_H453_V1.7481.00
217_E286_V1.7451.00
70_I93_V1.7451.00
665_S695_A1.7321.00
416_V421_V1.7241.00
46_V92_A1.7211.00
249_A266_L1.7181.00
152_S156_A1.7101.00
625_V670_I1.7091.00
272_L385_A1.7051.00
49_G70_I1.6941.00
23_A36_I1.6921.00
243_Q253_P1.6911.00
218_D289_K1.6891.00
729_S765_V1.6831.00
48_I90_K1.6791.00
386_A397_V1.6711.00
67_L75_P1.6711.00
414_I463_I1.6671.00
424_V467_E1.6661.00
526_E541_V1.6481.00
668_G691_L1.6371.00
124_Q138_A1.6331.00
433_E436_S1.6251.00
149_E152_S1.6251.00
288_R314_T1.6241.00
795_E801_V1.6231.00
281_G318_K1.6221.00
738_E797_T1.6161.00
564_S578_L1.6101.00
22_L186_V1.6091.00
99_V105_K1.6091.00
92_A154_A1.6081.00
629_V633_L1.5991.00
315_N318_K1.5991.00
389_I395_G1.5961.00
518_A561_L1.5931.00
723_T732_L1.5931.00
310_H355_A1.5851.00
85_V89_Q1.5751.00
92_A141_I1.5641.00
65_K114_E1.5631.00
325_V355_A1.5601.00
48_I148_A1.5511.00
260_I385_A1.5451.00
721_L794_L1.5441.00
314_T319_A1.5421.00
29_A189_I1.5391.00
247_M253_P1.5391.00
556_S559_P1.5381.00
123_L142_F1.5371.00
792_K795_E1.5321.00
310_H359_L1.5321.00
654_P674_H1.5271.00
167_L182_V1.5191.00
604_V625_V1.5061.00
456_V463_I1.5051.00
356_S366_S1.5021.00
753_Y759_E1.4961.00
788_S792_K1.4841.00
722_V759_E1.4821.00
54_R85_V1.4781.00
653_H675_P1.4781.00
242_M392_Y1.4641.00
277_Y341_L1.4631.00
230_I389_I1.4631.00
47_V95_T1.4591.00
92_A142_F1.4561.00
318_K330_E1.4541.00
55_E114_E1.4521.00
326_M363_S1.4481.00
187_A194_V1.4461.00
413_N455_T1.4461.00
149_E157_A1.4451.00
425_L474_A1.4441.00
720_A750_F1.4421.00
661_L664_G1.4371.00
260_I389_I1.4341.00
129_E137_Y1.4341.00
56_Q62_K1.4331.00
365_S369_F1.4291.00
653_H674_H1.4261.00
56_Q60_A1.4191.00
374_D458_S1.4130.99
643_E664_G1.4100.99
145_P148_A1.4050.99
178_N269_G1.3970.99
755_G758_M1.3960.99
662_L667_I1.3940.99
260_I392_Y1.3900.99
77_Q115_E1.3890.99
50_H150_T1.3860.99
736_I790_V1.3820.99
225_Y285_V1.3800.99
4_S162_D1.3760.99
511_E579_Y1.3720.99
226_T378_V1.3680.99
417_S420_K1.3630.99
566_S570_A1.3610.99
96_V109_A1.3610.99
257_V389_I1.3610.99
433_E481_N1.3590.99
286_V316_G1.3580.99
784_T788_S1.3570.99
415_H451_L1.3540.99
528_K563_D1.3530.99
652_L657_T1.3520.99
633_L642_I1.3500.99
562_L603_A1.3440.99
99_V103_N1.3410.99
235_I256_N1.3380.99
759_E762_K1.3320.99
422_S427_L1.3310.99
420_K423_S1.3310.99
444_T455_T1.3270.99
60_A64_N1.3250.99
272_L342_L1.3240.99
793_A797_T1.3240.99
212_I341_L1.3220.99
282_S315_N1.3140.99
311_L323_A1.3130.99
672_Q687_Y1.3130.99
12_V186_V1.3130.99
50_H146_N1.3120.99
60_A112_R1.3110.99
420_K470_I1.3100.99
322_V359_L1.3090.99
212_I280_F1.3080.99
792_K796_D1.3050.99
732_L765_V1.3040.99
57_H60_A1.3020.99
264_V384_R1.3020.99
643_E734_S1.3000.99
497_T500_Q1.3000.99
35_G166_E1.2990.99
76_V96_V1.2930.99
435_I439_K1.2930.99
90_K147_D1.2880.99
251_I364_E1.2870.99
242_M263_F1.2800.99
214_V227_A1.2760.99
418_A431_K1.2760.99
413_N456_V1.2750.99
362_R367_V1.2690.99
120_I143_V1.2670.99
413_N453_V1.2660.99
52_L87_K1.2620.99
290_A294_E1.2550.99
578_L603_A1.2550.99
285_V321_A1.2530.99
99_V104_F1.2510.99
755_G759_E1.2490.99
94_A98_A1.2440.99
421_V473_A1.2370.99
108_K115_E1.2360.99
226_T379_R1.2360.99
443_F456_V1.2340.99
390_H397_V1.2320.99
5_Y19_P1.2300.99
256_N393_A1.2280.99
762_K801_V1.2280.99
312_V319_A1.2240.99
51_V54_R1.2220.98
629_V689_F1.2210.98
405_D408_T1.2180.98
416_V470_I1.2160.98
439_K445_V1.2150.98
321_A365_S1.2140.98
771_Y786_A1.2120.98
561_L603_A1.2080.98
419_D450_D1.2080.98
215_K286_V1.2070.98
602_G625_V1.2060.98
652_L688_V1.2050.98
19_P163_A1.2020.98
184_Y459_R1.2020.98
513_A631_G1.1990.98
77_Q117_N1.1970.98
49_G78_I1.1950.98
510_L600_V1.1910.98
153_D156_A1.1900.98
297_V329_A1.1880.98
794_L800_A1.1870.98
424_V470_I1.1870.98
325_V352_V1.1870.98
70_I78_I1.1830.98
154_A158_L1.1780.98
362_R371_K1.1770.98
506_V693_L1.1760.98
731_Q734_S1.1760.98
261_T342_L1.1740.98
221_A351_K1.1660.98
496_L504_R1.1640.98
228_K386_A1.1620.98
65_K77_Q1.1620.98
284_E316_G1.1620.98
54_R86_D1.1600.98
448_A451_L1.1600.98
756_E760_E1.1570.98
386_A390_H1.1560.98
243_Q247_M1.1530.98
599_R690_E1.1470.98
771_Y783_V1.1470.98
31_I176_A1.1460.98
25_K190_L1.1460.98
278_D338_K1.1460.98
435_I452_L1.1450.98
351_K355_A1.1410.98
233_V257_V1.1400.98
46_V126_L1.1390.98
581_V693_L1.1350.98
367_V371_K1.1320.98
48_I157_A1.1280.97
85_V143_V1.1230.97
530_T537_S1.1220.97
216_I404_E1.1200.97
187_A193_E1.1180.97
719_I787_H1.1170.97
723_T763_K1.1140.97
154_A157_A1.1130.97
418_A452_L1.1130.97
515_L602_G1.1080.97
191_D436_S1.1050.97
379_R383_E1.1030.97
57_H112_R1.1020.97
289_K309_D1.0990.97
790_V794_L1.0970.97
780_E784_T1.0950.97
3_V182_V1.0950.97
272_L365_S1.0940.97
438_Y469_L1.0920.97
232_N338_K1.0910.97
120_I141_I1.0870.97
773_N782_E1.0860.97
234_T338_K1.0860.97
2_F166_E1.0840.97
245_K263_F1.0830.97
735_V739_A1.0810.97
144_F148_A1.0800.97
216_I223_P1.0770.97
445_V452_L1.0770.97
307_S310_H1.0750.97
288_R296_I1.0750.97
277_Y339_T1.0740.97
76_V117_N1.0740.97
274_A342_L1.0740.97
741_G744_L1.0730.97
238_S243_Q1.0710.97
108_K117_N1.0700.97
89_Q120_I1.0700.97
723_T800_A1.0680.96
83_P89_Q1.0630.96
69_D73_E1.0620.96
232_N339_T1.0620.96
110_K115_E1.0620.96
304_R361_L1.0620.96
716_T768_S1.0610.96
66_C85_V1.0600.96
50_H87_K1.0590.96
61_D112_R1.0580.96
412_N456_V1.0580.96
433_E437_I1.0550.96
509_F631_G1.0520.96
560_N582_G1.0510.96
756_E759_E1.0460.96
434_L473_A1.0450.96
19_P23_A1.0450.96
223_P346_Y1.0440.96
64_N85_V1.0430.96
467_E470_I1.0420.96
515_L604_V1.0410.96
446_G455_T1.0400.96
588_K595_V1.0380.96
746_E770_Q1.0370.96
38_Y41_E1.0340.96
72_A95_T1.0310.96
342_L389_I1.0300.96
292_E305_K1.0300.96
264_V388_L1.0280.96
225_Y347_F1.0260.96
174_A461_G1.0260.96
443_F454_V1.0230.95
231_K398_L1.0230.95
654_P675_P1.0200.95
177_M367_V1.0170.95
333_V340_I1.0150.95
5_Y9_E1.0140.95
48_I152_S1.0140.95
435_I445_V1.0140.95
652_L669_F1.0100.95
21_V24_E1.0090.95
67_L77_Q1.0070.95
64_N83_P1.0050.95
23_A165_L1.0010.95
279_R336_D0.9980.95
264_V267_E0.9970.95
625_V689_F0.9970.95
719_I769_L0.9970.95
31_I167_L0.9970.95
123_L129_E0.9970.95
240_L243_Q0.9970.95
321_A347_F0.9960.95
446_G453_V0.9940.95
54_R89_Q0.9940.95
735_V793_A0.9930.95
342_L385_A0.9920.95
384_R388_L0.9920.95
256_N392_Y0.9900.95
729_S767_F0.9900.95
260_I393_A0.9890.95
6_K9_E0.9890.95
169_L177_M0.9880.95
656_R687_Y0.9860.94
69_D75_P0.9860.94
261_T272_L0.9850.94
237_P256_N0.9840.94
285_V320_Q0.9800.94
598_E694_H0.9770.94
629_V660_I0.9750.94
188_A476_L0.9740.94
433_E477_Y0.9740.94
466_E470_I0.9710.94
64_N80_C0.9690.94
244_T247_M0.9690.94
604_V628_I0.9680.94
77_Q114_E0.9670.94
54_R87_K0.9670.94
629_V670_I0.9650.94
730_G733_E0.9650.94
93_V120_I0.9630.94
541_V552_I0.9610.94
235_I257_V0.9600.94
435_I447_E0.9580.94
503_R598_E0.9550.93
9_E15_K0.9490.93
81_G120_I0.9480.93
300_D304_R0.9480.93
32_E168_G0.9460.93
346_Y349_G0.9440.93
759_E801_V0.9420.93
412_N464_T0.9410.93
25_K189_I0.9410.93
293_N305_K0.9400.93
344_A382_A0.9390.93
292_E307_S0.9350.93
313_I347_F0.9340.93
52_L67_L0.9310.93
581_V600_V0.9300.93
641_S663_N0.9300.93
607_L619_P0.9300.93
731_Q797_T0.9290.93
557_L560_N0.9270.92
660_I668_G0.9250.92
710_P772_V0.9230.92
288_R312_V0.9200.92
306_L312_V0.9190.92
732_L767_F0.9180.92
310_H322_V0.9180.92
65_K79_I0.9180.92
753_Y757_H0.9170.92
342_L386_A0.9160.92
47_V70_I0.9160.92
207_Q210_D0.9120.92
769_L790_V0.9080.92
46_V100_L0.9070.92
333_V337_T0.9070.92
429_I434_L0.9050.92
731_Q798_Y0.9040.91
285_V347_F0.9040.91
225_Y344_A0.9030.91
379_R403_E0.9030.91
736_I747_V0.9020.91
124_Q129_E0.9010.91
30_G176_A0.8980.91
96_V108_K0.8980.91
714_S770_Q0.8970.91
561_L601_A0.8970.91
562_L673_V0.8960.91
9_E14_L0.8950.91
191_D440_R0.8940.91
224_L405_D0.8920.91
732_L798_Y0.8920.91
477_Y481_N0.8910.91
644_F660_I0.8900.91
739_A793_A0.8890.91
236_A394_G0.8880.91
602_G629_V0.8860.91
647_S659_N0.8860.91
474_A479_Y0.8840.91
411_A444_T0.8840.91
752_V765_V0.8840.91
599_R692_D0.8830.91
507_R581_V0.8820.90
633_L638_V0.8790.90
3_V179_M0.8770.90
57_H61_D0.8770.90
29_A476_L0.8770.90
33_V167_L0.8750.90
105_K108_K0.8730.90
523_L553_L0.8710.90
431_K447_E0.8710.90
78_I91_V0.8690.90
49_G68_V0.8690.90
506_V632_L0.8680.90
600_V689_F0.8670.90
329_A334_Q0.8660.90
80_C120_I0.8660.90
431_K452_L0.8640.90
199_T387_Q0.8630.89
752_V763_K0.8610.89
420_K424_V0.8590.89
309_D358_D0.8560.89
180_L196_L0.8550.89
294_E312_V0.8540.89
584_V599_R0.8540.89
758_M761_G0.8540.89
294_E314_T0.8520.89
70_I73_E0.8520.89
24_E28_R0.8520.89
539_N552_I0.8500.89
513_A628_I0.8500.89
743_L786_A0.8500.89
65_K111_L0.8490.89
427_L483_P0.8490.89
296_I314_T0.8490.89
206_E231_K0.8490.89
28_R480_D0.8480.89
575_S607_L0.8450.88
526_E530_T0.8440.88
273_H327_G0.8440.88
180_L268_Y0.8440.88
737_K747_V0.8430.88
436_S439_K0.8420.88
403_E406_H0.8410.88
17_M190_L0.8400.88
724_D763_K0.8390.88
82_A140_G0.8390.88
231_K277_Y0.8380.88
390_H393_A0.8380.88
740_G747_V0.8370.88
439_K444_T0.8350.88
48_I149_E0.8330.88
54_R83_P0.8300.88
745_K774_P0.8300.88
241_W392_Y0.8290.88
221_A348_N0.8290.88
320_Q330_E0.8280.87
176_A185_E0.8280.87
692_D695_A0.8280.87
278_D336_D0.8260.87
474_A482_I0.8250.87
67_L76_V0.8240.87
415_H448_A0.8230.87
208_A402_V0.8220.87
618_K624_V0.8220.87
745_K770_Q0.8200.87
296_I312_V0.8190.87
85_V120_I0.8180.87
755_G761_G0.8170.87
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643_E730_G0.5070.53
47_V71_G0.5070.53
162_D248_N0.5060.53
678_E688_V0.5060.53
196_L442_G0.5060.53
604_V624_V0.5060.53
45_G98_A0.5050.53
234_T256_N0.5050.53
214_V540_T0.5040.53
226_T403_E0.5040.53
55_E87_K0.5040.53
757_H761_G0.5040.53
12_V194_V0.5030.52
252_R326_M0.5030.52
781_E784_T0.5030.52
210_D231_K0.5030.52
174_A367_V0.5030.52
17_M21_V0.5020.52
441_L476_L0.5020.52
285_V312_V0.5020.52
48_I144_F0.5020.52
273_H326_M0.5020.52
26_I30_G0.5020.52
91_V141_I0.5020.52
720_A751_D0.5020.52
206_E390_H0.5010.52
176_A265_L0.5010.52
109_A117_N0.5000.52
53_E56_Q0.5000.52
537_S555_H0.5000.52
416_V467_E0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rhqB 2 0.9813 100 0.08 Contact Map
3pcoB 2 0.9826 100 0.087 Contact Map
4p72A 2 0.9789 100 0.088 Contact Map
1b7yB 2 0.9527 100 0.103 Contact Map
3l4gB 2 0.6679 100 0.52 Contact Map
2cxiA 3 0.3856 100 0.734 Contact Map
3cmqA 1 0.4117 100 0.755 Contact Map
2odrA 4 0.3495 100 0.785 Contact Map
2odrD 4 0.3495 100 0.785 Contact Map
2odrB 3 0.3507 100 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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