GREMLIN Database
SYFA - Phenylalanine--tRNA ligase alpha subunit
UniProt: P17921 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (326)
Sequences: 3364 (1727)
Seq/√Len: 95.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_K304_E6.5401.00
136_T139_Y4.1771.00
216_L290_V3.5661.00
255_T258_S3.5401.00
293_N296_K3.4651.00
21_S24_V3.1171.00
265_C276_C3.0151.00
259_V287_A2.9501.00
244_E264_T2.7881.00
138_Y143_S2.6981.00
137_D142_E2.6701.00
232_E245_I2.6451.00
75_K78_K2.5631.00
15_Q31_Q2.5371.00
116_E321_K2.4541.00
45_G48_K2.4041.00
117_I213_I2.3951.00
215_G310_F2.3931.00
296_K302_P2.3711.00
126_Y230_T2.3201.00
224_M259_V2.3011.00
231_L285_L2.2701.00
50_S53_E2.2551.00
300_F305_Y2.1961.00
217_V222_I2.1701.00
11_E15_Q2.1671.00
13_L71_A2.1401.00
296_K303_K2.1331.00
284_I317_I2.1221.00
76_N80_E2.1161.00
20_S24_V2.0981.00
82_E86_Q2.0681.00
276_C280_G2.0451.00
139_Y180_E2.0411.00
142_E148_K2.0271.00
11_E38_P2.0221.00
9_E67_R1.9441.00
6_K10_Q1.9391.00
226_D229_G1.9221.00
7_Q11_E1.9091.00
70_N74_D1.8581.00
86_Q90_G1.8471.00
31_Q38_P1.7761.00
265_C280_G1.7581.00
232_E236_K1.7491.00
10_Q14_E1.7301.00
276_C279_T1.7211.00
178_T182_H1.7021.00
265_C279_T1.6771.00
117_I314_V1.6711.00
203_D206_H1.6421.00
59_A63_E1.6421.00
155_M250_S1.6391.00
176_T298_A1.5911.00
19_A28_I1.5861.00
23_K27_D1.5861.00
78_K82_E1.5751.00
107_R111_T1.5211.00
138_Y180_E1.5101.00
129_E190_I1.5071.00
261_V285_L1.5021.00
51_A54_R1.4941.00
107_R115_E1.4891.00
179_M188_V1.4861.00
115_E118_E1.4741.00
140_N169_T1.4731.00
135_E177_R1.4521.00
120_L237_K1.4361.00
77_E81_E1.4271.00
14_E18_A1.4200.99
9_E13_L1.4180.99
16_V19_A1.4100.99
69_A73_A1.4080.99
200_D207_S1.4070.99
37_G40_T1.3980.99
187_P219_D1.3970.99
207_S331_Y1.3920.99
265_C275_V1.3920.99
26_N29_R1.3860.99
55_P59_A1.3470.99
200_D208_H1.3470.99
49_L57_M1.3440.99
243_R264_T1.3420.99
42_V61_A1.3380.99
162_T165_T1.3320.99
81_E85_K1.3310.99
22_L80_E1.3280.99
9_E64_V1.3260.99
123_G237_K1.3170.99
6_K9_E1.3080.99
312_M317_I1.3080.99
209_Q331_Y1.3070.99
7_Q10_Q1.3060.99
41_E44_R1.3000.99
236_K241_Q1.2960.99
175_Q290_V1.2840.99
22_L79_L1.2790.99
234_V238_M1.2690.99
238_M317_I1.2610.99
47_G54_R1.2550.99
57_M61_A1.2510.99
218_V295_L1.2480.99
68_I72_I1.2350.99
172_S214_E1.2240.98
146_L170_Q1.2190.98
27_D31_Q1.2110.98
146_L293_N1.2100.98
22_L83_E1.2080.98
83_E86_Q1.2050.98
16_V28_I1.2040.98
74_D78_K1.2040.98
248_R262_D1.2020.98
128_V191_I1.2000.98
12_A32_Y1.1990.98
235_A261_V1.1970.98
293_N297_M1.1950.98
129_E174_V1.1790.98
324_I330_F1.1780.98
10_Q13_L1.1740.98
140_N173_P1.1700.98
85_K89_A1.1660.98
43_L61_A1.1600.98
132_P177_R1.1590.98
124_M233_L1.1580.98
264_T276_C1.1550.98
114_I314_V1.1530.98
223_S226_D1.1530.98
143_S176_T1.1440.98
60_L63_E1.1430.98
277_K280_G1.1380.98
266_F276_C1.1350.98
53_E56_K1.1280.97
13_L17_E1.1260.97
138_Y142_E1.1240.97
61_A64_V1.1230.97
200_D203_D1.1180.97
15_Q32_Y1.1060.97
56_K60_L1.1060.97
265_C277_K1.1040.97
230_T308_F1.1020.97
26_N76_N1.0990.97
285_L312_M1.0930.97
265_C274_S1.0930.97
200_D205_T1.0920.97
12_A68_I1.0910.97
284_I320_L1.0830.97
13_L67_R1.0830.97
127_T182_H1.0830.97
266_F275_V1.0810.97
42_V45_G1.0660.96
128_V193_P1.0620.96
113_V116_E1.0620.96
129_E192_C1.0600.96
156_Q199_R1.0580.96
63_E67_R1.0580.96
19_A25_V1.0550.96
232_E247_L1.0520.96
261_V287_A1.0460.96
44_R47_G1.0380.96
191_I213_I1.0350.96
155_M170_Q1.0340.96
301_D304_E1.0310.96
252_F260_E1.0270.96
73_A77_E1.0270.96
87_K91_Q1.0240.95
231_L261_V1.0230.95
114_I118_E1.0110.95
143_S298_A1.0110.95
179_M300_F1.0100.95
118_E128_V1.0090.95
172_S175_Q1.0090.95
236_K242_D1.0090.95
83_E87_K1.0070.95
161_I166_L1.0070.95
274_S279_T1.0000.95
113_V318_A0.9940.95
190_I216_L0.9940.95
66_E70_N0.9880.94
118_E191_I0.9880.94
39_I64_V0.9870.94
146_L160_Y0.9870.94
73_A76_N0.9850.94
138_Y297_M0.9760.94
42_V57_M0.9720.94
24_V27_D0.9700.94
275_V319_M0.9700.94
21_S83_E0.9680.94
66_E69_A0.9660.94
327_I330_F0.9510.93
51_A55_P0.9510.93
26_N30_V0.9500.93
217_V230_T0.9470.93
137_D156_Q0.9450.93
14_E17_E0.9450.93
38_P41_E0.9430.93
86_Q89_A0.9390.93
233_L237_K0.9360.93
218_V306_Q0.9330.93
315_E330_F0.9320.93
84_M88_L0.9270.92
89_A92_T0.9200.92
113_V238_M0.9150.92
30_V34_G0.9100.92
200_D206_H0.9060.92
144_L176_T0.9020.91
88_L91_Q0.8970.91
245_I261_V0.8890.91
264_T279_T0.8880.91
113_V322_Y0.8880.91
82_E85_K0.8850.91
337_F341_F0.8830.90
148_K164_E0.8820.90
291_H298_A0.8780.90
39_I68_I0.8770.90
295_L300_F0.8740.90
112_V322_Y0.8710.90
170_Q173_P0.8700.90
143_S180_E0.8700.90
111_T115_E0.8660.90
46_M57_M0.8620.89
174_V192_C0.8560.89
6_K60_L0.8560.89
38_P42_V0.8550.89
57_M60_L0.8530.89
75_K82_E0.8520.89
62_N65_R0.8520.89
41_E45_G0.8490.89
266_F274_S0.8490.89
131_G174_V0.8470.89
318_A322_Y0.8460.88
211_M315_E0.8340.88
251_F291_H0.8300.88
40_T43_L0.8290.87
146_L156_Q0.8280.87
133_E197_Y0.8240.87
135_E173_P0.8220.87
12_A19_A0.8220.87
117_I191_I0.8160.87
109_P112_V0.8150.87
265_C278_G0.8150.87
213_I315_E0.8120.86
152_A156_Q0.8110.86
11_E14_E0.8070.86
110_L211_M0.8030.86
266_F282_I0.8030.86
207_S332_T0.8030.86
180_E298_A0.8020.86
182_H186_G0.7990.85
221_N304_E0.7980.85
266_F279_T0.7930.85
23_K83_E0.7910.85
29_R76_N0.7840.84
155_M251_F0.7840.84
67_R71_A0.7830.84
126_Y308_F0.7790.84
40_T44_R0.7760.84
250_S262_D0.7740.84
329_H332_T0.7740.84
71_A74_D0.7740.84
248_R260_E0.7720.83
166_L169_T0.7710.83
182_H185_K0.7680.83
224_M289_M0.7680.83
219_D305_Y0.7650.83
47_G51_A0.7640.83
222_I226_D0.7590.82
274_S280_G0.7580.82
325_D329_H0.7560.82
291_H296_K0.7510.82
178_T188_V0.7490.82
170_Q199_R0.7470.81
84_M87_K0.7460.81
179_M216_L0.7450.81
129_E178_T0.7450.81
337_F340_Q0.7440.81
46_M49_L0.7430.81
327_I331_Y0.7400.81
115_E119_D0.7390.81
235_A317_I0.7380.81
275_V279_T0.7370.81
79_L83_E0.7360.80
289_M308_F0.7340.80
13_L16_V0.7320.80
137_D152_A0.7320.80
220_K305_Y0.7290.80
295_L302_P0.7290.80
80_E83_E0.7270.80
264_T280_G0.7270.80
71_A75_K0.7250.79
49_L53_E0.7230.79
235_A284_I0.7190.79
137_D155_M0.7120.78
17_E78_K0.7120.78
119_D123_G0.7100.78
179_M298_A0.7100.78
211_M331_Y0.7090.78
221_N306_Q0.7090.78
44_R61_A0.7070.78
37_G55_P0.7030.77
45_G57_M0.7020.77
107_R112_V0.7020.77
235_A285_L0.6960.77
35_K40_T0.6920.76
171_T214_E0.6910.76
295_L298_A0.6900.76
12_A16_V0.6900.76
155_M169_T0.6880.76
117_I312_M0.6860.76
142_E156_Q0.6850.75
43_L65_R0.6840.75
70_N73_A0.6820.75
335_V339_S0.6820.75
43_L47_G0.6800.75
146_L152_A0.6770.75
255_T260_E0.6750.74
178_T190_I0.6730.74
161_I164_E0.6710.74
15_Q18_A0.6710.74
43_L46_M0.6660.73
174_V178_T0.6650.73
205_T319_M0.6650.73
205_T224_M0.6640.73
160_Y199_R0.6630.73
155_M201_N0.6620.73
75_K79_L0.6610.73
289_M295_L0.6610.73
7_Q27_D0.6590.73
119_D122_I0.6590.73
259_V310_F0.6570.72
275_V280_G0.6570.72
185_K304_E0.6570.72
82_E90_G0.6550.72
16_V72_I0.6520.72
243_R266_F0.6510.72
203_D208_H0.6510.72
274_S277_K0.6500.72
103_A339_S0.6490.71
179_M218_V0.6490.71
182_H188_V0.6460.71
176_T297_M0.6400.70
21_S25_V0.6380.70
219_D226_D0.6380.70
188_V216_L0.6380.70
290_V307_G0.6370.70
9_E63_E0.6360.70
22_L26_N0.6350.70
121_F234_V0.6340.70
110_L209_Q0.6330.70
42_V64_V0.6330.70
188_V300_F0.6330.70
23_K30_V0.6330.70
220_K302_P0.6320.69
204_A207_S0.6310.69
250_S260_E0.6300.69
233_L236_K0.6300.69
63_E66_E0.6280.69
42_V46_M0.6280.69
7_Q20_S0.6280.69
77_E80_E0.6260.69
16_V29_R0.6260.69
186_G300_F0.6250.69
12_A28_I0.6240.69
252_F283_E0.6220.68
250_S261_V0.6220.68
106_G112_V0.6200.68
18_A24_V0.6200.68
200_D255_T0.6190.68
122_I128_V0.6170.68
137_D146_L0.6150.67
147_P154_D0.6120.67
228_K287_A0.6050.66
189_K247_L0.6040.66
22_L76_N0.6040.66
46_M61_A0.6020.66
136_T165_T0.6000.66
129_E182_H0.5980.65
208_H332_T0.5960.65
10_Q20_S0.5950.65
228_K310_F0.5950.65
33_L69_A0.5950.65
138_Y298_A0.5930.65
275_V282_I0.5910.64
200_D258_S0.5910.64
201_N209_Q0.5910.64
64_V67_R0.5890.64
156_Q250_S0.5890.64
110_L207_S0.5880.64
190_I290_V0.5880.64
135_E140_N0.5860.64
172_S179_M0.5850.64
208_H327_I0.5840.63
36_K40_T0.5840.63
39_I42_V0.5830.63
203_D207_S0.5820.63
330_F337_F0.5820.63
171_T175_Q0.5820.63
250_S255_T0.5810.63
239_F254_F0.5810.63
211_M312_M0.5800.63
67_R70_N0.5800.63
213_I314_V0.5790.63
77_E82_E0.5780.63
43_L57_M0.5780.63
110_L201_N0.5770.63
250_S279_T0.5760.62
17_E71_A0.5760.62
20_S23_K0.5750.62
175_Q214_E0.5750.62
247_L259_V0.5740.62
204_A274_S0.5730.62
246_R281_W0.5720.62
186_G298_A0.5720.62
236_K244_E0.5720.62
243_R263_V0.5720.62
319_M323_G0.5710.62
37_G62_N0.5710.62
320_L327_I0.5710.62
195_K201_N0.5700.62
8_L11_E0.5700.62
291_H295_L0.5630.61
45_G50_S0.5610.60
114_I211_M0.5610.60
178_T181_K0.5600.60
327_I332_T0.5590.60
282_I318_A0.5590.60
18_A78_K0.5580.60
50_S56_K0.5580.60
10_Q41_E0.5570.60
178_T186_G0.5550.60
246_R262_D0.5540.59
116_E120_L0.5530.59
114_I170_Q0.5500.59
122_I189_K0.5500.59
129_E181_K0.5470.58
206_H327_I0.5460.58
23_K26_N0.5460.58
146_L149_E0.5440.58
149_E282_I0.5410.58
132_P135_E0.5400.57
43_L62_N0.5390.57
232_E244_E0.5380.57
172_S193_P0.5370.57
110_L315_E0.5350.57
126_Y189_K0.5320.56
263_V266_F0.5320.56
132_P174_V0.5320.56
199_R208_H0.5320.56
286_G313_G0.5310.56
116_E237_K0.5310.56
172_S290_V0.5300.56
174_V287_A0.5290.56
158_S300_F0.5290.56
126_Y217_V0.5270.56
179_M295_L0.5270.56
33_L68_I0.5260.56
193_P214_E0.5250.55
155_M199_R0.5240.55
224_M338_I0.5230.55
315_E331_Y0.5220.55
218_V298_A0.5220.55
189_K219_D0.5210.55
126_Y341_F0.5210.55
43_L54_R0.5210.55
289_M306_Q0.5210.55
142_E155_M0.5200.55
160_Y200_D0.5190.55
224_M282_I0.5180.54
112_V116_E0.5170.54
133_E195_K0.5170.54
7_Q14_E0.5150.54
222_I229_G0.5140.54
224_M251_F0.5140.54
174_V177_R0.5130.54
333_N338_I0.5130.54
188_V217_V0.5120.54
208_H211_M0.5110.53
16_V68_I0.5100.53
329_H337_F0.5090.53
12_A15_Q0.5090.53
50_S57_M0.5090.53
33_L62_N0.5080.53
215_G312_M0.5070.53
333_N337_F0.5050.53
277_K282_I0.5050.53
228_K284_I0.5040.52
235_A245_I0.5040.52
250_S258_S0.5010.52
28_I31_Q0.5000.52
301_D305_Y0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p72C 2 0.7122 100 0.332 Contact Map
1b7yA 2 0.6977 100 0.366 Contact Map
3pcoA 2 0.939 100 0.397 Contact Map
3l4gA 2 0.9593 100 0.511 Contact Map
3cmqA 1 0.7442 100 0.557 Contact Map
2rhqA 2 0.7703 100 0.566 Contact Map
2du3A 4 0.782 100 0.591 Contact Map
2du7A 7 0.7384 100 0.623 Contact Map
2odrC 4 0.7267 100 0.631 Contact Map
2odrA 4 0.7267 100 0.639 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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