GREMLIN Database
RSBX - Phosphoserine phosphatase RsbX
UniProt: P17906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (187)
Sequences: 569 (457)
Seq/√Len: 33.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_S60_K3.7811.00
16_Q25_C3.7561.00
45_G55_S3.4161.00
158_L180_L3.3061.00
42_V192_T3.2551.00
40_C196_G2.9671.00
43_A56_S2.8631.00
162_D166_H2.6661.00
158_L191_L2.6251.00
177_S195_L2.5851.00
114_L151_F2.4671.00
37_E94_K2.3940.99
40_C194_I2.3280.99
110_V155_T2.3020.99
72_E140_T2.1980.99
51_L54_E2.1560.99
135_P138_Y2.1450.99
55_S85_K2.0010.98
101_Q142_T1.9580.98
96_N99_Q1.9300.97
163_I166_H1.9270.97
25_C81_A1.9230.97
28_S56_S1.9100.97
89_T111_R1.9080.97
106_S126_P1.8860.97
59_I82_M1.8700.97
103_T140_T1.8700.97
14_V194_I1.8550.97
145_Y151_F1.7890.96
93_L151_F1.7860.96
82_M88_A1.7800.96
39_I94_K1.7690.96
91_S104_Y1.7410.95
91_S110_V1.7400.95
155_T192_T1.6910.94
70_D73_S1.6690.94
15_Y181_K1.6330.93
66_Y77_R1.5920.92
107_V131_L1.5840.92
146_E149_S1.5710.92
105_C140_T1.5660.92
74_I77_R1.5470.91
91_S153_I1.5180.90
104_Y126_P1.4960.90
71_V75_I1.4880.89
41_A63_V1.4660.89
113_I172_S1.4140.87
48_S132_S1.4120.87
62_L77_R1.4020.86
166_H169_K1.4000.86
78_C128_S1.3840.86
22_K48_S1.3780.85
130_Y161_P1.3430.84
89_T110_V1.3280.83
89_T131_L1.3280.83
71_V92_I1.2870.81
36_K98_E1.2840.81
17_L185_T1.2720.80
24_I53_N1.2620.80
62_L81_A1.2420.79
48_S130_Y1.2210.78
179_S183_Y1.2190.77
14_V29_F1.1820.75
73_S76_E1.1710.75
71_V105_C1.1660.74
58_A61_D1.1630.74
162_D169_K1.1560.74
111_R154_H1.1290.72
17_L181_K1.1260.72
113_I123_Y1.1200.71
114_L149_S1.1080.70
97_F147_K1.0870.69
90_A131_L1.0610.67
12_T31_M1.0570.67
72_E76_E1.0540.66
72_E95_I1.0490.66
62_L66_Y1.0380.65
124_P143_A1.0380.65
172_S176_I1.0370.65
181_K191_L1.0330.65
100_R146_E1.0180.64
102_F124_P1.0130.63
91_S112_F1.0120.63
154_H188_K1.0090.63
70_D98_E1.0050.63
111_R126_P1.0010.62
30_F63_V0.9980.62
93_L177_S0.9850.61
175_E182_M0.9820.61
163_I168_K0.9790.61
33_A38_L0.9640.59
163_I169_K0.9590.59
133_G140_T0.9470.58
73_S116_S0.9460.58
149_S197_Q0.9330.57
59_I85_K0.9310.57
11_Q173_V0.9290.57
55_S86_R0.9170.56
51_L158_L0.9170.56
173_V192_T0.9150.55
162_D167_L0.9120.55
38_L97_F0.9040.54
78_C131_L0.9010.54
99_Q120_E0.9010.54
107_V135_P0.8880.53
11_Q197_Q0.8820.53
74_I112_F0.8820.53
50_S139_K0.8810.53
52_A86_R0.8780.52
57_A95_I0.8760.52
42_V191_L0.8730.52
61_D65_N0.8720.52
13_L177_S0.8700.52
63_V79_N0.8700.52
116_S148_G0.8670.51
155_T178_N0.8660.51
38_L92_I0.8650.51
32_K67_A0.8620.51
49_G52_A0.8600.51
41_A60_K0.8560.50
131_L135_P0.8530.50
78_C90_A0.8500.50
125_L141_H0.8480.50
45_G86_R0.8480.50
14_V192_T0.8440.49
16_Q192_T0.8400.49
69_E73_S0.8380.49
82_M123_Y0.8310.48
112_F158_L0.8260.48
171_Q181_K0.8200.47
99_Q165_S0.8150.47
179_S182_M0.8130.47
110_V125_L0.8120.47
69_E77_R0.8100.47
93_L102_F0.8090.47
30_F41_A0.8080.46
53_N110_V0.8030.46
65_N114_L0.8020.46
60_K64_E0.7860.45
181_K186_S0.7730.44
34_D37_E0.7720.43
78_C130_Y0.7660.43
162_D168_K0.7640.43
78_C110_V0.7590.42
55_S59_I0.7490.42
91_S125_L0.7470.41
90_A162_D0.7460.41
143_A173_V0.7420.41
104_Y159_N0.7410.41
82_M95_I0.7410.41
137_K170_G0.7340.40
102_F149_S0.7270.40
163_I167_L0.7260.40
45_G59_I0.7240.40
150_K159_N0.7220.39
24_I50_S0.7210.39
152_I195_L0.7190.39
70_D100_R0.7160.39
193_Y196_G0.7090.38
91_S154_H0.7060.38
76_E137_K0.7040.38
176_I195_L0.7040.38
55_S106_S0.7020.38
103_T142_T0.6960.37
95_I155_T0.6860.37
55_S60_K0.6850.36
132_S151_F0.6810.36
102_F146_E0.6810.36
112_F143_A0.6790.36
10_I99_Q0.6790.36
60_K193_Y0.6780.36
106_S130_Y0.6770.36
44_D47_G0.6750.36
129_G157_G0.6750.36
44_D87_G0.6750.36
47_G87_G0.6750.36
44_D129_G0.6750.36
108_G157_G0.6750.36
108_G156_D0.6750.36
129_G156_D0.6750.36
44_D157_G0.6750.36
47_G108_G0.6750.36
47_G157_G0.6750.36
47_G156_D0.6750.36
47_G129_G0.6750.36
44_D156_D0.6750.36
108_G129_G0.6750.36
44_D108_G0.6750.36
87_G156_D0.6750.36
87_G157_G0.6750.36
87_G108_G0.6750.36
87_G129_G0.6750.36
91_S107_V0.6740.36
55_S158_L0.6740.36
57_A69_E0.6740.36
72_E171_Q0.6710.35
23_S76_E0.6670.35
36_K152_I0.6630.35
131_L151_F0.6580.34
40_C93_L0.6580.34
10_I38_L0.6570.34
32_K196_G0.6520.34
177_S193_Y0.6510.34
15_Y30_F0.6480.34
96_N170_G0.6470.34
149_S178_N0.6420.33
94_K151_F0.6410.33
83_K101_Q0.6370.33
91_S126_P0.6310.32
43_A154_H0.6300.32
99_Q144_T0.6280.32
78_C81_A0.6280.32
75_I90_A0.6280.32
57_A118_S0.6250.32
93_L112_F0.6240.32
33_A107_V0.6230.32
115_H145_Y0.6220.32
18_N163_I0.6200.32
71_V185_T0.6190.32
181_K192_T0.6180.31
176_I197_Q0.6160.31
36_K171_Q0.6130.31
74_I99_Q0.6120.31
74_I155_T0.6100.31
55_S188_K0.6100.31
34_D58_A0.6090.31
79_N130_Y0.6050.31
113_I154_H0.6010.30
111_R134_K0.5990.30
137_K169_K0.5980.30
50_S70_D0.5970.30
88_A115_H0.5960.30
48_S124_P0.5950.30
36_K65_N0.5900.29
112_F151_F0.5850.29
116_S122_F0.5850.29
81_A122_F0.5840.29
141_H172_S0.5840.29
11_Q72_E0.5840.29
25_C180_L0.5830.29
42_V142_T0.5830.29
61_D114_L0.5810.29
127_I141_H0.5810.29
124_P196_G0.5790.29
104_Y124_P0.5780.29
61_D68_S0.5740.28
178_N183_Y0.5720.28
29_F179_S0.5660.28
57_A138_Y0.5630.28
57_A66_Y0.5630.28
19_K22_K0.5610.27
48_S186_S0.5600.27
90_A158_L0.5590.27
59_I86_R0.5560.27
150_K197_Q0.5500.27
22_K191_L0.5500.27
19_K48_S0.5500.27
92_I192_T0.5480.27
72_E117_P0.5470.27
42_V56_S0.5390.26
39_I81_A0.5360.26
10_I20_E0.5350.26
75_I173_V0.5340.26
116_S144_T0.5330.26
73_S80_Q0.5290.25
100_R144_T0.5240.25
41_A112_F0.5210.25
82_M170_G0.5200.25
115_H127_I0.5190.25
123_Y134_K0.5150.25
25_C134_K0.5150.25
16_Q130_Y0.5080.24
62_L150_K0.5070.24
168_K179_S0.5060.24
55_S193_Y0.5060.24
72_E144_T0.5060.24
54_E103_T0.5010.24
48_S78_C0.5000.24
146_E152_I0.5000.24
127_I137_K0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w42A 1 1 100 0.48 Contact Map
3zt9A 1 0.9497 100 0.52 Contact Map
3pu9A 2 0.9698 99.9 0.596 Contact Map
3t91A 3 0.9497 99.9 0.607 Contact Map
3ke6A 2 0.995 99.9 0.616 Contact Map
3f79A 2 0.9799 99.9 0.623 Contact Map
2j82A 1 0.9196 99.9 0.65 Contact Map
2pk0A 1 0.9648 99.8 0.659 Contact Map
1txoA 1 0.9347 99.8 0.676 Contact Map
2jfrA 1 0.9497 99.8 0.676 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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