RSBX - BACSU - GREMLIN Contacts

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RSBX - Phosphoserine phosphatase RsbX

UniProt:	P17906	Sequences: MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVADGLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQFTYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNVPDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	199 (187)
Sequences:	569 (457)
Seq/√Len:	33.4

BACSU - RSBX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_S	60_K	3.781	1.00
16_Q	25_C	3.756	1.00
45_G	55_S	3.416	1.00
158_L	180_L	3.306	1.00
42_V	192_T	3.255	1.00
40_C	196_G	2.967	1.00
43_A	56_S	2.863	1.00
162_D	166_H	2.666	1.00
158_L	191_L	2.625	1.00
177_S	195_L	2.585	1.00
114_L	151_F	2.467	1.00
37_E	94_K	2.394	0.99
40_C	194_I	2.328	0.99
110_V	155_T	2.302	0.99
72_E	140_T	2.198	0.99
51_L	54_E	2.156	0.99
135_P	138_Y	2.145	0.99
55_S	85_K	2.001	0.98
101_Q	142_T	1.958	0.98
96_N	99_Q	1.930	0.97
163_I	166_H	1.927	0.97
25_C	81_A	1.923	0.97
28_S	56_S	1.910	0.97
89_T	111_R	1.908	0.97
106_S	126_P	1.886	0.97
59_I	82_M	1.870	0.97
103_T	140_T	1.870	0.97
14_V	194_I	1.855	0.97
145_Y	151_F	1.789	0.96
93_L	151_F	1.786	0.96
82_M	88_A	1.780	0.96
39_I	94_K	1.769	0.96
91_S	104_Y	1.741	0.95
91_S	110_V	1.740	0.95
155_T	192_T	1.691	0.94
70_D	73_S	1.669	0.94
15_Y	181_K	1.633	0.93
66_Y	77_R	1.592	0.92
107_V	131_L	1.584	0.92
146_E	149_S	1.571	0.92
105_C	140_T	1.566	0.92
74_I	77_R	1.547	0.91
91_S	153_I	1.518	0.90
104_Y	126_P	1.496	0.90
71_V	75_I	1.488	0.89
41_A	63_V	1.466	0.89
113_I	172_S	1.414	0.87
48_S	132_S	1.412	0.87
62_L	77_R	1.402	0.86
166_H	169_K	1.400	0.86
78_C	128_S	1.384	0.86
22_K	48_S	1.378	0.85
130_Y	161_P	1.343	0.84
89_T	110_V	1.328	0.83
89_T	131_L	1.328	0.83
71_V	92_I	1.287	0.81
36_K	98_E	1.284	0.81
17_L	185_T	1.272	0.80
24_I	53_N	1.262	0.80
62_L	81_A	1.242	0.79
48_S	130_Y	1.221	0.78
179_S	183_Y	1.219	0.77
14_V	29_F	1.182	0.75
73_S	76_E	1.171	0.75
71_V	105_C	1.166	0.74
58_A	61_D	1.163	0.74
162_D	169_K	1.156	0.74
111_R	154_H	1.129	0.72
17_L	181_K	1.126	0.72
113_I	123_Y	1.120	0.71
114_L	149_S	1.108	0.70
97_F	147_K	1.087	0.69
90_A	131_L	1.061	0.67
12_T	31_M	1.057	0.67
72_E	76_E	1.054	0.66
72_E	95_I	1.049	0.66
62_L	66_Y	1.038	0.65
124_P	143_A	1.038	0.65
172_S	176_I	1.037	0.65
181_K	191_L	1.033	0.65
100_R	146_E	1.018	0.64
102_F	124_P	1.013	0.63
91_S	112_F	1.012	0.63
154_H	188_K	1.009	0.63
70_D	98_E	1.005	0.63
111_R	126_P	1.001	0.62
30_F	63_V	0.998	0.62
93_L	177_S	0.985	0.61
175_E	182_M	0.982	0.61
163_I	168_K	0.979	0.61
33_A	38_L	0.964	0.59
163_I	169_K	0.959	0.59
133_G	140_T	0.947	0.58
73_S	116_S	0.946	0.58
149_S	197_Q	0.933	0.57
59_I	85_K	0.931	0.57
11_Q	173_V	0.929	0.57
55_S	86_R	0.917	0.56
51_L	158_L	0.917	0.56
173_V	192_T	0.915	0.55
162_D	167_L	0.912	0.55
38_L	97_F	0.904	0.54
78_C	131_L	0.901	0.54
99_Q	120_E	0.901	0.54
107_V	135_P	0.888	0.53
11_Q	197_Q	0.882	0.53
74_I	112_F	0.882	0.53
50_S	139_K	0.881	0.53
52_A	86_R	0.878	0.52
57_A	95_I	0.876	0.52
42_V	191_L	0.873	0.52
61_D	65_N	0.872	0.52
13_L	177_S	0.870	0.52
63_V	79_N	0.870	0.52
116_S	148_G	0.867	0.51
155_T	178_N	0.866	0.51
38_L	92_I	0.865	0.51
32_K	67_A	0.862	0.51
49_G	52_A	0.860	0.51
41_A	60_K	0.856	0.50
131_L	135_P	0.853	0.50
78_C	90_A	0.850	0.50
125_L	141_H	0.848	0.50
45_G	86_R	0.848	0.50
14_V	192_T	0.844	0.49
16_Q	192_T	0.840	0.49
69_E	73_S	0.838	0.49
82_M	123_Y	0.831	0.48
112_F	158_L	0.826	0.48
171_Q	181_K	0.820	0.47
99_Q	165_S	0.815	0.47
179_S	182_M	0.813	0.47
110_V	125_L	0.812	0.47
69_E	77_R	0.810	0.47
93_L	102_F	0.809	0.47
30_F	41_A	0.808	0.46
53_N	110_V	0.803	0.46
65_N	114_L	0.802	0.46
60_K	64_E	0.786	0.45
181_K	186_S	0.773	0.44
34_D	37_E	0.772	0.43
78_C	130_Y	0.766	0.43
162_D	168_K	0.764	0.43
78_C	110_V	0.759	0.42
55_S	59_I	0.749	0.42
91_S	125_L	0.747	0.41
90_A	162_D	0.746	0.41
143_A	173_V	0.742	0.41
104_Y	159_N	0.741	0.41
82_M	95_I	0.741	0.41
137_K	170_G	0.734	0.40
102_F	149_S	0.727	0.40
163_I	167_L	0.726	0.40
45_G	59_I	0.724	0.40
150_K	159_N	0.722	0.39
24_I	50_S	0.721	0.39
152_I	195_L	0.719	0.39
70_D	100_R	0.716	0.39
193_Y	196_G	0.709	0.38
91_S	154_H	0.706	0.38
76_E	137_K	0.704	0.38
176_I	195_L	0.704	0.38
55_S	106_S	0.702	0.38
103_T	142_T	0.696	0.37
95_I	155_T	0.686	0.37
55_S	60_K	0.685	0.36
132_S	151_F	0.681	0.36
102_F	146_E	0.681	0.36
112_F	143_A	0.679	0.36
10_I	99_Q	0.679	0.36
60_K	193_Y	0.678	0.36
106_S	130_Y	0.677	0.36
44_D	47_G	0.675	0.36
129_G	157_G	0.675	0.36
44_D	87_G	0.675	0.36
47_G	87_G	0.675	0.36
44_D	129_G	0.675	0.36
108_G	157_G	0.675	0.36
108_G	156_D	0.675	0.36
129_G	156_D	0.675	0.36
44_D	157_G	0.675	0.36
47_G	108_G	0.675	0.36
47_G	157_G	0.675	0.36
47_G	156_D	0.675	0.36
47_G	129_G	0.675	0.36
44_D	156_D	0.675	0.36
108_G	129_G	0.675	0.36
44_D	108_G	0.675	0.36
87_G	156_D	0.675	0.36
87_G	157_G	0.675	0.36
87_G	108_G	0.675	0.36
87_G	129_G	0.675	0.36
91_S	107_V	0.674	0.36
55_S	158_L	0.674	0.36
57_A	69_E	0.674	0.36
72_E	171_Q	0.671	0.35
23_S	76_E	0.667	0.35
36_K	152_I	0.663	0.35
131_L	151_F	0.658	0.34
40_C	93_L	0.658	0.34
10_I	38_L	0.657	0.34
32_K	196_G	0.652	0.34
177_S	193_Y	0.651	0.34
15_Y	30_F	0.648	0.34
96_N	170_G	0.647	0.34
149_S	178_N	0.642	0.33
94_K	151_F	0.641	0.33
83_K	101_Q	0.637	0.33
91_S	126_P	0.631	0.32
43_A	154_H	0.630	0.32
99_Q	144_T	0.628	0.32
78_C	81_A	0.628	0.32
75_I	90_A	0.628	0.32
57_A	118_S	0.625	0.32
93_L	112_F	0.624	0.32
33_A	107_V	0.623	0.32
115_H	145_Y	0.622	0.32
18_N	163_I	0.620	0.32
71_V	185_T	0.619	0.32
181_K	192_T	0.618	0.31
176_I	197_Q	0.616	0.31
36_K	171_Q	0.613	0.31
74_I	99_Q	0.612	0.31
74_I	155_T	0.610	0.31
55_S	188_K	0.610	0.31
34_D	58_A	0.609	0.31
79_N	130_Y	0.605	0.31
113_I	154_H	0.601	0.30
111_R	134_K	0.599	0.30
137_K	169_K	0.598	0.30
50_S	70_D	0.597	0.30
88_A	115_H	0.596	0.30
48_S	124_P	0.595	0.30
36_K	65_N	0.590	0.29
112_F	151_F	0.585	0.29
116_S	122_F	0.585	0.29
81_A	122_F	0.584	0.29
141_H	172_S	0.584	0.29
11_Q	72_E	0.584	0.29
25_C	180_L	0.583	0.29
42_V	142_T	0.583	0.29
61_D	114_L	0.581	0.29
127_I	141_H	0.581	0.29
124_P	196_G	0.579	0.29
104_Y	124_P	0.578	0.29
61_D	68_S	0.574	0.28
178_N	183_Y	0.572	0.28
29_F	179_S	0.566	0.28
57_A	138_Y	0.563	0.28
57_A	66_Y	0.563	0.28
19_K	22_K	0.561	0.27
48_S	186_S	0.560	0.27
90_A	158_L	0.559	0.27
59_I	86_R	0.556	0.27
150_K	197_Q	0.550	0.27
22_K	191_L	0.550	0.27
19_K	48_S	0.550	0.27
92_I	192_T	0.548	0.27
72_E	117_P	0.547	0.27
42_V	56_S	0.539	0.26
39_I	81_A	0.536	0.26
10_I	20_E	0.535	0.26
75_I	173_V	0.534	0.26
116_S	144_T	0.533	0.26
73_S	80_Q	0.529	0.25
100_R	144_T	0.524	0.25
41_A	112_F	0.521	0.25
82_M	170_G	0.520	0.25
115_H	127_I	0.519	0.25
123_Y	134_K	0.515	0.25
25_C	134_K	0.515	0.25
16_Q	130_Y	0.508	0.24
62_L	150_K	0.507	0.24
168_K	179_S	0.506	0.24
55_S	193_Y	0.506	0.24
72_E	144_T	0.506	0.24
54_E	103_T	0.501	0.24
48_S	78_C	0.500	0.24
146_E	152_I	0.500	0.24
127_I	137_K	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3w42A	1	1	100	0.48	Contact Map
3zt9A	1	0.9497	100	0.52	Contact Map
3pu9A	2	0.9698	99.9	0.596	Contact Map
3t91A	3	0.9497	99.9	0.607	Contact Map
3ke6A	2	0.995	99.9	0.616	Contact Map
3f79A	2	0.9799	99.9	0.623	Contact Map
2j82A	1	0.9196	99.9	0.65	Contact Map
2pk0A	1	0.9648	99.8	0.659	Contact Map
1txoA	1	0.9347	99.8	0.676	Contact Map
2jfrA	1	0.9497	99.8	0.676	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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