GREMLIN Database
RSBW - Serine-protein kinase RsbW
UniProt: P17904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (134)
Sequences: 1324 (931)
Seq/√Len: 80.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A58_A3.2091.00
83_A136_T2.8681.00
26_L71_F2.8611.00
54_A67_V2.8041.00
30_A78_L2.7981.00
126_E140_T2.7161.00
124_M127_V2.6041.00
26_L69_I2.5871.00
30_A43_L2.5641.00
77_R140_T2.5331.00
62_D65_G2.3121.00
9_E70_R2.3011.00
77_R142_Y2.0951.00
50_A120_M2.0801.00
9_E68_S1.9801.00
11_K66_E1.9761.00
124_M139_M1.9691.00
79_E138_A1.9601.00
43_L143_L1.9411.00
43_L124_M1.9331.00
11_K68_S1.9071.00
94_K99_G1.9001.00
46_A124_M1.8911.00
60_K87_D1.8221.00
120_M137_V1.8001.00
46_A119_L1.7491.00
81_I138_A1.7161.00
7_Y72_G1.6491.00
68_S83_A1.6131.00
72_G79_E1.6021.00
102_T106_T1.5971.00
74_F77_R1.5200.99
125_D141_K1.5190.99
70_R81_I1.5110.99
13_P66_E1.5020.99
60_K107_V1.4750.99
119_L122_T1.4150.99
51_C67_V1.3980.99
128_R138_A1.3510.99
59_Y65_G1.3300.98
69_I82_V1.2950.98
14_A59_Y1.2780.98
8_I71_F1.2500.98
76_D142_Y1.2230.97
36_T39_E1.2210.97
12_V55_V1.1780.97
96_Q121_E1.1670.96
130_Q136_T1.1640.96
107_V110_L1.1590.96
68_S85_E1.1500.96
12_V67_V1.1430.96
55_V67_V1.1350.96
127_V139_M1.1290.96
45_I123_L1.1230.96
134_G137_V1.1220.96
124_M141_K1.1130.95
23_R42_D1.0940.95
14_A67_V1.0790.94
12_V22_I1.0600.94
81_I136_T1.0590.94
90_D94_K1.0490.94
90_D93_Q1.0380.93
23_R48_S1.0210.93
79_E140_T0.9990.92
105_H108_D0.9970.92
40_I122_T0.9890.91
14_A64_N0.9830.91
12_V69_I0.9760.91
16_P19_V0.9710.91
117_L120_M0.9710.91
24_L28_G0.9530.90
10_M25_T0.9520.90
42_D46_A0.9450.89
30_A35_Y0.9450.89
71_F78_L0.9350.89
50_A82_V0.9320.89
23_R44_K0.9230.88
82_V139_M0.9220.88
75_E133_S0.9200.88
129_V135_V0.9140.88
56_Q113_G0.9020.87
13_P62_D0.9010.87
118_Y122_T0.9000.87
14_A65_G0.8900.86
38_D110_L0.8810.86
88_S135_V0.8530.84
37_Y119_L0.8510.84
48_S135_V0.8420.83
27_S44_K0.8410.83
25_T69_I0.8380.83
79_E130_Q0.8210.82
117_L129_V0.8160.81
15_Q25_T0.8080.81
48_S52_T0.8040.80
23_R135_V0.8010.80
8_I26_L0.7980.80
46_A80_V0.7950.80
19_V48_S0.7930.79
130_Q138_A0.7900.79
19_V35_Y0.7880.79
13_P64_N0.7790.78
21_I33_M0.7730.78
77_R85_E0.7630.77
35_Y143_L0.7580.76
84_D134_G0.7540.76
91_F94_K0.7520.76
120_M139_M0.7480.75
7_Y70_R0.7440.75
126_E142_Y0.7390.74
7_Y60_K0.7350.74
64_N128_R0.7210.73
23_R129_V0.7190.72
76_D92_D0.7180.72
14_A62_D0.7070.71
8_I21_I0.7060.71
72_G77_R0.7040.71
26_L73_V0.7020.71
66_E85_E0.7020.71
81_I87_D0.7010.70
80_V142_Y0.6980.70
48_S89_F0.6970.70
43_L78_L0.6920.69
50_A139_M0.6850.69
101_Y113_G0.6820.68
22_I69_I0.6740.67
39_E141_K0.6590.66
27_S37_Y0.6580.66
49_E116_G0.6530.65
49_E53_N0.6520.65
19_V112_E0.6500.65
15_Q77_R0.6410.64
64_N72_G0.6390.63
89_F92_D0.6380.63
40_I44_K0.6360.63
19_V22_I0.6340.63
46_A139_M0.6330.63
25_T71_F0.6280.62
74_F79_E0.6270.62
13_P30_A0.6190.61
96_Q99_G0.6150.60
56_Q135_V0.6110.60
53_N116_G0.6060.59
19_V44_K0.6060.59
13_P119_L0.6040.59
33_M73_V0.6010.59
59_Y67_V0.5990.58
110_L115_L0.5950.58
60_K64_N0.5930.58
107_V115_L0.5920.57
42_D80_V0.5900.57
47_V82_V0.5870.57
93_Q99_G0.5850.57
70_R83_A0.5820.56
45_I48_S0.5810.56
94_K111_S0.5790.56
81_I128_R0.5790.56
34_G122_T0.5770.56
58_A88_S0.5760.55
101_Y110_L0.5750.55
86_G114_G0.5670.54
92_D95_Q0.5660.54
15_Q64_N0.5660.54
75_E94_K0.5660.54
27_S124_M0.5640.54
19_V39_E0.5620.54
19_V45_I0.5610.54
56_Q110_L0.5590.53
7_Y66_E0.5590.53
8_I20_G0.5590.53
57_H86_G0.5540.53
110_L113_G0.5530.52
39_E47_V0.5530.52
39_E124_M0.5510.52
70_R130_Q0.5510.52
24_L119_L0.5510.52
107_V113_G0.5480.52
56_Q130_Q0.5460.52
67_V82_V0.5460.52
113_G119_L0.5450.51
105_H109_Q0.5430.51
76_D143_L0.5410.51
18_Y44_K0.5380.51
16_P42_D0.5370.50
60_K109_Q0.5360.50
50_A137_V0.5360.50
77_R126_E0.5320.50
7_Y79_E0.5300.49
20_G139_M0.5270.49
96_Q102_T0.5260.49
51_C105_H0.5250.49
9_E87_D0.5220.48
34_G40_I0.5220.48
113_G118_Y0.5150.48
7_Y10_M0.5140.47
16_P45_I0.5090.47
17_E62_D0.5090.47
61_E64_N0.5060.46
35_Y41_E0.5050.46
27_S115_L0.5020.46
129_V134_G0.5010.46
75_E78_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1th8A 2 0.8125 99.8 0.572 Contact Map
3ke6A 2 0.7937 99.8 0.58 Contact Map
4r3aA 1 0.825 99.1 0.722 Contact Map
3ehhA 2 0.725 99 0.738 Contact Map
4r39A 1 0.875 99 0.74 Contact Map
1i58A 2 0.8 98.9 0.743 Contact Map
4bixA 2 0.825 98.9 0.745 Contact Map
3ehgA 1 0.7188 98.9 0.75 Contact Map
3a0rA 2 0.8375 98.8 0.751 Contact Map
4i5sA 2 0.8313 98.8 0.751 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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