GREMLIN Database
RSBV - Anti-sigma-B factor antagonist
UniProt: P17903 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 109 (103)
Sequences: 2139 (1630)
Seq/√Len: 160.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_K106_G3.3771.00
47_C104_S2.6811.00
19_A50_D2.6741.00
49_K80_N2.4371.00
90_D95_K2.3731.00
79_E104_S2.3001.00
69_V74_G2.2761.00
62_F98_I2.1451.00
81_L89_F2.0261.00
22_I51_V2.0131.00
102_A106_G1.9391.00
48_L51_V1.9151.00
31_R55_D1.9131.00
46_I62_F1.9001.00
59_L92_T1.8771.00
86_I90_D1.8661.00
34_L65_T1.8231.00
60_G63_V1.7641.00
8_K17_N1.7381.00
35_V68_M1.6801.00
77_K99_D1.6041.00
77_K101_S1.5471.00
27_A61_V1.5321.00
60_G64_G1.5291.00
21_E87_R1.5171.00
18_I30_L1.5131.00
33_K36_P1.5091.00
9_Q42_A1.4731.00
66_F98_I1.4671.00
23_D26_S1.4501.00
43_D75_S1.4261.00
55_D60_G1.3941.00
31_R60_G1.3831.00
24_V55_D1.3371.00
12_N43_D1.3331.00
43_D74_G1.3211.00
78_L98_I1.3171.00
75_S99_D1.3061.00
36_P40_Q1.2951.00
35_V39_E1.1891.00
31_R64_G1.1801.00
23_D93_G1.1701.00
30_L61_V1.1661.00
9_Q12_N1.1291.00
86_I102_A1.1201.00
39_E68_M1.1161.00
45_R79_E1.0991.00
101_S107_G1.0921.00
17_N47_C1.0911.00
24_V54_M1.0530.99
6_D17_N1.0510.99
17_N50_D1.0380.99
45_R107_G1.0230.99
47_C80_N1.0030.99
63_V66_F0.9950.99
78_L89_F0.9650.99
86_I95_K0.9460.99
53_Y94_L0.9240.98
35_V65_T0.9240.98
54_M85_L0.9100.98
24_V59_L0.9050.98
13_D45_R0.9040.98
60_G94_L0.8800.98
60_G93_G0.8710.98
54_M88_L0.8620.97
32_E36_P0.8540.97
81_L86_I0.8530.97
29_V32_E0.8520.97
16_V65_T0.8510.97
17_N104_S0.8400.97
16_V34_L0.8340.97
22_I54_M0.8310.97
49_K81_L0.8230.97
63_V94_L0.7980.96
60_G67_K0.7950.96
38_A41_G0.7780.95
55_D94_L0.7750.95
78_L81_L0.7730.95
21_E93_G0.7720.95
60_G88_L0.7660.95
54_M60_G0.7650.95
55_D88_L0.7620.95
21_E55_D0.7490.94
59_L88_L0.7470.94
89_F100_I0.7440.94
41_G74_G0.7430.94
29_V33_K0.7380.94
66_F94_L0.7370.94
92_T97_I0.7360.94
7_V33_K0.7340.94
66_F70_K0.7140.93
88_L92_T0.7040.92
81_L100_I0.7030.92
57_T94_L0.6830.91
34_L46_I0.6790.91
52_S82_S0.6760.90
70_K75_S0.6690.90
22_I30_L0.6620.90
24_V89_F0.6550.89
46_I65_T0.6540.89
94_L98_I0.6490.89
21_E52_S0.6450.88
12_N42_A0.6380.88
27_A31_R0.6330.87
66_F92_T0.6320.87
20_G51_V0.6290.87
54_M98_I0.6260.87
37_L40_Q0.6250.87
45_R77_K0.6220.86
28_P32_E0.6180.86
46_I76_L0.6170.86
9_Q15_Q0.6140.86
62_F89_F0.6130.86
67_K94_L0.6090.85
35_V88_L0.6090.85
86_I100_I0.6040.85
62_F92_T0.6040.85
82_S85_L0.6030.85
48_L76_L0.5990.84
67_K92_T0.5980.84
87_R93_G0.5970.84
61_V64_G0.5950.84
48_L82_S0.5940.84
48_L62_F0.5940.84
23_D88_L0.5930.84
31_R76_L0.5830.83
101_S106_G0.5800.82
21_E24_V0.5760.82
55_D87_R0.5730.82
13_D43_D0.5700.81
61_V65_T0.5660.81
65_T76_L0.5600.80
17_N49_K0.5580.80
89_F98_I0.5560.80
59_L64_G0.5560.80
45_R104_S0.5530.79
38_A68_M0.5490.79
53_Y61_V0.5490.79
25_Y53_Y0.5470.79
20_G50_D0.5340.77
83_E90_D0.5320.77
66_F96_D0.5310.77
7_V37_L0.5250.76
33_K37_L0.5250.76
103_K107_G0.5230.75
15_Q41_G0.5180.75
14_I44_L0.5170.75
44_L76_L0.5150.74
60_G92_T0.5120.74
24_V93_G0.5070.73
57_T89_F0.5020.73
36_P39_E0.5010.72
54_M93_G0.5000.72
19_A106_G0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xs5A 1 0.9725 99.9 0.334 Contact Map
3zxnA 1 0.9817 99.9 0.336 Contact Map
1th8B 1 0.9908 99.9 0.336 Contact Map
1sboA 1 0.9817 99.9 0.353 Contact Map
4qtpA 2 0.9908 99.9 0.363 Contact Map
3t6oA 5 1 99.8 0.377 Contact Map
1h4xA 1 0.9725 99.8 0.378 Contact Map
3ny7A 1 0.9908 99.8 0.385 Contact Map
4hylA 2 0.9817 99.8 0.388 Contact Map
2ka5A 1 1 99.8 0.388 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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