GREMLIN Database
SP4B - SpoIVB peptidase
UniProt: P17896 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (395)
Sequences: 441 (367)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_E338_K8.3531.00
337_E365_R6.4501.00
321_K385_N5.3831.00
153_E182_L4.9711.00
343_I389_I4.8911.00
326_E340_D4.8531.00
312_L388_V4.6271.00
106_V388_V4.0481.00
332_D369_E3.9721.00
324_P340_D3.9211.00
319_E387_K3.8071.00
349_Q410_W3.7721.00
346_T407_H3.5021.00
237_V246_P3.1510.99
212_R242_D3.1440.99
169_I207_I3.0900.99
112_S259_V3.0060.99
319_E385_N2.7720.98
106_V314_V2.7560.98
312_L383_I2.7480.98
145_I181_L2.6350.98
352_P410_W2.5540.97
154_M165_V2.5340.97
273_K330_V2.4720.96
349_Q352_P2.4080.96
206_R339_F2.4000.96
210_Y273_K2.1860.93
315_A389_I2.1430.92
172_A176_G2.1280.92
210_Y330_V1.9780.88
132_T135_G1.9670.88
119_S247_I1.9560.88
80_G100_V1.9480.88
212_R243_T1.9230.87
233_A239_S1.9220.87
183_I192_T1.9140.87
361_I392_V1.8920.86
158_K310_Q1.8820.86
165_V211_I1.8800.86
212_R240_D1.8670.85
106_V408_I1.8640.85
356_G410_W1.8550.85
131_N200_E1.8450.85
408_I412_L1.8440.84
218_I334_D1.8420.84
115_V289_R1.8230.84
218_I409_E1.8180.84
98_V361_I1.8090.83
222_T391_A1.7960.83
154_M179_L1.7900.83
231_Y286_D1.7700.82
102_P218_I1.7620.82
91_F346_T1.7610.82
128_H275_A1.7290.80
333_D369_E1.7210.80
199_D202_E1.7060.79
210_Y237_V1.7040.79
237_V330_V1.6990.79
344_V360_K1.6950.79
108_P311_A1.6650.78
178_S193_K1.6620.78
117_L122_V1.6610.78
139_P216_A1.6250.76
11_L102_P1.6040.75
313_P386_G1.5900.74
159_I165_V1.5670.73
233_A295_I1.5600.73
405_G408_I1.5500.72
177_E310_Q1.5370.72
180_D191_K1.5360.72
237_V273_K1.5260.71
140_G144_G1.5140.71
140_G162_M1.5110.70
123_L272_E1.4890.69
357_M405_G1.4810.69
225_E228_T1.4720.68
332_D335_K1.4690.68
122_V249_V1.4680.68
328_L336_V1.4650.68
360_K369_E1.4570.67
108_P312_L1.4440.67
139_P143_A1.4430.67
155_N177_E1.4370.66
154_M181_L1.4310.66
139_P144_G1.4080.65
233_A257_S1.4080.65
91_F98_V1.4030.64
284_I406_V1.4020.64
26_L32_I1.3830.63
113_I233_A1.3770.63
192_T258_T1.3630.62
388_V408_I1.3580.62
112_S273_K1.3560.62
153_E158_K1.3560.62
140_G143_A1.3530.62
112_S330_V1.3450.61
259_V275_A1.3390.61
119_S159_I1.3350.60
341_I382_I1.3320.60
113_I254_I1.3190.60
308_S328_L1.3190.60
184_K248_V1.3130.59
91_F119_S1.3110.59
180_D193_K1.3110.59
144_G216_A1.3080.59
214_S255_V1.3060.59
218_I406_V1.3000.58
163_N361_I1.2990.58
129_Q141_E1.2870.58
151_I183_I1.2790.57
120_V158_K1.2690.56
106_V312_L1.2670.56
164_D167_P1.2570.56
10_G13_L1.2570.56
407_H410_W1.2510.55
122_V159_I1.2370.55
112_S414_E1.2310.54
81_E389_I1.2280.54
335_K365_R1.2270.54
232_G408_I1.2180.53
29_Y218_I1.2150.53
215_A356_G1.2140.53
119_S314_V1.2130.53
130_I197_E1.2070.53
238_I328_L1.2060.53
39_F339_F1.2020.52
185_R374_V1.1960.52
203_G413_S1.1960.52
108_P296_F1.1960.52
119_S213_D1.1940.52
328_L338_K1.1820.51
154_M251_N1.1800.51
159_I248_V1.1750.51
240_D243_T1.1750.51
334_D388_V1.1640.50
202_E253_E1.1640.50
303_I388_V1.1610.50
41_T86_Y1.1530.49
165_V181_L1.1530.49
169_I172_A1.1470.49
279_S319_E1.1430.49
259_V284_I1.1400.48
127_F169_I1.1350.48
81_E99_H1.1270.48
140_G277_F1.1160.47
84_L389_I1.1160.47
109_G352_P1.1040.46
231_Y275_A1.1040.46
221_M272_E1.1030.46
342_E360_K1.0990.46
91_F361_I1.0990.46
341_I389_I1.0850.45
152_I184_K1.0850.45
116_K253_E1.0740.44
176_G298_T1.0720.44
122_V165_V1.0700.44
210_Y275_A1.0670.44
262_I273_K1.0630.44
152_I189_K1.0620.44
145_I183_I1.0560.43
211_I267_G1.0530.43
214_S277_F1.0530.43
140_G216_A1.0420.42
225_E230_K1.0420.42
348_P407_H1.0400.42
162_M233_A1.0400.42
119_S123_L1.0380.42
14_L291_S1.0380.42
315_A319_E1.0380.42
267_G389_I1.0380.42
340_D365_R1.0360.42
108_P211_I1.0230.41
210_Y317_S1.0170.41
193_K389_I1.0170.41
207_I287_I1.0160.41
145_I209_L1.0160.41
113_I336_V1.0140.41
12_I16_S1.0130.41
104_L314_V1.0110.41
210_Y246_P1.0080.40
111_Q328_L0.9900.39
291_S361_I0.9880.39
141_E247_I0.9860.39
270_P325_A0.9850.39
231_Y259_V0.9830.39
152_I249_V0.9810.39
211_I402_S0.9750.38
399_D402_S0.9740.38
354_T407_H0.9700.38
215_A262_I0.9660.38
113_I262_I0.9630.38
48_T51_S0.9630.38
106_V113_I0.9590.37
41_T80_G0.9560.37
211_I408_I0.9540.37
316_F319_E0.9520.37
360_K383_I0.9510.37
116_K214_S0.9500.37
188_Q341_I0.9470.37
275_A402_S0.9470.37
102_P221_M0.9450.37
109_G329_T0.9420.37
109_G380_S0.9410.36
127_F140_G0.9410.36
116_K150_I0.9370.36
105_K311_A0.9270.36
51_S71_E0.9250.36
162_M214_S0.9230.35
216_A224_Y0.9210.35
259_V344_V0.9190.35
17_L47_E0.9190.35
199_D206_R0.9120.35
380_S396_F0.9110.35
386_G399_D0.9080.35
133_S266_T0.9080.35
336_V396_F0.9070.35
136_K155_N0.9070.35
284_I383_I0.9040.34
296_F316_F0.9030.34
98_V209_L0.9030.34
242_D357_M0.9000.34
255_V316_F0.8960.34
144_G223_F0.8950.34
291_S296_F0.8940.34
300_H335_K0.8940.34
207_I233_A0.8920.34
246_P330_V0.8910.34
170_Q204_K0.8880.33
78_K130_I0.8870.33
36_M96_T0.8860.33
207_I388_V0.8850.33
279_S320_V0.8840.33
146_E357_M0.8770.33
241_M316_F0.8760.33
70_H171_K0.8760.33
108_P319_E0.8760.33
162_M239_S0.8730.33
247_I356_G0.8610.32
341_I359_L0.8600.32
169_I189_K0.8600.32
264_K387_K0.8570.32
117_L211_I0.8530.32
160_E164_D0.8520.31
189_K195_I0.8510.31
162_M216_A0.8490.31
322_K340_D0.8480.31
327_I405_G0.8440.31
314_V408_I0.8420.31
259_V413_S0.8420.31
181_L288_N0.8420.31
104_L223_F0.8410.31
155_N179_L0.8410.31
41_T96_T0.8360.31
41_T51_S0.8310.30
346_T361_I0.8280.30
177_E383_I0.8250.30
141_E215_A0.8240.30
38_V181_L0.8210.30
328_L383_I0.8210.30
273_K329_T0.8180.30
312_L328_L0.8160.30
262_I336_V0.8120.29
138_S352_P0.8090.29
244_K348_P0.8070.29
221_M288_N0.8070.29
126_G247_I0.8040.29
176_G334_D0.8000.29
396_F399_D0.7990.29
237_V329_T0.7960.29
338_K383_I0.7940.28
37_R99_H0.7940.28
89_A239_S0.7920.28
117_L145_I0.7910.28
135_G254_I0.7890.28
43_T46_I0.7870.28
269_N361_I0.7860.28
15_V161_K0.7830.28
298_T302_P0.7800.28
265_G272_E0.7790.28
295_I305_N0.7790.28
349_Q356_G0.7790.28
212_R371_G0.7770.28
221_M257_S0.7770.28
254_I287_I0.7760.28
113_I215_A0.7740.27
232_G370_T0.7720.27
295_I409_E0.7710.27
141_E211_I0.7670.27
172_A196_P0.7670.27
72_I388_V0.7670.27
230_K312_L0.7660.27
98_V182_L0.7640.27
296_F327_I0.7590.27
119_S196_P0.7560.27
138_S410_W0.7550.27
246_P273_K0.7550.27
202_E269_N0.7540.26
232_G374_V0.7530.26
274_L356_G0.7500.26
400_P410_W0.7470.26
403_G411_M0.7450.26
313_P356_G0.7410.26
21_G202_E0.7400.26
210_Y244_K0.7400.26
78_K365_R0.7380.26
140_G214_S0.7370.26
262_I333_D0.7370.26
287_I315_A0.7360.26
38_V296_F0.7350.26
160_E287_I0.7340.25
273_K339_F0.7340.25
101_L335_K0.7320.25
345_S359_L0.7310.25
15_V23_C0.7310.25
116_K140_G0.7300.25
116_K144_G0.7300.25
241_M247_I0.7300.25
317_S354_T0.7290.25
175_T258_T0.7270.25
168_F328_L0.7240.25
119_S241_M0.7230.25
41_T53_N0.7200.25
95_K221_M0.7190.25
46_I50_L0.7180.25
275_A345_S0.7150.25
349_Q353_A0.7150.25
108_P341_I0.7120.24
38_V281_R0.7120.24
324_P342_E0.7110.24
144_G187_K0.7100.24
140_G209_L0.7100.24
182_L190_I0.7090.24
44_Q300_H0.7080.24
90_G295_I0.7080.24
151_I358_V0.7060.24
152_I182_L0.7050.24
216_A277_F0.7040.24
113_I232_G0.7030.24
162_M407_H0.7020.24
224_Y315_A0.7020.24
347_T357_M0.7000.24
355_K359_L0.6990.24
374_V412_L0.6970.24
227_K311_A0.6950.24
247_I273_K0.6930.24
232_G330_V0.6920.24
144_G277_F0.6900.23
159_I385_N0.6880.23
346_T396_F0.6840.23
20_V77_K0.6840.23
44_Q48_T0.6810.23
51_S100_V0.6810.23
12_I58_E0.6800.23
364_P368_K0.6790.23
231_Y299_L0.6760.23
344_V402_S0.6760.23
90_G101_L0.6750.23
206_R216_A0.6750.23
117_L147_A0.6740.23
306_N374_V0.6730.23
14_L337_E0.6730.23
244_K316_F0.6720.23
273_K336_V0.6710.23
19_S76_G0.6700.23
107_I397_V0.6680.23
223_F371_G0.6680.23
111_Q226_P0.6660.22
298_T332_D0.6650.22
44_Q181_L0.6650.22
330_V336_V0.6640.22
70_H361_I0.6630.22
88_L93_I0.6630.22
25_P329_T0.6620.22
233_A287_I0.6610.22
103_D319_E0.6610.22
321_K408_I0.6600.22
210_Y339_F0.6600.22
117_L383_I0.6590.22
31_L59_S0.6570.22
184_K189_K0.6570.22
261_S280_E0.6570.22
349_Q407_H0.6560.22
155_N356_G0.6550.22
341_I392_V0.6550.22
155_N178_S0.6520.22
221_M407_H0.6490.22
119_S242_D0.6470.22
42_Q79_S0.6460.22
159_I266_T0.6460.22
161_K197_E0.6450.22
180_D364_P0.6450.22
198_K281_R0.6440.21
99_H364_P0.6440.21
230_K298_T0.6440.21
165_V415_A0.6430.21
89_A275_A0.6430.21
119_S317_S0.6420.21
242_D367_L0.6410.21
104_L308_S0.6380.21
242_D383_I0.6370.21
41_T46_I0.6370.21
128_H354_T0.6360.21
123_L396_F0.6340.21
183_I190_I0.6340.21
103_D156_G0.6330.21
169_I257_S0.6330.21
169_I196_P0.6320.21
38_V72_I0.6310.21
273_K317_S0.6310.21
157_Q168_F0.6300.21
85_V207_I0.6280.21
379_G384_Q0.6280.21
378_S384_Q0.6280.21
128_H402_S0.6280.21
126_G216_A0.6260.21
215_A293_F0.6260.21
46_I164_D0.6260.21
169_I191_K0.6250.21
378_S381_P0.6250.21
127_F339_F0.6250.21
124_V145_I0.6240.21
106_V261_S0.6220.21
97_K119_S0.6210.21
55_Q357_M0.6210.21
127_F162_M0.6200.20
218_I374_V0.6200.20
223_F398_N0.6200.20
213_D327_I0.6200.20
176_G196_P0.6200.20
23_C163_N0.6190.20
253_E283_T0.6180.20
335_K385_N0.6170.20
83_E340_D0.6160.20
130_I261_S0.6160.20
116_K162_M0.6140.20
126_G357_M0.6130.20
43_T73_K0.6130.20
105_K155_N0.6110.20
299_L345_S0.6090.20
23_C26_L0.6090.20
93_I374_V0.6080.20
262_I374_V0.6080.20
32_I385_N0.6080.20
231_Y237_V0.6070.20
74_V337_E0.6060.20
331_I369_E0.6060.20
150_I218_I0.6040.20
314_V385_N0.6020.20
96_T232_G0.6020.20
266_T385_N0.6010.20
91_F137_K0.6010.20
231_Y295_I0.6000.20
24_K116_K0.6000.20
154_M228_T0.6000.20
137_K254_I0.5980.20
194_L299_L0.5950.19
176_G195_I0.5940.19
145_I331_I0.5930.19
76_G80_G0.5920.19
88_L256_K0.5910.19
190_I314_V0.5900.19
140_G150_I0.5890.19
125_V139_P0.5880.19
182_L191_K0.5880.19
181_L307_I0.5870.19
45_A52_V0.5870.19
354_T397_V0.5860.19
273_K356_G0.5860.19
23_C37_R0.5850.19
254_I277_F0.5850.19
152_I264_K0.5810.19
384_Q391_A0.5800.19
216_A255_V0.5790.19
152_I158_K0.5780.19
43_T59_S0.5770.19
46_I72_I0.5770.19
363_D371_G0.5760.19
109_G396_F0.5760.19
107_I224_Y0.5750.19
144_G253_E0.5730.19
84_L332_D0.5730.19
74_V249_V0.5730.19
287_I350_K0.5690.18
197_E248_V0.5690.18
228_T300_H0.5680.18
91_F172_A0.5680.18
239_S347_T0.5670.18
195_I300_H0.5670.18
113_I221_M0.5660.18
41_T101_L0.5660.18
157_Q374_V0.5640.18
74_V99_H0.5630.18
207_I288_N0.5630.18
133_S137_K0.5620.18
227_K339_F0.5610.18
404_Y411_M0.5610.18
140_G145_I0.5600.18
24_K28_E0.5600.18
109_G414_E0.5600.18
22_L389_I0.5590.18
11_L203_G0.5590.18
87_D179_L0.5580.18
317_S409_E0.5560.18
112_S329_T0.5540.18
75_T79_S0.5540.18
143_A216_A0.5530.18
150_I277_F0.5530.18
202_E257_S0.5520.18
144_G255_V0.5520.18
165_V267_G0.5510.18
275_A354_T0.5510.18
162_M339_F0.5510.18
230_K388_V0.5500.18
109_G349_Q0.5500.18
316_F406_V0.5490.18
351_F355_K0.5490.18
127_F237_V0.5490.18
132_T176_G0.5490.18
116_K260_T0.5490.18
133_S321_K0.5460.18
104_L414_E0.5460.18
262_I330_V0.5450.18
26_L314_V0.5440.18
329_T349_Q0.5440.18
105_K130_I0.5440.18
358_V380_S0.5440.18
123_L292_P0.5440.18
199_D204_K0.5430.18
393_T403_G0.5430.18
194_L347_T0.5400.17
25_P237_V0.5400.17
331_I416_G0.5390.17
254_I328_L0.5370.17
239_S407_H0.5370.17
101_L316_F0.5370.17
46_I181_L0.5370.17
112_S257_S0.5350.17
119_S206_R0.5340.17
155_N383_I0.5330.17
115_V254_I0.5330.17
381_P384_Q0.5320.17
125_V261_S0.5320.17
321_K387_K0.5310.17
146_E289_R0.5300.17
100_V126_G0.5300.17
40_E175_T0.5280.17
15_V32_I0.5250.17
17_L340_D0.5250.17
226_P231_Y0.5240.17
237_V275_A0.5240.17
83_E280_E0.5240.17
123_L410_W0.5240.17
120_V167_P0.5230.17
38_V70_H0.5230.17
139_P209_L0.5210.17
395_V403_G0.5200.17
17_L195_I0.5200.17
347_T397_V0.5180.17
116_K216_A0.5180.17
48_T52_V0.5180.17
157_Q202_E0.5170.17
124_V169_I0.5160.17
44_Q56_T0.5160.17
20_V124_V0.5150.17
36_M303_I0.5140.17
199_D374_V0.5140.17
105_K195_I0.5140.17
94_K245_K0.5140.17
357_M389_I0.5140.17
104_L108_P0.5140.17
210_Y231_Y0.5130.16
194_L260_T0.5130.16
303_I306_N0.5130.16
275_A356_G0.5120.16
129_Q210_Y0.5110.16
245_K299_L0.5110.16
329_T380_S0.5110.16
275_A325_A0.5110.16
46_I73_K0.5090.16
237_V339_F0.5080.16
94_K212_R0.5080.16
317_S339_F0.5080.16
358_V396_F0.5070.16
361_I383_I0.5060.16
20_V23_C0.5050.16
314_V412_L0.5050.16
74_V198_K0.5030.16
115_V412_L0.5030.16
314_V324_P0.5020.16
106_V267_G0.5020.16
215_A407_H0.5000.16
216_A257_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jj0A 4 0.3803 99.3 0.918 Contact Map
3i18A 1 0.223 99.2 0.921 Contact Map
2p3wA 2 0.2629 99.1 0.925 Contact Map
2l97A 1 0.2958 99 0.926 Contact Map
4o06A 1 0.2324 99 0.927 Contact Map
2zpmA 2 0.1854 99 0.928 Contact Map
4l8nA 2 0.3404 99 0.928 Contact Map
3wkmA 1 0.3944 99 0.928 Contact Map
2pzdA 2 0.2371 98.9 0.929 Contact Map
3cyyA 2 0.1831 98.8 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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