GREMLIN Database
ARGR - Arginine repressor
UniProt: P17893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (145)
Sequences: 1732 (1172)
Seq/√Len: 97.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_N28_M4.7731.00
88_D133_R4.3211.00
91_S135_P3.4381.00
9_K32_D3.4171.00
19_I28_M2.9231.00
9_K12_E2.2601.00
28_M31_Q2.1671.00
9_K34_Y2.0711.00
93_M131_I2.0091.00
108_A126_D1.9991.00
11_R64_L1.9411.00
18_E61_K1.9311.00
53_V63_S1.9211.00
107_G123_C1.9091.00
132_C141_V1.8831.00
91_S134_T1.8701.00
110_M145_L1.8571.00
134_T137_D1.8381.00
117_E144_R1.7141.00
45_I50_L1.7051.00
93_M129_L1.7041.00
30_K35_K1.6901.00
10_I19_I1.6811.00
132_C138_T1.6301.00
90_A119_M1.6241.00
137_D140_G1.5531.00
94_I142_K1.5491.00
12_E16_S1.5441.00
26_V41_V1.5011.00
111_D124_G1.4901.00
111_D120_G1.4801.00
111_D121_T1.4791.00
27_D31_Q1.4261.00
118_M130_I1.3840.99
13_I28_M1.3180.99
3_K47_E1.2870.99
138_T142_K1.2860.99
3_K7_H1.2810.99
6_R44_D1.2790.99
49_H54_P1.2690.99
100_P125_D1.2620.99
55_T61_K1.2600.99
19_I25_L1.2580.99
20_E24_E1.2340.99
139_E143_N1.2150.99
98_T124_G1.2060.98
89_S142_K1.2040.98
121_T124_G1.1890.98
100_P108_A1.1890.98
90_A93_M1.1830.98
20_E59_S1.1790.98
13_I19_I1.1760.98
18_E55_T1.1670.98
39_A43_R1.1580.98
78_R82_D1.1370.98
94_I132_C1.1290.98
21_T50_L1.1170.97
134_T138_T1.1130.97
89_S138_T1.1130.97
36_V41_V1.0940.97
111_D127_T1.0940.97
21_T45_I1.0920.97
96_L130_I1.0900.97
89_S94_I1.0890.97
18_E57_N1.0790.97
124_G127_T1.0790.97
10_I25_L1.0780.97
123_C128_I1.0700.97
46_K60_Y1.0660.97
83_A102_N1.0530.96
136_E139_E1.0520.96
80_L84_F1.0460.96
100_P126_D1.0420.96
94_I138_T1.0140.95
143_N147_E1.0100.95
83_A105_A1.0070.95
98_T107_G1.0050.95
101_G125_D1.0030.95
95_V127_T1.0010.95
7_H47_E0.9990.95
102_N105_A0.9950.95
14_I109_L0.9930.95
39_A52_K0.9840.95
54_P60_Y0.9800.95
117_E140_G0.9780.94
117_E133_R0.9760.94
55_T59_S0.9720.94
87_I94_I0.9680.94
21_T24_E0.9560.94
104_Q125_D0.9530.94
89_S135_P0.9480.93
115_W118_M0.9460.93
28_M32_D0.9370.93
87_I142_K0.9370.93
90_A138_T0.9270.93
98_T103_A0.9060.92
120_G127_T0.9050.92
95_V120_G0.8930.91
98_T102_N0.8910.91
119_M124_G0.8900.91
95_V124_G0.8880.91
14_I50_L0.8820.91
142_K146_L0.8800.91
84_F96_L0.8800.91
90_A132_C0.8780.91
22_Q38_Q0.8750.90
14_I46_K0.8480.89
40_T44_D0.8470.89
41_V102_N0.8450.89
86_K97_K0.8440.89
37_T43_R0.8430.89
103_A126_D0.8390.88
87_I96_L0.8350.88
41_V45_I0.8320.88
79_A109_L0.8210.87
23_D52_K0.8080.87
111_D126_D0.8050.86
107_G111_D0.7970.86
31_Q87_I0.7940.86
120_G124_G0.7910.85
5_Q34_Y0.7900.85
135_P138_T0.7780.84
107_G121_T0.7630.83
122_I131_I0.7620.83
7_H48_L0.7590.83
23_D46_K0.7580.83
107_G128_I0.7560.83
104_Q122_I0.7520.82
79_A106_I0.7490.82
90_A134_T0.7390.81
104_Q128_I0.7380.81
94_I119_M0.7380.81
136_E140_G0.7290.80
13_I17_N0.7290.80
22_Q42_S0.7270.80
50_L80_L0.7240.80
95_V111_D0.7220.80
89_S131_I0.7200.80
21_T52_K0.7160.79
60_Y80_L0.7130.79
94_I141_V0.7040.78
37_T44_D0.7040.78
103_A111_D0.6960.77
16_S32_D0.6940.77
55_T58_G0.6790.75
88_D119_M0.6720.75
91_S138_T0.6710.75
38_Q42_S0.6670.74
92_H131_I0.6640.74
143_N146_L0.6560.73
27_D116_D0.6560.73
15_T65_P0.6550.73
24_E28_M0.6520.73
80_L145_L0.6510.72
26_V36_V0.6400.71
46_K54_P0.6360.71
135_P140_G0.6350.71
13_I105_A0.6340.70
95_V121_T0.6320.70
133_R137_D0.6290.70
119_M133_R0.6240.69
111_D119_M0.6240.69
39_A44_D0.6210.69
19_I39_A0.6200.69
20_E23_D0.6160.68
68_Q71_N0.6140.68
17_N32_D0.6100.67
7_H11_R0.6090.67
95_V123_C0.6010.66
76_L108_A0.5980.66
15_T66_A0.5960.66
6_R10_I0.5930.65
90_A124_G0.5910.65
10_I44_D0.5890.65
115_W144_R0.5840.64
121_T127_T0.5840.64
18_E59_S0.5800.64
90_A131_I0.5790.63
14_I28_M0.5770.63
111_D123_C0.5750.63
46_K104_Q0.5740.63
10_I41_V0.5720.63
102_N109_L0.5710.62
98_T106_I0.5620.61
121_T130_I0.5610.61
36_V50_L0.5610.61
30_K41_V0.5570.61
49_H83_A0.5570.61
37_T40_T0.5540.60
62_Y101_G0.5540.60
49_H71_N0.5450.59
7_H50_L0.5450.59
20_E45_I0.5410.58
27_D35_K0.5370.58
133_R139_E0.5350.57
107_G124_G0.5340.57
94_I120_G0.5330.57
108_A112_N0.5330.57
104_Q126_D0.5320.57
122_I129_L0.5310.57
103_A124_G0.5280.56
6_R40_T0.5250.56
44_D47_E0.5220.56
15_T130_I0.5220.56
27_D74_S0.5170.55
141_V144_R0.5150.55
89_S139_E0.5150.55
73_L113_L0.5130.54
35_K143_N0.5100.54
33_G127_T0.5090.54
76_L99_M0.5080.54
16_S35_K0.5080.54
31_Q69_R0.5070.54
91_S94_I0.5070.54
98_T111_D0.5050.53
3_K6_R0.5020.53
116_D140_G0.5020.53
92_H125_D0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v4gA 5 0.9329 100 0.046 Contact Map
3lapA 6 1 100 0.075 Contact Map
1b4aA 5 0.9799 100 0.156 Contact Map
2p5mA 4 0.5503 99.9 0.541 Contact Map
2zfzA 4 0.5302 99.9 0.547 Contact Map
1b4bA 4 0.4765 99.9 0.558 Contact Map
1xxaA 4 0.4765 99.8 0.566 Contact Map
2p5kA 1 0.4228 99.1 0.736 Contact Map
2fu4A 2 0.4362 97 0.848 Contact Map
2w48A 3 0.9195 96.7 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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