GREMLIN Database
CISA - Putative DNA recombinase
UniProt: P17867 Sequences:
 Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 500 (451)
Sequences: 4911 (4272)
Seq/√Len: 201.1
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_M202_M4.7891.00
39_Y60_D4.7091.00
271_P274_Q4.5651.00
156_K167_L4.0961.00
53_A56_R3.6091.00
180_Y198_H3.3731.00
182_T274_Q3.2551.00
272_A276_D3.2531.00
198_H202_M3.1771.00
176_M180_Y2.9231.00
37_L56_R2.8291.00
390_E428_K2.8051.00
167_L170_E2.7311.00
4_I27_C2.6221.00
158_V165_E2.6161.00
304_R486_E2.5401.00
383_E435_K2.5251.00
61_A66_I2.4971.00
391_I429_Q2.4711.00
24_I28_I2.4571.00
387_I432_L2.4491.00
304_R311_T2.4281.00
182_T278_A2.4091.00
384_L436_C2.4061.00
156_K165_E2.3931.00
6_V24_I2.3551.00
60_D65_L2.2661.00
47_E126_K2.2571.00
24_I38_K2.2511.00
306_G490_V2.2311.00
230_E263_T2.2001.00
179_N274_Q2.1561.00
230_E272_A2.1561.00
391_I432_L2.1551.00
225_S230_E2.1261.00
125_E132_R2.0991.00
347_E351_N2.0891.00
310_N331_K2.0371.00
387_I436_C2.0321.00
219_R223_M2.0281.00
275_W279_Q1.9851.00
179_N183_D1.9711.00
176_M198_H1.9611.00
112_Q127_A1.9491.00
388_E440_Q1.9121.00
388_E436_C1.8921.00
223_M283_G1.8591.00
31_A35_D1.8511.00
171_A175_R1.8481.00
228_K272_A1.8451.00
394_T429_Q1.8201.00
178_F278_A1.8091.00
41_D53_A1.7981.00
394_T425_L1.7941.00
28_I38_K1.7611.00
125_E129_I1.7501.00
395_K429_Q1.7351.00
180_Y185_K1.7331.00
25_E29_K1.6871.00
302_L481_N1.6721.00
62_S90_E1.6621.00
140_K145_M1.6581.00
100_F103_G1.6441.00
166_I269_I1.6381.00
82_M89_D1.6241.00
57_L69_V1.6211.00
196_A218_V1.6181.00
170_E207_K1.6141.00
178_F270_V1.5951.00
223_M282_L1.5931.00
71_C98_L1.5651.00
181_F222_L1.5611.00
414_D417_E1.5601.00
263_T272_A1.5601.00
276_D280_E1.5581.00
10_T13_Q1.5551.00
185_K198_H1.5531.00
193_N197_L1.5491.00
182_T277_Y1.5431.00
153_Y173_I1.5421.00
268_A272_A1.5321.00
3_A66_I1.5171.00
477_K481_N1.5101.00
198_H201_Q1.5101.00
429_Q433_T1.5071.00
399_K424_E1.4951.00
395_K433_T1.4681.00
54_L57_L1.4671.00
177_I195_I1.4661.00
424_E428_K1.4611.00
178_F227_Y1.4571.00
168_E175_R1.4571.00
472_T475_D1.4541.00
423_I427_K1.4511.00
299_L351_N1.4351.00
158_V161_K1.4321.00
431_Q435_K1.4311.00
171_A269_I1.4301.00
88_D115_F1.4261.00
84_Q119_G1.4211.00
31_A70_I1.4211.00
123_E127_A1.4181.00
116_A120_A1.4161.00
357_E360_K1.4161.00
108_S111_G1.4071.00
225_S228_K1.4051.00
61_A69_V1.4031.00
177_I199_L1.4001.00
180_Y202_M1.3931.00
166_I171_A1.3911.00
397_G410_D1.3901.00
391_I436_C1.3801.00
128_K132_R1.3771.00
200_T213_W1.3741.00
297_Y314_G1.3611.00
384_L388_E1.3611.00
81_L116_A1.3601.00
281_L285_S1.3561.00
225_S232_R1.3521.00
418_I422_I1.3511.00
403_T421_Q1.3471.00
56_R60_D1.3401.00
228_K275_W1.3401.00
196_A200_T1.3311.00
222_L278_A1.3261.00
192_V219_R1.3241.00
390_E393_K1.3221.00
3_A57_L1.3121.00
421_Q424_E1.3121.00
177_I221_I1.3091.00
130_K134_S1.3071.00
58_R87_I1.3051.00
77_L87_I1.3041.00
113_L124_F1.2981.00
24_I40_A1.2931.00
433_T437_N1.2851.00
138_L142_K1.2851.00
27_C70_I1.2821.00
126_K130_K1.2771.00
61_A96_I1.2691.00
197_L201_Q1.2621.00
383_E386_L1.2591.00
307_K341_C1.2581.00
394_T432_L1.2531.00
436_C440_Q1.2431.00
126_K129_I1.2391.00
384_L440_Q1.2391.00
214_H217_V1.2341.00
75_D122_S1.2341.00
398_R429_Q1.2321.00
8_V13_Q1.2291.00
59_E63_K1.2271.00
391_I433_T1.2231.00
139_Q143_K1.2221.00
71_C100_F1.2181.00
231_H265_T1.2181.00
303_V350_L1.2171.00
113_L121_I1.2121.00
352_R356_G1.2121.00
109_P131_E1.2101.00
205_K213_W1.2031.00
392_E395_K1.1991.00
428_K431_Q1.1961.00
270_V278_A1.1891.00
6_V20_I1.1881.00
394_T428_K1.1811.00
158_V163_T1.1801.00
39_Y57_L1.1721.00
327_Y347_E1.1611.00
409_D421_Q1.1561.00
113_L120_A1.1541.00
225_S261_Q1.1511.00
81_L85_L1.1481.00
75_D132_R1.1451.00
181_F282_L1.1441.00
62_S94_R1.1381.00
73_D132_R1.1361.00
173_I204_V1.1361.00
59_E62_S1.1341.00
178_F275_W1.1321.00
180_Y183_D1.1271.00
172_K175_R1.1161.00
6_V38_K1.1141.00
181_F281_L1.1111.00
387_I435_K1.1111.00
85_L116_A1.1101.00
74_P122_S1.1091.00
4_I35_D1.1091.00
146_I164_L1.1071.00
3_A39_Y1.1061.00
196_A215_R1.1031.00
384_L439_I1.1031.00
155_Y227_Y1.1031.00
74_P115_F1.1021.00
399_K420_A1.0991.00
435_K438_E1.0961.00
80_K123_E1.0951.00
346_S349_K1.0931.00
44_F52_P1.0851.00
435_K439_I1.0841.00
405_I415_I1.0841.00
274_Q278_A1.0831.00
427_K431_Q1.0831.00
484_V487_V1.0731.00
274_Q277_Y1.0711.00
380_L439_I1.0691.00
177_I218_V1.0691.00
169_E172_K1.0691.00
72_Y135_S1.0671.00
49_L54_L1.0641.00
78_S84_Q1.0611.00
315_K328_T1.0591.00
206_T209_G1.0591.00
400_R405_I1.0561.00
125_E128_K1.0511.00
222_L279_Q1.0431.00
398_R422_I1.0421.00
103_G118_R1.0421.00
173_I177_I1.0391.00
156_K168_E1.0381.00
281_L284_Q1.0341.00
174_I178_F1.0321.00
4_I38_K1.0321.00
54_L87_I1.0311.00
69_V91_L1.0271.00
74_P100_F1.0201.00
61_A91_L1.0171.00
430_N434_E1.0141.00
46_G78_S1.0111.00
230_E264_V1.0111.00
192_V196_A1.0111.00
182_T281_L1.0091.00
398_R426_Q1.0031.00
129_I136_G1.0021.00
97_P106_A0.9981.00
228_K276_D0.9981.00
180_Y195_I0.9941.00
400_R411_D0.9921.00
325_Y347_E0.9911.00
186_S194_G0.9871.00
257_P261_Q0.9871.00
421_Q425_L0.9861.00
5_Y41_D0.9841.00
385_E388_E0.9831.00
181_F195_I0.9821.00
174_I269_I0.9751.00
405_I418_I0.9700.99
174_I227_Y0.9690.99
195_I218_V0.9650.99
303_V327_Y0.9630.99
432_L436_C0.9620.99
430_N433_T0.9610.99
164_L226_S0.9610.99
393_K410_D0.9610.99
305_C308_C0.9600.99
54_L77_L0.9590.99
80_K89_D0.9570.99
136_G140_K0.9570.99
26_A72_Y0.9550.99
326_V346_S0.9540.99
410_D415_I0.9380.99
417_E426_Q0.9370.99
68_Q99_I0.9360.99
74_P103_G0.9280.99
40_A53_A0.9270.99
324_Y346_S0.9270.99
27_C101_V0.9240.99
232_R235_K0.9240.99
224_N227_Y0.9240.99
8_V19_S0.9230.99
178_F182_T0.9220.99
299_L347_E0.9210.99
173_I176_M0.9200.99
275_W278_A0.9190.99
81_L119_G0.9160.99
318_K323_D0.9130.99
387_I391_I0.9120.99
132_R135_S0.9070.99
175_R274_Q0.9030.99
137_R140_K0.9010.99
205_K212_V0.8990.99
14_A17_G0.8990.99
176_M179_N0.8990.99
129_I133_T0.8990.99
185_K194_G0.8970.99
112_Q123_E0.8960.99
6_V40_A0.8920.99
277_Y280_E0.8920.99
54_L83_N0.8920.99
397_G409_D0.8910.99
139_Q142_K0.8900.99
228_K268_A0.8900.99
174_I221_I0.8890.99
355_W359_F0.8870.99
306_G488_T0.8850.99
308_C329_C0.8850.99
305_C329_C0.8770.99
114_F118_R0.8770.99
302_L480_V0.8730.99
398_R425_L0.8730.99
434_E438_E0.8720.99
84_Q115_F0.8720.99
92_R112_Q0.8720.99
426_Q430_N0.8710.99
299_L354_V0.8710.99
297_Y300_S0.8700.99
3_A60_D0.8700.99
228_K271_P0.8680.99
391_I394_T0.8670.99
230_E261_Q0.8670.99
204_V213_W0.8650.99
58_R90_E0.8630.99
199_L213_W0.8630.99
33_T68_Q0.8630.99
60_D66_I0.8620.99
397_G425_L0.8610.99
415_I419_K0.8590.99
33_T70_I0.8580.99
115_F119_G0.8570.99
297_Y327_Y0.8570.99
227_Y270_V0.8550.99
81_L123_E0.8520.99
398_R402_L0.8520.99
280_E284_Q0.8520.99
400_R403_T0.8510.99
71_C77_L0.8510.99
153_Y170_E0.8490.99
130_K133_T0.8490.99
13_Q17_G0.8440.99
392_E396_K0.8440.99
383_E439_I0.8440.99
434_E437_N0.8430.99
394_T397_G0.8420.99
184_H195_I0.8420.99
192_V282_L0.8390.99
179_N182_T0.8380.99
44_F48_L0.8360.98
155_Y166_I0.8340.98
87_I91_L0.8320.98
404_L412_D0.8300.98
35_D38_K0.8300.98
168_E172_K0.8250.98
172_K179_N0.8240.98
133_T137_R0.8230.98
419_K423_I0.8220.98
259_E262_I0.8210.98
30_K70_I0.8200.98
200_T212_V0.8190.98
274_Q281_L0.8170.98
117_M120_A0.8170.98
181_F285_S0.8160.98
39_Y65_L0.8120.98
58_R62_S0.8120.98
90_E94_R0.8110.98
194_G197_L0.8100.98
223_M279_Q0.8100.98
192_V218_V0.8090.98
82_M86_I0.8070.98
390_E394_T0.8060.98
400_R404_L0.8030.98
145_M162_R0.8000.98
68_Q97_P0.7980.98
393_K397_G0.7980.98
18_S21_D0.7960.98
388_E392_E0.7950.98
61_A94_R0.7950.98
216_Q220_Q0.7940.98
432_L435_K0.7930.98
348_N352_R0.7920.98
153_Y213_W0.7910.98
206_T213_W0.7910.98
73_D128_K0.7910.98
173_I199_L0.7860.98
307_K491_D0.7830.98
298_L480_V0.7830.98
227_Y278_A0.7830.98
298_L351_N0.7800.98
159_K162_R0.7790.98
178_F274_Q0.7760.98
50_E55_N0.7760.98
314_G325_Y0.7740.98
13_Q16_K0.7730.97
298_L327_Y0.7730.97
66_I96_I0.7720.97
39_Y56_R0.7720.97
166_I267_P0.7720.97
417_E422_I0.7700.97
151_K157_F0.7700.97
73_D103_G0.7680.97
398_R417_E0.7680.97
480_V484_V0.7670.97
280_E283_G0.7650.97
113_L116_A0.7650.97
309_G488_T0.7630.97
4_I24_I0.7620.97
312_M489_I0.7620.97
114_F121_I0.7610.97
381_S443_M0.7580.97
77_L84_Q0.7580.97
386_L390_E0.7560.97
412_D419_K0.7540.97
73_D118_R0.7530.97
84_Q88_D0.7520.97
180_Y184_H0.7510.97
172_K176_M0.7470.97
326_V344_E0.7460.97
22_S26_A0.7450.97
110_E113_L0.7440.97
454_N458_R0.7440.97
205_K209_G0.7430.97
155_Y268_A0.7400.97
351_N355_W0.7400.97
314_G327_Y0.7390.97
279_Q282_L0.7390.97
258_E261_Q0.7390.97
113_L117_M0.7370.97
199_L218_V0.7360.97
380_L442_K0.7360.97
312_M342_G0.7360.97
45_S48_L0.7340.97
154_G227_Y0.7320.97
8_V17_G0.7320.97
141_M233_Q0.7320.97
91_L96_I0.7300.96
299_L303_V0.7230.96
22_S72_Y0.7220.96
230_E265_T0.7220.96
192_V215_R0.7220.96
159_K165_E0.7220.96
49_L83_N0.7220.96
196_A213_W0.7190.96
380_L443_M0.7190.96
473_L476_K0.7180.96
25_E139_Q0.7170.96
77_L98_L0.7160.96
116_A119_G0.7150.96
6_V27_C0.7120.96
19_S23_Q0.7120.96
133_T136_G0.7100.96
479_I483_I0.7080.96
24_I27_C0.7070.96
22_S139_Q0.7070.96
390_E432_L0.7060.96
232_R261_Q0.7050.96
299_L487_V0.7050.96
116_A121_I0.7030.96
437_N440_Q0.7020.96
37_L60_D0.7020.96
27_C35_D0.7010.96
72_Y102_N0.7000.96
114_F120_A0.6970.95
22_S135_S0.6950.95
396_K400_R0.6940.95
175_R179_N0.6890.95
171_A174_I0.6870.95
49_L78_S0.6850.95
117_M121_I0.6850.95
436_C443_M0.6850.95
380_L384_L0.6830.95
440_Q444_K0.6830.95
167_L172_K0.6830.95
422_I426_Q0.6820.95
122_S132_R0.6800.95
129_I132_R0.6770.95
314_G347_E0.6760.95
20_I42_E0.6750.95
156_K170_E0.6740.94
391_I395_K0.6720.94
153_Y174_I0.6700.94
425_L429_Q0.6700.94
395_K399_K0.6690.94
218_V221_I0.6690.94
57_L60_D0.6680.94
138_L141_M0.6650.94
177_I213_W0.6650.94
137_R141_M0.6640.94
221_I227_Y0.6640.94
438_E442_K0.6630.94
462_Y465_S0.6630.94
296_N300_S0.6610.94
124_F127_A0.6610.94
88_D98_L0.6600.94
111_G118_R0.6590.94
273_E277_Y0.6590.94
412_D415_I0.6560.94
401_L409_D0.6520.93
146_I152_L0.6500.93
37_L65_L0.6500.93
183_D186_S0.6480.93
110_E124_F0.6470.93
420_A424_E0.6460.93
452_S455_A0.6460.93
257_P260_E0.6460.93
81_L120_A0.6440.93
331_K335_G0.6440.93
388_E391_I0.6430.93
140_K147_I0.6430.93
151_K164_L0.6420.93
173_I213_W0.6400.93
70_I99_I0.6360.93
354_V357_E0.6360.93
72_Y132_R0.6340.93
30_K33_T0.6340.93
219_R282_L0.6310.92
370_S373_E0.6280.92
165_E168_E0.6270.92
394_T398_R0.6270.92
105_Y111_G0.6270.92
356_G360_K0.6250.92
176_M199_L0.6250.92
395_K398_R0.6240.92
3_A36_V0.6240.92
270_V274_Q0.6230.92
80_K83_N0.6230.92
114_F117_M0.6220.92
332_N343_K0.6210.92
402_L409_D0.6200.92
397_G403_T0.6180.92
10_T43_G0.6180.92
168_E171_A0.6170.91
55_N58_R0.6160.91
76_R79_R0.6150.91
385_E389_K0.6140.91
194_G198_H0.6140.91
303_V487_V0.6140.91
26_A135_S0.6110.91
18_S136_G0.6090.91
124_F128_K0.6090.91
264_V272_A0.6080.91
181_F192_V0.6050.91
78_S87_I0.6040.91
12_E16_K0.6040.91
404_L421_Q0.6020.90
451_S455_A0.6000.90
41_D44_F0.5930.90
27_C31_A0.5930.90
113_L118_R0.5920.90
387_I390_E0.5920.90
264_V267_P0.5920.90
46_G79_R0.5910.90
401_L421_Q0.5890.90
30_K99_I0.5880.89
283_G286_K0.5880.89
88_D119_G0.5870.89
166_I170_E0.5870.89
303_V312_M0.5860.89
121_I128_K0.5860.89
400_R409_D0.5850.89
60_D63_K0.5840.89
37_L53_A0.5840.89
451_S454_N0.5810.89
327_Y351_N0.5810.89
11_E42_E0.5800.89
74_P84_Q0.5780.89
471_L475_D0.5780.89
457_K461_D0.5740.88
46_G83_N0.5730.88
317_R326_V0.5710.88
150_S208_K0.5700.88
328_T333_Y0.5700.88
86_I90_E0.5700.88
269_I278_A0.5690.88
181_F278_A0.5690.88
228_K270_V0.5690.88
121_I124_F0.5670.88
402_L417_E0.5670.88
231_H266_I0.5670.88
215_R219_R0.5650.88
175_R269_I0.5610.87
174_I278_A0.5590.87
200_T206_T0.5580.87
416_D430_N0.5580.87
277_Y281_L0.5580.87
74_P119_G0.5580.87
358_I483_I0.5580.87
8_V43_G0.5570.87
403_T425_L0.5570.87
414_D426_Q0.5550.87
345_M350_L0.5550.87
49_L87_I0.5540.86
391_I398_R0.5530.86
396_K399_K0.5520.86
82_M85_L0.5500.86
276_D279_Q0.5490.86
440_Q443_M0.5490.86
157_F162_R0.5490.86
19_S22_S0.5490.86
413_L422_I0.5480.86
298_L473_L0.5480.86
14_A18_S0.5480.86
332_N340_G0.5460.86
60_D64_G0.5450.86
405_I412_D0.5450.86
165_E267_P0.5450.86
153_Y206_T0.5440.85
118_R121_I0.5420.85
425_L428_K0.5400.85
228_K232_R0.5390.85
3_A67_S0.5390.85
17_G42_E0.5380.85
105_Y118_R0.5370.85
179_N184_H0.5370.85
176_M204_V0.5360.85
381_S385_E0.5360.85
156_K169_E0.5360.85
66_I91_L0.5350.85
424_E427_K0.5350.85
206_T210_A0.5350.85
429_Q432_L0.5340.84
28_I36_V0.5340.84
359_F464_Q0.5330.84
226_S267_P0.5330.84
104_E118_R0.5320.84
20_I40_A0.5320.84
8_V22_S0.5320.84
402_L418_I0.5310.84
33_T67_S0.5310.84
485_K488_T0.5300.84
193_N215_R0.5290.84
473_L477_K0.5290.84
304_R488_T0.5290.84
8_V12_E0.5280.84
73_D102_N0.5280.84
8_V14_A0.5270.84
298_L477_K0.5260.84
10_T14_A0.5240.83
118_R128_K0.5240.83
78_S83_N0.5230.83
403_T415_I0.5220.83
128_K135_S0.5220.83
39_Y53_A0.5220.83
396_K411_D0.5210.83
122_S125_E0.5210.83
360_K363_T0.5200.83
91_L98_L0.5200.83
330_R334_S0.5200.83
108_S112_Q0.5200.83
198_H203_G0.5200.83
182_T275_W0.5190.83
49_L58_R0.5180.83
192_V223_M0.5170.83
174_I177_I0.5150.82
226_S266_I0.5150.82
10_T126_K0.5150.82
141_M260_E0.5140.82
316_K323_D0.5140.82
199_L204_V0.5140.82
262_I265_T0.5140.82
312_M328_T0.5130.82
166_I172_K0.5130.82
164_L265_T0.5130.82
427_K430_N0.5130.82
89_D93_K0.5130.82
111_G124_F0.5120.82
83_N86_I0.5120.82
4_I28_I0.5120.82
207_K217_V0.5110.82
141_M147_I0.5110.82
307_K343_K0.5100.82
55_N59_E0.5100.82
103_G128_K0.5100.82
302_L484_V0.5100.82
401_L422_I0.5090.82
228_K278_A0.5090.82
225_S235_K0.5090.82
313_T330_R0.5090.82
116_A123_E0.5070.81
384_L443_M0.5070.81
353_H356_G0.5070.81
192_V222_L0.5060.81
401_L418_I0.5040.81
116_A127_A0.5020.81
149_D157_F0.5020.81
389_K393_K0.5020.81
56_R59_E0.5010.81
234_Y237_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity
HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bqqA 2 0.57 100 0.383 Contact Map
4kisA 2 0.626 100 0.488 Contact Map
2r0qC 3 0.368 100 0.623 Contact Map
1gdtA 2 0.362 100 0.662 Contact Map
3uj3X 2 0.246 100 0.671 Contact Map
3g13A 2 0.296 100 0.676 Contact Map
3guvA 2 0.28 100 0.68 Contact Map
2gm5A 4 0.246 100 0.727 Contact Map
3bvpA 4 0.26 100 0.733 Contact Map
3lhkA 2 0.282 100 0.737 Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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