FTSZ - BACSU - GREMLIN Contacts

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FTSZ - Cell division protein FtsZ

UniProt:	P17865	Sequences: MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVNTDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVTAGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDTLIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIMSNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQEAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSIKTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	382 (336)
Sequences:	3190 (1523)
Seq/√Len:	83.1

ECOLI - FTSZ
BACSU - FTSZ
HALSA - FTSZ2 FTSZ1 Q9HNV2 Q9HSE9 Q9HHS0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_V	61_I	5.229	1.00
79_K	153_A	4.582	1.00
111_T	150_G	4.238	1.00
86_K	119_Q	4.025	1.00
230_I	305_E	4.019	1.00
86_K	120_I	3.987	1.00
137_T	167_D	3.896	1.00
153_A	156_E	3.525	1.00
32_E	54_K	3.377	1.00
236_R	274_E	3.369	1.00
119_Q	157_A	3.254	1.00
235_N	239_E	3.122	1.00
91_E	94_K	3.109	1.00
19_V	113_A	3.074	1.00
85_S	88_Q	3.055	1.00
232_T	305_E	2.983	1.00
130_G	158_V	2.840	1.00
101_V	114_A	2.799	1.00
262_M	279_A	2.773	1.00
158_V	161_L	2.626	1.00
105_M	151_I	2.617	1.00
268_T	300_E	2.582	1.00
134_R	144_Q	2.552	1.00
119_Q	123_D	2.550	1.00
185_E	188_N	2.479	1.00
141_R	145_L	2.390	1.00
215_K	219_S	2.210	1.00
188_N	191_R	2.184	1.00
15_K	96_A	2.142	1.00
86_K	90_E	2.141	1.00
24_N	49_A	2.127	1.00
90_E	124_L	2.087	1.00
134_R	148_A	2.065	1.00
79_K	83_E	2.044	1.00
80_K	83_E	2.005	1.00
43_V	117_I	1.963	1.00
266_G	270_L	1.961	1.00
17_I	93_L	1.957	1.00
152_S	156_E	1.951	1.00
90_E	120_I	1.929	1.00
218_M	313_T	1.910	1.00
28_N	54_K	1.908	1.00
130_G	161_L	1.903	1.00
96_A	99_V	1.839	1.00
90_E	123_D	1.830	1.00
230_I	307_V	1.822	1.00
238_A	277_E	1.789	1.00
76_E	80_K	1.748	1.00
93_L	124_L	1.735	1.00
145_L	149_G	1.732	1.00
231_A	239_E	1.683	1.00
239_E	242_K	1.654	1.00
238_A	242_K	1.645	1.00
47_A	51_N	1.625	1.00
149_G	153_A	1.624	1.00
31_I	55_A	1.614	1.00
83_E	119_Q	1.609	1.00
27_V	42_A	1.598	1.00
41_I	57_V	1.592	1.00
241_A	282_V	1.582	1.00
280_D	284_S	1.580	1.00
275_V	294_F	1.566	1.00
191_R	195_Q	1.565	1.00
59_M	92_A	1.546	1.00
160_T	218_M	1.545	1.00
87_E	90_E	1.541	1.00
269_N	303_K	1.528	1.00
178_P	181_E	1.526	1.00
276_Q	280_D	1.521	0.99
173_V	185_E	1.515	0.99
93_L	99_V	1.511	0.99
29_R	187_D	1.510	0.99
28_N	53_S	1.497	0.99
120_I	124_L	1.496	0.99
41_I	55_A	1.491	0.99
269_N	304_D	1.485	0.99
103_A	132_V	1.480	0.99
176_N	273_Y	1.479	0.99
205_G	297_V	1.479	0.99
88_Q	91_E	1.477	0.99
200_L	209_L	1.454	0.99
217_I	259_G	1.450	0.99
130_G	154_M	1.429	0.99
134_R	251_E	1.420	0.99
207_I	294_F	1.399	0.99
73_A	293_I	1.391	0.99
42_A	50_L	1.376	0.99
82_A	113_A	1.371	0.99
206_L	296_S	1.369	0.99
245_I	310_V	1.333	0.99
43_V	89_I	1.312	0.98
19_V	117_I	1.302	0.98
270_L	306_I	1.294	0.98
148_A	152_S	1.292	0.98
352_Q	355_N	1.289	0.98
67_R	97_D	1.277	0.98
351_P	359_R	1.259	0.98
242_K	246_S	1.249	0.98
237_A	241_A	1.242	0.98
180_L	298_I	1.237	0.98
76_E	79_K	1.233	0.98
177_T	182_A	1.220	0.98
259_G	290_V	1.220	0.98
15_K	39_E	1.219	0.98
99_V	126_A	1.218	0.98
180_L	268_T	1.213	0.97
260_V	286_S	1.189	0.97
181_E	184_R	1.187	0.97
74_N	216_T	1.187	0.97
173_V	177_T	1.186	0.97
255_D	285_A	1.179	0.97
142_K	291_N	1.174	0.97
278_A	306_I	1.169	0.97
17_I	43_V	1.167	0.97
31_I	40_Y	1.150	0.96
131_V	194_V	1.138	0.96
35_V	191_R	1.133	0.96
168_R	171_E	1.127	0.96
356_T	359_R	1.124	0.96
325_P	329_S	1.123	0.96
193_G	226_M	1.122	0.96
302_L	307_V	1.121	0.96
160_T	221_K	1.115	0.96
96_A	126_A	1.106	0.96
73_A	216_T	1.081	0.95
179_M	296_S	1.077	0.95
324_K	328_P	1.077	0.95
354_Q	360_H	1.076	0.95
153_A	157_A	1.071	0.95
61_I	113_A	1.065	0.95
151_I	163_V	1.052	0.94
71_A	77_V	1.050	0.94
24_N	42_A	1.049	0.94
341_V	351_P	1.044	0.94
239_E	243_K	1.043	0.94
326_Q	329_S	1.040	0.94
265_T	297_V	1.038	0.94
26_A	30_M	1.037	0.94
281_I	285_A	1.035	0.94
225_L	252_A	1.035	0.94
195_Q	199_D	1.033	0.94
355_N	360_H	1.032	0.94
19_V	101_V	1.027	0.93
232_T	304_D	1.026	0.93
36_Q	203_T	1.021	0.93
259_G	287_D	1.018	0.93
263_N	297_V	1.017	0.93
18_G	23_G	1.013	0.93
326_Q	331_N	1.010	0.93
12_A	97_D	1.006	0.93
63_A	88_Q	1.005	0.93
90_E	94_K	1.002	0.93
176_N	271_S	1.001	0.93
170_L	276_Q	0.995	0.92
41_I	92_A	0.993	0.92
149_G	152_S	0.992	0.92
258_Q	287_D	0.987	0.92
270_L	275_V	0.982	0.92
351_P	355_N	0.979	0.92
354_Q	357_V	0.977	0.92
92_A	96_A	0.977	0.92
39_E	57_V	0.976	0.92
299_N	307_V	0.971	0.91
236_R	271_S	0.965	0.91
352_Q	358_S	0.964	0.91
240_A	308_V	0.963	0.91
28_N	52_L	0.963	0.91
140_G	292_M	0.962	0.91
70_G	108_G	0.955	0.91
20_G	23_G	0.953	0.91
42_A	53_S	0.947	0.90
280_D	283_A	0.946	0.90
353_Q	356_T	0.946	0.90
59_M	89_I	0.942	0.90
227_G	244_A	0.941	0.90
351_P	358_S	0.941	0.90
324_K	329_S	0.940	0.90
89_I	120_I	0.939	0.90
32_E	184_R	0.938	0.90
33_N	191_R	0.937	0.90
237_A	306_I	0.936	0.90
205_G	263_N	0.934	0.90
29_R	193_G	0.934	0.90
352_Q	356_T	0.932	0.90
354_Q	358_S	0.931	0.90
217_I	293_I	0.916	0.89
286_S	290_V	0.915	0.89
325_P	328_P	0.915	0.89
354_Q	359_R	0.914	0.89
21_G	25_N	0.909	0.88
82_A	116_V	0.908	0.88
142_K	146_Q	0.906	0.88
326_Q	330_L	0.905	0.88
357_V	360_H	0.902	0.88
98_M	129_V	0.901	0.88
99_V	117_I	0.901	0.88
229_G	240_A	0.901	0.88
65_L	80_K	0.898	0.88
116_V	120_I	0.889	0.87
103_A	114_A	0.889	0.87
87_E	91_E	0.887	0.87
351_P	360_H	0.881	0.87
134_R	151_I	0.881	0.87
353_Q	359_R	0.879	0.87
238_A	281_I	0.870	0.86
184_R	187_D	0.866	0.86
30_M	40_Y	0.865	0.86
15_K	41_I	0.862	0.86
265_T	302_L	0.861	0.86
325_P	330_L	0.860	0.85
169_I	186_A	0.852	0.85
101_V	117_I	0.848	0.85
355_N	359_R	0.847	0.85
82_A	89_I	0.844	0.84
57_V	92_A	0.844	0.84
144_Q	148_A	0.843	0.84
177_T	273_Y	0.843	0.84
281_I	284_S	0.838	0.84
279_A	294_F	0.833	0.84
355_N	358_S	0.828	0.83
167_D	171_E	0.828	0.83
353_Q	357_V	0.828	0.83
178_P	271_S	0.825	0.83
321_D	324_K	0.824	0.83
12_A	209_L	0.823	0.83
168_R	247_S	0.822	0.83
97_D	170_L	0.820	0.83
98_M	218_M	0.811	0.82
167_D	170_L	0.811	0.82
341_V	360_H	0.809	0.82
324_K	327_R	0.807	0.82
235_N	277_E	0.802	0.81
101_V	118_A	0.802	0.81
174_D	273_Y	0.800	0.81
72_G	108_G	0.799	0.81
42_A	55_A	0.798	0.81
74_N	80_K	0.792	0.80
63_A	85_S	0.791	0.80
221_K	228_I	0.790	0.80
169_I	272_L	0.788	0.80
325_P	331_N	0.787	0.80
340_S	359_R	0.786	0.80
352_Q	359_R	0.784	0.80
353_Q	360_H	0.783	0.80
329_S	353_Q	0.782	0.80
145_L	289_D	0.782	0.80
206_L	275_V	0.779	0.79
327_R	331_N	0.777	0.79
60_Q	63_A	0.776	0.79
105_M	132_V	0.775	0.79
266_G	275_V	0.773	0.79
351_P	354_Q	0.772	0.79
223_S	262_M	0.769	0.78
341_V	357_V	0.769	0.78
89_I	93_L	0.767	0.78
229_G	244_A	0.764	0.78
26_A	40_Y	0.762	0.78
39_E	96_A	0.761	0.78
240_A	244_A	0.760	0.78
44_N	71_A	0.757	0.77
53_S	58_K	0.757	0.77
341_V	355_N	0.756	0.77
152_S	155_K	0.755	0.77
327_R	330_L	0.753	0.77
93_L	96_A	0.751	0.77
52_L	280_D	0.748	0.77
179_M	183_F	0.747	0.76
330_L	352_Q	0.745	0.76
102_T	176_N	0.744	0.76
174_D	185_E	0.743	0.76
353_Q	358_S	0.741	0.76
287_D	290_V	0.740	0.76
42_A	58_K	0.740	0.76
340_S	353_Q	0.735	0.75
278_A	308_V	0.734	0.75
247_S	315_F	0.734	0.75
262_M	308_V	0.729	0.75
259_G	314_G	0.728	0.75
134_R	311_I	0.728	0.75
323_T	341_V	0.728	0.75
340_S	352_Q	0.725	0.74
126_A	225_L	0.723	0.74
306_I	318_Q	0.722	0.74
12_A	212_A	0.720	0.74
242_K	281_I	0.718	0.74
98_M	277_E	0.718	0.74
341_V	354_Q	0.715	0.73
356_T	360_H	0.712	0.73
145_L	148_A	0.712	0.73
233_G	236_R	0.711	0.73
137_T	280_D	0.711	0.73
196_G	209_L	0.710	0.73
323_T	360_H	0.708	0.72
165_P	189_V	0.708	0.72
311_I	315_F	0.705	0.72
340_S	357_V	0.704	0.72
42_A	54_K	0.704	0.72
259_G	291_N	0.704	0.72
116_V	119_Q	0.703	0.72
155_K	223_S	0.702	0.72
70_G	78_G	0.698	0.71
155_K	316_I	0.693	0.71
65_L	77_V	0.692	0.71
94_K	124_L	0.692	0.71
276_Q	283_A	0.685	0.70
175_K	277_E	0.681	0.70
352_Q	357_V	0.680	0.69
134_R	165_P	0.679	0.69
322_V	352_Q	0.678	0.69
16_V	169_I	0.678	0.69
44_N	108_G	0.678	0.69
175_K	234_E	0.676	0.69
132_V	163_V	0.675	0.69
26_A	190_L	0.675	0.69
351_P	357_V	0.671	0.68
206_L	298_I	0.665	0.68
73_A	81_A	0.665	0.68
22_G	315_F	0.664	0.68
129_V	313_T	0.658	0.67
195_Q	228_I	0.658	0.67
352_Q	360_H	0.656	0.67
55_A	116_V	0.656	0.67
138_F	183_F	0.655	0.67
138_F	294_F	0.655	0.67
22_G	133_T	0.654	0.66
200_L	311_I	0.653	0.66
120_I	123_D	0.653	0.66
340_S	354_Q	0.651	0.66
122_K	220_N	0.650	0.66
216_T	293_I	0.649	0.66
328_P	331_N	0.648	0.66
68_G	108_G	0.647	0.66
143_R	293_I	0.647	0.66
268_T	298_I	0.646	0.66
203_T	297_V	0.645	0.65
351_P	356_T	0.644	0.65
221_K	259_G	0.643	0.65
102_T	190_L	0.641	0.65
323_T	329_S	0.641	0.65
43_V	92_A	0.639	0.65
341_V	359_R	0.639	0.65
341_V	358_S	0.638	0.65
318_Q	330_L	0.635	0.64
320_K	352_Q	0.634	0.64
87_E	92_A	0.633	0.64
326_Q	341_V	0.630	0.64
266_G	306_I	0.629	0.63
175_K	273_Y	0.629	0.63
80_K	84_E	0.626	0.63
9_D	54_K	0.626	0.63
16_V	40_Y	0.626	0.63
253_A	260_V	0.625	0.63
323_T	353_Q	0.625	0.63
195_Q	299_N	0.625	0.63
34_E	308_V	0.624	0.63
266_G	298_I	0.623	0.63
48_Q	208_N	0.619	0.62
33_N	184_R	0.619	0.62
322_V	353_Q	0.618	0.62
329_S	357_V	0.616	0.62
28_N	31_I	0.616	0.62
321_D	341_V	0.615	0.62
330_L	354_Q	0.615	0.62
37_G	123_D	0.614	0.62
196_G	226_M	0.613	0.61
77_V	80_K	0.613	0.61
142_K	145_L	0.612	0.61
48_Q	69_L	0.612	0.61
260_V	312_A	0.609	0.61
187_D	279_A	0.608	0.61
146_Q	149_G	0.608	0.61
199_D	202_A	0.607	0.61
340_S	355_N	0.607	0.61
330_L	351_P	0.605	0.60
319_E	322_V	0.604	0.60
318_Q	321_D	0.603	0.60
231_A	308_V	0.603	0.60
206_L	264_I	0.601	0.60
47_A	225_L	0.600	0.60
322_V	360_H	0.599	0.60
201_I	214_V	0.599	0.60
258_Q	316_I	0.597	0.59
52_L	204_P	0.596	0.59
130_G	151_I	0.596	0.59
340_S	351_P	0.594	0.59
169_I	187_D	0.592	0.59
35_V	202_A	0.590	0.59
255_D	288_Q	0.590	0.59
193_G	228_I	0.590	0.59
31_I	56_E	0.587	0.58
323_T	328_P	0.587	0.58
327_R	353_Q	0.586	0.58
330_L	360_H	0.586	0.58
323_T	326_Q	0.585	0.58
35_V	195_Q	0.584	0.58
28_N	55_A	0.583	0.58
86_K	123_D	0.583	0.58
122_K	159_D	0.583	0.58
317_E	322_V	0.580	0.57
325_P	341_V	0.580	0.57
44_N	72_G	0.576	0.57
299_N	302_L	0.576	0.57
29_R	43_V	0.575	0.57
321_D	354_Q	0.574	0.56
265_T	313_T	0.574	0.56
267_G	271_S	0.573	0.56
100_F	224_A	0.572	0.56
35_V	105_M	0.571	0.56
33_N	188_N	0.568	0.56
324_K	331_N	0.567	0.56
330_L	355_N	0.566	0.55
236_R	269_N	0.564	0.55
12_A	69_L	0.562	0.55
13_S	199_D	0.562	0.55
320_K	359_R	0.561	0.55
227_G	313_T	0.559	0.55
325_P	352_Q	0.558	0.54
95_G	126_A	0.558	0.54
173_V	178_P	0.556	0.54
127_L	211_F	0.556	0.54
252_A	262_M	0.553	0.54
40_Y	105_M	0.552	0.54
51_N	58_K	0.551	0.53
49_A	73_A	0.550	0.53
320_K	351_P	0.550	0.53
13_S	95_G	0.549	0.53
323_T	354_Q	0.549	0.53
324_K	354_Q	0.548	0.53
10_G	67_R	0.548	0.53
318_Q	322_V	0.547	0.53
93_L	121_A	0.546	0.53
200_L	234_E	0.546	0.53
39_E	56_E	0.546	0.53
217_I	290_V	0.542	0.52
98_M	162_I	0.542	0.52
327_R	358_S	0.541	0.52
171_E	238_A	0.541	0.52
322_V	340_S	0.540	0.52
9_D	51_N	0.540	0.52
10_G	47_A	0.539	0.52
319_E	323_T	0.539	0.52
132_V	154_M	0.539	0.52
319_E	360_H	0.538	0.52
101_V	130_G	0.537	0.52
146_Q	291_N	0.534	0.51
233_G	304_D	0.534	0.51
220_N	258_Q	0.533	0.51
171_E	180_L	0.533	0.51
331_N	341_V	0.533	0.51
114_A	154_M	0.533	0.51
322_V	326_Q	0.533	0.51
327_R	356_T	0.533	0.51
48_Q	140_G	0.532	0.51
226_M	259_G	0.531	0.51
195_Q	203_T	0.531	0.51
44_N	68_G	0.531	0.51
78_G	108_G	0.530	0.51
320_K	356_T	0.529	0.51
74_N	77_V	0.529	0.51
11_L	131_V	0.529	0.51
167_D	276_Q	0.529	0.51
214_V	261_L	0.528	0.50
40_Y	187_D	0.528	0.50
30_M	162_I	0.528	0.50
331_N	360_H	0.527	0.50
187_D	275_V	0.527	0.50
326_Q	340_S	0.526	0.50
179_M	275_V	0.525	0.50
68_G	72_G	0.524	0.50
17_I	99_V	0.523	0.50
26_A	102_T	0.522	0.50
330_L	340_S	0.520	0.49
196_G	309_T	0.520	0.49
194_V	248_P	0.520	0.49
236_R	306_I	0.519	0.49
196_G	290_V	0.519	0.49
236_R	270_L	0.519	0.49
328_P	351_P	0.519	0.49
36_Q	88_Q	0.517	0.49
320_K	353_Q	0.517	0.49
204_P	297_V	0.516	0.49
61_I	180_L	0.514	0.49
178_P	191_R	0.514	0.49
98_M	211_F	0.513	0.48
28_N	320_K	0.513	0.48
25_N	72_G	0.513	0.48
44_N	69_L	0.512	0.48
180_L	200_L	0.512	0.48
94_K	120_I	0.509	0.48
22_G	26_A	0.509	0.48
25_N	111_T	0.508	0.48
258_Q	314_G	0.508	0.48
330_L	341_V	0.504	0.47
105_M	150_G	0.504	0.47
242_K	261_L	0.503	0.47
123_D	216_T	0.503	0.47
160_T	224_A	0.503	0.47
165_P	205_G	0.503	0.47
174_D	228_I	0.502	0.47
322_V	327_R	0.502	0.47
286_S	292_M	0.502	0.47
253_A	285_A	0.501	0.47
246_S	281_I	0.501	0.47
341_V	352_Q	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vxyA	2	0.801	100	0.214	Contact Map
4m8iA	1	0.8141	100	0.221	Contact Map
2vawA	1	0.822	100	0.223	Contact Map
1rq2A	2	0.788	100	0.233	Contact Map
2r751	1	0.8429	100	0.273	Contact Map
1ofuA	1	0.801	100	0.278	Contact Map
1w5fA	2	0.8168	100	0.281	Contact Map
2vapA	1	0.8586	100	0.287	Contact Map
4ei7A	1	0.877	100	0.308	Contact Map
4b45A	1	0.8194	100	0.355	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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