GREMLIN Database
FTSZ - Cell division protein FtsZ
UniProt: P17865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (336)
Sequences: 3190 (1523)
Seq/√Len: 83.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V61_I5.2291.00
79_K153_A4.5821.00
111_T150_G4.2381.00
86_K119_Q4.0251.00
230_I305_E4.0191.00
86_K120_I3.9871.00
137_T167_D3.8961.00
153_A156_E3.5251.00
32_E54_K3.3771.00
236_R274_E3.3691.00
119_Q157_A3.2541.00
235_N239_E3.1221.00
91_E94_K3.1091.00
19_V113_A3.0741.00
85_S88_Q3.0551.00
232_T305_E2.9831.00
130_G158_V2.8401.00
101_V114_A2.7991.00
262_M279_A2.7731.00
158_V161_L2.6261.00
105_M151_I2.6171.00
268_T300_E2.5821.00
134_R144_Q2.5521.00
119_Q123_D2.5501.00
185_E188_N2.4791.00
141_R145_L2.3901.00
215_K219_S2.2101.00
188_N191_R2.1841.00
15_K96_A2.1421.00
86_K90_E2.1411.00
24_N49_A2.1271.00
90_E124_L2.0871.00
134_R148_A2.0651.00
79_K83_E2.0441.00
80_K83_E2.0051.00
43_V117_I1.9631.00
266_G270_L1.9611.00
17_I93_L1.9571.00
152_S156_E1.9511.00
90_E120_I1.9291.00
218_M313_T1.9101.00
28_N54_K1.9081.00
130_G161_L1.9031.00
96_A99_V1.8391.00
90_E123_D1.8301.00
230_I307_V1.8221.00
238_A277_E1.7891.00
76_E80_K1.7481.00
93_L124_L1.7351.00
145_L149_G1.7321.00
231_A239_E1.6831.00
239_E242_K1.6541.00
238_A242_K1.6451.00
47_A51_N1.6251.00
149_G153_A1.6241.00
31_I55_A1.6141.00
83_E119_Q1.6091.00
27_V42_A1.5981.00
41_I57_V1.5921.00
241_A282_V1.5821.00
280_D284_S1.5801.00
275_V294_F1.5661.00
191_R195_Q1.5651.00
59_M92_A1.5461.00
160_T218_M1.5451.00
87_E90_E1.5411.00
269_N303_K1.5281.00
178_P181_E1.5261.00
276_Q280_D1.5210.99
173_V185_E1.5150.99
93_L99_V1.5110.99
29_R187_D1.5100.99
28_N53_S1.4970.99
120_I124_L1.4960.99
41_I55_A1.4910.99
269_N304_D1.4850.99
103_A132_V1.4800.99
176_N273_Y1.4790.99
205_G297_V1.4790.99
88_Q91_E1.4770.99
200_L209_L1.4540.99
217_I259_G1.4500.99
130_G154_M1.4290.99
134_R251_E1.4200.99
207_I294_F1.3990.99
73_A293_I1.3910.99
42_A50_L1.3760.99
82_A113_A1.3710.99
206_L296_S1.3690.99
245_I310_V1.3330.99
43_V89_I1.3120.98
19_V117_I1.3020.98
270_L306_I1.2940.98
148_A152_S1.2920.98
352_Q355_N1.2890.98
67_R97_D1.2770.98
351_P359_R1.2590.98
242_K246_S1.2490.98
237_A241_A1.2420.98
180_L298_I1.2370.98
76_E79_K1.2330.98
177_T182_A1.2200.98
259_G290_V1.2200.98
15_K39_E1.2190.98
99_V126_A1.2180.98
180_L268_T1.2130.97
260_V286_S1.1890.97
181_E184_R1.1870.97
74_N216_T1.1870.97
173_V177_T1.1860.97
255_D285_A1.1790.97
142_K291_N1.1740.97
278_A306_I1.1690.97
17_I43_V1.1670.97
31_I40_Y1.1500.96
131_V194_V1.1380.96
35_V191_R1.1330.96
168_R171_E1.1270.96
356_T359_R1.1240.96
325_P329_S1.1230.96
193_G226_M1.1220.96
302_L307_V1.1210.96
160_T221_K1.1150.96
96_A126_A1.1060.96
73_A216_T1.0810.95
179_M296_S1.0770.95
324_K328_P1.0770.95
354_Q360_H1.0760.95
153_A157_A1.0710.95
61_I113_A1.0650.95
151_I163_V1.0520.94
71_A77_V1.0500.94
24_N42_A1.0490.94
341_V351_P1.0440.94
239_E243_K1.0430.94
326_Q329_S1.0400.94
265_T297_V1.0380.94
26_A30_M1.0370.94
281_I285_A1.0350.94
225_L252_A1.0350.94
195_Q199_D1.0330.94
355_N360_H1.0320.94
19_V101_V1.0270.93
232_T304_D1.0260.93
36_Q203_T1.0210.93
259_G287_D1.0180.93
263_N297_V1.0170.93
18_G23_G1.0130.93
326_Q331_N1.0100.93
12_A97_D1.0060.93
63_A88_Q1.0050.93
90_E94_K1.0020.93
176_N271_S1.0010.93
170_L276_Q0.9950.92
41_I92_A0.9930.92
149_G152_S0.9920.92
258_Q287_D0.9870.92
270_L275_V0.9820.92
351_P355_N0.9790.92
354_Q357_V0.9770.92
92_A96_A0.9770.92
39_E57_V0.9760.92
299_N307_V0.9710.91
236_R271_S0.9650.91
352_Q358_S0.9640.91
240_A308_V0.9630.91
28_N52_L0.9630.91
140_G292_M0.9620.91
70_G108_G0.9550.91
20_G23_G0.9530.91
42_A53_S0.9470.90
280_D283_A0.9460.90
353_Q356_T0.9460.90
59_M89_I0.9420.90
227_G244_A0.9410.90
351_P358_S0.9410.90
324_K329_S0.9400.90
89_I120_I0.9390.90
32_E184_R0.9380.90
33_N191_R0.9370.90
237_A306_I0.9360.90
205_G263_N0.9340.90
29_R193_G0.9340.90
352_Q356_T0.9320.90
354_Q358_S0.9310.90
217_I293_I0.9160.89
286_S290_V0.9150.89
325_P328_P0.9150.89
354_Q359_R0.9140.89
21_G25_N0.9090.88
82_A116_V0.9080.88
142_K146_Q0.9060.88
326_Q330_L0.9050.88
357_V360_H0.9020.88
98_M129_V0.9010.88
99_V117_I0.9010.88
229_G240_A0.9010.88
65_L80_K0.8980.88
116_V120_I0.8890.87
103_A114_A0.8890.87
87_E91_E0.8870.87
351_P360_H0.8810.87
134_R151_I0.8810.87
353_Q359_R0.8790.87
238_A281_I0.8700.86
184_R187_D0.8660.86
30_M40_Y0.8650.86
15_K41_I0.8620.86
265_T302_L0.8610.86
325_P330_L0.8600.85
169_I186_A0.8520.85
101_V117_I0.8480.85
355_N359_R0.8470.85
82_A89_I0.8440.84
57_V92_A0.8440.84
144_Q148_A0.8430.84
177_T273_Y0.8430.84
281_I284_S0.8380.84
279_A294_F0.8330.84
355_N358_S0.8280.83
167_D171_E0.8280.83
353_Q357_V0.8280.83
178_P271_S0.8250.83
321_D324_K0.8240.83
12_A209_L0.8230.83
168_R247_S0.8220.83
97_D170_L0.8200.83
98_M218_M0.8110.82
167_D170_L0.8110.82
341_V360_H0.8090.82
324_K327_R0.8070.82
235_N277_E0.8020.81
101_V118_A0.8020.81
174_D273_Y0.8000.81
72_G108_G0.7990.81
42_A55_A0.7980.81
74_N80_K0.7920.80
63_A85_S0.7910.80
221_K228_I0.7900.80
169_I272_L0.7880.80
325_P331_N0.7870.80
340_S359_R0.7860.80
352_Q359_R0.7840.80
353_Q360_H0.7830.80
329_S353_Q0.7820.80
145_L289_D0.7820.80
206_L275_V0.7790.79
327_R331_N0.7770.79
60_Q63_A0.7760.79
105_M132_V0.7750.79
266_G275_V0.7730.79
351_P354_Q0.7720.79
223_S262_M0.7690.78
341_V357_V0.7690.78
89_I93_L0.7670.78
229_G244_A0.7640.78
26_A40_Y0.7620.78
39_E96_A0.7610.78
240_A244_A0.7600.78
44_N71_A0.7570.77
53_S58_K0.7570.77
341_V355_N0.7560.77
152_S155_K0.7550.77
327_R330_L0.7530.77
93_L96_A0.7510.77
52_L280_D0.7480.77
179_M183_F0.7470.76
330_L352_Q0.7450.76
102_T176_N0.7440.76
174_D185_E0.7430.76
353_Q358_S0.7410.76
287_D290_V0.7400.76
42_A58_K0.7400.76
340_S353_Q0.7350.75
278_A308_V0.7340.75
247_S315_F0.7340.75
262_M308_V0.7290.75
259_G314_G0.7280.75
134_R311_I0.7280.75
323_T341_V0.7280.75
340_S352_Q0.7250.74
126_A225_L0.7230.74
306_I318_Q0.7220.74
12_A212_A0.7200.74
242_K281_I0.7180.74
98_M277_E0.7180.74
341_V354_Q0.7150.73
356_T360_H0.7120.73
145_L148_A0.7120.73
233_G236_R0.7110.73
137_T280_D0.7110.73
196_G209_L0.7100.73
323_T360_H0.7080.72
165_P189_V0.7080.72
311_I315_F0.7050.72
340_S357_V0.7040.72
42_A54_K0.7040.72
259_G291_N0.7040.72
116_V119_Q0.7030.72
155_K223_S0.7020.72
70_G78_G0.6980.71
155_K316_I0.6930.71
65_L77_V0.6920.71
94_K124_L0.6920.71
276_Q283_A0.6850.70
175_K277_E0.6810.70
352_Q357_V0.6800.69
134_R165_P0.6790.69
322_V352_Q0.6780.69
16_V169_I0.6780.69
44_N108_G0.6780.69
175_K234_E0.6760.69
132_V163_V0.6750.69
26_A190_L0.6750.69
351_P357_V0.6710.68
206_L298_I0.6650.68
73_A81_A0.6650.68
22_G315_F0.6640.68
129_V313_T0.6580.67
195_Q228_I0.6580.67
352_Q360_H0.6560.67
55_A116_V0.6560.67
138_F183_F0.6550.67
138_F294_F0.6550.67
22_G133_T0.6540.66
200_L311_I0.6530.66
120_I123_D0.6530.66
340_S354_Q0.6510.66
122_K220_N0.6500.66
216_T293_I0.6490.66
328_P331_N0.6480.66
68_G108_G0.6470.66
143_R293_I0.6470.66
268_T298_I0.6460.66
203_T297_V0.6450.65
351_P356_T0.6440.65
221_K259_G0.6430.65
102_T190_L0.6410.65
323_T329_S0.6410.65
43_V92_A0.6390.65
341_V359_R0.6390.65
341_V358_S0.6380.65
318_Q330_L0.6350.64
320_K352_Q0.6340.64
87_E92_A0.6330.64
326_Q341_V0.6300.64
266_G306_I0.6290.63
175_K273_Y0.6290.63
80_K84_E0.6260.63
9_D54_K0.6260.63
16_V40_Y0.6260.63
253_A260_V0.6250.63
323_T353_Q0.6250.63
195_Q299_N0.6250.63
34_E308_V0.6240.63
266_G298_I0.6230.63
48_Q208_N0.6190.62
33_N184_R0.6190.62
322_V353_Q0.6180.62
329_S357_V0.6160.62
28_N31_I0.6160.62
321_D341_V0.6150.62
330_L354_Q0.6150.62
37_G123_D0.6140.62
196_G226_M0.6130.61
77_V80_K0.6130.61
142_K145_L0.6120.61
48_Q69_L0.6120.61
260_V312_A0.6090.61
187_D279_A0.6080.61
146_Q149_G0.6080.61
199_D202_A0.6070.61
340_S355_N0.6070.61
330_L351_P0.6050.60
319_E322_V0.6040.60
318_Q321_D0.6030.60
231_A308_V0.6030.60
206_L264_I0.6010.60
47_A225_L0.6000.60
322_V360_H0.5990.60
201_I214_V0.5990.60
258_Q316_I0.5970.59
52_L204_P0.5960.59
130_G151_I0.5960.59
340_S351_P0.5940.59
169_I187_D0.5920.59
35_V202_A0.5900.59
255_D288_Q0.5900.59
193_G228_I0.5900.59
31_I56_E0.5870.58
323_T328_P0.5870.58
327_R353_Q0.5860.58
330_L360_H0.5860.58
323_T326_Q0.5850.58
35_V195_Q0.5840.58
28_N55_A0.5830.58
86_K123_D0.5830.58
122_K159_D0.5830.58
317_E322_V0.5800.57
325_P341_V0.5800.57
44_N72_G0.5760.57
299_N302_L0.5760.57
29_R43_V0.5750.57
321_D354_Q0.5740.56
265_T313_T0.5740.56
267_G271_S0.5730.56
100_F224_A0.5720.56
35_V105_M0.5710.56
33_N188_N0.5680.56
324_K331_N0.5670.56
330_L355_N0.5660.55
236_R269_N0.5640.55
12_A69_L0.5620.55
13_S199_D0.5620.55
320_K359_R0.5610.55
227_G313_T0.5590.55
325_P352_Q0.5580.54
95_G126_A0.5580.54
173_V178_P0.5560.54
127_L211_F0.5560.54
252_A262_M0.5530.54
40_Y105_M0.5520.54
51_N58_K0.5510.53
49_A73_A0.5500.53
320_K351_P0.5500.53
13_S95_G0.5490.53
323_T354_Q0.5490.53
324_K354_Q0.5480.53
10_G67_R0.5480.53
318_Q322_V0.5470.53
93_L121_A0.5460.53
200_L234_E0.5460.53
39_E56_E0.5460.53
217_I290_V0.5420.52
98_M162_I0.5420.52
327_R358_S0.5410.52
171_E238_A0.5410.52
322_V340_S0.5400.52
9_D51_N0.5400.52
10_G47_A0.5390.52
319_E323_T0.5390.52
132_V154_M0.5390.52
319_E360_H0.5380.52
101_V130_G0.5370.52
146_Q291_N0.5340.51
233_G304_D0.5340.51
220_N258_Q0.5330.51
171_E180_L0.5330.51
331_N341_V0.5330.51
114_A154_M0.5330.51
322_V326_Q0.5330.51
327_R356_T0.5330.51
48_Q140_G0.5320.51
226_M259_G0.5310.51
195_Q203_T0.5310.51
44_N68_G0.5310.51
78_G108_G0.5300.51
320_K356_T0.5290.51
74_N77_V0.5290.51
11_L131_V0.5290.51
167_D276_Q0.5290.51
214_V261_L0.5280.50
40_Y187_D0.5280.50
30_M162_I0.5280.50
331_N360_H0.5270.50
187_D275_V0.5270.50
326_Q340_S0.5260.50
179_M275_V0.5250.50
68_G72_G0.5240.50
17_I99_V0.5230.50
26_A102_T0.5220.50
330_L340_S0.5200.49
196_G309_T0.5200.49
194_V248_P0.5200.49
236_R306_I0.5190.49
196_G290_V0.5190.49
236_R270_L0.5190.49
328_P351_P0.5190.49
36_Q88_Q0.5170.49
320_K353_Q0.5170.49
204_P297_V0.5160.49
61_I180_L0.5140.49
178_P191_R0.5140.49
98_M211_F0.5130.48
28_N320_K0.5130.48
25_N72_G0.5130.48
44_N69_L0.5120.48
180_L200_L0.5120.48
94_K120_I0.5090.48
22_G26_A0.5090.48
25_N111_T0.5080.48
258_Q314_G0.5080.48
330_L341_V0.5040.47
105_M150_G0.5040.47
242_K261_L0.5030.47
123_D216_T0.5030.47
160_T224_A0.5030.47
165_P205_G0.5030.47
174_D228_I0.5020.47
322_V327_R0.5020.47
286_S292_M0.5020.47
253_A285_A0.5010.47
246_S281_I0.5010.47
341_V352_Q0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vxyA 2 0.801 100 0.214 Contact Map
4m8iA 1 0.8141 100 0.221 Contact Map
2vawA 1 0.822 100 0.223 Contact Map
1rq2A 2 0.788 100 0.233 Contact Map
2r751 1 0.8429 100 0.273 Contact Map
1ofuA 1 0.801 100 0.278 Contact Map
1w5fA 2 0.8168 100 0.281 Contact Map
2vapA 1 0.8586 100 0.287 Contact Map
4ei7A 1 0.877 100 0.308 Contact Map
4b45A 1 0.8194 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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