HIS8 - BACSU - GREMLIN Contacts

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HIS8 - Histidinol-phosphate aminotransferase

UniProt:	P17731	Sequences: MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICSPNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (332)
Sequences:	43934 (30432)
Seq/√Len:	1670.2

ECOLI - YBDL ALAC ALAA AVTA YJIR HIS8 MALY YDCR
BACSU - HIS8 AAT1 YUGH AAT2 PATA MTNE AAT3 YDFD YISV CBL YCXD YDEL YDEF GABR YHDI
HALSA - HIS8 Q9HRM6 Q9HQK2 Q9HRX4 Q9HQW2 Q9HPL0
SULSO - AAT Y104 HIS8 Q97YX5 Q97TY7 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_H	56_Q	3.249	1.00
107_N	128_E	3.059	1.00
87_G	93_I	3.005	1.00
72_R	267_D	2.835	1.00
281_A	346_K	2.811	1.00
285_Q	350_E	2.793	1.00
102_L	127_A	2.695	1.00
280_N	284_Q	2.663	1.00
296_K	308_D	2.617	1.00
171_E	175_L	2.539	1.00
106_T	154_Q	2.411	1.00
237_A	242_I	2.363	1.00
146_L	183_S	2.341	1.00
351_E	355_I	2.318	1.00
107_N	130_R	2.223	1.00
285_Q	346_K	2.135	1.00
95_Q	99_R	2.133	1.00
345_T	348_Q	2.109	1.00
170_S	173_E	2.106	1.00
287_Y	291_K	2.072	1.00
68_A	263_I	2.069	1.00
45_E	49_E	2.050	1.00
289_F	353_L	2.017	1.00
112_A	131_E	1.997	1.00
289_F	292_T	1.987	1.00
71_T	81_E	1.890	1.00
72_R	75_K	1.888	1.00
232_V	262_A	1.871	1.00
319_A	323_K	1.845	1.00
312_P	315_E	1.795	1.00
289_F	357_A	1.794	1.00
175_L	179_E	1.789	1.00
144_A	148_A	1.784	1.00
285_Q	289_F	1.770	1.00
188_V	218_L	1.766	1.00
49_E	53_H	1.752	1.00
139_S	173_E	1.748	1.00
67_A	71_T	1.723	1.00
119_K	123_V	1.715	1.00
146_L	176_A	1.698	1.00
351_E	354_A	1.687	1.00
48_K	52_H	1.672	1.00
83_S	239_E	1.659	1.00
122_A	127_A	1.659	1.00
82_T	239_E	1.654	1.00
144_A	147_E	1.651	1.00
71_T	75_K	1.648	1.00
181_V	187_V	1.647	1.00
141_D	144_A	1.636	1.00
53_H	264_A	1.623	1.00
255_S	258_G	1.621	1.00
74_S	81_E	1.617	1.00
75_K	267_D	1.617	1.00
291_K	297_C	1.616	1.00
192_A	220_T	1.597	1.00
107_N	152_Q	1.586	1.00
288_D	292_T	1.581	1.00
97_I	216_M	1.573	1.00
315_E	319_A	1.568	1.00
119_K	131_E	1.563	1.00
323_K	358_E	1.555	1.00
142_L	176_A	1.547	1.00
72_R	263_I	1.546	1.00
184_R	214_N	1.540	1.00
108_T	122_A	1.539	1.00
289_F	354_A	1.534	1.00
318_Q	322_E	1.533	1.00
346_K	350_E	1.532	1.00
112_A	133_A	1.516	1.00
34_L	352_I	1.514	1.00
284_Q	288_D	1.512	1.00
109_V	153_T	1.479	1.00
176_A	179_E	1.466	1.00
107_N	150_D	1.462	1.00
278_Q	346_K	1.462	1.00
98_C	122_A	1.462	1.00
73_L	234_Y	1.460	1.00
97_I	188_V	1.444	1.00
90_S	218_L	1.440	1.00
235_G	245_I	1.439	1.00
287_Y	297_C	1.432	1.00
49_E	52_H	1.425	1.00
143_D	176_A	1.424	1.00
282_G	346_K	1.412	1.00
79_V	236_I	1.409	1.00
66_S	260_A	1.408	1.00
286_Y	305_V	1.407	1.00
289_F	350_E	1.404	1.00
313_A	331_N	1.404	1.00
173_E	176_A	1.397	1.00
107_N	153_T	1.387	1.00
110_T	129_V	1.387	1.00
287_Y	305_V	1.383	1.00
263_I	267_D	1.379	1.00
278_Q	281_A	1.376	1.00
315_E	318_Q	1.372	1.00
155_V	188_V	1.361	1.00
104_D	126_G	1.359	1.00
273_A	277_E	1.355	1.00
48_K	56_Q	1.355	1.00
327_V	339_L	1.355	1.00
292_T	357_A	1.355	1.00
314_D	331_N	1.339	1.00
221_F	262_A	1.335	1.00
306_L	330_G	1.335	1.00
64_G	246_E	1.333	1.00
135_R	173_E	1.329	1.00
50_A	264_A	1.327	1.00
149_I	180_R	1.326	1.00
50_A	53_H	1.317	1.00
181_V	185_V	1.313	1.00
51_L	261_A	1.312	1.00
319_A	322_E	1.305	1.00
77_L	236_I	1.305	1.00
308_D	338_S	1.303	1.00
286_Y	353_L	1.302	1.00
51_L	55_I	1.294	1.00
29_D	324_G	1.285	1.00
308_D	337_T	1.274	1.00
133_A	144_A	1.273	1.00
244_Q	247_P	1.262	1.00
219_R	234_Y	1.260	1.00
80_S	83_S	1.252	1.00
146_L	180_R	1.243	1.00
142_L	180_R	1.240	1.00
88_N	92_E	1.240	1.00
180_R	185_V	1.236	1.00
146_L	150_D	1.232	1.00
99_R	125_E	1.225	1.00
135_R	144_A	1.214	1.00
179_E	183_S	1.212	1.00
171_E	203_P	1.203	1.00
278_Q	282_G	1.203	1.00
103_N	106_T	1.200	1.00
171_E	207_P	1.196	1.00
205_T	208_L	1.184	1.00
307_I	341_I	1.184	1.00
68_A	267_D	1.179	1.00
109_V	132_I	1.177	1.00
172_G	175_L	1.174	1.00
243_R	247_P	1.174	1.00
172_G	176_A	1.170	1.00
98_C	157_W	1.163	1.00
93_I	235_G	1.161	1.00
213_S	238_D	1.160	1.00
264_A	267_D	1.153	1.00
98_C	102_L	1.148	1.00
283_L	343_I	1.145	1.00
179_E	182_P	1.144	1.00
175_L	208_L	1.143	1.00
68_A	260_A	1.141	1.00
350_E	354_A	1.134	1.00
182_P	211_K	1.132	1.00
182_P	212_Y	1.132	1.00
53_H	57_Q	1.130	1.00
85_I	242_I	1.125	1.00
186_L	216_M	1.123	1.00
264_A	268_D	1.119	1.00
323_K	355_I	1.119	1.00
76_H	269_Q	1.118	1.00
269_Q	273_A	1.115	1.00
67_A	81_E	1.113	1.00
320_L	327_V	1.109	1.00
283_L	287_Y	1.109	1.00
277_E	280_N	1.108	1.00
135_R	141_D	1.102	1.00
156_V	185_V	1.096	1.00
314_D	318_Q	1.096	1.00
260_A	263_I	1.087	1.00
216_M	237_A	1.079	1.00
282_G	285_Q	1.078	1.00
348_Q	351_E	1.078	1.00
70_R	74_S	1.078	1.00
317_F	327_V	1.074	1.00
273_A	276_V	1.072	1.00
64_G	70_R	1.063	1.00
46_A	268_D	1.062	1.00
285_Q	288_D	1.061	1.00
149_I	185_V	1.056	1.00
354_A	358_E	1.049	1.00
92_E	249_R	1.047	1.00
150_D	153_T	1.030	1.00
147_E	151_E	1.030	1.00
171_E	208_L	1.028	1.00
53_H	56_Q	1.021	1.00
277_E	281_A	1.014	1.00
46_A	49_E	1.011	1.00
100_A	248_A	1.011	1.00
73_L	86_F	1.007	1.00
30_K	324_G	1.002	1.00
271_F	274_S	1.001	1.00
102_L	108_T	1.000	1.00
199_A	300_S	0.998	1.00
274_S	278_Q	0.997	1.00
198_T	280_N	0.991	1.00
270_A	274_S	0.989	1.00
30_K	351_E	0.984	1.00
216_M	235_G	0.982	1.00
295_L	309_F	0.970	1.00
288_D	291_K	0.969	1.00
72_R	76_H	0.968	1.00
313_A	337_T	0.961	1.00
69_L	86_F	0.960	1.00
80_S	239_E	0.959	1.00
205_T	209_L	0.959	1.00
73_L	84_L	0.959	1.00
45_E	48_K	0.958	1.00
122_A	129_V	0.953	1.00
182_P	213_S	0.944	1.00
102_L	155_V	0.943	1.00
182_P	214_N	0.941	1.00
108_T	155_V	0.939	1.00
239_E	243_R	0.938	1.00
132_I	148_A	0.937	1.00
186_L	214_N	0.936	1.00
114_T	159_C	0.935	1.00
178_L	215_L	0.928	1.00
175_L	211_K	0.927	1.00
77_L	234_Y	0.927	1.00
68_A	71_T	0.925	1.00
101_F	155_V	0.913	1.00
142_L	146_L	0.912	1.00
186_L	241_L	0.908	1.00
83_S	242_I	0.907	1.00
84_L	236_I	0.906	1.00
74_S	84_L	0.904	1.00
314_D	329_S	0.901	1.00
320_L	356_L	0.897	1.00
293_H	357_A	0.894	1.00
143_D	147_E	0.892	1.00
123_V	129_V	0.889	1.00
313_A	329_S	0.889	1.00
271_F	275_C	0.879	1.00
143_D	146_L	0.878	1.00
41_Y	278_Q	0.874	1.00
49_E	56_Q	0.873	1.00
111_A	140_H	0.869	1.00
118_Y	157_W	0.867	1.00
93_I	218_L	0.863	1.00
101_F	186_L	0.862	1.00
88_N	255_S	0.862	1.00
216_M	241_L	0.862	1.00
242_I	246_E	0.861	1.00
274_S	277_E	0.861	1.00
283_L	299_P	0.859	1.00
309_F	339_L	0.858	1.00
281_A	285_Q	0.857	1.00
96_I	249_R	0.856	1.00
90_S	220_T	0.855	1.00
341_I	352_I	0.855	1.00
109_V	148_A	0.854	1.00
232_V	254_T	0.848	1.00
48_K	55_I	0.845	1.00
120_H	123_V	0.841	1.00
66_S	259_Q	0.838	1.00
317_F	329_S	0.838	1.00
232_V	258_G	0.838	1.00
218_L	235_G	0.835	1.00
111_A	132_I	0.829	1.00
85_I	245_I	0.827	1.00
67_A	70_R	0.827	1.00
76_H	195_E	0.825	1.00
66_S	263_I	0.823	1.00
153_T	185_V	0.822	1.00
74_S	80_S	0.822	1.00
142_L	177_F	0.821	1.00
316_L	339_L	0.816	1.00
28_L	324_G	0.816	1.00
197_V	200_E	0.814	1.00
327_V	341_I	0.812	1.00
347_E	350_E	0.806	1.00
270_A	273_A	0.805	1.00
46_A	264_A	0.805	1.00
284_Q	287_Y	0.801	1.00
142_L	173_E	0.799	1.00
286_Y	289_F	0.797	1.00
50_A	54_E	0.797	1.00
286_Y	349_N	0.787	1.00
112_A	334_G	0.785	1.00
83_S	212_Y	0.784	1.00
91_D	117_Q	0.784	1.00
204_E	207_P	0.783	1.00
58_L	260_A	0.780	1.00
312_P	336_P	0.779	1.00
237_A	245_I	0.775	1.00
224_A	272_I	0.774	1.00
306_L	338_S	0.772	1.00
331_N	336_P	0.771	1.00
90_S	192_A	0.767	1.00
282_G	349_N	0.767	1.00
100_A	245_I	0.766	1.00
109_V	145_M	0.764	1.00
316_L	320_L	0.760	1.00
281_A	284_Q	0.759	1.00
130_R	148_A	0.758	1.00
42_G	48_K	0.757	1.00
30_K	348_Q	0.756	1.00
355_I	358_E	0.756	1.00
69_L	73_L	0.751	1.00
162_N	165_T	0.746	1.00
195_E	224_A	0.746	1.00
325_Y	355_I	0.744	1.00
134_L	162_N	0.743	1.00
197_V	202_Y	0.742	1.00
149_I	153_T	0.739	1.00
92_E	96_I	0.738	1.00
272_I	276_V	0.736	1.00
139_S	170_S	0.734	1.00
85_I	235_G	0.732	1.00
310_K	337_T	0.730	1.00
178_L	187_V	0.729	1.00
321_L	326_I	0.727	1.00
168_Y	301_Q	0.721	1.00
286_Y	343_I	0.718	1.00
280_N	283_L	0.717	1.00
171_E	201_D	0.716	1.00
68_A	72_R	0.716	1.00
107_N	154_Q	0.712	1.00
46_A	271_F	0.711	1.00
191_E	217_I	0.709	1.00
76_H	225_Y	0.706	1.00
75_K	78_N	0.705	1.00
74_S	79_V	0.702	1.00
189_L	205_T	0.702	1.00
288_D	350_E	0.702	1.00
260_A	264_A	0.702	1.00
110_T	122_A	0.699	1.00
99_R	248_A	0.699	1.00
95_Q	125_E	0.697	1.00
256_R	260_A	0.694	1.00
132_I	144_A	0.692	1.00
246_E	249_R	0.691	1.00
206_V	217_I	0.689	1.00
237_A	241_L	0.688	1.00
296_K	310_K	0.688	1.00
97_I	245_I	0.686	1.00
354_A	357_A	0.684	1.00
96_I	245_I	0.683	1.00
54_E	57_Q	0.683	1.00
205_T	215_L	0.679	1.00
285_Q	353_L	0.677	1.00
135_R	139_S	0.677	1.00
39_N	279_N	0.674	1.00
298_Y	308_D	0.673	1.00
79_V	83_S	0.673	1.00
290_A	307_I	0.669	1.00
52_H	55_I	0.669	1.00
108_T	127_A	0.668	1.00
206_V	209_L	0.664	1.00
51_L	257_L	0.664	1.00
240_N	243_R	0.663	1.00
198_T	301_Q	0.660	1.00
145_M	180_R	0.658	1.00
158_I	174_L	0.657	1.00
295_L	307_I	0.656	1.00
289_F	293_H	0.656	1.00
203_P	208_L	0.652	1.00
57_Q	264_A	0.650	1.00
140_H	173_E	0.649	1.00
87_G	235_G	0.649	1.00
325_Y	352_I	0.648	1.00
76_H	194_Y	0.647	1.00
72_R	266_L	0.645	1.00
194_Y	219_R	0.645	1.00
210_S	213_S	0.645	1.00
238_D	241_L	0.644	1.00
118_Y	122_A	0.642	1.00
169_T	173_E	0.641	1.00
140_H	145_M	0.640	1.00
102_L	106_T	0.636	1.00
70_R	81_E	0.635	1.00
110_T	131_E	0.634	1.00
199_A	280_N	0.634	1.00
318_Q	321_L	0.633	1.00
261_A	264_A	0.631	1.00
160_S	191_E	0.629	1.00
89_G	231_R	0.628	1.00
275_C	279_N	0.627	1.00
111_A	162_N	0.627	1.00
43_C	46_A	0.626	1.00
169_T	174_L	0.625	1.00
276_V	280_N	0.625	1.00
77_L	217_I	0.623	1.00
221_F	234_Y	0.623	1.00
307_I	338_S	0.622	1.00
317_F	321_L	0.621	1.00
91_D	115_F	0.621	1.00
147_E	150_D	0.619	1.00
32_V	351_E	0.619	1.00
325_Y	356_L	0.617	1.00
109_V	156_V	0.614	1.00
65_Y	70_R	0.614	1.00
133_A	148_A	0.613	1.00
130_R	153_T	0.613	1.00
213_S	240_N	0.612	1.00
176_A	180_R	0.610	1.00
105_K	128_E	0.609	1.00
34_L	349_N	0.609	1.00
243_R	246_E	0.608	1.00
198_T	283_L	0.607	1.00
43_C	47_A	0.606	1.00
130_R	150_D	0.606	1.00
330_G	333_L	0.601	1.00
95_Q	121_N	0.600	1.00
313_A	317_F	0.599	1.00
196_Y	279_N	0.598	1.00
69_L	262_A	0.595	1.00
136_P	298_Y	0.590	1.00
193_Y	304_F	0.587	1.00
85_I	246_E	0.585	1.00
139_S	167_T	0.585	1.00
40_P	282_G	0.584	1.00
191_E	204_E	0.584	1.00
259_Q	263_I	0.584	1.00
168_Y	197_V	0.581	1.00
145_M	156_V	0.579	1.00
85_I	237_A	0.571	1.00
153_T	156_V	0.570	1.00
48_K	51_L	0.567	1.00
157_W	188_V	0.565	1.00
70_R	246_E	0.564	1.00
191_E	194_Y	0.562	1.00
31_V	326_I	0.561	1.00
136_P	296_K	0.560	1.00
148_A	151_E	0.558	1.00
297_C	305_V	0.557	1.00
43_C	48_K	0.557	1.00
46_A	270_A	0.556	1.00
86_F	232_V	0.555	1.00
136_P	308_D	0.555	1.00
150_D	183_S	0.555	1.00
293_H	353_L	0.553	1.00
285_Q	349_N	0.553	1.00
98_C	127_A	0.552	1.00
45_E	56_Q	0.552	1.00
44_S	47_A	0.552	1.00
181_V	184_R	0.551	1.00
54_E	264_A	0.551	1.00
275_C	278_Q	0.551	1.00
100_A	244_Q	0.550	1.00
187_V	205_T	0.550	1.00
54_E	261_A	0.547	1.00
94_I	121_N	0.545	1.00
351_E	358_E	0.545	1.00
167_T	300_S	0.544	1.00
28_L	31_V	0.543	1.00
33_K	36_S	0.542	1.00
221_F	266_L	0.542	1.00
54_E	260_A	0.542	1.00
313_A	336_P	0.542	1.00
110_T	119_K	0.541	1.00
71_T	74_S	0.541	1.00
292_T	350_E	0.539	1.00
160_S	168_Y	0.539	1.00
98_C	155_V	0.538	1.00
249_R	254_T	0.538	1.00
106_T	152_Q	0.537	1.00
180_R	183_S	0.537	1.00
98_C	121_N	0.535	1.00
202_Y	206_V	0.533	1.00
133_A	141_D	0.530	1.00
103_N	154_Q	0.528	1.00
79_V	84_L	0.527	1.00
225_Y	269_Q	0.527	1.00
203_P	207_P	0.525	1.00
50_A	261_A	0.525	1.00
116_P	332_A	0.522	1.00
207_P	210_S	0.521	1.00
317_F	339_L	0.521	1.00
33_K	38_E	0.520	1.00
88_N	254_T	0.518	1.00
74_S	78_N	0.518	1.00
98_C	125_E	0.517	1.00
178_L	181_V	0.516	1.00
254_T	259_Q	0.516	1.00
254_T	258_G	0.515	1.00
286_Y	352_I	0.515	1.00
132_I	140_H	0.514	1.00
69_L	72_R	0.513	1.00
97_I	101_F	0.512	1.00
204_E	208_L	0.511	1.00
347_E	351_E	0.511	1.00
146_L	149_I	0.510	1.00
93_I	233_G	0.508	1.00
97_I	155_V	0.508	1.00
258_G	261_A	0.508	1.00
161_P	301_Q	0.507	1.00
178_L	182_P	0.507	1.00
199_A	283_L	0.507	1.00
155_V	186_L	0.505	1.00
182_P	210_S	0.505	1.00
131_E	335_F	0.502	1.00
71_T	267_D	0.501	1.00
269_Q	272_I	0.501	1.00
189_L	217_I	0.500	1.00
212_Y	215_L	0.500	1.00
74_S	83_S	0.500	1.00
223_K	231_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ffhA	2	0.9778	100	0.276	Contact Map
3getA	2	0.9944	100	0.285	Contact Map
3ly1A	2	0.9389	100	0.301	Contact Map
4wbtA	2	0.9806	100	0.315	Contact Map
1vp4A	2	0.9917	100	0.315	Contact Map
3piuA	2	0.9528	100	0.317	Contact Map
3dydA	2	0.95	100	0.318	Contact Map
1fg7A	2	0.95	100	0.32	Contact Map
2zc0A	4	0.9917	100	0.321	Contact Map
3ezsA	2	0.9667	100	0.322	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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