GREMLIN Database
HIS8 - Histidinol-phosphate aminotransferase
UniProt: P17731 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (332)
Sequences: 43934 (30432)
Seq/√Len: 1670.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_H56_Q3.2491.00
107_N128_E3.0591.00
87_G93_I3.0051.00
72_R267_D2.8351.00
281_A346_K2.8111.00
285_Q350_E2.7931.00
102_L127_A2.6951.00
280_N284_Q2.6631.00
296_K308_D2.6171.00
171_E175_L2.5391.00
106_T154_Q2.4111.00
237_A242_I2.3631.00
146_L183_S2.3411.00
351_E355_I2.3181.00
107_N130_R2.2231.00
285_Q346_K2.1351.00
95_Q99_R2.1331.00
345_T348_Q2.1091.00
170_S173_E2.1061.00
287_Y291_K2.0721.00
68_A263_I2.0691.00
45_E49_E2.0501.00
289_F353_L2.0171.00
112_A131_E1.9971.00
289_F292_T1.9871.00
71_T81_E1.8901.00
72_R75_K1.8881.00
232_V262_A1.8711.00
319_A323_K1.8451.00
312_P315_E1.7951.00
289_F357_A1.7941.00
175_L179_E1.7891.00
144_A148_A1.7841.00
285_Q289_F1.7701.00
188_V218_L1.7661.00
49_E53_H1.7521.00
139_S173_E1.7481.00
67_A71_T1.7231.00
119_K123_V1.7151.00
146_L176_A1.6981.00
351_E354_A1.6871.00
48_K52_H1.6721.00
83_S239_E1.6591.00
122_A127_A1.6591.00
82_T239_E1.6541.00
144_A147_E1.6511.00
71_T75_K1.6481.00
181_V187_V1.6471.00
141_D144_A1.6361.00
53_H264_A1.6231.00
255_S258_G1.6211.00
74_S81_E1.6171.00
75_K267_D1.6171.00
291_K297_C1.6161.00
192_A220_T1.5971.00
107_N152_Q1.5861.00
288_D292_T1.5811.00
97_I216_M1.5731.00
315_E319_A1.5681.00
119_K131_E1.5631.00
323_K358_E1.5551.00
142_L176_A1.5471.00
72_R263_I1.5461.00
184_R214_N1.5401.00
108_T122_A1.5391.00
289_F354_A1.5341.00
318_Q322_E1.5331.00
346_K350_E1.5321.00
112_A133_A1.5161.00
34_L352_I1.5141.00
284_Q288_D1.5121.00
109_V153_T1.4791.00
176_A179_E1.4661.00
107_N150_D1.4621.00
278_Q346_K1.4621.00
98_C122_A1.4621.00
73_L234_Y1.4601.00
97_I188_V1.4441.00
90_S218_L1.4401.00
235_G245_I1.4391.00
287_Y297_C1.4321.00
49_E52_H1.4251.00
143_D176_A1.4241.00
282_G346_K1.4121.00
79_V236_I1.4091.00
66_S260_A1.4081.00
286_Y305_V1.4071.00
289_F350_E1.4041.00
313_A331_N1.4041.00
173_E176_A1.3971.00
107_N153_T1.3871.00
110_T129_V1.3871.00
287_Y305_V1.3831.00
263_I267_D1.3791.00
278_Q281_A1.3761.00
315_E318_Q1.3721.00
155_V188_V1.3611.00
104_D126_G1.3591.00
273_A277_E1.3551.00
48_K56_Q1.3551.00
327_V339_L1.3551.00
292_T357_A1.3551.00
314_D331_N1.3391.00
221_F262_A1.3351.00
306_L330_G1.3351.00
64_G246_E1.3331.00
135_R173_E1.3291.00
50_A264_A1.3271.00
149_I180_R1.3261.00
50_A53_H1.3171.00
181_V185_V1.3131.00
51_L261_A1.3121.00
319_A322_E1.3051.00
77_L236_I1.3051.00
308_D338_S1.3031.00
286_Y353_L1.3021.00
51_L55_I1.2941.00
29_D324_G1.2851.00
308_D337_T1.2741.00
133_A144_A1.2731.00
244_Q247_P1.2621.00
219_R234_Y1.2601.00
80_S83_S1.2521.00
146_L180_R1.2431.00
142_L180_R1.2401.00
88_N92_E1.2401.00
180_R185_V1.2361.00
146_L150_D1.2321.00
99_R125_E1.2251.00
135_R144_A1.2141.00
179_E183_S1.2121.00
171_E203_P1.2031.00
278_Q282_G1.2031.00
103_N106_T1.2001.00
171_E207_P1.1961.00
205_T208_L1.1841.00
307_I341_I1.1841.00
68_A267_D1.1791.00
109_V132_I1.1771.00
172_G175_L1.1741.00
243_R247_P1.1741.00
172_G176_A1.1701.00
98_C157_W1.1631.00
93_I235_G1.1611.00
213_S238_D1.1601.00
264_A267_D1.1531.00
98_C102_L1.1481.00
283_L343_I1.1451.00
179_E182_P1.1441.00
175_L208_L1.1431.00
68_A260_A1.1411.00
350_E354_A1.1341.00
182_P211_K1.1321.00
182_P212_Y1.1321.00
53_H57_Q1.1301.00
85_I242_I1.1251.00
186_L216_M1.1231.00
264_A268_D1.1191.00
323_K355_I1.1191.00
76_H269_Q1.1181.00
269_Q273_A1.1151.00
67_A81_E1.1131.00
320_L327_V1.1091.00
283_L287_Y1.1091.00
277_E280_N1.1081.00
135_R141_D1.1021.00
156_V185_V1.0961.00
314_D318_Q1.0961.00
260_A263_I1.0871.00
216_M237_A1.0791.00
282_G285_Q1.0781.00
348_Q351_E1.0781.00
70_R74_S1.0781.00
317_F327_V1.0741.00
273_A276_V1.0721.00
64_G70_R1.0631.00
46_A268_D1.0621.00
285_Q288_D1.0611.00
149_I185_V1.0561.00
354_A358_E1.0491.00
92_E249_R1.0471.00
150_D153_T1.0301.00
147_E151_E1.0301.00
171_E208_L1.0281.00
53_H56_Q1.0211.00
277_E281_A1.0141.00
46_A49_E1.0111.00
100_A248_A1.0111.00
73_L86_F1.0071.00
30_K324_G1.0021.00
271_F274_S1.0011.00
102_L108_T1.0001.00
199_A300_S0.9981.00
274_S278_Q0.9971.00
198_T280_N0.9911.00
270_A274_S0.9891.00
30_K351_E0.9841.00
216_M235_G0.9821.00
295_L309_F0.9701.00
288_D291_K0.9691.00
72_R76_H0.9681.00
313_A337_T0.9611.00
69_L86_F0.9601.00
80_S239_E0.9591.00
205_T209_L0.9591.00
73_L84_L0.9591.00
45_E48_K0.9581.00
122_A129_V0.9531.00
182_P213_S0.9441.00
102_L155_V0.9431.00
182_P214_N0.9411.00
108_T155_V0.9391.00
239_E243_R0.9381.00
132_I148_A0.9371.00
186_L214_N0.9361.00
114_T159_C0.9351.00
178_L215_L0.9281.00
175_L211_K0.9271.00
77_L234_Y0.9271.00
68_A71_T0.9251.00
101_F155_V0.9131.00
142_L146_L0.9121.00
186_L241_L0.9081.00
83_S242_I0.9071.00
84_L236_I0.9061.00
74_S84_L0.9041.00
314_D329_S0.9011.00
320_L356_L0.8971.00
293_H357_A0.8941.00
143_D147_E0.8921.00
123_V129_V0.8891.00
313_A329_S0.8891.00
271_F275_C0.8791.00
143_D146_L0.8781.00
41_Y278_Q0.8741.00
49_E56_Q0.8731.00
111_A140_H0.8691.00
118_Y157_W0.8671.00
93_I218_L0.8631.00
101_F186_L0.8621.00
88_N255_S0.8621.00
216_M241_L0.8621.00
242_I246_E0.8611.00
274_S277_E0.8611.00
283_L299_P0.8591.00
309_F339_L0.8581.00
281_A285_Q0.8571.00
96_I249_R0.8561.00
90_S220_T0.8551.00
341_I352_I0.8551.00
109_V148_A0.8541.00
232_V254_T0.8481.00
48_K55_I0.8451.00
120_H123_V0.8411.00
66_S259_Q0.8381.00
317_F329_S0.8381.00
232_V258_G0.8381.00
218_L235_G0.8351.00
111_A132_I0.8291.00
85_I245_I0.8271.00
67_A70_R0.8271.00
76_H195_E0.8251.00
66_S263_I0.8231.00
153_T185_V0.8221.00
74_S80_S0.8221.00
142_L177_F0.8211.00
316_L339_L0.8161.00
28_L324_G0.8161.00
197_V200_E0.8141.00
327_V341_I0.8121.00
347_E350_E0.8061.00
270_A273_A0.8051.00
46_A264_A0.8051.00
284_Q287_Y0.8011.00
142_L173_E0.7991.00
286_Y289_F0.7971.00
50_A54_E0.7971.00
286_Y349_N0.7871.00
112_A334_G0.7851.00
83_S212_Y0.7841.00
91_D117_Q0.7841.00
204_E207_P0.7831.00
58_L260_A0.7801.00
312_P336_P0.7791.00
237_A245_I0.7751.00
224_A272_I0.7741.00
306_L338_S0.7721.00
331_N336_P0.7711.00
90_S192_A0.7671.00
282_G349_N0.7671.00
100_A245_I0.7661.00
109_V145_M0.7641.00
316_L320_L0.7601.00
281_A284_Q0.7591.00
130_R148_A0.7581.00
42_G48_K0.7571.00
30_K348_Q0.7561.00
355_I358_E0.7561.00
69_L73_L0.7511.00
162_N165_T0.7461.00
195_E224_A0.7461.00
325_Y355_I0.7441.00
134_L162_N0.7431.00
197_V202_Y0.7421.00
149_I153_T0.7391.00
92_E96_I0.7381.00
272_I276_V0.7361.00
139_S170_S0.7341.00
85_I235_G0.7321.00
310_K337_T0.7301.00
178_L187_V0.7291.00
321_L326_I0.7271.00
168_Y301_Q0.7211.00
286_Y343_I0.7181.00
280_N283_L0.7171.00
171_E201_D0.7161.00
68_A72_R0.7161.00
107_N154_Q0.7121.00
46_A271_F0.7111.00
191_E217_I0.7091.00
76_H225_Y0.7061.00
75_K78_N0.7051.00
74_S79_V0.7021.00
189_L205_T0.7021.00
288_D350_E0.7021.00
260_A264_A0.7021.00
110_T122_A0.6991.00
99_R248_A0.6991.00
95_Q125_E0.6971.00
256_R260_A0.6941.00
132_I144_A0.6921.00
246_E249_R0.6911.00
206_V217_I0.6891.00
237_A241_L0.6881.00
296_K310_K0.6881.00
97_I245_I0.6861.00
354_A357_A0.6841.00
96_I245_I0.6831.00
54_E57_Q0.6831.00
205_T215_L0.6791.00
285_Q353_L0.6771.00
135_R139_S0.6771.00
39_N279_N0.6741.00
298_Y308_D0.6731.00
79_V83_S0.6731.00
290_A307_I0.6691.00
52_H55_I0.6691.00
108_T127_A0.6681.00
206_V209_L0.6641.00
51_L257_L0.6641.00
240_N243_R0.6631.00
198_T301_Q0.6601.00
145_M180_R0.6581.00
158_I174_L0.6571.00
295_L307_I0.6561.00
289_F293_H0.6561.00
203_P208_L0.6521.00
57_Q264_A0.6501.00
140_H173_E0.6491.00
87_G235_G0.6491.00
325_Y352_I0.6481.00
76_H194_Y0.6471.00
72_R266_L0.6451.00
194_Y219_R0.6451.00
210_S213_S0.6451.00
238_D241_L0.6441.00
118_Y122_A0.6421.00
169_T173_E0.6411.00
140_H145_M0.6401.00
102_L106_T0.6361.00
70_R81_E0.6351.00
110_T131_E0.6341.00
199_A280_N0.6341.00
318_Q321_L0.6331.00
261_A264_A0.6311.00
160_S191_E0.6291.00
89_G231_R0.6281.00
275_C279_N0.6271.00
111_A162_N0.6271.00
43_C46_A0.6261.00
169_T174_L0.6251.00
276_V280_N0.6251.00
77_L217_I0.6231.00
221_F234_Y0.6231.00
307_I338_S0.6221.00
317_F321_L0.6211.00
91_D115_F0.6211.00
147_E150_D0.6191.00
32_V351_E0.6191.00
325_Y356_L0.6171.00
109_V156_V0.6141.00
65_Y70_R0.6141.00
133_A148_A0.6131.00
130_R153_T0.6131.00
213_S240_N0.6121.00
176_A180_R0.6101.00
105_K128_E0.6091.00
34_L349_N0.6091.00
243_R246_E0.6081.00
198_T283_L0.6071.00
43_C47_A0.6061.00
130_R150_D0.6061.00
330_G333_L0.6011.00
95_Q121_N0.6001.00
313_A317_F0.5991.00
196_Y279_N0.5981.00
69_L262_A0.5951.00
136_P298_Y0.5901.00
193_Y304_F0.5871.00
85_I246_E0.5851.00
139_S167_T0.5851.00
40_P282_G0.5841.00
191_E204_E0.5841.00
259_Q263_I0.5841.00
168_Y197_V0.5811.00
145_M156_V0.5791.00
85_I237_A0.5711.00
153_T156_V0.5701.00
48_K51_L0.5671.00
157_W188_V0.5651.00
70_R246_E0.5641.00
191_E194_Y0.5621.00
31_V326_I0.5611.00
136_P296_K0.5601.00
148_A151_E0.5581.00
297_C305_V0.5571.00
43_C48_K0.5571.00
46_A270_A0.5561.00
86_F232_V0.5551.00
136_P308_D0.5551.00
150_D183_S0.5551.00
293_H353_L0.5531.00
285_Q349_N0.5531.00
98_C127_A0.5521.00
45_E56_Q0.5521.00
44_S47_A0.5521.00
181_V184_R0.5511.00
54_E264_A0.5511.00
275_C278_Q0.5511.00
100_A244_Q0.5501.00
187_V205_T0.5501.00
54_E261_A0.5471.00
94_I121_N0.5451.00
351_E358_E0.5451.00
167_T300_S0.5441.00
28_L31_V0.5431.00
33_K36_S0.5421.00
221_F266_L0.5421.00
54_E260_A0.5421.00
313_A336_P0.5421.00
110_T119_K0.5411.00
71_T74_S0.5411.00
292_T350_E0.5391.00
160_S168_Y0.5391.00
98_C155_V0.5381.00
249_R254_T0.5381.00
106_T152_Q0.5371.00
180_R183_S0.5371.00
98_C121_N0.5351.00
202_Y206_V0.5331.00
133_A141_D0.5301.00
103_N154_Q0.5281.00
79_V84_L0.5271.00
225_Y269_Q0.5271.00
203_P207_P0.5251.00
50_A261_A0.5251.00
116_P332_A0.5221.00
207_P210_S0.5211.00
317_F339_L0.5211.00
33_K38_E0.5201.00
88_N254_T0.5181.00
74_S78_N0.5181.00
98_C125_E0.5171.00
178_L181_V0.5161.00
254_T259_Q0.5161.00
254_T258_G0.5151.00
286_Y352_I0.5151.00
132_I140_H0.5141.00
69_L72_R0.5131.00
97_I101_F0.5121.00
204_E208_L0.5111.00
347_E351_E0.5111.00
146_L149_I0.5101.00
93_I233_G0.5081.00
97_I155_V0.5081.00
258_G261_A0.5081.00
161_P301_Q0.5071.00
178_L182_P0.5071.00
199_A283_L0.5071.00
155_V186_L0.5051.00
182_P210_S0.5051.00
131_E335_F0.5021.00
71_T267_D0.5011.00
269_Q272_I0.5011.00
189_L217_I0.5001.00
212_Y215_L0.5001.00
74_S83_S0.5001.00
223_K231_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ffhA 2 0.9778 100 0.276 Contact Map
3getA 2 0.9944 100 0.285 Contact Map
3ly1A 2 0.9389 100 0.301 Contact Map
4wbtA 2 0.9806 100 0.315 Contact Map
1vp4A 2 0.9917 100 0.315 Contact Map
3piuA 2 0.9528 100 0.317 Contact Map
3dydA 2 0.95 100 0.318 Contact Map
1fg7A 2 0.95 100 0.32 Contact Map
2zc0A 4 0.9917 100 0.321 Contact Map
3ezsA 2 0.9667 100 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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