GREMLIN Database
DNAJ - Chaperone protein DnaJ
UniProt: P17631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 375 (349)
Sequences: 5249 (3353)
Seq/√Len: 179.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_S20_E3.8431.00
147_T204_D3.5361.00
18_K59_D3.3941.00
278_Q283_D3.1731.00
130_A315_V3.1341.00
341_K348_E3.1131.00
164_H190_H3.0511.00
154_K200_N2.9731.00
134_E220_T2.9341.00
30_K36_I2.9271.00
160_E199_K2.8901.00
134_E218_N2.8641.00
284_E295_K2.7601.00
154_K203_A2.6201.00
266_D317_N2.5371.00
170_Q185_R2.5261.00
269_Y329_V2.5091.00
127_E258_H2.4861.00
273_P333_V2.4801.00
268_I326_Q2.4751.00
125_S256_R2.4171.00
343_K347_R2.3141.00
138_E214_R2.2731.00
136_T216_K2.2601.00
63_A67_Q2.2521.00
123_T256_R2.2271.00
271_E329_V2.1451.00
163_S190_H2.1441.00
128_D135_T2.1331.00
304_T334_T2.1191.00
4_R48_E2.1111.00
43_D47_K2.0811.00
215_K236_Q2.0521.00
339_T342_Q2.0181.00
341_K344_D1.9841.00
345_I348_E1.9781.00
307_K327_H1.9731.00
271_E331_R1.9531.00
172_N183_V1.9351.00
143_E213_K1.9331.00
37_N42_S1.9241.00
123_T254_H1.9201.00
284_E297_K1.9171.00
302_T330_V1.8981.00
171_L189_H1.8321.00
4_R9_V1.8201.00
40_A43_D1.8181.00
28_L49_V1.8121.00
344_D348_E1.7831.00
286_E293_K1.7571.00
119_Q252_V1.7491.00
275_T278_Q1.7491.00
227_D254_H1.7451.00
276_F280_A1.7421.00
121_T254_H1.7381.00
60_Q64_H1.7301.00
309_R325_D1.7301.00
136_T218_N1.7181.00
147_T154_K1.7051.00
64_H73_P1.7041.00
116_A238_E1.6961.00
164_H189_H1.6911.00
125_S128_D1.6851.00
146_E204_D1.6661.00
60_Q63_A1.6491.00
128_D133_K1.6461.00
291_H323_Q1.6431.00
308_F330_V1.6411.00
4_R8_E1.6301.00
273_P331_R1.6171.00
6_Y55_T1.6171.00
286_E295_K1.5901.00
6_Y51_E1.5891.00
146_E213_K1.5741.00
227_D255_V1.5691.00
28_L31_K1.5521.00
280_A346_I1.5401.00
16_A21_I1.5291.00
341_K352_V1.5261.00
159_P196_K1.5251.00
32_Y49_V1.5231.00
3_K70_H1.5111.00
71_T74_N1.4841.00
225_V229_Q1.4761.00
174_E181_K1.4721.00
38_K41_G1.4701.00
13_S20_E1.4641.00
153_A157_T1.4611.00
348_E351_E1.4541.00
346_I349_F1.4281.00
274_L279_A1.4181.00
64_H68_F1.4141.00
126_F268_I1.4081.00
278_Q350_A1.4011.00
225_V253_F1.3951.00
138_E216_K1.3821.00
130_A290_L1.3771.00
268_I315_V1.3681.00
12_V21_I1.3441.00
59_D62_R1.3371.00
157_T200_N1.3261.00
260_F270_C1.3251.00
172_N185_R1.3241.00
307_K329_V1.3201.00
299_P308_F1.3101.00
146_E211_I1.3051.00
122_M253_F1.2951.00
142_E210_K1.2731.00
5_D8_E1.2681.00
144_T149_K1.2591.00
28_L32_Y1.2591.00
230_Q250_F1.2561.00
164_H171_L1.2521.00
190_H204_D1.2411.00
15_S20_E1.2401.00
3_K8_E1.2401.00
294_V313_K1.2371.00
173_V186_R1.2371.00
264_D267_D1.2141.00
19_D23_K1.2051.00
140_P212_K1.2001.00
229_Q318_V1.1971.00
88_G91_G1.1961.00
226_D266_D1.1911.00
141_R215_K1.1911.00
126_F315_V1.1791.00
70_H73_P1.1741.00
349_F353_S1.1701.00
32_Y45_K1.1661.00
122_M221_I1.1601.00
68_F72_D1.1591.00
269_Y327_H1.1561.00
25_Y50_K1.1501.00
202_C205_C1.1491.00
344_D347_R1.1451.00
276_F334_T1.1421.00
277_A280_A1.1361.00
27_K30_K1.1331.00
91_G97_S1.1281.00
272_M285_V1.1221.00
340_D347_R1.1221.00
280_A334_T1.1141.00
181_K184_N1.1131.00
316_Q323_Q1.1121.00
312_G325_D1.1021.00
296_L308_F1.0931.00
5_D14_K1.0901.00
45_K48_E1.0881.00
267_D327_H1.0881.00
296_L328_I1.0861.00
347_R350_A1.0841.00
163_S197_I1.0831.00
233_L251_V1.0791.00
190_H197_I1.0701.00
233_L236_Q1.0681.00
270_C326_Q1.0681.00
129_A255_V1.0671.00
140_P214_R1.0581.00
64_H72_D1.0561.00
290_L326_Q1.0551.00
145_C148_C1.0501.00
124_L129_A1.0481.00
304_T331_R1.0461.00
161_T196_K1.0441.00
347_R351_E1.0441.00
40_A44_E1.0371.00
121_T252_V1.0331.00
289_T294_V1.0220.99
142_E212_K1.0210.99
161_T166_G1.0210.99
3_K51_E1.0200.99
341_K345_I1.0200.99
131_F315_V1.0180.99
51_E70_H1.0150.99
230_Q252_V1.0070.99
147_T155_P0.9990.99
278_Q285_V0.9980.99
274_L298_I0.9870.99
41_G44_E0.9850.99
260_F288_P0.9840.99
147_T164_H0.9750.99
342_Q349_F0.9740.99
267_D325_D0.9650.99
99_I102_G0.9620.99
129_A226_D0.9580.99
32_Y37_N0.9550.99
114_Q117_D0.9540.99
257_A262_E0.9510.99
93_D97_S0.9470.99
95_I99_I0.9460.99
294_V310_L0.9440.99
126_F129_A0.9440.99
129_A315_V0.9430.99
127_E131_F0.9420.99
9_V48_E0.9390.99
27_K31_K0.9350.99
29_S46_F0.9330.99
232_R250_F0.9300.99
143_E215_K0.9290.99
317_N320_G0.9280.99
11_G24_A0.9250.99
204_D211_I0.9230.99
54_E57_S0.9180.99
130_A323_Q0.9160.99
302_T308_F0.9140.99
50_K54_E0.9120.99
262_E271_E0.9100.99
288_P293_K0.9100.99
64_H71_T0.9090.99
145_C205_C0.9090.99
340_D344_D0.9070.99
12_V15_S0.9070.99
148_C162_C0.9030.99
89_G92_F0.9000.99
354_G357_P0.8970.99
280_A338_L0.8950.99
345_I349_F0.8910.99
145_C202_C0.8830.98
309_R327_H0.8810.98
113_R241_I0.8790.98
311_R325_D0.8740.98
277_A349_F0.8730.98
87_F91_G0.8720.98
221_I253_F0.8700.98
162_C165_C0.8690.98
155_P158_N0.8630.98
58_D61_K0.8630.98
4_R70_H0.8620.98
38_K42_S0.8620.98
317_N322_G0.8610.98
141_R236_Q0.8560.98
276_F346_I0.8550.98
153_A159_P0.8520.98
160_E197_I0.8510.98
151_S155_P0.8500.98
73_P77_F0.8460.98
119_Q230_Q0.8460.98
226_D229_Q0.8410.98
350_A357_P0.8350.98
310_L326_Q0.8320.98
131_F291_H0.8320.98
305_G331_R0.8310.98
93_D102_G0.8290.98
124_L128_D0.8290.98
129_A225_V0.8260.98
300_A343_K0.8250.98
74_N77_F0.8240.98
120_Y137_I0.8240.98
266_D315_V0.8230.98
156_G159_P0.8220.98
270_C288_P0.8210.98
240_G245_P0.8200.97
108_D111_A0.8160.97
160_E163_S0.8120.97
162_C188_C0.8120.97
194_T242_N0.8110.97
46_F50_K0.8110.97
203_A206_G0.8100.97
92_F97_S0.8070.97
277_A346_I0.8030.97
110_N242_N0.8000.97
210_K241_I0.7970.97
163_S166_G0.7960.97
95_I98_S0.7920.97
272_M330_V0.7910.97
92_F95_I0.7910.97
223_A316_Q0.7900.97
348_E352_V0.7900.97
277_A350_A0.7890.97
342_Q346_I0.7890.97
298_I330_V0.7870.97
28_L45_K0.7850.97
162_C167_G0.7840.97
85_G88_G0.7830.97
59_D63_A0.7830.97
90_F94_D0.7830.97
296_L310_L0.7760.97
124_L225_V0.7750.96
106_R109_P0.7740.96
39_E43_D0.7730.96
188_C191_C0.7730.96
217_I236_Q0.7720.96
194_T197_I0.7710.96
219_V251_V0.7700.96
167_G195_G0.7680.96
338_L342_Q0.7680.96
270_C328_I0.7670.96
44_E48_E0.7660.96
109_P112_P0.7650.96
94_D97_S0.7620.96
340_D343_K0.7620.96
342_Q352_V0.7570.96
155_P200_N0.7560.96
222_P225_V0.7540.96
9_V49_V0.7540.96
73_P76_G0.7530.96
53_Y57_S0.7520.96
90_F97_S0.7510.96
174_E182_V0.7500.96
141_R238_E0.7480.96
147_T203_A0.7470.96
154_K157_T0.7450.96
130_A289_T0.7410.95
112_P245_P0.7410.95
126_F130_A0.7320.95
217_I233_L0.7320.95
126_F255_V0.7280.95
264_D269_Y0.7270.95
94_D98_S0.7200.95
153_A198_I0.7170.95
313_K323_Q0.7170.95
64_H67_Q0.7160.95
208_K241_I0.7150.95
72_D76_G0.7140.94
287_V326_Q0.7120.94
12_V62_R0.7120.94
333_V336_T0.7120.94
87_F90_F0.7110.94
145_C150_G0.7100.94
168_S172_N0.7100.94
345_I352_V0.7090.94
126_F258_H0.7070.94
350_A354_G0.7070.94
25_Y54_E0.7070.94
122_M135_T0.7070.94
86_D90_F0.7040.94
122_M251_V0.7040.94
219_V233_L0.7000.94
339_T352_V0.7000.94
111_A242_N0.6960.94
31_K45_K0.6940.94
141_R213_K0.6930.94
6_Y70_H0.6890.93
84_G87_F0.6880.93
148_C205_C0.6860.93
72_D75_Q0.6860.93
124_L255_V0.6830.93
189_H192_E0.6830.93
23_K27_K0.6820.93
293_K313_K0.6810.93
32_Y42_S0.6800.93
151_S156_G0.6780.93
117_D250_F0.6780.93
42_S45_K0.6780.93
131_F323_Q0.6770.93
269_Y307_K0.6760.93
45_K49_V0.6730.93
227_D257_A0.6710.92
283_D298_I0.6680.92
37_N41_G0.6670.92
279_A282_G0.6660.92
126_F131_F0.6650.92
303_Q336_T0.6630.92
303_Q334_T0.6620.92
188_C193_G0.6600.92
71_T75_Q0.6590.92
241_I244_G0.6590.92
231_L253_F0.6580.92
93_D99_I0.6570.92
148_C202_C0.6550.92
3_K48_E0.6520.91
174_E183_V0.6510.91
114_Q245_P0.6490.91
44_E47_K0.6480.91
187_V192_E0.6470.91
188_C195_G0.6450.91
198_I201_K0.6440.91
148_C188_C0.6440.91
29_S36_I0.6440.91
291_H313_K0.6440.91
272_M328_I0.6400.91
88_G93_D0.6390.91
81_G84_G0.6380.90
145_C162_C0.6340.90
162_C195_G0.6280.90
39_E42_S0.6270.90
350_A355_N0.6260.90
144_T239_P0.6250.90
19_D26_R0.6230.89
170_Q187_V0.6220.89
148_C165_C0.6180.89
118_L238_E0.6180.89
151_S159_P0.6180.89
3_K9_V0.6170.89
342_Q353_S0.6150.89
124_L133_K0.6150.89
159_P200_N0.6140.89
150_G207_G0.6140.89
277_A353_S0.6130.89
162_C191_C0.6130.89
18_K57_S0.6120.89
260_F273_P0.6100.88
60_Q67_Q0.6090.88
70_H74_N0.6090.88
91_G100_F0.6090.88
8_E13_S0.6070.88
270_C273_P0.6070.88
302_T306_T0.6050.88
114_Q248_D0.6040.88
202_C207_G0.6040.88
175_Q182_V0.6040.88
191_C195_G0.6020.88
98_S102_G0.6020.88
148_C207_G0.6000.88
165_C195_G0.5980.87
262_E269_Y0.5980.87
107_R110_N0.5960.87
288_P326_Q0.5950.87
338_L346_I0.5930.87
142_E208_K0.5920.87
145_C167_G0.5910.87
146_E149_K0.5910.87
310_L313_K0.5900.87
279_A332_V0.5900.87
141_R239_P0.5900.87
86_D89_G0.5890.87
162_C193_G0.5880.87
200_N203_A0.5860.86
145_C191_C0.5820.86
118_L141_R0.5820.86
210_K239_P0.5820.86
39_E45_K0.5820.86
159_P198_I0.5790.86
141_R246_A0.5790.86
12_V20_E0.5790.86
145_C165_C0.5790.86
8_E14_K0.5790.86
152_G207_G0.5770.85
165_C191_C0.5760.85
282_G301_G0.5760.85
90_F95_I0.5740.85
91_G99_I0.5720.85
289_T315_V0.5720.85
91_G95_I0.5720.85
88_G95_I0.5710.85
37_N40_A0.5710.85
303_Q306_T0.5690.85
235_G248_D0.5680.85
258_H270_C0.5670.84
173_V184_N0.5650.84
51_E54_E0.5650.84
168_S186_R0.5640.84
167_G188_C0.5630.84
142_E238_E0.5620.84
103_G106_R0.5600.84
262_E329_V0.5590.84
120_Y251_V0.5580.84
115_G237_G0.5580.84
165_C188_C0.5570.83
139_I249_L0.5570.83
274_L330_V0.5560.83
261_F290_L0.5550.83
279_A303_Q0.5540.83
6_Y65_Y0.5530.83
64_H74_N0.5530.83
275_T283_D0.5510.83
237_G244_G0.5510.83
117_D232_R0.5500.83
55_T73_P0.5490.83
280_A301_G0.5480.82
240_G243_G0.5480.82
273_P277_A0.5480.82
167_G193_G0.5480.82
124_L221_I0.5470.82
353_S357_P0.5450.82
131_F223_A0.5450.82
13_S17_S0.5410.82
258_H261_F0.5410.82
270_C287_V0.5410.82
26_R30_K0.5390.81
172_N181_K0.5390.81
132_G165_C0.5390.81
8_E70_H0.5380.81
115_G240_G0.5380.81
92_F98_S0.5370.81
285_V298_I0.5360.81
150_G162_C0.5340.81
274_L278_Q0.5330.81
87_F102_G0.5320.81
90_F102_G0.5320.81
290_L315_V0.5300.80
290_L293_K0.5290.80
334_T346_I0.5290.80
93_D100_F0.5280.80
304_T332_V0.5270.80
130_A133_K0.5260.80
139_I215_K0.5260.80
165_C202_C0.5260.80
153_A201_K0.5250.80
149_K155_P0.5250.80
97_S100_F0.5250.80
167_G191_C0.5240.80
69_G72_D0.5240.80
158_N196_K0.5230.79
91_G94_D0.5220.79
43_D46_F0.5220.79
186_R189_H0.5200.79
148_C167_G0.5200.79
128_D131_F0.5200.79
169_G195_G0.5190.79
148_C191_C0.5180.79
41_G45_K0.5180.79
208_K211_I0.5170.79
191_C205_C0.5160.79
303_Q332_V0.5130.78
61_K64_H0.5120.78
117_D247_G0.5120.78
20_E23_K0.5110.78
148_C152_G0.5110.78
162_C169_G0.5110.78
62_R65_Y0.5100.78
145_C207_G0.5090.78
22_K26_R0.5080.78
223_A318_V0.5080.78
117_D248_D0.5070.77
3_K74_N0.5060.77
16_A20_E0.5050.77
232_R248_D0.5050.77
144_T210_K0.5040.77
209_G222_P0.5030.77
90_F93_D0.5030.77
165_C205_C0.5000.76
174_E184_N0.5000.76
92_F96_F0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lz8A 2 0.504 100 0.324 Contact Map
4j80A 2 0.72 100 0.356 Contact Map
1nltA 1 0.5947 100 0.452 Contact Map
2q2gA 3 0.464 100 0.602 Contact Map
3agxA 2 0.464 100 0.603 Contact Map
1c3gA 2 0.448 100 0.617 Contact Map
4j7zA 1 0.2827 100 0.74 Contact Map
1bq0A 1 0.2027 100 0.754 Contact Map
3i38A 5 0.2773 99.9 0.77 Contact Map
2ctrA 1 0.2267 99.9 0.77 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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