DNAJ - BACSU - GREMLIN Contacts

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DNAJ - Chaperone protein DnaJ

UniProt:	P17631	Sequences: MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDEKFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGGGTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPETCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKINVTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTFAQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVTPTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	375 (349)
Sequences:	5249 (3353)
Seq/√Len:	179.5

ECOLI - DNAJ CBPA
BACSU - DNAJ
HALSA - DNAJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_S	20_E	3.843	1.00
147_T	204_D	3.536	1.00
18_K	59_D	3.394	1.00
278_Q	283_D	3.173	1.00
130_A	315_V	3.134	1.00
341_K	348_E	3.113	1.00
164_H	190_H	3.051	1.00
154_K	200_N	2.973	1.00
134_E	220_T	2.934	1.00
30_K	36_I	2.927	1.00
160_E	199_K	2.890	1.00
134_E	218_N	2.864	1.00
284_E	295_K	2.760	1.00
154_K	203_A	2.620	1.00
266_D	317_N	2.537	1.00
170_Q	185_R	2.526	1.00
269_Y	329_V	2.509	1.00
127_E	258_H	2.486	1.00
273_P	333_V	2.480	1.00
268_I	326_Q	2.475	1.00
125_S	256_R	2.417	1.00
343_K	347_R	2.314	1.00
138_E	214_R	2.273	1.00
136_T	216_K	2.260	1.00
63_A	67_Q	2.252	1.00
123_T	256_R	2.227	1.00
271_E	329_V	2.145	1.00
163_S	190_H	2.144	1.00
128_D	135_T	2.133	1.00
304_T	334_T	2.119	1.00
4_R	48_E	2.111	1.00
43_D	47_K	2.081	1.00
215_K	236_Q	2.052	1.00
339_T	342_Q	2.018	1.00
341_K	344_D	1.984	1.00
345_I	348_E	1.978	1.00
307_K	327_H	1.973	1.00
271_E	331_R	1.953	1.00
172_N	183_V	1.935	1.00
143_E	213_K	1.933	1.00
37_N	42_S	1.924	1.00
123_T	254_H	1.920	1.00
284_E	297_K	1.917	1.00
302_T	330_V	1.898	1.00
171_L	189_H	1.832	1.00
4_R	9_V	1.820	1.00
40_A	43_D	1.818	1.00
28_L	49_V	1.812	1.00
344_D	348_E	1.783	1.00
286_E	293_K	1.757	1.00
119_Q	252_V	1.749	1.00
275_T	278_Q	1.749	1.00
227_D	254_H	1.745	1.00
276_F	280_A	1.742	1.00
121_T	254_H	1.738	1.00
60_Q	64_H	1.730	1.00
309_R	325_D	1.730	1.00
136_T	218_N	1.718	1.00
147_T	154_K	1.705	1.00
64_H	73_P	1.704	1.00
116_A	238_E	1.696	1.00
164_H	189_H	1.691	1.00
125_S	128_D	1.685	1.00
146_E	204_D	1.666	1.00
60_Q	63_A	1.649	1.00
128_D	133_K	1.646	1.00
291_H	323_Q	1.643	1.00
308_F	330_V	1.641	1.00
4_R	8_E	1.630	1.00
273_P	331_R	1.617	1.00
6_Y	55_T	1.617	1.00
286_E	295_K	1.590	1.00
6_Y	51_E	1.589	1.00
146_E	213_K	1.574	1.00
227_D	255_V	1.569	1.00
28_L	31_K	1.552	1.00
280_A	346_I	1.540	1.00
16_A	21_I	1.529	1.00
341_K	352_V	1.526	1.00
159_P	196_K	1.525	1.00
32_Y	49_V	1.523	1.00
3_K	70_H	1.511	1.00
71_T	74_N	1.484	1.00
225_V	229_Q	1.476	1.00
174_E	181_K	1.472	1.00
38_K	41_G	1.470	1.00
13_S	20_E	1.464	1.00
153_A	157_T	1.461	1.00
348_E	351_E	1.454	1.00
346_I	349_F	1.428	1.00
274_L	279_A	1.418	1.00
64_H	68_F	1.414	1.00
126_F	268_I	1.408	1.00
278_Q	350_A	1.401	1.00
225_V	253_F	1.395	1.00
138_E	216_K	1.382	1.00
130_A	290_L	1.377	1.00
268_I	315_V	1.368	1.00
12_V	21_I	1.344	1.00
59_D	62_R	1.337	1.00
157_T	200_N	1.326	1.00
260_F	270_C	1.325	1.00
172_N	185_R	1.324	1.00
307_K	329_V	1.320	1.00
299_P	308_F	1.310	1.00
146_E	211_I	1.305	1.00
122_M	253_F	1.295	1.00
142_E	210_K	1.273	1.00
5_D	8_E	1.268	1.00
144_T	149_K	1.259	1.00
28_L	32_Y	1.259	1.00
230_Q	250_F	1.256	1.00
164_H	171_L	1.252	1.00
190_H	204_D	1.241	1.00
15_S	20_E	1.240	1.00
3_K	8_E	1.240	1.00
294_V	313_K	1.237	1.00
173_V	186_R	1.237	1.00
264_D	267_D	1.214	1.00
19_D	23_K	1.205	1.00
140_P	212_K	1.200	1.00
229_Q	318_V	1.197	1.00
88_G	91_G	1.196	1.00
226_D	266_D	1.191	1.00
141_R	215_K	1.191	1.00
126_F	315_V	1.179	1.00
70_H	73_P	1.174	1.00
349_F	353_S	1.170	1.00
32_Y	45_K	1.166	1.00
122_M	221_I	1.160	1.00
68_F	72_D	1.159	1.00
269_Y	327_H	1.156	1.00
25_Y	50_K	1.150	1.00
202_C	205_C	1.149	1.00
344_D	347_R	1.145	1.00
276_F	334_T	1.142	1.00
277_A	280_A	1.136	1.00
27_K	30_K	1.133	1.00
91_G	97_S	1.128	1.00
272_M	285_V	1.122	1.00
340_D	347_R	1.122	1.00
280_A	334_T	1.114	1.00
181_K	184_N	1.113	1.00
316_Q	323_Q	1.112	1.00
312_G	325_D	1.102	1.00
296_L	308_F	1.093	1.00
5_D	14_K	1.090	1.00
45_K	48_E	1.088	1.00
267_D	327_H	1.088	1.00
296_L	328_I	1.086	1.00
347_R	350_A	1.084	1.00
163_S	197_I	1.083	1.00
233_L	251_V	1.079	1.00
190_H	197_I	1.070	1.00
233_L	236_Q	1.068	1.00
270_C	326_Q	1.068	1.00
129_A	255_V	1.067	1.00
140_P	214_R	1.058	1.00
64_H	72_D	1.056	1.00
290_L	326_Q	1.055	1.00
145_C	148_C	1.050	1.00
124_L	129_A	1.048	1.00
304_T	331_R	1.046	1.00
161_T	196_K	1.044	1.00
347_R	351_E	1.044	1.00
40_A	44_E	1.037	1.00
121_T	252_V	1.033	1.00
289_T	294_V	1.022	0.99
142_E	212_K	1.021	0.99
161_T	166_G	1.021	0.99
3_K	51_E	1.020	0.99
341_K	345_I	1.020	0.99
131_F	315_V	1.018	0.99
51_E	70_H	1.015	0.99
230_Q	252_V	1.007	0.99
147_T	155_P	0.999	0.99
278_Q	285_V	0.998	0.99
274_L	298_I	0.987	0.99
41_G	44_E	0.985	0.99
260_F	288_P	0.984	0.99
147_T	164_H	0.975	0.99
342_Q	349_F	0.974	0.99
267_D	325_D	0.965	0.99
99_I	102_G	0.962	0.99
129_A	226_D	0.958	0.99
32_Y	37_N	0.955	0.99
114_Q	117_D	0.954	0.99
257_A	262_E	0.951	0.99
93_D	97_S	0.947	0.99
95_I	99_I	0.946	0.99
294_V	310_L	0.944	0.99
126_F	129_A	0.944	0.99
129_A	315_V	0.943	0.99
127_E	131_F	0.942	0.99
9_V	48_E	0.939	0.99
27_K	31_K	0.935	0.99
29_S	46_F	0.933	0.99
232_R	250_F	0.930	0.99
143_E	215_K	0.929	0.99
317_N	320_G	0.928	0.99
11_G	24_A	0.925	0.99
204_D	211_I	0.923	0.99
54_E	57_S	0.918	0.99
130_A	323_Q	0.916	0.99
302_T	308_F	0.914	0.99
50_K	54_E	0.912	0.99
262_E	271_E	0.910	0.99
288_P	293_K	0.910	0.99
64_H	71_T	0.909	0.99
145_C	205_C	0.909	0.99
340_D	344_D	0.907	0.99
12_V	15_S	0.907	0.99
148_C	162_C	0.903	0.99
89_G	92_F	0.900	0.99
354_G	357_P	0.897	0.99
280_A	338_L	0.895	0.99
345_I	349_F	0.891	0.99
145_C	202_C	0.883	0.98
309_R	327_H	0.881	0.98
113_R	241_I	0.879	0.98
311_R	325_D	0.874	0.98
277_A	349_F	0.873	0.98
87_F	91_G	0.872	0.98
221_I	253_F	0.870	0.98
162_C	165_C	0.869	0.98
155_P	158_N	0.863	0.98
58_D	61_K	0.863	0.98
4_R	70_H	0.862	0.98
38_K	42_S	0.862	0.98
317_N	322_G	0.861	0.98
141_R	236_Q	0.856	0.98
276_F	346_I	0.855	0.98
153_A	159_P	0.852	0.98
160_E	197_I	0.851	0.98
151_S	155_P	0.850	0.98
73_P	77_F	0.846	0.98
119_Q	230_Q	0.846	0.98
226_D	229_Q	0.841	0.98
350_A	357_P	0.835	0.98
310_L	326_Q	0.832	0.98
131_F	291_H	0.832	0.98
305_G	331_R	0.831	0.98
93_D	102_G	0.829	0.98
124_L	128_D	0.829	0.98
129_A	225_V	0.826	0.98
300_A	343_K	0.825	0.98
74_N	77_F	0.824	0.98
120_Y	137_I	0.824	0.98
266_D	315_V	0.823	0.98
156_G	159_P	0.822	0.98
270_C	288_P	0.821	0.98
240_G	245_P	0.820	0.97
108_D	111_A	0.816	0.97
160_E	163_S	0.812	0.97
162_C	188_C	0.812	0.97
194_T	242_N	0.811	0.97
46_F	50_K	0.811	0.97
203_A	206_G	0.810	0.97
92_F	97_S	0.807	0.97
277_A	346_I	0.803	0.97
110_N	242_N	0.800	0.97
210_K	241_I	0.797	0.97
163_S	166_G	0.796	0.97
95_I	98_S	0.792	0.97
272_M	330_V	0.791	0.97
92_F	95_I	0.791	0.97
223_A	316_Q	0.790	0.97
348_E	352_V	0.790	0.97
277_A	350_A	0.789	0.97
342_Q	346_I	0.789	0.97
298_I	330_V	0.787	0.97
28_L	45_K	0.785	0.97
162_C	167_G	0.784	0.97
85_G	88_G	0.783	0.97
59_D	63_A	0.783	0.97
90_F	94_D	0.783	0.97
296_L	310_L	0.776	0.97
124_L	225_V	0.775	0.96
106_R	109_P	0.774	0.96
39_E	43_D	0.773	0.96
188_C	191_C	0.773	0.96
217_I	236_Q	0.772	0.96
194_T	197_I	0.771	0.96
219_V	251_V	0.770	0.96
167_G	195_G	0.768	0.96
338_L	342_Q	0.768	0.96
270_C	328_I	0.767	0.96
44_E	48_E	0.766	0.96
109_P	112_P	0.765	0.96
94_D	97_S	0.762	0.96
340_D	343_K	0.762	0.96
342_Q	352_V	0.757	0.96
155_P	200_N	0.756	0.96
222_P	225_V	0.754	0.96
9_V	49_V	0.754	0.96
73_P	76_G	0.753	0.96
53_Y	57_S	0.752	0.96
90_F	97_S	0.751	0.96
174_E	182_V	0.750	0.96
141_R	238_E	0.748	0.96
147_T	203_A	0.747	0.96
154_K	157_T	0.745	0.96
130_A	289_T	0.741	0.95
112_P	245_P	0.741	0.95
126_F	130_A	0.732	0.95
217_I	233_L	0.732	0.95
126_F	255_V	0.728	0.95
264_D	269_Y	0.727	0.95
94_D	98_S	0.720	0.95
153_A	198_I	0.717	0.95
313_K	323_Q	0.717	0.95
64_H	67_Q	0.716	0.95
208_K	241_I	0.715	0.95
72_D	76_G	0.714	0.94
287_V	326_Q	0.712	0.94
12_V	62_R	0.712	0.94
333_V	336_T	0.712	0.94
87_F	90_F	0.711	0.94
145_C	150_G	0.710	0.94
168_S	172_N	0.710	0.94
345_I	352_V	0.709	0.94
126_F	258_H	0.707	0.94
350_A	354_G	0.707	0.94
25_Y	54_E	0.707	0.94
122_M	135_T	0.707	0.94
86_D	90_F	0.704	0.94
122_M	251_V	0.704	0.94
219_V	233_L	0.700	0.94
339_T	352_V	0.700	0.94
111_A	242_N	0.696	0.94
31_K	45_K	0.694	0.94
141_R	213_K	0.693	0.94
6_Y	70_H	0.689	0.93
84_G	87_F	0.688	0.93
148_C	205_C	0.686	0.93
72_D	75_Q	0.686	0.93
124_L	255_V	0.683	0.93
189_H	192_E	0.683	0.93
23_K	27_K	0.682	0.93
293_K	313_K	0.681	0.93
32_Y	42_S	0.680	0.93
151_S	156_G	0.678	0.93
117_D	250_F	0.678	0.93
42_S	45_K	0.678	0.93
131_F	323_Q	0.677	0.93
269_Y	307_K	0.676	0.93
45_K	49_V	0.673	0.93
227_D	257_A	0.671	0.92
283_D	298_I	0.668	0.92
37_N	41_G	0.667	0.92
279_A	282_G	0.666	0.92
126_F	131_F	0.665	0.92
303_Q	336_T	0.663	0.92
303_Q	334_T	0.662	0.92
188_C	193_G	0.660	0.92
71_T	75_Q	0.659	0.92
241_I	244_G	0.659	0.92
231_L	253_F	0.658	0.92
93_D	99_I	0.657	0.92
148_C	202_C	0.655	0.92
3_K	48_E	0.652	0.91
174_E	183_V	0.651	0.91
114_Q	245_P	0.649	0.91
44_E	47_K	0.648	0.91
187_V	192_E	0.647	0.91
188_C	195_G	0.645	0.91
198_I	201_K	0.644	0.91
148_C	188_C	0.644	0.91
29_S	36_I	0.644	0.91
291_H	313_K	0.644	0.91
272_M	328_I	0.640	0.91
88_G	93_D	0.639	0.91
81_G	84_G	0.638	0.90
145_C	162_C	0.634	0.90
162_C	195_G	0.628	0.90
39_E	42_S	0.627	0.90
350_A	355_N	0.626	0.90
144_T	239_P	0.625	0.90
19_D	26_R	0.623	0.89
170_Q	187_V	0.622	0.89
148_C	165_C	0.618	0.89
118_L	238_E	0.618	0.89
151_S	159_P	0.618	0.89
3_K	9_V	0.617	0.89
342_Q	353_S	0.615	0.89
124_L	133_K	0.615	0.89
159_P	200_N	0.614	0.89
150_G	207_G	0.614	0.89
277_A	353_S	0.613	0.89
162_C	191_C	0.613	0.89
18_K	57_S	0.612	0.89
260_F	273_P	0.610	0.88
60_Q	67_Q	0.609	0.88
70_H	74_N	0.609	0.88
91_G	100_F	0.609	0.88
8_E	13_S	0.607	0.88
270_C	273_P	0.607	0.88
302_T	306_T	0.605	0.88
114_Q	248_D	0.604	0.88
202_C	207_G	0.604	0.88
175_Q	182_V	0.604	0.88
191_C	195_G	0.602	0.88
98_S	102_G	0.602	0.88
148_C	207_G	0.600	0.88
165_C	195_G	0.598	0.87
262_E	269_Y	0.598	0.87
107_R	110_N	0.596	0.87
288_P	326_Q	0.595	0.87
338_L	346_I	0.593	0.87
142_E	208_K	0.592	0.87
145_C	167_G	0.591	0.87
146_E	149_K	0.591	0.87
310_L	313_K	0.590	0.87
279_A	332_V	0.590	0.87
141_R	239_P	0.590	0.87
86_D	89_G	0.589	0.87
162_C	193_G	0.588	0.87
200_N	203_A	0.586	0.86
145_C	191_C	0.582	0.86
118_L	141_R	0.582	0.86
210_K	239_P	0.582	0.86
39_E	45_K	0.582	0.86
159_P	198_I	0.579	0.86
141_R	246_A	0.579	0.86
12_V	20_E	0.579	0.86
145_C	165_C	0.579	0.86
8_E	14_K	0.579	0.86
152_G	207_G	0.577	0.85
165_C	191_C	0.576	0.85
282_G	301_G	0.576	0.85
90_F	95_I	0.574	0.85
91_G	99_I	0.572	0.85
289_T	315_V	0.572	0.85
91_G	95_I	0.572	0.85
88_G	95_I	0.571	0.85
37_N	40_A	0.571	0.85
303_Q	306_T	0.569	0.85
235_G	248_D	0.568	0.85
258_H	270_C	0.567	0.84
173_V	184_N	0.565	0.84
51_E	54_E	0.565	0.84
168_S	186_R	0.564	0.84
167_G	188_C	0.563	0.84
142_E	238_E	0.562	0.84
103_G	106_R	0.560	0.84
262_E	329_V	0.559	0.84
120_Y	251_V	0.558	0.84
115_G	237_G	0.558	0.84
165_C	188_C	0.557	0.83
139_I	249_L	0.557	0.83
274_L	330_V	0.556	0.83
261_F	290_L	0.555	0.83
279_A	303_Q	0.554	0.83
6_Y	65_Y	0.553	0.83
64_H	74_N	0.553	0.83
275_T	283_D	0.551	0.83
237_G	244_G	0.551	0.83
117_D	232_R	0.550	0.83
55_T	73_P	0.549	0.83
280_A	301_G	0.548	0.82
240_G	243_G	0.548	0.82
273_P	277_A	0.548	0.82
167_G	193_G	0.548	0.82
124_L	221_I	0.547	0.82
353_S	357_P	0.545	0.82
131_F	223_A	0.545	0.82
13_S	17_S	0.541	0.82
258_H	261_F	0.541	0.82
270_C	287_V	0.541	0.82
26_R	30_K	0.539	0.81
172_N	181_K	0.539	0.81
132_G	165_C	0.539	0.81
8_E	70_H	0.538	0.81
115_G	240_G	0.538	0.81
92_F	98_S	0.537	0.81
285_V	298_I	0.536	0.81
150_G	162_C	0.534	0.81
274_L	278_Q	0.533	0.81
87_F	102_G	0.532	0.81
90_F	102_G	0.532	0.81
290_L	315_V	0.530	0.80
290_L	293_K	0.529	0.80
334_T	346_I	0.529	0.80
93_D	100_F	0.528	0.80
304_T	332_V	0.527	0.80
130_A	133_K	0.526	0.80
139_I	215_K	0.526	0.80
165_C	202_C	0.526	0.80
153_A	201_K	0.525	0.80
149_K	155_P	0.525	0.80
97_S	100_F	0.525	0.80
167_G	191_C	0.524	0.80
69_G	72_D	0.524	0.80
158_N	196_K	0.523	0.79
91_G	94_D	0.522	0.79
43_D	46_F	0.522	0.79
186_R	189_H	0.520	0.79
148_C	167_G	0.520	0.79
128_D	131_F	0.520	0.79
169_G	195_G	0.519	0.79
148_C	191_C	0.518	0.79
41_G	45_K	0.518	0.79
208_K	211_I	0.517	0.79
191_C	205_C	0.516	0.79
303_Q	332_V	0.513	0.78
61_K	64_H	0.512	0.78
117_D	247_G	0.512	0.78
20_E	23_K	0.511	0.78
148_C	152_G	0.511	0.78
162_C	169_G	0.511	0.78
62_R	65_Y	0.510	0.78
145_C	207_G	0.509	0.78
22_K	26_R	0.508	0.78
223_A	318_V	0.508	0.78
117_D	248_D	0.507	0.77
3_K	74_N	0.506	0.77
16_A	20_E	0.505	0.77
232_R	248_D	0.505	0.77
144_T	210_K	0.504	0.77
209_G	222_P	0.503	0.77
90_F	93_D	0.503	0.77
165_C	205_C	0.500	0.76
174_E	184_N	0.500	0.76
92_F	96_F	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lz8A	2	0.504	100	0.324	Contact Map
4j80A	2	0.72	100	0.356	Contact Map
1nltA	1	0.5947	100	0.452	Contact Map
2q2gA	3	0.464	100	0.602	Contact Map
3agxA	2	0.464	100	0.603	Contact Map
1c3gA	2	0.448	100	0.617	Contact Map
4j7zA	1	0.2827	100	0.74	Contact Map
1bq0A	1	0.2027	100	0.754	Contact Map
3i38A	5	0.2773	99.9	0.77	Contact Map
2ctrA	1	0.2267	99.9	0.77	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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