GREMLIN Database
RIBT - Protein RibT
UniProt: P17622 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (116)
Sequences: 266 (206)
Seq/√Len: 19.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D39_D3.8091.00
101_P109_F3.2791.00
23_E32_T3.0360.99
73_V81_G2.5770.97
10_E34_K2.4430.96
56_A66_V2.3890.96
64_S97_Q2.2390.94
44_L58_G2.2140.94
57_I86_M2.1610.93
73_V82_I2.1580.93
3_I53_I2.0730.91
59_V90_L2.0610.91
13_A44_L1.9540.89
71_I86_M1.9260.88
4_R7_K1.8870.87
66_V94_F1.8600.86
48_K51_E1.7600.83
31_Q93_L1.7150.81
61_K101_P1.6800.80
64_S96_T1.6800.80
21_P24_K1.6740.79
42_R69_R1.5730.75
32_T112_C1.5440.73
36_Y58_G1.5140.72
99_L110_E1.5050.71
14_M24_K1.5030.71
102_N105_T1.5010.71
5_Y19_F1.4960.71
42_R47_W1.4440.68
87_M103_E1.3870.65
49_E85_Q1.3860.65
83_G108_F1.3660.64
64_S90_L1.3030.60
73_V86_M1.2910.59
58_G111_R1.2880.59
19_F31_Q1.2770.58
57_I68_I1.2680.58
22_N79_H1.2670.58
54_V67_E1.2570.57
80_Q99_L1.2340.56
35_D42_R1.2160.55
53_I74_N1.2040.54
9_F89_A1.1920.53
86_M108_F1.1910.53
50_D56_A1.1810.52
23_E67_E1.1810.52
7_K10_E1.1770.52
81_G86_M1.1530.51
36_Y44_L1.1450.50
60_E88_D1.1300.49
101_P104_L1.1260.49
90_L106_Q1.1090.48
60_E101_P1.1020.47
25_D57_I1.0750.46
60_E64_S1.0510.44
76_S82_I1.0390.43
85_Q110_E1.0350.43
8_S32_T1.0310.43
44_L71_I1.0130.42
19_F55_G1.0120.42
25_D37_E0.9930.41
33_I43_Q0.9920.41
7_K99_L0.9920.41
66_V99_L0.9670.39
29_L44_L0.9590.39
55_G68_I0.9490.38
92_H105_T0.9460.38
82_I86_M0.9370.37
54_V61_K0.9330.37
16_L58_G0.9320.37
104_L114_G0.9270.37
60_E102_N0.9050.35
38_T89_A0.8990.35
66_V95_K0.8890.34
52_D70_H0.8760.34
33_I56_A0.8760.34
87_M112_C0.8750.34
77_H80_Q0.8690.33
21_P26_L0.8640.33
44_L52_D0.8540.32
71_I77_H0.8490.32
31_Q105_T0.8440.32
106_Q113_Q0.8420.32
49_E68_I0.8360.31
31_Q34_K0.8350.31
12_I18_S0.8130.30
32_T73_V0.8110.30
5_Y98_V0.8100.30
20_M48_K0.8050.30
24_K44_L0.8030.30
20_M23_E0.8020.30
57_I93_L0.7980.29
40_T92_H0.7980.29
56_A95_K0.7970.29
55_G86_M0.7870.29
22_N106_Q0.7860.29
41_D92_H0.7710.28
5_Y87_M0.7670.28
49_E54_V0.7450.27
70_H78_R0.7400.26
64_S107_S0.7310.26
33_I67_E0.7240.26
19_F77_H0.7210.26
38_T92_H0.7160.25
19_F111_R0.7160.25
61_K94_F0.7120.25
56_A88_D0.7030.25
105_T109_F0.6930.24
28_Q93_L0.6920.24
21_P78_R0.6780.24
71_I111_R0.6770.23
39_D72_S0.6750.23
65_E107_S0.6700.23
105_T112_C0.6670.23
6_K52_D0.6650.23
69_R100_V0.6610.23
62_K68_I0.6590.23
71_I105_T0.6530.22
59_V66_V0.6480.22
1_M11_K0.6480.22
4_R36_Y0.6470.22
13_A70_H0.6470.22
9_F56_A0.6450.22
44_L70_H0.6440.22
84_K112_C0.6370.22
9_F53_I0.6330.22
27_K84_K0.6300.21
68_I115_Q0.6300.21
85_Q92_H0.6300.21
42_R60_E0.6250.21
14_M74_N0.6230.21
7_K43_Q0.6100.21
85_Q88_D0.6060.20
68_I109_F0.5960.20
45_F59_V0.5920.20
14_M68_I0.5900.20
69_R116_Q0.5870.20
45_F85_Q0.5870.20
102_N112_C0.5860.20
25_D60_E0.5860.20
41_D107_S0.5730.19
5_Y13_A0.5730.19
22_N67_E0.5710.19
61_K97_Q0.5650.19
10_E28_Q0.5620.19
84_K101_P0.5600.19
34_K96_T0.5550.18
5_Y80_Q0.5520.18
24_K52_D0.5490.18
70_H105_T0.5490.18
49_E69_R0.5450.18
4_R10_E0.5420.18
18_S95_K0.5420.18
1_M47_W0.5390.18
48_K81_G0.5370.18
4_R48_K0.5350.18
7_K72_S0.5340.18
9_F55_G0.5340.18
98_V113_Q0.5320.18
23_E81_G0.5290.17
38_T63_D0.5280.17
24_K90_L0.5260.17
20_M108_F0.5240.17
42_R112_C0.5180.17
13_A37_E0.5170.17
27_K32_T0.5160.17
20_M73_V0.5150.17
39_D63_D0.5100.17
88_D113_Q0.5080.17
39_D66_V0.5030.16
10_E31_Q0.5020.16
55_G71_I0.5020.16
50_D86_M0.5020.16
6_K44_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zpaA 1 0.9597 97.1 0.856 Contact Map
3s6fA 2 0.9677 97 0.858 Contact Map
2pr1A 3 0.9516 97 0.859 Contact Map
3mgdA 2 0.9919 96.9 0.86 Contact Map
2ganA 2 1 96.9 0.86 Contact Map
4cryB 1 0.9274 96.9 0.86 Contact Map
3ey5A 1 0.9435 96.8 0.861 Contact Map
1r57A 1 0.75 96.8 0.861 Contact Map
2fl4A 2 1 96.8 0.862 Contact Map
1s3zA 2 0.9919 96.6 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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