GREMLIN Database
RIBBA - Riboflavin biosynthesis protein RibBA
UniProt: P17620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (370)
Sequences: 2618 (1410)
Seq/√Len: 73.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_Y341_D4.8201.00
11_A16_E4.7231.00
48_A55_I4.0711.00
63_I66_R3.9551.00
165_N175_E3.5661.00
209_D220_K3.4931.00
346_N366_S3.0891.00
206_R222_Y2.9291.00
280_I288_L2.8641.00
206_R341_D2.8531.00
277_L288_L2.7491.00
48_A164_M2.7321.00
238_M281_A2.7081.00
7_E186_K2.6891.00
36_A157_A2.6601.00
11_A186_K2.6571.00
139_A194_I2.6311.00
145_A158_G2.5921.00
314_Y322_A2.5901.00
255_E292_R2.5161.00
32_F179_I2.4611.00
57_T109_L2.4511.00
3_H7_E2.4401.00
114_S119_F2.4241.00
65_D129_I2.4181.00
37_E155_P2.4091.00
61_E132_K2.3641.00
165_N169_T2.3501.00
34_A43_V2.3471.00
112_S155_P2.3341.00
10_D14_K2.3331.00
226_N229_D2.3311.00
8_A188_I2.3041.00
104_F108_A2.3001.00
59_L64_A2.2691.00
179_I183_H2.2591.00
88_I109_L2.2071.00
344_V347_M2.1681.00
348_K369_E2.1261.00
211_T218_T2.1221.00
61_E65_D2.0781.00
287_V344_V2.0641.00
64_A129_I2.0481.00
209_D222_Y2.0291.00
35_L154_S2.0021.00
4_P7_E1.9841.00
38_H154_S1.9811.00
205_E227_E1.9761.00
205_E225_T1.9061.00
32_F51_G1.9061.00
61_E129_I1.8811.00
222_Y237_V1.8761.00
54_L97_I1.8311.00
348_K371_V1.8241.00
44_I106_V1.7901.00
106_V125_I1.7871.00
177_I187_M1.7561.00
211_T220_K1.7491.00
177_I181_K1.7481.00
64_A69_L1.7461.00
62_E132_K1.7191.00
278_N282_A1.6601.00
275_A278_N1.6461.00
49_T52_R1.6431.00
244_G285_R1.6311.00
347_M365_L1.6220.99
210_I221_V1.6210.99
33_V160_I1.6110.99
21_V189_T1.6080.99
104_F107_Q1.6000.99
223_G301_I1.5820.99
247_P346_N1.5810.99
108_A119_F1.5740.99
215_D274_H1.5590.99
210_I304_L1.5520.99
302_N325_F1.5240.99
44_I55_I1.5230.99
308_K312_Q1.5220.99
71_P129_I1.5160.99
247_P368_S1.5140.99
12_L35_L1.5080.99
87_S126_F1.5040.99
46_F183_H1.4880.99
178_E181_K1.4670.99
283_E348_K1.4620.99
241_V248_V1.4560.99
90_H108_A1.4550.99
57_T88_I1.4510.99
19_I180_A1.4480.99
40_T43_V1.4470.99
49_T166_E1.4460.99
10_D13_K1.4450.99
20_V188_I1.4300.99
246_E285_R1.4070.99
108_A111_D1.3950.98
321_E327_P1.3950.98
245_E285_R1.3860.98
206_R224_Y1.3770.98
173_V187_M1.3760.98
148_L188_I1.3540.98
20_V144_A1.3470.98
44_I159_V1.3470.98
60_S156_G1.3440.98
18_I148_L1.3250.98
163_I171_A1.3120.98
5_I193_L1.3100.98
55_I164_M1.3050.98
54_L126_F1.3050.98
5_I188_I1.2830.97
175_E178_E1.2810.97
12_L18_I1.2790.97
17_V34_A1.2680.97
206_R209_D1.2650.97
145_A160_I1.2610.97
333_G362_G1.2560.97
21_V187_M1.2440.97
17_V32_F1.2430.97
21_V173_V1.2410.97
110_L157_A1.2320.97
41_P103_S1.2200.96
289_L338_I1.2190.96
237_V287_V1.2180.96
236_F288_L1.2040.96
274_H281_A1.2030.96
59_L157_A1.2020.96
19_I185_L1.1970.96
221_V234_V1.1950.96
131_K137_K1.1890.96
208_V304_L1.1890.96
257_L262_F1.1820.96
103_S107_Q1.1710.95
49_T182_K1.1700.95
207_E225_T1.1670.95
216_F278_N1.1530.95
279_Q350_L1.1410.95
329_L357_I1.1400.95
248_V285_R1.1320.94
111_D114_S1.1270.94
9_L12_L1.1270.94
55_I161_C1.1260.94
78_D120_Q1.1220.94
8_A20_V1.1160.94
136_L197_R1.1150.94
361_E366_S1.1150.94
249_L371_V1.1130.94
90_H93_T1.1130.94
9_L151_A1.1130.94
32_F163_I1.1120.94
63_I155_P1.1090.94
45_N52_R1.1020.94
94_K101_E1.1010.94
233_H292_R1.0990.94
39_A44_I1.0900.93
355_R359_G1.0890.93
3_H181_K1.0820.93
208_V308_K1.0670.93
247_P369_E1.0650.92
241_V244_G1.0630.92
58_P146_V1.0560.92
147_D197_R1.0560.92
279_Q283_E1.0550.92
249_L283_E1.0490.92
91_R120_Q1.0460.92
279_Q371_V1.0440.92
335_G362_G1.0440.92
11_A14_K1.0420.92
79_S120_Q1.0390.91
165_N171_A1.0350.91
180_A185_L1.0350.91
273_L288_L1.0310.91
214_T219_F1.0300.91
50_H182_K1.0270.91
335_G365_L1.0250.91
16_E186_K1.0250.91
39_A103_S1.0220.91
346_N368_S1.0160.91
92_E104_F1.0150.91
12_L149_A1.0080.90
213_P218_T1.0070.90
149_A157_A1.0010.90
165_N182_K0.9760.89
17_V43_V0.9720.89
197_R201_T0.9710.88
33_V141_H0.9680.88
242_P245_E0.9660.88
93_T101_E0.9660.88
108_A114_S0.9650.88
60_S63_I0.9640.88
32_F183_H0.9640.88
173_V189_T0.9630.88
60_S64_A0.9630.88
298_I320_N0.9600.88
225_T232_E0.9580.88
244_G248_V0.9560.88
19_I163_I0.9560.88
45_N51_G0.9510.87
58_P160_I0.9500.87
215_D271_P0.9470.87
48_A51_G0.9470.87
318_E321_E0.9460.87
58_P145_A0.9430.87
357_I367_I0.9400.87
151_A193_L0.9390.87
235_A287_V0.9390.87
89_D119_F0.9380.87
41_P100_Q0.9340.86
139_A333_G0.9320.86
48_A54_L0.9320.86
30_G176_L0.9310.86
77_T120_Q0.9310.86
39_A43_V0.9220.86
26_R31_D0.9210.86
34_A39_A0.9210.86
308_K311_E0.9180.85
78_D83_A0.9170.85
133_G137_K0.9120.85
335_G347_M0.9080.85
89_D93_T0.9080.85
215_D265_H0.9070.85
66_R114_S0.9060.85
32_F185_L0.9040.85
245_E346_N0.9010.84
235_A342_L0.8970.84
256_C269_C0.8950.84
241_V285_R0.8940.84
57_T106_V0.8940.84
106_V159_V0.8890.84
44_I47_M0.8870.83
223_G234_V0.8850.83
279_Q282_A0.8780.83
163_I176_L0.8770.83
71_P83_A0.8740.83
61_E64_A0.8720.82
359_G362_G0.8700.82
332_Y357_I0.8700.82
115_V118_D0.8680.82
302_N305_K0.8680.82
52_R164_M0.8680.82
93_T119_F0.8660.82
339_L344_V0.8640.82
325_F329_L0.8620.82
59_L109_L0.8610.82
68_D121_R0.8610.82
190_I193_L0.8590.81
37_E154_S0.8570.81
256_C267_C0.8560.81
110_L155_P0.8550.81
151_A196_Y0.8540.81
139_A335_G0.8520.81
233_H338_I0.8490.81
246_E346_N0.8460.80
240_D244_G0.8420.80
54_L87_S0.8380.80
236_F277_L0.8380.80
203_L334_I0.8380.80
3_H186_K0.8370.80
259_G269_C0.8370.80
141_H144_A0.8360.80
203_L363_Y0.8320.79
12_L34_A0.8320.79
33_V145_A0.8270.79
249_L348_K0.8240.79
57_T110_L0.8220.79
130_A146_V0.8190.78
100_Q169_T0.8180.78
3_H189_T0.8180.78
173_V177_I0.8130.78
141_H190_I0.8060.77
90_H119_F0.8060.77
329_L355_R0.8060.77
347_M362_G0.8030.77
337_Q363_Y0.8030.77
256_C259_G0.8000.77
181_K184_Q0.7980.76
139_A362_G0.7950.76
89_D121_R0.7940.76
80_H120_Q0.7930.76
27_E31_D0.7930.76
215_D263_G0.7900.76
340_R345_R0.7880.76
309_L320_N0.7810.75
203_L337_Q0.7810.75
252_V291_L0.7790.75
250_V347_M0.7770.75
55_I126_F0.7730.74
20_V158_G0.7710.74
358_A361_E0.7690.74
93_T120_Q0.7670.74
51_G179_I0.7670.74
54_L161_C0.7640.73
84_F126_F0.7640.73
264_S267_C0.7610.73
68_D117_S0.7590.73
66_R155_P0.7560.73
80_H141_H0.7560.73
216_F274_H0.7550.72
333_G337_Q0.7540.72
90_H101_E0.7520.72
77_T121_R0.7510.72
46_F179_I0.7460.72
338_I350_L0.7440.71
222_Y235_A0.7410.71
180_A187_M0.7400.71
262_F273_L0.7400.71
136_L147_D0.7400.71
194_I197_R0.7390.71
262_F290_Y0.7390.71
78_D89_D0.7330.70
171_A176_L0.7330.70
132_K137_K0.7300.70
57_T125_I0.7290.70
249_L279_Q0.7280.70
9_L152_C0.7260.69
32_F46_F0.7260.69
257_L261_V0.7250.69
31_D162_E0.7230.69
332_Y336_A0.7210.69
329_L332_Y0.7160.68
50_H183_H0.7140.68
333_G359_G0.7100.68
223_G232_E0.7070.67
88_I119_F0.7070.67
296_R299_G0.7060.67
214_T217_G0.7050.67
31_D82_T0.7050.67
78_D81_H0.7030.67
259_G290_Y0.6990.67
221_V304_L0.6980.66
178_E182_K0.6960.66
137_K331_N0.6950.66
195_Q199_N0.6950.66
26_R29_E0.6950.66
248_V287_V0.6900.66
97_I161_C0.6880.65
52_R97_I0.6860.65
144_A193_L0.6840.65
20_V33_V0.6840.65
64_A71_P0.6830.65
7_E11_A0.6820.65
256_C303_K0.6820.65
93_T108_A0.6810.65
5_I11_A0.6800.64
114_S118_D0.6760.64
19_I179_I0.6750.64
89_D109_L0.6680.63
72_M126_F0.6680.63
303_K307_Y0.6670.63
35_L38_H0.6650.63
240_D285_R0.6620.62
304_L308_K0.6590.62
258_T272_Q0.6580.62
51_G54_L0.6570.62
57_T89_D0.6570.62
350_L373_L0.6550.61
259_G267_C0.6530.61
62_E66_R0.6530.61
27_E162_E0.6520.61
275_A279_Q0.6510.61
192_D195_Q0.6510.61
51_G164_M0.6510.61
212_L236_F0.6500.61
248_V345_R0.6500.61
242_P247_P0.6500.61
294_E298_I0.6480.61
26_R162_E0.6470.61
258_T264_S0.6460.60
244_G247_P0.6430.60
316_T319_A0.6410.60
250_V287_V0.6410.60
44_I48_A0.6390.60
219_F277_L0.6380.59
26_R82_T0.6380.59
298_I309_L0.6360.59
328_D332_Y0.6350.59
17_V179_I0.6350.59
101_E104_F0.6340.59
359_G363_Y0.6340.59
191_K195_Q0.6340.59
326_L329_L0.6320.59
225_T301_I0.6310.59
303_K353_N0.6290.58
264_S307_Y0.6280.58
141_H145_A0.6260.58
144_A188_I0.6260.58
295_G298_I0.6250.58
244_G346_N0.6230.58
61_E131_K0.6220.58
266_R307_Y0.6220.58
90_H104_F0.6220.58
167_D172_R0.6210.57
299_G303_K0.6210.57
272_Q307_Y0.6190.57
17_V185_L0.6190.57
247_P285_R0.6180.57
59_L146_V0.6170.57
213_P264_S0.6160.57
27_E82_T0.6160.57
254_S272_Q0.6160.57
12_L158_G0.6140.57
59_L63_I0.6140.57
73_V121_R0.6120.56
238_M284_G0.6110.56
3_H177_I0.6110.56
70_H129_I0.6100.56
202_T341_D0.6090.56
340_R362_G0.6080.56
82_T162_E0.6080.56
126_F168_G0.6060.56
357_I370_R0.6050.55
12_L33_V0.6040.55
258_T269_C0.6020.55
43_V103_S0.6010.55
83_A131_K0.6000.55
266_R360_L0.5990.55
51_G161_C0.5990.55
223_G304_L0.5960.54
44_I54_L0.5960.54
266_R311_E0.5960.54
242_P285_R0.5950.54
31_D142_T0.5920.54
272_Q353_N0.5920.54
60_S132_K0.5890.54
201_T337_Q0.5890.54
94_K172_R0.5880.53
222_Y342_L0.5880.53
261_V311_E0.5870.53
125_I174_P0.5860.53
65_D68_D0.5860.53
83_A160_I0.5800.52
239_G287_V0.5770.52
232_E301_I0.5770.52
310_Q313_G0.5770.52
296_R353_N0.5750.52
272_Q296_R0.5740.52
29_E141_H0.5740.52
306_A324_G0.5720.51
90_H120_Q0.5710.51
93_T104_F0.5690.51
101_E108_A0.5690.51
50_H166_E0.5690.51
76_N82_T0.5670.51
136_L198_Y0.5650.51
213_P266_R0.5650.51
280_I286_G0.5630.50
69_L85_T0.5630.50
242_P246_E0.5630.50
320_N323_L0.5630.50
29_E142_T0.5630.50
245_E344_V0.5630.50
233_H252_V0.5610.50
88_I110_L0.5600.50
269_C290_Y0.5590.50
307_Y324_G0.5580.50
256_C264_S0.5580.50
264_S269_C0.5570.50
26_R142_T0.5560.49
203_L227_E0.5550.49
60_S66_R0.5550.49
149_A154_S0.5550.49
295_G306_A0.5540.49
252_V289_L0.5540.49
33_V78_D0.5540.49
355_R358_A0.5530.49
303_K328_D0.5530.49
41_P107_Q0.5520.49
100_Q104_F0.5520.49
8_A18_I0.5510.49
63_I114_S0.5500.49
25_D191_K0.5500.49
82_T142_T0.5490.49
256_C295_G0.5490.49
12_L152_C0.5490.49
48_A52_R0.5490.49
351_T357_I0.5490.49
79_S83_A0.5480.48
99_A164_M0.5460.48
335_G338_I0.5450.48
45_N54_L0.5450.48
48_A97_I0.5450.48
319_A323_L0.5440.48
334_I337_Q0.5440.48
35_L152_C0.5440.48
133_G333_G0.5440.48
58_P128_L0.5420.48
254_S356_K0.5420.48
268_D296_R0.5410.48
258_T307_Y0.5400.47
92_E108_A0.5400.47
294_E303_K0.5400.47
252_V365_L0.5390.47
258_T303_K0.5390.47
23_D191_K0.5390.47
267_C307_Y0.5380.47
34_A103_S0.5380.47
3_H187_M0.5360.47
64_A130_A0.5360.47
297_G328_D0.5350.47
31_D56_C0.5350.47
17_V51_G0.5340.47
335_G363_Y0.5330.47
258_T294_E0.5330.47
6_E199_N0.5330.47
316_T320_N0.5330.47
54_L168_G0.5320.46
194_I333_G0.5320.46
54_L164_M0.5320.46
31_D141_H0.5320.46
335_G359_G0.5300.46
267_C295_G0.5290.46
62_E156_G0.5290.46
348_K368_S0.5290.46
133_G362_G0.5270.46
247_P366_S0.5260.46
333_G338_I0.5250.46
107_Q110_L0.5250.46
218_T238_M0.5230.45
249_L280_I0.5220.45
274_H278_N0.5220.45
335_G358_A0.5200.45
195_Q364_G0.5200.45
35_L129_I0.5200.45
39_A159_V0.5200.45
77_T84_F0.5180.45
249_L284_G0.5180.45
258_T356_K0.5170.45
272_Q298_I0.5170.45
48_A126_F0.5160.44
19_I32_F0.5150.44
331_N334_I0.5130.44
254_S258_T0.5130.44
35_L149_A0.5130.44
228_V337_Q0.5120.44
316_T324_G0.5110.44
283_E371_V0.5110.44
213_P307_Y0.5110.44
71_P74_E0.5110.44
57_T157_A0.5110.44
210_I311_E0.5110.44
328_D356_K0.5100.44
5_I8_A0.5090.44
43_V110_L0.5080.43
165_N168_G0.5080.43
82_T170_M0.5080.43
258_T306_A0.5060.43
316_T356_K0.5060.43
263_G274_H0.5060.43
291_L373_L0.5040.43
52_R163_I0.5030.43
256_C360_L0.5030.43
298_I323_L0.5010.43
306_A316_T0.5010.43
337_Q362_G0.5010.43
69_L109_L0.5010.43
295_G299_G0.5000.43
295_G324_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i14A 2 0.804 100 0.119 Contact Map
4ffjA 2 0.4874 100 0.531 Contact Map
1k4iA 2 0.5101 100 0.537 Contact Map
4p6dA 2 0.4899 100 0.54 Contact Map
1g57A 2 0.505 100 0.542 Contact Map
3mioA 2 0.4774 100 0.542 Contact Map
1tksA 2 0.4849 100 0.547 Contact Map
1snnA 2 0.4925 100 0.55 Contact Map
2bz1A 2 0.4347 100 0.582 Contact Map
3ur8A 1 0.2085 53.6 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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