GREMLIN Database
YPUF - Uncharacterized protein YpuF
UniProt: P17617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 174 (168)
Sequences: 255 (212)
Seq/√Len: 16.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E16_T4.5531.00
44_G74_L3.5281.00
66_L69_N3.4240.99
124_C135_W3.0100.98
86_L115_I2.8100.98
12_E25_I2.7970.97
38_R47_Q2.7770.97
145_F149_K2.5270.95
26_L43_V2.4720.95
18_D24_E2.4470.94
161_E165_E2.4400.94
8_D127_E2.4270.94
47_Q66_L2.3260.93
48_L111_I2.2620.92
140_A143_N2.1340.89
34_P37_K2.0820.88
149_K165_E1.9730.85
163_E166_I1.9410.84
18_D21_E1.9370.84
21_E24_E1.9370.84
86_L113_L1.9280.83
57_R148_D1.9260.83
51_A66_L1.8640.81
65_R69_N1.8150.79
98_V111_I1.7870.78
117_D120_L1.7320.76
155_R162_R1.7200.75
64_K99_Y1.7050.75
55_H98_V1.6990.75
165_E169_R1.6980.74
55_H60_T1.6300.71
110_S139_S1.5850.69
141_L146_L1.5040.65
51_A67_M1.4800.64
48_L95_M1.4560.62
18_D120_L1.4530.62
24_E120_L1.4530.62
18_D149_K1.4500.62
24_E149_K1.4500.62
74_L121_E1.4360.61
45_F158_V1.4250.61
44_G73_I1.4100.60
11_V15_A1.4050.59
6_Y42_W1.3350.55
102_I110_S1.3190.55
14_H42_W1.2940.53
7_I124_C1.2830.52
47_Q52_L1.2820.52
47_Q50_V1.2730.52
38_R66_L1.2550.51
6_Y10_L1.2450.50
21_E120_L1.2110.48
108_Y136_G1.2100.48
19_Y70_S1.1970.47
49_A124_C1.1900.47
166_I170_K1.1820.46
43_V73_I1.1620.45
48_L91_L1.1500.45
14_H26_L1.1290.43
140_A146_L1.1210.43
48_L86_L1.1060.42
151_R169_R1.1050.42
10_L17_R1.1040.42
122_E148_D1.0960.42
17_R110_S1.0890.41
150_H153_R1.0590.39
18_D50_V1.0410.38
24_E50_V1.0410.38
154_D162_R1.0390.38
38_R69_N1.0350.38
155_R158_V1.0240.38
50_V128_C1.0200.37
102_I105_V1.0180.37
17_R108_Y1.0180.37
50_V85_G1.0150.37
18_D42_W1.0110.37
24_E42_W1.0110.37
25_I154_D1.0070.37
9_Y164_K0.9970.36
21_E149_K0.9870.35
31_K43_V0.9860.35
51_A99_Y0.9800.35
8_D148_D0.9730.35
2_Y6_Y0.9730.35
145_F152_L0.9670.34
14_H31_K0.9600.34
6_Y128_C0.9590.34
41_Y45_F0.9570.34
139_S143_N0.9550.34
15_A128_C0.9550.34
38_R52_L0.9540.34
13_F26_L0.9520.34
98_V109_K0.9450.33
3_P108_Y0.9350.33
3_P29_Y0.9350.33
63_A148_D0.9320.33
47_Q165_E0.9310.33
26_L113_L0.9300.32
121_E125_R0.9100.31
25_I149_K0.9040.31
34_P69_N0.8980.31
69_N165_E0.8940.31
31_K57_R0.8890.30
11_V40_R0.8820.30
37_K47_Q0.8770.30
154_D158_V0.8740.30
2_Y117_D0.8540.29
139_S146_L0.8530.29
70_S102_I0.8510.29
19_Y110_S0.8460.28
100_E122_E0.8450.28
10_L117_D0.8450.28
49_A74_L0.8440.28
42_W50_V0.8430.28
10_L120_L0.8390.28
6_Y117_D0.8280.27
133_Y143_N0.8230.27
10_L42_W0.8180.27
97_S122_E0.8160.27
71_I99_Y0.8120.27
106_S122_E0.8070.27
55_H108_Y0.8070.27
9_Y51_A0.8060.26
52_L55_H0.8040.26
115_I120_L0.8040.26
57_R114_P0.8020.26
36_K47_Q0.8020.26
5_A33_D0.8020.26
98_V101_Q0.8010.26
28_E158_V0.8000.26
37_K146_L0.7970.26
6_Y84_L0.7920.26
14_H114_P0.7900.26
81_V103_E0.7860.26
6_Y50_V0.7860.26
36_K50_V0.7850.26
45_F98_V0.7840.25
163_E167_E0.7820.25
75_Q96_Q0.7800.25
87_D130_K0.7720.25
145_F148_D0.7720.25
19_Y46_I0.7690.25
45_F84_L0.7680.25
165_E168_R0.7680.25
57_R150_H0.7580.24
60_T105_V0.7500.24
123_A168_R0.7490.24
4_K28_E0.7490.24
121_E127_E0.7470.24
61_A84_L0.7380.23
21_E42_W0.7340.23
100_E107_A0.7340.23
15_A124_C0.7320.23
156_T163_E0.7220.23
20_F23_H0.7210.23
57_R63_A0.7210.23
38_R41_Y0.7190.23
29_Y151_R0.7160.23
28_E162_R0.7120.22
18_D91_L0.7120.22
24_E91_L0.7120.22
4_K8_D0.7120.22
57_R155_R0.7060.22
7_I76_A0.7030.22
12_E159_I0.7020.22
102_I108_Y0.7010.22
10_L21_E0.6960.22
166_I169_R0.6950.22
33_D37_K0.6900.22
137_Q156_T0.6890.21
123_A160_R0.6820.21
3_P42_W0.6760.21
9_Y160_R0.6750.21
34_P121_E0.6730.21
26_L46_I0.6730.21
2_Y10_L0.6690.21
7_I28_E0.6610.20
17_R112_I0.6590.20
47_Q149_K0.6560.20
92_L126_I0.6530.20
33_D39_K0.6530.20
19_Y26_L0.6510.20
10_L18_D0.6510.20
10_L24_E0.6510.20
21_E50_V0.6450.20
146_L149_K0.6440.20
101_Q106_S0.6420.20
34_P149_K0.6390.20
70_S97_S0.6370.19
44_G70_S0.6310.19
67_M102_I0.6280.19
126_I168_R0.6270.19
35_P106_S0.6260.19
7_I142_S0.6230.19
25_I123_A0.6190.19
98_V108_Y0.6180.19
4_K148_D0.6100.19
25_I73_I0.6020.18
53_Y63_A0.6010.18
14_H43_V0.5950.18
140_A164_K0.5930.18
9_Y17_R0.5900.18
15_A67_M0.5890.18
94_L112_I0.5890.18
7_I32_E0.5880.18
9_Y28_E0.5870.18
138_P143_N0.5860.18
134_T137_Q0.5840.18
48_L113_L0.5820.18
52_L149_K0.5820.18
55_H67_M0.5820.18
82_E157_D0.5810.18
9_Y110_S0.5750.17
10_L50_V0.5750.17
75_Q93_E0.5750.17
5_A147_I0.5690.17
44_G66_L0.5670.17
45_F96_Q0.5650.17
48_L152_L0.5630.17
13_F44_G0.5610.17
67_M107_A0.5590.17
66_L70_S0.5550.17
39_K76_A0.5550.17
52_L165_E0.5530.17
70_S111_I0.5520.17
59_N150_H0.5500.16
12_E136_G0.5490.16
94_L114_P0.5450.16
35_P160_R0.5440.16
32_E121_E0.5370.16
17_R124_C0.5370.16
136_G170_K0.5370.16
14_H84_L0.5360.16
9_Y61_A0.5350.16
68_A103_E0.5350.16
158_V161_E0.5330.16
158_V165_E0.5330.16
5_A14_H0.5310.16
6_Y21_E0.5280.16
153_R162_R0.5250.16
86_L118_E0.5220.16
17_R128_C0.5190.16
138_P144_I0.5170.15
142_S146_L0.5160.15
95_M119_K0.5160.15
21_E47_Q0.5140.15
48_L120_L0.5140.15
37_K40_R0.5100.15
93_E97_S0.5020.15
44_G91_L0.5020.15
26_L73_I0.5020.15
43_V77_E0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ijqA 1 0.7356 100 0.641 Contact Map
2cwyA 1 0.5402 99.9 0.684 Contact Map
4rykA 2 0.5747 77.2 0.94 Contact Map
4bt9A 2 0.5287 66.8 0.945 Contact Map
1qqeA 1 0.6782 65.5 0.945 Contact Map
3ro3A 1 0.4368 52.9 0.949 Contact Map
3ro2A 1 0.4138 43.1 0.952 Contact Map
1tjcA 2 0.523 43 0.952 Contact Map
4h7yA 1 0.5287 41.9 0.952 Contact Map
3nf1A 1 0.4195 41.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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