GREMLIN Database
AADK - Aminoglycoside 6-adenylyltransferase
UniProt: P17585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (272)
Sequences: 415 (298)
Seq/√Len: 18.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_R269_D6.4591.00
22_R128_D5.5351.00
67_K95_E4.9941.00
63_E68_R4.6531.00
193_M257_V3.9041.00
162_V165_Y3.8631.00
226_E252_K3.4081.00
179_I183_N3.2470.99
198_I215_M3.1580.99
233_V238_E2.9240.99
27_E46_S2.8820.99
149_A153_D2.5940.97
187_R230_T2.4980.96
99_K161_M2.4610.96
27_E121_V2.4330.96
173_N216_K2.3740.95
269_D273_T2.3540.95
15_A24_V2.3480.95
92_I100_L2.3080.94
14_F64_I2.2820.94
75_E154_D2.1860.92
195_A208_M2.1480.92
175_I228_M2.1200.91
180_D211_N2.0450.89
251_R273_T2.0190.89
162_V181_H2.0020.88
190_L249_L1.9410.87
120_L139_D1.9220.86
89_S103_T1.8740.85
194_M253_Y1.8630.84
7_M98_N1.8410.84
32_N120_L1.8240.83
25_T123_V1.7770.81
92_I102_L1.7700.81
169_G177_F1.7670.81
167_V276_T1.7480.80
254_S265_Y1.7450.80
195_A212_Y1.7340.80
29_S44_D1.7290.80
194_M215_M1.7290.80
165_Y181_H1.7050.79
7_M47_Y1.6840.78
175_I179_I1.6610.77
13_D17_N1.6390.76
147_P196_W1.6390.76
158_E189_N1.6280.75
191_L227_L1.6180.75
119_G141_Q1.6110.74
5_Q9_D1.6010.74
197_H223_E1.5920.74
265_Y269_D1.5790.73
69_I266_P1.5750.73
12_L24_V1.5700.72
59_D73_K1.5470.71
40_F171_A1.5380.71
197_H256_A1.5260.70
34_N120_L1.5180.70
152_F258_S1.5160.70
75_E84_L1.4760.68
244_F276_T1.4500.66
146_R261_L1.4480.66
27_E99_K1.4010.63
105_I113_Y1.4000.63
59_D90_Y1.3790.62
26_L31_T1.3570.61
95_E271_G1.3340.60
169_G213_K1.3320.59
47_Y98_N1.3290.59
255_K267_D1.3190.59
183_N187_R1.3090.58
26_L45_I1.2920.57
119_G212_Y1.2890.57
91_I158_E1.2830.56
187_R210_K1.2740.56
42_D101_D1.2660.55
25_T46_S1.2580.55
11_F152_F1.2400.54
44_D101_D1.2390.54
163_S243_L1.2390.54
30_R94_F1.2360.54
88_F106_P1.2310.53
7_M11_F1.1990.51
4_E30_R1.1950.51
247_Y276_T1.1880.51
32_N210_K1.1860.51
27_E118_D1.1780.50
52_V104_L1.1780.50
167_V240_W1.1770.50
32_N209_G1.1670.49
27_E119_G1.1660.49
164_T272_I1.1650.49
5_Q129_S1.1590.49
93_L275_Y1.1570.49
112_D217_R1.1550.49
28_G42_D1.1510.48
3_S150_R1.1500.48
61_W167_V1.1480.48
159_F250_F1.1330.47
58_N262_A1.1240.47
19_E22_R1.1160.46
139_D143_W1.1140.46
275_Y278_G1.1080.46
72_Q158_E1.1000.45
29_S101_D1.0940.45
170_L174_E1.0850.44
262_A270_E1.0840.44
32_N118_D1.0840.44
61_W160_W1.0680.43
21_I59_D1.0620.43
28_G101_D1.0550.43
3_S261_L1.0540.42
49_V169_G1.0440.42
72_Q169_G1.0420.42
155_C193_M1.0410.42
24_V27_E1.0390.42
199_A204_Y1.0280.41
52_V89_S1.0260.41
223_E253_Y1.0260.41
35_I242_S1.0220.41
38_D42_D1.0160.40
62_L177_F1.0160.40
259_E262_A1.0140.40
149_A263_Y1.0130.40
114_F123_V1.0090.40
194_M198_I1.0080.40
4_E37_P0.9940.39
28_G172_R0.9940.39
46_S121_V0.9900.39
247_Y273_T0.9890.39
145_K264_K0.9850.38
67_K277_E0.9780.38
189_N192_R0.9760.38
34_N139_D0.9760.38
70_M272_I0.9750.38
91_I157_N0.9740.38
31_T114_F0.9730.38
216_K236_Y0.9700.37
178_A243_L0.9700.37
14_F35_I0.9670.37
144_I259_E0.9620.37
25_T121_V0.9610.37
42_D172_R0.9580.37
101_D172_R0.9510.36
2_R94_F0.9490.36
91_I161_M0.9450.36
32_N35_I0.9430.36
72_Q99_K0.9430.36
62_L73_K0.9430.36
73_K88_F0.9340.35
143_W207_S0.9320.35
38_D101_D0.9300.35
74_P204_Y0.9250.35
149_A264_K0.9220.35
9_D13_D0.9160.34
95_E171_A0.9140.34
2_R6_E0.9100.34
72_Q91_I0.9070.34
39_N171_A0.9070.34
107_I151_E0.9020.34
23_L107_I0.8970.33
81_P154_D0.8970.33
1_M6_E0.8940.33
107_I173_N0.8890.33
41_Q231_Y0.8890.33
12_L125_L0.8880.33
220_S223_E0.8820.33
93_L178_A0.8810.32
221_N225_E0.8780.32
88_F162_V0.8780.32
3_S16_L0.8760.32
177_F181_H0.8750.32
112_D231_Y0.8740.32
267_D270_E0.8700.32
16_L268_Y0.8670.32
181_H227_L0.8660.32
119_G138_N0.8660.32
251_R265_Y0.8590.31
274_K278_G0.8580.31
170_L240_W0.8560.31
72_Q209_G0.8490.31
119_G207_S0.8480.31
72_Q102_L0.8430.30
70_M73_K0.8410.30
155_C250_F0.8400.30
4_E94_F0.8390.30
136_T145_K0.8360.30
101_D168_K0.8330.30
139_D207_S0.8280.30
120_L209_G0.8260.30
197_H220_S0.8230.29
29_S42_D0.8210.29
165_Y177_F0.8200.29
163_S247_Y0.8200.29
123_V246_C0.8140.29
129_S217_R0.8140.29
118_D142_Y0.8120.29
51_D54_S0.8090.29
2_R92_I0.8040.28
161_M177_F0.7990.28
30_R43_Y0.7960.28
173_N236_Y0.7940.28
162_V185_I0.7910.28
75_E87_W0.7910.28
34_N217_R0.7890.28
136_T245_T0.7800.27
38_D44_D0.7770.27
214_F257_V0.7730.27
160_W269_D0.7710.27
91_I99_K0.7710.27
98_N219_L0.7650.27
89_S189_N0.7610.26
66_G168_K0.7590.26
171_A278_G0.7570.26
71_M228_M0.7530.26
225_E263_Y0.7530.26
202_K253_Y0.7510.26
85_G256_A0.7480.26
170_L234_N0.7470.26
143_W180_D0.7340.25
91_I97_G0.7330.25
46_S99_K0.7330.25
176_L181_H0.7330.25
67_K259_E0.7320.25
9_D233_V0.7310.25
69_I235_G0.7310.25
17_N129_S0.7300.25
10_I47_Y0.7280.25
237_Q258_S0.7270.25
9_D148_T0.7260.25
42_D168_K0.7260.25
200_S204_Y0.7230.25
268_Y277_E0.7210.24
10_I92_I0.7190.24
10_I14_F0.7180.24
110_A114_F0.7170.24
252_K262_A0.7160.24
123_V218_Y0.7140.24
119_G140_R0.7090.24
87_W105_I0.7090.24
85_G165_Y0.7080.24
74_P88_F0.7060.24
32_N187_R0.7020.24
2_R30_R0.7010.24
239_M242_S0.7000.24
54_S58_N0.6990.24
221_N235_G0.6960.23
263_Y269_D0.6960.23
216_K263_Y0.6950.23
189_N232_S0.6910.23
178_A227_L0.6910.23
44_D168_K0.6900.23
2_R96_D0.6850.23
201_Q238_E0.6830.23
7_M214_F0.6820.23
151_E225_E0.6800.23
165_Y169_G0.6770.23
266_P269_D0.6710.22
114_F134_K0.6710.22
225_E238_E0.6700.22
108_R149_A0.6700.22
148_T184_E0.6700.22
43_Y209_G0.6670.22
44_D172_R0.6650.22
48_F148_T0.6630.22
208_M212_Y0.6620.22
141_Q276_T0.6610.22
5_Q255_K0.6560.22
190_L224_W0.6540.22
102_L213_K0.6510.21
69_I93_L0.6470.21
237_Q262_A0.6460.21
65_F96_D0.6450.21
27_E48_F0.6440.21
99_K177_F0.6440.21
20_R54_S0.6440.21
75_E89_S0.6430.21
43_Y65_F0.6420.21
162_V186_V0.6420.21
28_G38_D0.6380.21
90_Y218_Y0.6350.21
117_N202_K0.6350.21
28_G44_D0.6350.21
92_I275_Y0.6340.21
176_L227_L0.6320.21
251_R266_P0.6310.21
255_K277_E0.6310.21
99_K209_G0.6290.21
52_V56_K0.6280.21
41_Q210_K0.6280.21
61_W94_F0.6240.20
186_V223_E0.6200.20
142_Y209_G0.6190.20
120_L141_Q0.6190.20
56_K119_G0.6160.20
5_Q242_S0.6150.20
126_D172_R0.6150.20
242_S245_T0.6130.20
121_V134_K0.6130.20
155_C189_N0.6130.20
17_N264_K0.6110.20
57_E235_G0.6090.20
91_I169_G0.6070.20
25_T48_F0.6070.20
73_K103_T0.6050.20
221_N264_K0.6050.20
195_A234_N0.6040.20
157_N193_M0.6040.20
168_K172_R0.6030.20
49_V209_G0.6020.19
30_R126_D0.5990.19
66_G172_R0.5980.19
23_L177_F0.5970.19
69_I278_G0.5960.19
57_E148_T0.5950.19
149_A217_R0.5950.19
198_I253_Y0.5930.19
169_G214_F0.5930.19
230_T242_S0.5910.19
186_V189_N0.5900.19
167_V179_I0.5900.19
38_D172_R0.5900.19
86_N100_L0.5870.19
86_N278_G0.5860.19
53_E57_E0.5860.19
45_I54_S0.5840.19
212_Y276_T0.5840.19
65_F218_Y0.5830.19
236_Y257_V0.5820.19
183_N233_V0.5820.19
25_T89_S0.5810.19
2_R43_Y0.5800.19
99_K168_K0.5780.19
104_L243_L0.5760.18
45_I195_A0.5750.18
74_P91_I0.5740.18
107_I226_E0.5730.18
25_T103_T0.5720.18
136_T193_M0.5700.18
17_N53_E0.5700.18
47_Y204_Y0.5700.18
106_P243_L0.5690.18
130_F140_R0.5690.18
3_S215_M0.5680.18
175_I263_Y0.5670.18
102_L169_G0.5670.18
41_Q209_G0.5660.18
99_K169_G0.5650.18
179_I232_S0.5630.18
57_E112_D0.5630.18
228_M236_Y0.5620.18
167_V181_H0.5590.18
21_I117_N0.5580.18
39_N278_G0.5580.18
47_Y275_Y0.5570.18
37_P43_Y0.5550.18
204_Y250_F0.5530.18
3_S6_E0.5520.18
18_D24_V0.5510.18
214_F265_Y0.5500.18
6_E146_R0.5500.18
72_Q213_K0.5490.18
119_G174_E0.5480.17
169_G209_G0.5470.17
175_I236_Y0.5470.17
26_L210_K0.5430.17
68_R92_I0.5420.17
20_R55_F0.5410.17
182_L216_K0.5390.17
92_I96_D0.5390.17
204_Y261_L0.5390.17
35_I214_F0.5340.17
72_Q165_Y0.5340.17
70_M146_R0.5330.17
148_T274_K0.5330.17
117_N141_Q0.5320.17
129_S140_R0.5320.17
102_L142_Y0.5300.17
164_T275_Y0.5300.17
157_N168_K0.5280.17
142_Y155_C0.5260.17
158_E186_V0.5260.17
8_M26_L0.5250.17
221_N267_D0.5230.17
94_F142_Y0.5210.17
60_Q267_D0.5210.17
29_S172_R0.5210.17
170_L186_V0.5200.17
176_L224_W0.5190.16
88_F102_L0.5170.16
225_E259_E0.5160.16
14_F266_P0.5150.16
68_R104_L0.5150.16
121_V178_A0.5140.16
29_S38_D0.5140.16
75_E192_R0.5140.16
22_R127_K0.5130.16
94_F131_I0.5130.16
90_Y243_L0.5120.16
262_A274_K0.5080.16
268_Y271_G0.5060.16
152_F252_K0.5050.16
86_N134_K0.5040.16
148_T229_S0.5030.16
156_C250_F0.5020.16
232_S238_E0.5020.16
203_G263_Y0.5020.16
73_K104_L0.5020.16
40_F190_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pbeA 1 0.9261 100 0.249 Contact Map
3jz0A 2 0.9049 100 0.478 Contact Map
1knyA 2 0.7887 98.2 0.908 Contact Map
1no5A 4 0.3345 96.3 0.934 Contact Map
4ebjA 2 0.8627 95.3 0.938 Contact Map
2rffA 1 0.331 93.9 0.943 Contact Map
1wotA 1 0.3275 93.7 0.943 Contact Map
3c18A 2 0.8169 93.4 0.944 Contact Map
1ylqA 2 0.3134 92.5 0.946 Contact Map
4cs6A 1 0.7852 85.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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